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dr. J.J. Luykx Assistant Professor - medical

  • Neurology & Neurosurgery


Research Programs


Jurjen Luykx obtained his medical degree at Utrecht University in 2005. He was a visiting scholar and was trained in neurogenetics at the University of California, Los Angeles (UCLA) in 2006/2007. In 2012 he finished his residency in psychiatry and has since held several clinical consultant positions at psychiatric hospitals in Arnhem and the Utrecht area. In March 2013 he obtained his PhD in neuropsychiatric genetics at Utrecht University. Starting February 1st, 2019 he heads the residency program at GGNet Mental Healthy in Apeldoorn, where he also sees outpatients suffering from a range of psychiatric disorders.

Education and positions in academia

Current: University Medical Center Utrecht Utrecht, The Netherlands
Human Neurogenetics Unit, Head of Program in Psychiatric Genetics 
2007 – 2013 University Medical Center Utrecht Utrecht
Ph.D. program (“Determinants of Neurotransmitters in Cerebrospinal Fluid and Plasma”)
2006 – 2007 University of California (UCLA) Los Angeles, USA
Program in Neurogenetics
1999 – 2005 Utrecht University Utrecht
Doctor of Medicine

Research line

We welcome master students with an interest in psychiatric genetics coming from different backgrounds. A lot of the work we do concerns biostatistics; some of the work also involves wet lab activities.With our lab of postdocs, PhD students, lab technicians, bioinformaticians we focus on the following projects:

• Targeted DNA and RNA sequencing in schizophrenia and bipolar disorder
• Genetic overlap studies: ALS-schizophrenia, OCD-schizophrenia, metabolic traits-schizophrenia, and EEG-epilepsy
• Other genetic studies in psychiatric patients: PTSD-related phenotypes; Pathway analysis studies in schizophrenia; Genetics of clozapine use (www.clozinstudy.com); Genetics of antipsychotic-induced weight gain; Genetics of ECT responsiveness; EEG genomics.
• I am also country coordinator for the Prednisolone trial (placebo-controlled randomized trial studying the effects of prednisolone addition to antipsychotics), EULAST (European randomized controlled trial studying treatment effects of oral vs depot antipsychotics and pharmacogenetics in schizophrenia) and RAPSODI (trial into add-on of raloxifene vs. placebo in the treatment of schizophrenia).

Professional associations

• Psychiatric Genomics Consortium (PGC) - Eating Disorders working group & Obsessive-Compulsive Disorder and Tourette Syndrome working group & Post-Traumatic Stress Disorder working group & Substance Use Disorders steering committee & MDD working group & ENIGMA-EEG working group & ENIGMA-cortex working group

Highlighted publications

• B.D. Lin, A. Alkema, …. & J.J. Luykx. Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable bidirectional Mendelian Randomization study (International Journal of Epidemiology, in press): using both univariate and multivariate MR we find evidence that dyslipidemia has a role in schizophrenia independent of medication status.

•J.J. Luykx, R. van der Spek, …., Annelien Bredenoord & Ger Palmboom. Unconsented genetic testing in psychiatry: an (almost) no go? (Lancet Psychiatry, 2019). 

• D. Schijven, J.H. Veldink & J.J. Luykx. Genetic cross-disorder analysis in psychiatry: from methodology to clinical utility (British Journal of Psychiatry, 2019): in this paper we discuss the ramifications and clinical implications of genetic cross-disorder research for patients and psychiatrists.

• R. McLaughlin, D. Schijven,….. & O. Hardiman / J.H. Veldink / J.J. Luykx (shared supervision). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia (Nature Communications, 2017): under my supervision the first evidence of genetic overlap between schizophrenia and ALS was discovered.

• M. Lancee, C.M.C. Lemmens, … & J.J. Luykx. Outcome reporting bias in trials investigating antipsychotic drugs (Translational Psychiatry, 2017): here, we demonstrated the nature and degree of outcome reporting bias in antipsychotics trials.

• J.J. Luykx, S.C. Bakker, et al. Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma (Molecular Psychiatry, 2015): we outline the first genetic evidence of the involvement of schizophrenia risk genes in determining neurotransmitter coagonist levels in CSF.

Fellowship and Awards

  • Amount



    Funded by

    €200,000 (personal grant)


    Next-generation targeted sequencing

    Brain division, UMCU

    €149,000 (main applicant)


    Emergency psychiatry guidelines


    €309,000 (main applicant)


    Imaging genomics

    ALS foundation

    €260,000 (co-applicant)


    Genetic Counseling Consortium


Research Output (42)

Prevention of Infanticide and Suicide in the Postpartum Period - The Importance of Emergency Care

Luykx Jurjen J., Di Florio Arianna, Bergink Veerle 1 dec 2019, In: JAMA Psychiatry. 76 , p. 1221-1222 2 p.

Coding and non-coding RNA abnormalities in bipolar disorder

Luykx Jurjen J., Giuliani Fabrizio, Giuliani Giuliano, Veldink Jan 1 nov 2019, In: Genes. 10

Multivariate genome-wide analysis of stress-related quantitative phenotypes

Schijven Dick, Geuze Elbert, Vinkers Christiaan H., Pulit Sara L., Schür Remmelt R., Malgaz Marie, Bekema Erwin, Medic Jelena, van der Kust Kendrick E., Veldink Jan H., Boks Marco P., Vermetten Eric, Luykx Jurjen J. 9 okt 2019, In: European Neuropsychopharmacology. 29 , p. 1354-1364 11 p.


Lin Bochao, Alkema Anne, Zinkstok Janneke, Lars Libuda, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Roger Adan, Luykx Jurjen okt 2019, In: European Neuropsychopharmacology. 29 , p. S211-S211

Unconsented genetic testing in psychiatry:an (almost) no go?

Luykx Jurjen J., van der Spek Rick, van Veen Sisco, Lo-A-Foe Wonnie, Giesbertz Noor A.A., Bredenoord Annelien L., Palmboom Ger G. 1 aug 2019, In: The Lancet Psychiatry. 6 , p. 641-642 2 p.

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Watson Hunna J, Yilmaz Zeynep, Thornton Laura M, Hübel Christopher, Coleman Jonathan R I, Gaspar Héléna A, Bryois Julien, Hinney Anke, Leppä Virpi M, Mattheisen Manuel, Medland Sarah E, Ripke Stephan, Yao Shuyang, Giusti-Rodríguez Paola, Hanscombe Ken B, Purves Kirstin L, Adan Roger A H, Alfredsson Lars, Ando Tetsuya, Andreassen Ole A, Baker Jessica H, Berrettini Wade H, Boehm Ilka, Boni Claudette, Perica Vesna Boraska, Buehren Katharina, Burghardt Roland, Cassina Matteo, Cichon Sven, Clementi Maurizio, Cone Roger D, Courtet Philippe, Crow Scott, Crowley James J, Danner Unna N, Davis Oliver S P, de Zwaan Martina, Dedoussis George, Degortes Daniela, DeSocio Janiece E, Dick Danielle M, Dikeos Dimitris, Dina Christian, Dmitrzak-Weglarz Monika, Docampo Elisa, Duncan Laramie E, Egberts Karin, Kas Martien J H, Lin Bochao Danae, Ophoff Roel A, Luykx Jurjen , 15 jul 2019, In: Nature Genetics. 51 , p. 1207-1214 8 p.

Differences between physicians' and nurse practitioners' viewpoints on reasons for clozapine underprescription

Okhuijsen-Pfeifer Cynthia, Cohen Dan, Bogers Jan P A M, de Vos Cato M H, Huijsman Elianne A H, Kahn René S, Luykx Jurjen J 29 mei 2019, In: Brain and Behavior. 9

Amisulpride effectief bij eerste psychotische episode

Luykx Jurjen, Van De Kraats Gerben 1 apr 2019, In: Tijdschrift voor Psychiatrie. 61 1 p.

The effect of genetic vulnerability and military deployment on the development of post-traumatic stress disorder and depressive symptoms

Schur Remmelt R., Schijven Dick, Boks Marco P., Rutten Bart P. F., Stein Murray B., Veldink Jan H., Joels Marian, Geuze Elbert, Vermetten Eric, Luykx Jurjen J., Vinkers Christiaan H. mrt 2019, In: European Neuropsychopharmacology. 29 , p. 405-415

All Research Output (42)
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