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prof. dr. ir. J. Malda

prof. dr. ir. J. Malda

Full Professor
prof. dr. ir. J. Malda
  • Department of Orthopaedics

Biography

Biography

  1. Our research group focuses on biofabrication and biomaterials design, in particular for the regeneration of (osteo) chondral defects. We are developing novel biofabriaction strategies, as well and “bioinks” for 3D printing. These hydrogel-based “inks” are both designed to drive specific differentiation of the embedded and/or endogenous cells, as well as to allow fabrication with high shape fidelity in order to generate constructs that are a blueprint of the real tissue. In addition, we are adopting bioreactor technology to mature the generated tissue constructs. Finally, approaches towards the translation of the constructs in veterinary (equine) and human clinics are pursued, including its use as an in vitro platform for testing. 

    Areas of interest 
    - Joint regeneration 
    - Biofabrication 

    - Biomaterial development

    - Bioreactors

    - Extracellular matrix-derived scaffolds 

    - Nutrient limitation 

Side Activities

Hoogleraar Biofabrication in Translational Regenerative Medicine (0,7FTE), Afdeling Orthopaedie, UMC Utrecht
Secretary General van de International Cartilage Repair and Joint Restoration Society (ICRS; 2022-2023)
Voormalig President van de International Society for Biofabrication (ISBF; 2014-2018)
Board member International Society for Biofabrication (ISBF; 2014-2022)
Scientific Advisor, SentryX B.V.

Fellowship and Awards

Anna Prize 2017, Anna Foundation and Nederlandse Orthopaedische Vereniging

Nanonica Prize 2015 for the breakthrough of the year in the field of nanotechnology, Nanonica Europe

ERC Consolidator Grant ERC-2014-CoG_647426

NWO Veni FellowshipPrinten van levend kraakbeen 

Research Output (214)

Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissues

Daghrery Arwa, Ferreira Jessica A., Xu Jinping, Golafshan Nasim, Kaigler Darnell, Bhaduri Sarit B., Malda Jos, Castilho Miguel, Bottino Marco C. Jan 2023, In: Bioactive Materials. 19 , p. 268-281 14 p.

Robust gelatin hydrogels for local sustained release of bupivacaine following spinal surgery

Steverink Jasper G., van Tol Floris R., Oosterman Bas J., Vermonden Tina, Verlaan Jorrit Jan, Malda Jos, Piluso Susanna 1 Jul 2022, In: Acta Biomaterialia. 146 , p. 145-158 14 p.

Bioink with cartilage-derived extracellular matrix microfibers enables spatial control of vascular capillary formation in bioprinted constructs

Terpstra Margo L., Li Jinyu, Mensinga Anneloes, de Ruijter Mylène, van Rijen Mattie H.P., Androulidakis Charalampos, Galiotis Costas, Papantoniou Ioannis, Matsusaki Michiya, Malda Jos, Levato Riccardo Jul 2022, In: Biofabrication. 14 , p. 1-20

Viscoelastic Chondroitin Sulfate and Hyaluronic Acid Double-Network Hydrogels with Reversible Cross-Links

Mihajlovic Marko, Rikkers Margot, Mihajlovic Milos, Viola Martina, Schuiringa Gerke, Ilochonwu Blessing C., Masereeuw Rosalinde, Vonk Lucienne, Malda Jos, Ito Keita, Vermonden Tina 14 Mar 2022, In: Biomacromolecules. 23 , p. 1350-1365 16 p.

The clinical potential of articular cartilage-derived progenitor cells:a systematic review

Rikkers Margot, Korpershoek Jasmijn V, Levato Riccardo, Malda Jos, Vonk Lucienne A 10 Jan 2022, In: npj Regenerative Medicine. 7 , p. 1-20

Volumetric Bioprinting of Organoids and Optically Tuned Hydrogels to Build Liver-Like Metabolic Biofactories

Bernal Paulina Nuñez, Bouwmeester Manon, Madrid-Wolff Jorge, Falandt Marc, Florczak Sammy, Rodriguez Nuria Ginés, Li Yang, Größbacher Gabriel, Samsom Roos Anne, van Wolferen Monique, van der Laan Luc J.W., Delrot Paul, Loterie Damien, Malda Jos, Moser Christophe, Spee Bart, Levato Riccardo 2022, In: Advanced materials. 34

Fabrication of MSC-laden composites of hyaluronic acid hydrogels reinforced with MEW scaffolds for cartilage repair

Galarraga Jonathan H, Locke Ryan C, Witherel Claire E, Stoeckl Brendan D, Castilho Miguel, Mauck Robert L, Malda Jos, Levato Riccardo, Burdick Jason A 1 Dec 2021, In: Biofabrication. 14

Platelet-rich plasma does not inhibit inflammation or promote regeneration in human osteoarthritic chondrocytes in vitro despite increased proliferation Response

Rikkers Margot, Dijkstra Koen, Terhaard Bastiaan F., Admiraal Jon, Levato Riccardo, Malda Jos, Vonk Lucienne A. Dec 2021, In: Cartilage. 13 , p. 1824S-1826S

3D extrusion bioprinting

Zhang Yu Shrike, Haghiashtiani Ghazaleh, Hübscher Tania, Kelly Daniel J., Lee Jia Min, Lutolf Matthias, McAlpine Michael C., Yeong Wai Yee, Zenobi-Wong Marcy, Malda Jos Dec 2021, In: Nature Reviews Methods Primers. 1

3D-Printed Regenerative Magnesium Phosphate Implant Ensures Stability and Restoration of Hip Dysplasia

Golafshan Nasim, Willemsen Koen, Kadumudi Firoz Babu, Vorndran Elke, Dolatshahi-Pirouz Alireza, Weinans Harrie, van der Wal Bart C.H., Malda Jos, Castilho Miguel 3 Nov 2021, In: Advanced Healthcare Materials. 10 , p. 1-12

All research output

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