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dr. J.J. Luykx

dr. J.J. Luykx

Assistant Professor - medical
  • Psychiatry

Research Programs

Brain

Biography

Biography

Jurjen Luykx obtained his medical degree at Utrecht University in 2005. He was a visiting scholar and was trained in neurogenetics at the University of California, Los Angeles (UCLA) in 2006/2007. In 2012 he finished his residency in psychiatry and has since held several clinical consultant positions at psychiatric hospitals in Arnhem and the Utrecht area. In March 2013 he obtained his PhD in neuropsychiatric genetics at Utrecht University. Starting February 1st, 2019 he heads the residency program at GGNet Mental Healthy in Apeldoorn, where he also sees outpatients suffering from a range of psychiatric disorders.

Education and positions in academia

Current: University Medical Center Utrecht Utrecht, The Netherlands
Human Neurogenetics Unit, Head of Program in Psychiatric Genetics 
2007 – 2013 University Medical Center Utrecht Utrecht
Ph.D. program (“Determinants of Neurotransmitters in Cerebrospinal Fluid and Plasma”)
2006 – 2007 University of California (UCLA) Los Angeles, USA
Program in Neurogenetics
1999 – 2005 Utrecht University Utrecht
Doctor of Medicine

Research line

We welcome master students with an interest in psychiatric genetics coming from different backgrounds. A lot of the work we do concerns biostatistics; some of the work also involves wet lab activities.With our lab of postdocs, PhD students, lab technicians, bioinformaticians we focus on the following projects:

• Targeted DNA and RNA sequencing in schizophrenia and bipolar disorder
• Genetic overlap studies: ALS-schizophrenia, OCD-schizophrenia, metabolic traits-schizophrenia, and EEG-epilepsy
• Other genetic studies in psychiatric patients: PTSD-related phenotypes; Pathway analysis studies in schizophrenia; Genetics of clozapine use (www.clozinstudy.com); Genetics of antipsychotic-induced weight gain; Genetics of ECT responsiveness; EEG genomics.
• I am also country coordinator for the Prednisolone trial (placebo-controlled randomized trial studying the effects of prednisolone addition to antipsychotics), EULAST (European randomized controlled trial studying treatment effects of oral vs depot antipsychotics and pharmacogenetics in schizophrenia) and RAPSODI (trial into add-on of raloxifene vs. placebo in the treatment of schizophrenia).

Professional associations

• Psychiatric Genomics Consortium (PGC) - Eating Disorders working group & Obsessive-Compulsive Disorder and Tourette Syndrome working group & Post-Traumatic Stress Disorder working group & Substance Use Disorders steering committee & MDD working group & ENIGMA-EEG working group & ENIGMA-cortex working group

Highlighted publications

• B.D. Lin, A. Alkema, …. & J.J. Luykx. Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable bidirectional Mendelian Randomization study (International Journal of Epidemiology, in press): using both univariate and multivariate MR we find evidence that dyslipidemia has a role in schizophrenia independent of medication status.

•J.J. Luykx, R. van der Spek, …., Annelien Bredenoord & Ger Palmboom. Unconsented genetic testing in psychiatry: an (almost) no go? (Lancet Psychiatry, 2019). 

• D. Schijven, J.H. Veldink & J.J. Luykx. Genetic cross-disorder analysis in psychiatry: from methodology to clinical utility (British Journal of Psychiatry, 2019): in this paper we discuss the ramifications and clinical implications of genetic cross-disorder research for patients and psychiatrists.

• R. McLaughlin, D. Schijven,….. & O. Hardiman / J.H. Veldink / J.J. Luykx (shared supervision). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia (Nature Communications, 2017): under my supervision the first evidence of genetic overlap between schizophrenia and ALS was discovered.

• M. Lancee, C.M.C. Lemmens, … & J.J. Luykx. Outcome reporting bias in trials investigating antipsychotic drugs (Translational Psychiatry, 2017): here, we demonstrated the nature and degree of outcome reporting bias in antipsychotics trials.

• J.J. Luykx, S.C. Bakker, et al. Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma (Molecular Psychiatry, 2015): we outline the first genetic evidence of the involvement of schizophrenia risk genes in determining neurotransmitter coagonist levels in CSF.

Fellowship and Awards

Amount

Year

Topic

Funded by

€200,000 (personal grant)

2014

Next-generation targeted sequencing

Brain division, UMCU

€149,000 (main applicant)

2015

Emergency psychiatry guidelines

SKMS

€309,000 (main applicant)

2017

Imaging genomics

ALS foundation

€260,000 (co-applicant)

2018

Genetic Counseling Consortium

COST

Research Output (132)

Genetic determinants associated with response to clozapine in schizophrenia:An umbrella review

Van Der Horst Marte Z., Papadimitriou Georgia, Luykx Jurjen J. 1 Oct 2022, In: Psychiatric Genetics. 32 , p. 163-170 8 p.

The future of antipsychotics studies:How innovative designs may benefit patients with psychotic disorders

Luykx Jurjen J. Sep 2022, In: European Neuropsychopharmacology. 62 , p. 46-48 3 p.

A polygenic-informed approach to a predictive EEG signature empowers antidepressant treatment prediction:A proof-of-concept study

Meijs Hannah, Prentice Amourie, Lin Bochao D., De Wilde Bieke, Van Hecke Jan, Niemegeers Peter, van Eijk Kristel, Luykx Jurjen J., Arns Martijn Sep 2022, In: European Neuropsychopharmacology. 62 , p. 49-60 12 p.

The association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls:Results from the EUGEI study

Fusar-Poli Laura, Pries Lotta-Katrin, van Os Jim, Radhakrishnan Rajiv, Pençe Ayşegül Yay, Erzin Gamze, Delespaul Philippe, Kenis Gunter, Luykx Jurjen J, Lin Bochao D, Akdede Berna, Binbay Tolga, Altınyazar Vesile, Yalınçetin Berna, Gümüş-Akay Güvem, Cihan Burçin, Soygür Haldun, Ulaş Halis, Cankurtaran Eylem Şahin, Kaymak Semra Ulusoy, Mihaljevic Marina M, Andric-Petrovic Sanja, Mirjanic Tijana, Bernardo Miguel, Mezquida Gisela, Amoretti Silvia, Bobes Julio, Saiz Pilar A, García-Portilla Maria Paz, Sanjuan Julio, Aguilar Eduardo J, Santos José Luis, Jiménez-López Estela, Arrojo Manuel, Carracedo Angel, López Gonzalo, González-Peñas Javier, Parellada Mara, Maric Nadja P, Atbaşoğlu Cem, Üçok Alp, Alptekin Köksal, Saka Meram Can, Aguglia Eugenio, Arango Celso, Rutten Bart Pf, Guloksuz Sinan, 30 Aug 2022, In: European Neuropsychopharmacology. 63 , p. 47-59 13 p.

Event-related potentials and use of psychotropic medication in major psychiatric disorders

Kool Lindy, Oranje Bob, Meijs Hannah, De Wilde Bieke, Van Hecke Jan, Niemegeers Peter, Luykx Jurjen J. Aug 2022, In: Psychiatry Research. 314 , p. 1-10

A computational solution for bolstering reliability of epigenetic clocks:implications for clinical trials and longitudinal tracking

Higgins-Chen Albert T., Thrush Kyra L., Wang Yunzhang, Minteer Christopher J., Kuo Pei Lun, Wang Meng, Niimi Peter, Sturm Gabriel, Lin Jue, Moore Ann Zenobia, Bandinelli Stefania, Vinkers Christiaan H., Vermetten Eric, Rutten Bart P.F., Geuze Elbert, Okhuijsen-Pfeifer Cynthia, van der Horst Marte Z., Schreiter Stefanie, Gutwinski Stefan, Luykx Jurjen J., Picard Martin, Ferrucci Luigi, Crimmins Eileen M., Boks Marco P., Hägg Sara, Hu-Seliger Tina T., Levine Morgan E. Jul 2022, In: Nature Aging. 2 , p. 644-661 18 p.

Optimal Doses of Specific Antipsychotics for Relapse Prevention in a Nationwide Cohort of Patients with Schizophrenia

Taipale Heidi, Tanskanen Antti, Luykx Jurjen J., Solmi Marco, Leucht Stefan, Correll Christoph U., Tiihonen Jari 21 Jun 2022, In: Schizophrenia bulletin. 48 , p. 774-784 11 p.

Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD:A genomic structural equation modelling approach

Bountress Kaitlin E., Brick Leslie A., Sheerin Christina, Grotzinger Andrew, Bustamante Daniel, Hawn Sage E., Gillespie Nathan, Kirkpatrick Robert M., Kranzler Henry, Morey Rajendra, Edenberg Howard J., Maihofer Adam X., Disner Seth, Ashley-Koch Allison, Peterson Roseann, Lori Adriana, Stein Dan J., Kimbrel Nathan, Nievergelt Caroline, Andreassen Ole A., Luykx Jurjen, Javanbakht Arash, Youssef Nagy A., Amstadter Ananda B., 1 May 2022, In: Drug and Alcohol Dependence. 234 , p. 1-8

Toward Ecologically Sustainable Mental Health Care-A Call for Action from Within Psychiatry

Luykx Jurjen J., Voetterl Helena T.S. 13 Apr 2022, In: JAMA Psychiatry. 79 , p. 524-525 2 p.

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Okhuijsen-Pfeifer C, van der Horst M Z, Bousman C A, Lin B, van Eijk K R, Ripke S, Ayhan Y, Babaoglu M O, Bak M, Alink W, van Beek H, Beld E, Bouhuis A, Edlinger M, Erdogan I M, Ertuğrul A, Yoca G, Everall I P, Görlitz T, Grootens K P, Gutwinski S, Hallikainen T, Jeger-Land E, de Koning M, Lähteenvuo M, Legge S E, Leucht S, Morgenroth C, Müderrisoğlu A, Narang A, Pantelis C, Pardiñas A F, Oviedo-Salcedo T, Schneider-Thoma J, Schreiter S, Repo-Tiihonen E, Tuppurainen H, Veereschild M, Veerman S, de Vos M, Wagner E, Cohen D, Bogers J P A M, Walters J T R, Yağcıoğlu A E Anil, Tiihonen J, Hasan A, Luykx J J, 7 Apr 2022, In: Translational Psychiatry. 12

All research output

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