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dr. J.J. Luykx

dr. J.J. Luykx

Assistant Professor - medical
  • Psychiatry

Research Programs

Brain

Biography

Biography

Jurjen Luykx obtained his medical degree at Utrecht University in 2005. He was a visiting scholar and was trained in neurogenetics at the University of California, Los Angeles (UCLA) in 2006/2007. In 2012 he finished his residency in psychiatry and has since held several clinical consultant positions at psychiatric hospitals in Arnhem and the Utrecht area. In March 2013 he obtained his PhD in neuropsychiatric genetics at Utrecht University. Starting February 1st, 2019 he heads the residency program at GGNet Mental Healthy in Apeldoorn, where he also sees outpatients suffering from a range of psychiatric disorders.

Education and positions in academia

Current: University Medical Center Utrecht Utrecht, The Netherlands
Human Neurogenetics Unit, Head of Program in Psychiatric Genetics 
2007 – 2013 University Medical Center Utrecht Utrecht
Ph.D. program (“Determinants of Neurotransmitters in Cerebrospinal Fluid and Plasma”)
2006 – 2007 University of California (UCLA) Los Angeles, USA
Program in Neurogenetics
1999 – 2005 Utrecht University Utrecht
Doctor of Medicine

Research line

We welcome master students with an interest in psychiatric genetics coming from different backgrounds. A lot of the work we do concerns biostatistics; some of the work also involves wet lab activities.With our lab of postdocs, PhD students, lab technicians, bioinformaticians we focus on the following projects:

• Targeted DNA and RNA sequencing in schizophrenia and bipolar disorder
• Genetic overlap studies: ALS-schizophrenia, OCD-schizophrenia, metabolic traits-schizophrenia, and EEG-epilepsy
• Other genetic studies in psychiatric patients: PTSD-related phenotypes; Pathway analysis studies in schizophrenia; Genetics of clozapine use (www.clozinstudy.com); Genetics of antipsychotic-induced weight gain; Genetics of ECT responsiveness; EEG genomics.
• I am also country coordinator for the Prednisolone trial (placebo-controlled randomized trial studying the effects of prednisolone addition to antipsychotics), EULAST (European randomized controlled trial studying treatment effects of oral vs depot antipsychotics and pharmacogenetics in schizophrenia) and RAPSODI (trial into add-on of raloxifene vs. placebo in the treatment of schizophrenia).

Professional associations

• Psychiatric Genomics Consortium (PGC) - Eating Disorders working group & Obsessive-Compulsive Disorder and Tourette Syndrome working group & Post-Traumatic Stress Disorder working group & Substance Use Disorders steering committee & MDD working group & ENIGMA-EEG working group & ENIGMA-cortex working group

Highlighted publications

• B.D. Lin, A. Alkema, …. & J.J. Luykx. Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable bidirectional Mendelian Randomization study (International Journal of Epidemiology, in press): using both univariate and multivariate MR we find evidence that dyslipidemia has a role in schizophrenia independent of medication status.

•J.J. Luykx, R. van der Spek, …., Annelien Bredenoord & Ger Palmboom. Unconsented genetic testing in psychiatry: an (almost) no go? (Lancet Psychiatry, 2019). 

• D. Schijven, J.H. Veldink & J.J. Luykx. Genetic cross-disorder analysis in psychiatry: from methodology to clinical utility (British Journal of Psychiatry, 2019): in this paper we discuss the ramifications and clinical implications of genetic cross-disorder research for patients and psychiatrists.

• R. McLaughlin, D. Schijven,….. & O. Hardiman / J.H. Veldink / J.J. Luykx (shared supervision). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia (Nature Communications, 2017): under my supervision the first evidence of genetic overlap between schizophrenia and ALS was discovered.

• M. Lancee, C.M.C. Lemmens, … & J.J. Luykx. Outcome reporting bias in trials investigating antipsychotic drugs (Translational Psychiatry, 2017): here, we demonstrated the nature and degree of outcome reporting bias in antipsychotics trials.

• J.J. Luykx, S.C. Bakker, et al. Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma (Molecular Psychiatry, 2015): we outline the first genetic evidence of the involvement of schizophrenia risk genes in determining neurotransmitter coagonist levels in CSF.

Fellowship and Awards

Amount

Year

Topic

Funded by

€200,000 (personal grant)

2014

Next-generation targeted sequencing

Brain division, UMCU

€149,000 (main applicant)

2015

Emergency psychiatry guidelines

SKMS

€309,000 (main applicant)

2017

Imaging genomics

ALS foundation

€260,000 (co-applicant)

2018

Genetic Counseling Consortium

COST

Research Output (94)

Polygenic Risk Scores for Genetic Counseling in Psychiatry:Lessons Learned from other Fields of Medicine

Eeltink E, van der Horst M Z, Zinkstok J R, Aalfs C M, Luykx J J feb 2021, In: Neuroscience and Biobehavioral Reviews. 121 , p. 119-127 9 p.

Genetic underpinnings of schizophrenia-related electroencephalographical intermediate phenotypes:A systematic review and meta-analysis

Hederih Jure, Nuninga Jasper O., van Eijk Kristel, van Dellen Edwin, Smit Dirk J.A., Oranje Bob, Luykx Jurjen J. 10 jan 2021, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 104

Study protocol of a randomized, double-blind, placebo-controlled, multi-center trial to treat antipsychotic-induced weight gain:the Metformin-Lifestyle in antipsychotic users (MELIA) trial

de Boer Nini, Guloksuz Sinan, van Baal Caroline, Willebrands Leonie, Deenik Jeroen, Vinkers Christiaan H., Rossum Inge Winter van, Zinkstok Janneke, Wilting Ingeborg, Zantvoord Jasper B., Backx Frank, Swildens Wilma E., Schouw Marieke, Bogers Jan, Hulshof Folkwin, de Knijff Rudolf, Duindam Peter, Veereschild Mike, Bak Maarten, Frederix Geert, de Haan Lieuwe, van Os Jim, Cahn Wiepke, Luykx Jurjen J. 5 jan 2021, In: BMC Psychiatry. 21

Morbidity and mortality in schizophrenia with comorbid substance use disorders

Lähteenvuo Markku, Batalla Albert, Luykx Jurjen J., Mittendorfer-Rutz Ellenor, Tanskanen Antti, Tiihonen Jari, Taipale Heidi 2021, In: Acta Psychiatrica Scandinavica. 144 , p. 42-49 8 p.

Effects of Smoking Status on Remission and Metabolic and Cognitive Outcomes in Schizophrenia Patients Treated with Clozapine

Wagner Elias, Oviedo-Salcedo Tatiana, Pelzer Nicola, Strube Wolfgang, Maurus Isabel, Gutwinski Stefan, Schreiter Stefanie, Kleymann Phillip, Morgenroth Carla Lou, Okhuijsen-Pfeifer Cynthia, Luykx Jurjen J., Falkai Peter, Schneider-Axmann Thomas, Hasan Alkomiet 1 nov 2020, In: Pharmacopsychiatry. 53 , p. 273-283 11 p.

In the aftermath of clozapine discontinuation:comparative effectiveness and safety of antipsychotics in patients with schizophrenia who discontinue clozapine

Luykx Jurjen J., Stam Noraly, Tanskanen Antti, Tiihonen Jari, Taipale Heidi 1 sep 2020, In: The British journal of psychiatry : the journal of mental science. 217 , p. 498-505 8 p.

Safe and informed prescribing of psychotropic medication during the COVID-19 pandemic

Luykx Jurjen J., van Veen Sisco M.P., Risselada Arne, Naarding Paul, Tijdink Joeri K., Vinkers Christiaan H. 1 sep 2020, In: The British journal of psychiatry : the journal of mental science. 217 , p. 471-474 4 p.

The role of rare compound heterozygous events in autism spectrum disorder

Lin Bochao Danae, Colas Fabrice, Nijman Isaac J., Medic Jelena, Brands William, Parr Jeremy R., van Eijk Kristel R., Klauck Sabine M., Chiocchetti Andreas G., Freitag Christine M., Maestrini Elena, Bacchelli Elena, Coon Hilary, Vicente Astrid, Oliveira Guiomar, Pagnamenta Alistair T., Gallagher Louise, Ennis Sean, Anney Richard, Bourgeron Thomas, Luykx Jurjen J., Vorstman Jacob 22 jun 2020, In: Translational Psychiatry. 10 , p. 1-8

Prednisolone versus placebo addition in the treatment of patients with recent-onset psychotic disorder:A trial design

Nasib Lyliana G., Sommer Iris E., Winter - Van Rossum Inge, De Vries Jacqueline, Gangadin Shiral S., Oomen Priscilla P., Judge Gurmeet, Blom Renske E., Luykx Jurjen J., Van Beveren Nico J.M., Veen Natalie D., Kroken Rune A., Johnsen Erik L. 8 jun 2020, In: Trials. 21 , p. 1-13

Association of preceding psychosis risk states and non-psychotic mental disorders with incidence of clinical psychosis in the general population:a prospective study in the NEMESIS-2 cohort

Guloksuz Sinan, Pries Lotta Katrin, ten Have Margreet, de Graaf Ron, van Dorsselaer Saskia, Klingenberg Boris, Bak Maarten, Lin Bochao D, van Eijk Kristel R., Delespaul Philippe, van Amelsvoort Therese, Luykx Jurjen J., Rutten Bart P.F., van Os Jim 1 jun 2020, In: World Psychiatry. 19 , p. 199-205 7 p.

All research output

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