dr. F.S.S. Leijten

dr. F.S.S. Leijten

Assistant Professor
dr. F.S.S. Leijten
  • Neurologen

Research Programs




Dr. Frans S.S. Leijten (1960) studied medicine at Utrecht University and obtained his MD in 1986. He became a neurologist and clinical neurophysiologist in 1994. In 1996 he defended his PhD thesis on critical illness polyneuropathy at Leiden University. He worked as an epileptologist at epilepsy center SEIN, then called Meer en Bosch, in Heemstede, from 1994-1996. Since then, he has been working at the University Medical Center Utrecht, where he is now head of the EEG department and the monitoring unit for invasive EEG recordings. He is also chairman of the National Dutch Epilepsy Surgery Taskforce. He is a member of the European Childhood Epilepsy Surgery Group U-TASK and of the European Network for Epilepsy Research ENER. He is a member of the Consilium Neurologicum, responsible for the education of neurology residents in the Netherlands. He has received various educational awards and is a well-known speaker at congresses.

Research line

His research focuses on intractable focal epilepsy and epilepsy surgery. His team explored the clinical use of new advanced neuroimaging methods, clinical decision-making in focal epilepsy, quality-of-life and coping issues in intractable epilepsy, and new treatments. He is engaged in a national collaboration which led to the develop a device to detect seizures during the night (Nightwatch). Recent research focuses on networks in the intracranial EEG measured on the cortex. Together with the department of Applied Mathematics of Twente University, he is engaged in developing a neural mass computer model that can represent the epileptic cortex of individual patients. For a demonstration tool, look at .

Using epileptic network knowledge, he has started a clinical trial of closed loop cortical stimulation in patients with intractable epilepsy in the primary sensorimotor cortex. Dr Leijten has over 150 publications in peer-review journals and is the editor of a Dutch textbook on clinical epilepsy. 

Most recent key publications

1: Demuru M, Kalitzin S, Zweiphenning W, Van Blooijs D, Van ’t Klooster M,  Van Eijsden P, Leijten F, Zijlmans M, on behalf of the RESPECT group. The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from  group-level to patient-level analysis. Sci Rep 2020;10:14654.

2: Hebbink J, Huiskamp G, Van Gils SA, Leijten FSS, Meijer HGE. Pathological responses to single pulse electrical stimuli in epilepsy: the role of feedforward inhibition. Eur J Neurosci 2020;51:1122-36.

3: Arends JBAM, Thijs RD, Gutter T, Ungureanu C, Cluitmans P, Van Dijk J, Van Andel J, Tan F, De Weerd A, Vledder B, Hofstra W, Lazeron R,  Van Thiel G, Roes KCB, Leijten F, and the Dutch Tele-Epilepsy Consortium. Multimodal nocturnal seizure detection in a residential care setting: a long-term prospective trial. Neurology 2018;91:e2010-9.

4: Van Blooijs D, Leijten FSS, Van Rijen PC, Meijer HGE, Huiskamp GJM. Evoked directional network characteristics of epileptogenic tissue derived from Single Pulse Electrical Stimulation. Hum Brain Mapp 2018;39:4611-22.

5: Hebbink J, Meijer H, Huiskamp GJ, Van Gils S, Leijten FS. Phenomenological network models: lessons for epilepsy surgery. Epilepsia 2017;58:e147-51.


2020 SKO (Senior Teaching Qualification)

Side Activities

(1) I am chair of the TeleEpilepsy consortium that has developed a medical device to detect nocturnal motor seizures, NightWatch, together with a commercial partner, LivAssured. There are no direct financial ties, but a percentage of future profit from the sales of NightWatch will be made available to the consortium for further research in epilepsy.

(2)  I am a consultant of and hold shares in ProLira, a start-up company that developed DeltaScan, a device to detect delirium making use of EEG technology.

Fellowship and Awards

1: 2020 ZonMW parel for neural mass research

2: 2012 Editor's Choice of best publication in NeuroImage

3: 2012 Editor's Choice of best publication in Human Brain Mapping

4: 2009 SUMMA medical teacher of the year

5: 2004 VAANdrager national prize for best teacher in Neurology 

Research Output (219)

Multimodal nocturnal seizure detection in children with epilepsy:a prospective, multicenter, long-term, in-home trial

van Westrhenen Anouk, Lazeron Richard H C, van Dijk Johannes P, Leijten Frans S S, Thijs Roland D, 17 May 2023, In: Epilepsia. 64 , p. 2137-2152 16 p.

Developmental trajectory of transmission speed in the human brain

van Blooijs Dorien, van den Boom Max A, van der Aar Jaap F, Huiskamp Geertjan M, Castegnaro Giulio, Demuru Matteo, Zweiphenning Willemiek J E M, van Eijsden Pieter, Miller Kai J, Leijten Frans S S, Hermes Dora 9 Mar 2023, In: Nature Neuroscience. 26 , p. 537-541 5 p.

Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial):a randomised, single-blind, adaptive non-inferiority trial

Zweiphenning Willemiek, Klooster Maryse A.van t., van Klink Nicole E.C., Leijten Frans S.S., Ferrier Cyrille H., Gebbink Tineke, Huiskamp Geertjan, van Zandvoort Martine J.E., van Schooneveld Monique M.J., Bourez M., Goemans Sophie, Straumann Sven, van Rijen Peter C., Gosselaar Peter H., van Eijsden Pieter, Otte Willem M., van Diessen Eric, Braun Kees P.J., Zijlmans Maeike, Bloemen-Carlier Eltje M., Cibulková Veronika, de Munnink Renee, van der Salm Sandra, Eijkemans Martinus J.C., Ophorst-van Eck Janine M., Velders Anouk, van Asch Charlotte J.J., Zwemmer Jack, van Regteren-van Griethuysen Renate, Smeding Henriette, van der Berg Lydia, de Bresser Jeroen, de Kort Gérard A.P., Dankbaar Jan Willem, Nov 2022, In: The Lancet. Neurology. 21 , p. 982-993 12 p.

An automated electroencephalography algorithm to detect polymorphic delta activity in acute encephalopathy presenting as postoperative delirium

Ditzel Fienke L, Hut Suzanne Ca, Dijkstra-Kersten Sandra Ma, Numan Tianne, Leijten Frans Ss, van den Boogaard Mark, Slooter Arjen Jc 13 Sep 2022, In: Psychiatry and Clinical Neurosciences. 76 , p. 676-678 3 p.

Multimodal nocturnal seizure detection:Do we need to adapt algorithms for children?

Lazeron Richard H C, Thijs Roland D, Arends Johan, Gutter Thea, Cluitmans Pierre, Van Dijk Johannes, Tan Francis I Y, Hofstra Wytske, Donjacour Claire E H M, Leijten Frans, 6 Jun 2022, In: Epilepsia Open. 7 , p. 406-413 8 p.

Optimal timing of interictal FDG-PET for epilepsy surgery:A systematic review on time since last seizure

de Laat Nienke N., Tolboom Nelleke, Leijten Frans S.S. 2022, In: Epilepsia Open. 7 , p. 512-517 6 p.

A Practical Workflow for Organizing Clinical Intraoperative and Long-term iEEG Data in BIDS

Demuru Matteo, van Blooijs Dorien, Zweiphenning Willemiek, Hermes Dora, Leijten Frans, Zijlmans Maeike, 2022, In: Neuroinformatics. 20 , p. 727-736 10 p.

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse, van Huffelen Alexander, van Klink Nicole, Benders Manon, de Vries Linda, Leijten Frans, Jansen Floor E., Braun Kees, Zijlmans Maeike Nov 2021, In: Epilepsia. 62 , p. 114-115

High-resolution electric source imaging for presurgical evaluation of tuberous sclerosis complex patients

Mouthaan Brian E., Jansen Floor E., Colon Albert J., Huiskamp Geertjan M., van Eijsden Pieter, Leijten Frans S.S., Braun Kees P.J. 29 Oct 2021, In: Clinical Neurophysiology. 133 , p. 126-134 9 p.

Decoding four hand gestures with a single bipolar pair of electrocorticography electrodes

Verwoert Maxime, Vansteensel Mariska J., Freudenburg Zachary V., Aarnoutse Erik J., Leijten Frans S.S., Ramsey Nick F., Branco Mariana P. 4 Oct 2021, In: Journal of Neural Engineering. 18 , p. 1-10

All research output

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