dr. F.S.S. (Frans) Leijten

Associate Professor - medical
dr. F.S.S. (Frans) Leijten
  • Neurologen

Research Programs




Dr. Frans S.S. Leijten (1960) studied medicine at Utrecht University and obtained his MD in 1986. He became a neurologist and clinical neurophysiologist in 1994. In 1996 he defended his PhD thesis on critical illness polyneuropathy at Leiden University. He worked as an epileptologist at epilepsy center SEIN, then called Meer en Bosch, in Heemstede, from 1994-1996. Since then, he has been working at the University Medical Center Utrecht, where he is now head of the EEG department and the monitoring unit for invasive EEG recordings. He is also chairman of the National Dutch Epilepsy Surgery Taskforce. He is a member of the European Childhood Epilepsy Surgery Group U-TASK and of the European Network for Epilepsy Research ENER. He is a member of the Consilium Neurologicum, responsible for the education of neurology residents in the Netherlands. He has received various educational awards and is a well-known speaker at congresses.

Research line

His research focuses on intractable focal epilepsy and epilepsy surgery. His team explored the clinical use of new advanced neuroimaging methods, clinical decision-making in focal epilepsy, quality-of-life and coping issues in intractable epilepsy, and new treatments. He is engaged in a national collaboration which led to the develop a device to detect seizures during the night (Nightwatch). Recent research focuses on networks in the intracranial EEG measured on the cortex. Together with the department of Applied Mathematics of Twente University, he is engaged in developing a neural mass computer model that can represent the epileptic cortex of individual patients. For a demonstration tool, look at .

Using epileptic network knowledge, he has started a clinical trial of closed loop cortical stimulation in patients with intractable epilepsy in the primary sensorimotor cortex. Dr Leijten has over 150 publications in peer-review journals and is the editor of a Dutch textbook on clinical epilepsy. 

Most recent key publications

1: Demuru M, Kalitzin S, Zweiphenning W, Van Blooijs D, Van ’t Klooster M,  Van Eijsden P, Leijten F, Zijlmans M, on behalf of the RESPECT group. The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from  group-level to patient-level analysis. Sci Rep 2020;10:14654.

2: Hebbink J, Huiskamp G, Van Gils SA, Leijten FSS, Meijer HGE. Pathological responses to single pulse electrical stimuli in epilepsy: the role of feedforward inhibition. Eur J Neurosci 2020;51:1122-36.

3: Arends JBAM, Thijs RD, Gutter T, Ungureanu C, Cluitmans P, Van Dijk J, Van Andel J, Tan F, De Weerd A, Vledder B, Hofstra W, Lazeron R,  Van Thiel G, Roes KCB, Leijten F, and the Dutch Tele-Epilepsy Consortium. Multimodal nocturnal seizure detection in a residential care setting: a long-term prospective trial. Neurology 2018;91:e2010-9.

4: Van Blooijs D, Leijten FSS, Van Rijen PC, Meijer HGE, Huiskamp GJM. Evoked directional network characteristics of epileptogenic tissue derived from Single Pulse Electrical Stimulation. Hum Brain Mapp 2018;39:4611-22.

5: Hebbink J, Meijer H, Huiskamp GJ, Van Gils S, Leijten FS. Phenomenological network models: lessons for epilepsy surgery. Epilepsia 2017;58:e147-51.


2020 SKO (Senior Teaching Qualification)

Fellowship and Awards

1: 2020 ZonMW parel for neural mass research

2: 2012 Editor's Choice of best publication in NeuroImage

3: 2012 Editor's Choice of best publication in Human Brain Mapping

4: 2009 SUMMA medical teacher of the year

5: 2004 VAANdrager national prize for best teacher in Neurology 

Research Output (207)

Detailed somatotopy of tongue movement in the human sensorimotor cortex:A case study

Schippers Anouck, Vansteensel Mariska J, Freudenburg Zachary V, Leijten Frans S S, Ramsey Nick F 19 jan 2021, In: Brain stimulation. 14 , p. 287-289 3 p.

Corticosteroids versus clobazam in epileptic encephalopathy with ESES:a European multicentre randomised controlled clinical trial (RESCUE ESES*)

van den Munckhof Bart, Arzimanoglou Alexis, Perucca Emilio, van Teeseling Heleen C, Leijten Frans S S, Braun Kees P J, Jansen Floor E, 23 nov 2020, In: Trials. 21 , p. 1-11

Validation of virtual resection on intraoperative interictal data acquired during epilepsy surgery

Demuru Matteo, Zweiphenning Willemiek, van Blooijs Dorien, Van Eijsden Pieter, Leijten Frans, Zijlmans Maeike, Kalitzin Stiliyan 21 okt 2020, In: Journal of Neural Engineering. 17 , p. 1-10

The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery:from group-level to patient-level analysis

Demuru Matteo, Kalitzin Stiliyan, Zweiphenning Willemiek, van Blooijs Dorien, van’t Klooster Maryse, Van Eijsden Pieter, Leijten Frans, Zijlmans Maeike, Braun Kees, Ferrier Cyrille, Gebbink Tineke, Gosselaar Peter, Huiskamp Geertjan, van Klink Nicole, Ophorst Janine, van Rijen Peter, van der Salm Sandra, Winter Anouk Velders de, 4 sep 2020, In: Scientific Reports. 10

Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis:a retrospective multicentre cohort study

Lamberink Herm J., Otte Willem M., Blümcke Ingmar, Braun Kees PJ, Aichholzer Martin, Amorim Isabel, Aparicio Javier, Aronica Eleonora, Arzimanoglou Alexis, Barba Carmen, Beck Jürgen, Becker Albert, Beckervordersandforth Jan C., Bien Christian G., Bodi Istvan, Braun Kees PJ, Catenoix Helene, Chassoux Francine, Chipaux Mathilde, Cloppenborg Thomas, Coras Roland, Cross J. Helen, De Palma Luca, De Tisi Jane, Deleo Francesco, Devaux Bertrand, Di Gennaro Giancarlo, Dorfmüller Georg, Duncan John S., Elger Christian, Ernst Katharina, Esposito Vincenzo, Feucht Martha, Gadze Zeljka Petelin, Garbelli Rita, Geleijns Karin, Gil-Nagel Antonio, Grote Alexander, Grunwald Thomas, Guerrini Renzo, Hamer Hajo, Honavar Mrinalini, Jacques Thomas S., Jakovcevic Antonia, Kalina Adam, Jansen Floor, Leijten Frans, van Rijen Peter, Spliet Wim GM, Mühlebner Angelika, , , sep 2020, In: The Lancet Neurology. 19 , p. 748-757 10 p.

Intracranial Recordings Reveal Unique Shape and Timing of Responses in Human Visual Cortex during Illusory Visual Events

de Jong Maartje C, Vansteensel Mariska J, van Ee Raymond, Leijten Frans S S, Ramsey Nick F, Dijkerman H Chris, Dumoulin Serge O, Knapen Tomas 22 jun 2020, In: Current Biology. 30 , p. 3089-3100.e4

Sleep slow wave homeostasis and cognitive functioning in children with electrical status epilepticus in sleep

van den Munckhof Bart, Gefferie Silvano R, van Noort Suus A M, van Teeseling Heleen C, Schijvens Mischa P, Smit William, Teunissen Nico W, Plate Joost D J, Huiskamp Geert Jan M, Leijten Frans S S, Braun Kees P J, Jansen Floor E, Bölsterli Bigna K 6 mei 2020, In: Sleep. 43 , p. 1-9

The resolution revolution:Comparing spikes and high frequency oscillations in high-density and standard intra-operative electrocorticography of the same patient

Zweiphenning Willemiek J E M, van Diessen Eric, Aarnoutse Erik J, Leijten Frans S S, van Rijen Peter C, Braun Kees P J, Zijlmans Maeike 2 mrt 2020, In: Clinical Neurophysiology. 131 , p. 1040-1043 4 p.

Perinatal thalamic injury: MRI predictors of electrical status epilepticus in sleep and long-term neurodevelopment

van den Munckhof Bart, Zwart Anne F, Weeke Lauren C, Claessens Nathalie H P, Plate Joost D J, Leemans Alexander, Kuijf Hugo J, van Teeseling Heleen C, Leijten Frans S S, Benders Manon J N, Braun Kees P J, de Vries Linda S, Jansen Floor E 25 feb 2020, In: NeuroImage. Clinical. 26 9 p.

Electrocorticographic dissociation of alpha and beta rhythmic activity in the human sensorimotor system

Stolk Arjen, Brinkman Loek, Van Steensel Mariska J, Aarnoutse Erik, Leijten Frans Ss, Dijkerman Chris H, Knight Robert T, de Lange Floris P, Toni Ivan 1 okt 2019, In: eLife. 8

All research output

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