dr. R.C.W. (René) Mandl Associate Professor

Psychiatry

Contact

r.mandl@umcutrecht.nl

Research Programs

Brain

Biography

René C. W. Mandl obtained his Masters degree in Informatics (artificial intelligence) at the University of Amsterdam in 1996, after which he started to work as a scientific programmer at the Department of Psychiatry of the University Medical Center Utrecht. He started his PhD project (part-time) in 2004 and in 2009 he successfully defended his PhD thesis titled: “Tract-based analysis in schizophrenia: Measuring structure and function along white matter tracts”. Currently he holds a permanent position as an associate professor (research) at the Department of Psychiatry and his research expertise includes diffusion-weighted imaging, structural MRI, functional MRI, MR spectroscopy and the development of new analysis methods.He also worked from 2014 until 2019 as senior researcher (part time) at the CNSR, Psychiatric Center Glostrup, Denmark. He is involved in several international collaborations such as YOUTH, ENIGMA, and TACTICS.

Research line

New analysis methods for (ultra-) high field MRI in psychiatric research

Most recent key publications

1. Nuninga JO, Mandl RCW, Boks MP, et al. Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T. Mol Psychiatry. 2019. doi:10.1038/s41380-019-0392-6

2. Legind CS, Broberg BV, Mandl RCW, et al. Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders: a (1)[H]-spectroscopy twin study. Neuropsychopharmacology. 2019;44(3):581-589. doi:10.1038/s41386-018-0236-0

3. Gangadin SS, Nasib LG, Sommer IEC, Mandl RCW. MRI investigation of immune dysregulation in schizophrenia. Curr Opin Psychiatry. 2019. doi:10.1097/yco.0000000000000498

4. Ferguson B, Petridou N, Fracasso A, et al. Detailed T1-Weighted Profiles from the Human Cortex Measured in Vivo at 3 Tesla MRI. Neuroinformatics. 2018:1-16.

5. Jessen K, Mandl RCW, Fagerlund B, et al. Patterns of Cortical Structures and Cognition in Antipsychotic-Naïve Patients With First-Episode Schizophrenia: A Partial Least Squares Correlation Analysis. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2018.

Research Output (58)

SLEEP MEASURES AND THEIR INFLAMMATORY AND CLINICAL CORRELATES IN INDIVIDUALS WITH SCHIZOPHRENIA

Legind Christian, Broberg Brian, Brouwer Rachel, Mandl Rene, Ebdrup Bjorn H., Anhoj Simon, Jensen Maria H., Hilker Rikke Prime, Fagerlund Birgitte, Pol Hilleke Hulshoff, Glenthoj Birte, Rostrup Egill apr 2019, In: Schizophrenia Bulletin. 45 , p. S311-S311

Heritability of Cerebral Blood Flow and the Correlation to Schizophrenia Spectrum Disorders:A Pseudo-continuous Arterial Spin Labeling Twin Study

Legind Christian S, Broberg Brian V, Brouwer Rachel, Mandl René C W, Ebdrup Bjørn H, Anhøj Simon J, Jensen Maria H, Hilker Rikke, Fagerlund Birgitte, Hulshoff Pol Hilleke E, Glenthøj Birte Y, Rostrup Egill 18 feb 2019, In: Schizophrenia Bulletin. 45 , p. 1231-1241 11 p.

Interhemispheric connectivity and hemispheric specialization in schizophrenia patients and their unaffected siblings

Chang Xiao, Collin Guusje, Mandl Rene C. W., Cahn Wiepke, Kahn Rene S. 7 jan 2019, In: Neuroimage: Clinical [E]. 21

Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder:Results from the EU-AIMS Longitudinal European Autism Project

Oldehinkel Marianne, Mennes Maarten, Marquand Andre, Charman Tony, Tillmann Julian, Ecker Christine, Dell'Acqua Flavio, Brandeis Daniel, Banaschewski Tobias, Baumeister Sarah, Moessnang Carolin, Baron-Cohen Simon, Holt Rosemary, Bölte Sven, Durston Sarah, Kundu Prantik, Lombardo Michael V., Spooren Will, Loth Eva, Murphy Declan G.M., Beckmann Christian F., Buitelaar Jan K., Ahmad Jumana, Ambrosino Sara, Auyeung Bonnie, Bourgeron Thomas, Bours Carsten, Brammer Michael, Brogna Claudia, de Bruijn Yvette, Chakrabarti Bhismadev, Cornelissen Ineke, Crawley Daisy, Dumas Guillaume, Faulkner Jessica, Frouin Vincent, Garcés Pilar, Goyard David, Ham Lindsay, Hayward Hannah, Hipp Joerg, Johnson Mark H., Jones Emily J.H., Lai Meng Chuan, Liogier D'ardhuy Xavier, Lythgoe David J., Mandl René, Mason Luke, Meyer-Lindenberg Andreas, Oranje Bob, 1 jan 2019, In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 4 , p. 260-270 11 p.

HERITABILITY AND CORRELATION TO SCHIZOPHRENIA SPECTRUM DISORDER OF GLUTAMATE AND OTHER NEUROMETABOLITE LEVELS IN ANTERIOR CINGULATE AND LEFT THALAMUS: A REGISTER BASED MAGNETIC RESONANCE TWIN STUDY

Legind Christian, Broberg Brian, Mandl Rene, Brouwer Rachel, Anhoj Simon, Hilker Rikke, Jensen Maria H., McGuire Philip, Pol Hilleke E. Hulshoff, Fagerlund Birgitte, Rostrup Egill, Glenthoj Birte apr 2018, In: Schizophrenia Bulletin. 44 , p. S83-S83

Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders:a <sup>1</sup> [H]-spectroscopy twin study

Legind Christian Stefan, Broberg Brian Villumsen, Mandl René Christiaan William, Brouwer Rachel, Anhøj Simon Jesper, Hilker Rikke, Jensen Maria Høj, McGuire Philip, Pol Hilleke Hulshoff, Fagerlund Birgitte, Rostrup Egill, Glenthøj Birte Yding 2018, In: Neuropsychopharmacology. 44 , p. 581-589 9 p.

Intelligence and brain efficiency:Investigating the association between working memory performance, glutamate, and GABA

Marsman Anouk, Mandl René C.W., Klomp Dennis W.J., Cahn Wiepke, Kahn René S., Luijten Peter R., Hulshoff Pol Hilleke E. sep 2017, In: Frontiers in Psychiatry [E]. 8

CORTICAL THICKNESS IN ANTIPSYCHOTIC-NAIVE FIRST-EPISODE SCHIZOPHRENIA PATIENTS AND ASSOCIATIONS WITH CAUDATE D2/3 BINDING POTENTIALS.

Jessen Kasper, Ebdrup Bjorn H., Fagerlund Birgitte, Wulff Sanne, Nielsen Mette O., Mandl Rene C. W., Rostrup Egill, Glenthoj Birte Y. mrt 2017, In: Schizophrenia Bulletin. 43 , p. S144-S144

GLOBAL MICRO-STRUCTURAL WHITE MATTER ALTERATIONS IN THE FIRST-EPISODE ANTIPSYCHOTIC-NAIVE SCHIZOPHRENIA PATIENTS AFTER 6 WEEKS OF SELECTIVE D2/3 RECEPTOR BLOCKADE

Raghava Jayachandra Mitta, Ebdrup Bjorn H., Nielsen Mette O., Rostrup Egill, Mandl Rene C. W., Glenthoj Birte Y. mrt 2017, In: Schizophrenia Bulletin. 43 , p. S239-S240

COGNITION AND WHITE MATTER INTEGRITY IN ANTIPSYCHOTIC-NAIVE FIRST-EPISODE SCHIZOPHRENIA PATIENTS

Jensen Marie B., Raghava Jayachandra M., Mandl Rene C. W., Rostrup Egill, Nielsen Mette O., Jensen Maria H., Glenthoj Birte Y., Ebdrup Bjorn H., Fagerlund Birgitte mrt 2017, In: Schizophrenia Bulletin. 43 , p. S126-S127

All Research Output (58)