dr. M.J. (Magdalena) Lorenowicz

Assistant Professor
dr. M.J. (Magdalena) Lorenowicz
  • Group Coffer, section Stem Cells



 Magdalena Lorenowicz studied Biotechnology at the Jagiellonian University in Kraków. In September 2001 she moved to Amsterdam to start her Ph.D. research. During her Ph.D. studies she investigated the role of cAMP signalling in the regulation of leukocyte chemotaxis and endothelial barrier function. After completion of her thesis, Magdalena moved to the Hubrecht Institute in Utrecht, where supported by prestigious VENI award (2008) she focused on the mechanism of Wnt secretion, combining the genetics of C. elegans with cutting edge cell biology techniques in mammalian cells. In April 2012 she joined the Department of Cell Biology and Center for Molecular Medicine at Universty Medical Center Utrecht to set up her own research line investigating molecular mechanisms regulating the immunosuppressive and regenerative properties of the human mesenchymal stem/stromal cells (MSC) with the ultimate goal to directly link her expertise in studying cell-cell communication with clinical applications. Since 2015 she works as independent research fellow at Regenerative Medicine Center Utrecht. Here she expanded her research group and works on the interphase of fundamental research and regenerative medicine and continues to investigate biology of MSC and their in vivo function with the final goal to improve MSC-based therapies.

Personal website:

Side Activities

2018- present-  Coordinator and innovator of bio-tech block of the Selective Utrecht Medical Master programme 

Reviewer for international journals including: Developmental Biology; EMBO Journal; Journal of Leukocyte Biology; Journal of Extracellular Vesicles, Molecular Cancer, Autophagy, Fontiers in Immunology, Tissue Engineering and Regenerative Medicine, Cellular Physiology and Biochemistry; Scientific Reports; Theranostics; Osteoarthritis and Cartilage; Archivum Immunologiae et Therapiae Experimentalis

Reviewer for grant organisations: Medical Research Council UK


Fellowship and Awards

2019        Grant from Dutch Paediatric Cancer Foundation (Kika); €125K

2018        - Personal grant from Dutch Arthritis Foundation (ReumaNederland); €150k

               - Personal grant from K.F. Hein Fonds/Utrechts Universiteitsfonds; €10K

2017    Translationeel Adult Stamcelonderzoek (TAS) Game changer grant from ZonMW; €400K; together with Dr. L. Vonk
2016    Young investigator award at 13th ICRS World Congress, Naples, Italy (together with Dr. L. Vonk)

2013    - Personal grant from Wilhelmina Children’s Hospital (WKZ) Foundation; €150K;

           - Grant from Dutch Arthritis Foundation (Reumafonds); €250K;

2010    EMBO conference series Travel award
International C. elegans meeting; “Development and Gene Expression”, Heidelberg, Germany

2009    The best poster award at EMBO conference “Endocytic machineries in control of cell signalling and tissue morphogenesis”, Chania, Greece.

2008     VENI fellowship from The Netherlands Organisation for Scientific Research (NWO) Life Sciences; €208K;

Research Output (16)

Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile

van der Wagen Lotte E, Miranda-Bedate Alberto, Janssen Anke, Fernando Febilla, Appukudige Nagesha, van Dooremalen Sanne F.J., Westinga Kasper, Admiraal Rick, Lorenowicz Magdalena J, Huls Gerwin, Janssen Jeroen J W M, Broers Annoek E C, van der Velden Walter J F M, van Marwijk Kooy Rien, Hazenberg Mette D, de Haar Colin, Lindemans Caroline, Jan Boelens Jaap, Kuball Jürgen 1 jan 2020, In: Bone Marrow Transplantation. 55 , p. 2188-2192 5 p.

Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities

Varderidou-Minasian Suzy, Lorenowicz Magdalena J. 2020, In: Theranostics. 10 , p. 5979-5997 19 p.

Mesenchymal stromal/stem cell-derived extracellular vesicles promote human cartilage regeneration in vitro

Vonk Lucienne A., van Dooremalen Sanne F.J., Liv Nalan, Klumperman Judith, Coffer Paul J., Saris Daniël B.F., Lorenowicz Magdalena J. 2018, In: Theranostics. 8 , p. 906-920 15 p.

Minimal information for studies of extracellular vesicles 2018 (MISEV2018):a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Thery Clotilde, Witwer Kenneth W., Aikawa Elena, Jose Alcaraz Maria, Anderson Johnathon D., Andriantsitohaina Ramaroson, Antoniou Anna, Arab Tanina, Archer Fabienne, Atkin-Smith Georgia K., Ayre D. Craig, Bach Jean-Marie, Bachurski Daniel, Baharvand Hossein, Balaj Leonora, Baldacchino Shawn, Bauer Natalie N., Baxter Amy A., Bebawy Mary, Beckham Carla, Zavec Apolonija Bedina, Benmoussa Abderrahim, Berardi Anna C., Bergese Paolo, Bielska Ewa, Blenkiron Cherie, Bobis-Wozowicz Sylwia, Boilard Eric, Boireau Wilfrid, Bongiovanni Antonella, Borras Francesc E., Bosch Steffi, Boulanger Chantal M., Breakefield Xandra, Breglio Andrew M., Brennan Meadhbh A., Brigstock David R., Brisson Alain, Broekman Marike L. D., Bromberg Jacqueline F., Bryl-Gorecka Paulina, Buch Shilpa, Buck Amy H., Burger Dylan, Lorenowicz Magdalena J., Maas Sybren L. N., Schiffelers Raymond M., Vader Pieter, van Balkom Bas W. M., Yuana Yuana, 2018, In: Journal of Extracellular Vesicles. 7

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - An ISEV position paper

Mateescu Bogdan, Kowal Emma J K, van Balkom Bas W M, Bartel Sabine, Bhattacharyya Suvendra N., Buzás Edit I., Buck Amy H., de Candia Paola, Chow Franklin W N, Das Saumya, Driedonks Tom A P, Fernández-Messina Lola, Haderk Franziska, Hill Andrew F., Jones Jennifer C., Van Keuren-Jensen Kendall R., Lai Charles P., Lässer Cecilia, di Liegro Italia, Lunavat Taral R., Lorenowicz Magdalena J., Maas Sybren L N, Mäger Imre, Mittelbrunn Maria, Momma Stefan, Mukherjee Kamalika, Nawaz Muhammed, Pegtel D. Michiel, Pfaffl Michael W., Schiffelers Raymond M., Tahara Hidetoshi, Théry Clotilde, Tosar Juan Pablo, Wauben Marca H M, Witwer Kenneth W., Nolte-'t Hoen Esther N M 2017, In: Journal of Extracellular Vesicles. 6

Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation

Gómez-Puerto M C, Verhagen L P, Braat A K, Lam E W-F, Coffer P J, Lorenowicz M J 17 aug 2016, In: Autophagy. 12 , p. 1804-1816

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Lener Thomas, Gimona Mario, Aigner Ludwig, Börger Verena, Buzas Edit, Camussi Giovanni, Chaput Nathalie, Chatterjee Devasis, Court Felipe A, Del Portillo Hernando A, O'Driscoll Lorraine, Fais Stefano, Falcon-Perez Juan M, Felderhoff-Mueser Ursula, Fraile Lorenzo, Gho Yong Song, Görgens André, Gupta Ramesh C, Hendrix An, Hermann Dirk M, Hill Andrew F, Hochberg Fred, Horn Peter A, de Kleijn Dominique, Kordelas Lambros, Kramer Boris W, Krämer-Albers Eva-Maria, Laner-Plamberger Sandra, Laitinen Saara, Leonardi Tommaso, Lorenowicz Magdalena J , Lim Sai Kiang, Lötvall Jan, Maguire Casey A, Marcilla Antonio, Nazarenko Irina, Ochiya Takahiro, Patel Tushar, Pedersen Shona, Pocsfalvi Gabriella, Pluchino Stefano, Quesenberry Peter, Reischl Ilona G, Rivera Francisco J, Sanzenbacher Ralf, Schallmoser Katharina, Slaper-Cortenbach Ineke, Strunk Dirk, Tonn Torsten, Vader Pieter, van Balkom Bas W M, Wauben Marca, Andaloussi Samir El, Théry Clotilde, Rohde Eva, Giebel Bernd 2015, In: Journal of Extracellular Vesicles. 4 , p. 30087

Protein kinase CK2 is required for Wntless internalization and Wnt secretion

de Groot R.E.A., Rappel S.B., Lorenowicz M.J., Korswagen H.C. 2014, In: Cellular signalling. 26 , p. 2601-2605 5 p.

Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants.

Lorenowicz M.J., Macurkova M., Harterink M., Middelkoop T.C., de Groot R., Betist M.C., Korswagen H.C. 2014, In: Cellular signalling. 26 , p. 19-31 13 p.

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

Harterink M., Port F., Lorenowicz M.J., McGough I.J., Silhankova M., Betist M.C., Weering J.R.T., van Heesbeen R.G.H.P., Middelkoop T.C., Basler K., Cullen P.J., Korswagen H.C. 2011, In: Nature Cell Biology. 13 , p. 914-923 10 p.

All research output

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