Back

dr. J.J. Luykx

Assistant Professor - medical

  • Neurology & Neurosurgery

Research Programs

Biography

Jurjen Luykx obtained his medical degree at Utrecht University in 2005. He was a visiting scholar and was trained in neurogenetics at the University of California, Los Angeles (UCLA) in 2006/2007. In 2012 he finished his residency in psychiatry and has since held several clinical consultant positions at psychiatric hospitals in Arnhem and the Utrecht area. In March 2013 he obtained his PhD in neuropsychiatric genetics at Utrecht University. Starting February 1st, 2019 he heads the residency program at GGNet Mental Healthy in Apeldoorn, where he also sees outpatients suffering from a range of psychiatric disorders.

Education and positions in academia

Current: University Medical Center Utrecht Utrecht, The Netherlands
Human Neurogenetics Unit, Head of Program in Psychiatric Genetics 
2007 – 2013 University Medical Center Utrecht Utrecht
Ph.D. program (“Determinants of Neurotransmitters in Cerebrospinal Fluid and Plasma”)
2006 – 2007 University of California (UCLA) Los Angeles, USA
Program in Neurogenetics
1999 – 2005 Utrecht University Utrecht
Doctor of Medicine

Research line

We welcome master students with an interest in psychiatric genetics coming from different backgrounds. A lot of the work we do concerns biostatistics; some of the work also involves wet lab activities.With our lab of postdocs, PhD students, lab technicians, bioinformaticians we focus on the following projects:

• Targeted DNA and RNA sequencing in schizophrenia and bipolar disorder
• Genetic overlap studies: ALS-schizophrenia, OCD-schizophrenia, metabolic traits-schizophrenia, and EEG-epilepsy
• Other genetic studies in psychiatric patients: PTSD-related phenotypes; Pathway analysis studies in schizophrenia; Genetics of clozapine use (www.clozinstudy.com); Genetics of antipsychotic-induced weight gain; Genetics of ECT responsiveness; EEG genomics.
• I am also country coordinator for the Prednisolone trial (placebo-controlled randomized trial studying the effects of prednisolone addition to antipsychotics), EULAST (European randomized controlled trial studying treatment effects of oral vs depot antipsychotics and pharmacogenetics in schizophrenia) and RAPSODI (trial into add-on of raloxifene vs. placebo in the treatment of schizophrenia).

Professional associations

• Psychiatric Genomics Consortium (PGC) - Eating Disorders working group & Obsessive-Compulsive Disorder and Tourette Syndrome working group & Post-Traumatic Stress Disorder working group & Substance Use Disorders steering committee & MDD working group & ENIGMA-EEG working group & ENIGMA-cortex working group

Highlighted publications

• B.D. Lin, A. Alkema, …. & J.J. Luykx. Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable bidirectional Mendelian Randomization study (International Journal of Epidemiology, in press): using both univariate and multivariate MR we find evidence that dyslipidemia has a role in schizophrenia independent of medication status.

•J.J. Luykx, R. van der Spek, …., Annelien Bredenoord & Ger Palmboom. Unconsented genetic testing in psychiatry: an (almost) no go? (Lancet Psychiatry, 2019). 

• D. Schijven, J.H. Veldink & J.J. Luykx. Genetic cross-disorder analysis in psychiatry: from methodology to clinical utility (British Journal of Psychiatry, 2019): in this paper we discuss the ramifications and clinical implications of genetic cross-disorder research for patients and psychiatrists.

• R. McLaughlin, D. Schijven,….. & O. Hardiman / J.H. Veldink / J.J. Luykx (shared supervision). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia (Nature Communications, 2017): under my supervision the first evidence of genetic overlap between schizophrenia and ALS was discovered.

• M. Lancee, C.M.C. Lemmens, … & J.J. Luykx. Outcome reporting bias in trials investigating antipsychotic drugs (Translational Psychiatry, 2017): here, we demonstrated the nature and degree of outcome reporting bias in antipsychotics trials.

• J.J. Luykx, S.C. Bakker, et al. Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma (Molecular Psychiatry, 2015): we outline the first genetic evidence of the involvement of schizophrenia risk genes in determining neurotransmitter coagonist levels in CSF.

Fellowship and Awards

  • Amount

    Year

    Topic

    Funded by

    €200,000 (personal grant)

    2014

    Next-generation targeted sequencing

    Brain division, UMCU

    €149,000 (main applicant)

    2015

    Emergency psychiatry guidelines

    SKMS

    €309,000 (main applicant)

    2017

    Imaging genomics

    ALS foundation

    €260,000 (co-applicant)

    2018

    Genetic Counseling Consortium

    COST

Research Output (64)

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Lee Phil H., Anttila Verneri, Won Hyejung, Feng Yen-Chen A., Rosenthal Jacob, Zhu Zhaozhong, Tucker-Drob Elliot M., Nivard Michel G., Grotzinger Andrew D., Posthuma Danielle, Wang Meg M-J, Yu Dongmei, Stahl Eli A., Walters Ray-mond K., Anney Richard J. L., Duncan Laramie E., Ge Tian, Adolfsson Rolf, Banaschewski Tobias, Belangero Sintia, Cook Edwin H., Coppola Giovanni, Derks Eske M., Hoekstra Pieter J., Kaprio Jaakko, Keski-Rahkonen Anna, Kirov George, Kranzler Henry R., Luykx Jurjen J., Rohde Luis A., Zai Clement C., Agerbo Esben, Arranz M. J., Asherson Philip, Baekvad-Hansen Marie, Baldursson Gisli, Bellgrove Mark, Belliveau Richard A., Jr., Buitelaar Jan, Burton Christie L., Bybjerg-Grauholm Jonas, Casas Miguel, Cerrato Felecia, Chambert Kimberly, Churchhouse Claire, Gormand Bru, Ophoff Roel A., Adan Roger A. H., Kas Martien J. H., van Os Jim, 12 dec 2019, In: Cell. 179 , p. 1469-1482.e11

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Nievergelt Caroline M., Maihofer Adam X., Klengel Torsten, Atkinson Elizabeth G., Chen Chia Yen, Choi Karmel W., Coleman Jonathan R.I., Dalvie Shareefa, Duncan Laramie E., Gelernter Joel, Levey Daniel F., Logue Mark W., Polimanti Renato, Provost Allison C., Ratanatharathorn Andrew, Stein Murray B., Torres Katy, Aiello Allison E., Almli Lynn M., Amstadter Ananda B., Andersen Søren B., Andreassen Ole A., Arbisi Paul A., Ashley-Koch Allison E., Austin S. Bryn, Avdibegovic Esmina, Babić Dragan, Bækvad-Hansen Marie, Baker Dewleen G., Beckham Jean C., Bierut Laura J., Bisson Jonathan I., Boks Marco P., Bolger Elizabeth A., Børglum Anders D., Bradley Bekh, Brashear Megan, Breen Gerome, Bryant Richard A., Bustamante Angela C., Bybjerg-Grauholm Jonas, Calabrese Joseph R., Caldas-de-Almeida José M., Dale Anders M., Geuze Elbert, Luykx Jurjen J., Rutten Bart P.F., Schijven Dick, Vermetten Eric, Vinkers Christiaan H., 1 dec 2019, In: Nature Communications. 10 1 p.

Prevention of Infanticide and Suicide in the Postpartum Period - The Importance of Emergency Care

Luykx Jurjen J., Di Florio Arianna, Bergink Veerle 1 dec 2019, In: JAMA Psychiatry. 76 , p. 1221-1222 2 p.

Coding and non-coding RNA abnormalities in bipolar disorder

Luykx Jurjen J., Giuliani Fabrizio, Giuliani Giuliano, Veldink Jan 1 nov 2019, In: Genes. 10

Multivariate genome-wide analysis of stress-related quantitative phenotypes

Schijven Dick, Geuze Elbert, Vinkers Christiaan H., Pulit Sara L., Schür Remmelt R., Malgaz Marie, Bekema Erwin, Medic Jelena, van der Kust Kendrick E., Veldink Jan H., Boks Marco P., Vermetten Eric, Luykx Jurjen J. 9 okt 2019, In: European Neuropsychopharmacology. 29 , p. 1354-1364 11 p.

ASSESSING CAUSAL LINKS BETWEEN METABOLIC TRAITS, INFLAMMATION AND SCHIZOPHRENIA: A UNIVARIABLE AND MULTIVARIABLE BIDIRECTIONAL MENDELIAN RANDOMIZATION STUDY

Lin Bochao, Alkema Anne, Zinkstok Janneke, Lars Libuda, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Roger Adan, Luykx Jurjen okt 2019, In: European Neuropsychopharmacology. 29 , p. S211-S211

Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples:The Results From the EUGEI Study

Pries Lotta Katrin, Lage-Castellanos Agustin, Delespaul Philippe, Kenis Gunter, Luykx Jurjen J., Lin Bochao D., Richards Alexander L., Akdede Berna, Binbay Tolga, Altinyazar Vesile, Yalinçetin Berna, Gümüş-Akay Güvem, Cihan Burçin, Soygür Haldun, Ulaş Halis, Cankurtaran Eylem Şahin, Kaymak Semra Ulusoy, Mihaljevic Marina M., Petrovic Sanja Andric, Mirjanic Tijana, Bernardo Miguel, Cabrera Bibiana, Bobes Julio, Saiz Pilar A., García-Portilla María Paz, Sanjuan Julio, Aguilar Eduardo J., Santos José Luis, Jiménez-López Estela, Arrojo Manuel, Carracedo Angel, López Gonzalo, González-Peñas Javier, Parellada Mara, Maric Nadja P., Atbaşoğlu Cem, Ucok Alp, Alptekin Köksal, Saka Meram Can, Arango Celso, O'Donovan Michael, Rutten Bart P.F., van Os Jim, Guloksuz Sinan, 1 sep 2019, In: Schizophrenia Bulletin. 45 , p. 960-965 6 p.

Phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients (from the OPTiMiSE cohort)

Pandit R, Cianci D, Ter Hark S E, Winter-van Rossum I, Ebdrup B H, Broberg B V, Garcia-Portilla M P, Bobes J, Vinkers C H, Kahn R S, Guloksuz S, Huitema A D R, Luykx J J sep 2019, In: Acta Psychiatrica Scandinavica. 140 , p. 283-290 8 p.

Assessing causal links between metabolic traits, inflammation and schizophrenia:a univariable and multivariable, bidirectional Mendelian-randomization study

Lin Bochao D., Alkema Anne, Peters Triinu, Zinkstok Janneke, Libuda Lars, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Adan Roger, Luykx Jurjen J. 31 aug 2019, In: International Journal of Epidemiology. 48 , p. 1505-1514 10 p.

Unconsented genetic testing in psychiatry:an (almost) no go?

Luykx Jurjen J., van der Spek Rick, van Veen Sisco, Lo-A-Foe Wonnie, Giesbertz Noor A.A., Bredenoord Annelien L., Palmboom Ger G. 1 aug 2019, In: The Lancet Psychiatry. 6 , p. 641-642 2 p.

All Research Output (64)