prof. dr. L.P.H. (Luke) Leenen

prof. dr. L.P.H. (Luke) Leenen

Full Professor
prof. dr. L.P.H. (Luke) Leenen
  • Division of Surgical Specialties

Research Programs

Infection & Immunity



Luke PH Leenen (1957) graduated from medical school of the Radboud University in Nijmegen in 1982. From 1980 until 1985 he was a research fellow in the anatomical department of the Radboud University. He earned his PhD (1985) in basic neuroanatomical research on an electron microscopical analysis of the pyramidal tract of the rat.

From 1985 until 1988 he trained as a surgical resident at the Radboud University Hospital Nijmegen (Program director: Prof de Boer, later Prof Goris). He continued (1988-1991) his training in the Elisabeth Hospital Tilburg (Prof van Vroonhoven, later Prof vd Werken). After completion of his residency he visited Prof Waneboo in Providence for a oncology fellowship, followed by a AO fellowship in Chur (CH) with Prof Ruedi. From 1992 on he was staff surgeon at the Canisius Hospital Nijmegen responsible for Trauma and was appointed director of the Emergency Department.

From June 1993 he returned to Tilburg as a staff surgeon responsible for Trauma and Intensive Care.
He went to Utrecht in 1999 as a staff surgeon for Trauma and Intensive Care. He is the director for Surgical Intensive Care (until 2005), Emergency Department and the Major Incident Hospital (Calamiteitenhospitaal). In 2000 he was appointed professor of “Integral quality management in hospitals”. In 2002 he was appointed Professor of Trauma

Side Activities

Secretary of the Dutch Trauma Society (1993-1999)

Founding board member and secretary of the European Trauma Society (currently ESTES). European Society of Trauma and Emergency Surgery  ( past president

Board member of the World Coalition for the care of Trauma. 
founding father of the Dutch ATLS foundation.

Chairman of the Dutch Advanced Life Support Group

Member of the supervisory board of the Regional Ambulance service (RAVU).
part of the group reengineering the Dutch Medical Disaster organization (GHOR) (1995-1999)

Research Output (273)

An increase in CD62Ldim neutrophils precedes the development of pulmonary embolisms in COVID-19 patients

Spijkerman Roy, Jorritsma Nikita Kn, Bongers Suzanne H, Bindels Bas Jj, Jukema Bernard N, Hesselink Lillian, Hietbrink Falco, Leenen Luke Ph, van Goor Harriët Mr, Vrisekoop N, Kaasjager Karin Ah, Koenderman Leo, , Cremer Olaf 22 jan 2021, In: Scandinavian Journal of Immunology. 93 8 p.

Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation:A normal response to an abnormal situation

Spijkerman Roy, Bongers Suzanne H, Bindels Bas J J, Tinnevelt Gerjen H, Giustarini Giulio, Jorritsma Nikita K N, Buitenwerf Wiebe, van Spengler Daan E J, Delemarre Eveline M, Nierkens Stefan, van Goor Harriët M R, Jansen Jeroen J, Vrisekoop Nienke, Hietbrink Falco, Leenen Luke P H, Kaasjager Karin A H, Koenderman Leo, jan 2021, In: Journal of Leukocyte Biology. 109 , p. 99-114 16 p.

Dilemma of crystalloid resuscitation in non-exsanguinating polytrauma:What is too much?

Van Wessem Karlijn, Hietbrink Falco, Leenen Luke 28 okt 2020, In: Trauma Surgery and Acute Care Open. 5 , p. 1-7

Global changes in mortality rates in polytrauma patients admitted to the ICU - A systematic review

Van Breugel Johanna M.M., Niemeyer Menco J.S., Houwert Roderick M., Groenwold Rolf H.H., Leenen Luke P.H., Van Wessem Karlijn J.P. 30 sep 2020, In: World Journal of Emergency Surgery. 15

Point-of-Care Analysis of Neutrophil Phenotypes:A First Step Toward Immuno-Based Precision Medicine in the Trauma ICU

Spijkerman Roy, Hesselink Lillian, Bongers Suzanne, van Wessem Karlijn J P, Vrisekoop Nienke, Hietbrink Falco, Koenderman Leo, Leenen Luke P H jul 2020, In: Critical care explorations. 2 9 p.

The evolution of trauma care in the Netherlands over 20 years

Hietbrink Falco, Houwert Roderick M., van Wessem Karlijn J.P., Simmermacher Rogier K.J., Govaert Geertje A.M., de Jong Mirjam B., de Bruin Ivar G.J., de Graaf Johan, Leenen Loek P.H. 1 apr 2020, In: European Journal of Trauma and Emergency Surgery. 46 , p. 329-335 7 p.

New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma

Hesselink Lillian, Spijkerman Roy, de Fraiture Emma, Bongers Suzanne, Van Wessem Karlijn J P, Vrisekoop Nienke, Koenderman Leo, Leenen Luke P H, Hietbrink Falco 14 mrt 2020, In: Intensive Care Medicine Experimental. 8 , p. 1-12

Attenuation of MODS-related and ARDS-related mortality makes infectious complications a remaining challenge in the severely injured

Van Wessem Karlijn J.P., Hietbrink Falco, Leenen Luke P.H. 4 feb 2020, In: Trauma Surgery and Acute Care Open. 5 , p. 1-6

The role of emergency medical service providers in the decision-making process of prehospital trauma triage

van Rein Eveline A.J., Sadiqi Said, Lansink Koen W.W., Lichtveld Rob A., van Vliet Risco, Oner F. Cumhur, Leenen Luke P.H., van Heijl Mark 1 feb 2020, In: European Journal of Trauma and Emergency Surgery. 46 , p. 131-146 16 p.

Persistent inflammation, immunosuppression and catabolism syndrome (PICS) after polytrauma:A rare syndrome with major consequences

Hesselink Lillian, Hoepelman Ruben J., Spijkerman Roy, de Groot Mark C.H., van Wessem Karlijn J.P., Koenderman Leo, Leenen Luke P.H., Hietbrink Falco 10 jan 2020, In: Journal of Clinical medicine. 9 13 p.

All research output

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