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dr. R.C.W. (René) Mandl

Associate Professor
dr. R.C.W. (René) Mandl
  • Psychiatry

Research Programs

Brain

Biography

Biography

René C. W. Mandl obtained his Masters degree in Informatics (artificial intelligence) at the University of Amsterdam in 1996, after which he started to work as a scientific programmer at the Department of Psychiatry of the University Medical Center Utrecht. He started his PhD project (part-time) in 2004 and in 2009 he successfully defended his PhD thesis titled: “Tract-based analysis in schizophrenia: Measuring structure and function along white matter tracts”. Currently he holds a permanent position as an associate professor (research) at the Department of Psychiatry and his research expertise includes diffusion-weighted imaging, structural MRI, functional MRI, MR spectroscopy and the development of new analysis methods.He also worked from 2014 until 2019 as senior researcher (part time) at the CNSR, Psychiatric Center Glostrup, Denmark. He is involved in several international collaborations such as YOUTH, ENIGMA, and TACTICS. 

Research line

New analysis methods for (ultra-) high field MRI in psychiatric research

Most recent key publications

1.        Nuninga JO, Mandl RCW, Boks MP, et al. Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T. Mol Psychiatry. 2019. doi:10.1038/s41380-019-0392-6

2.        Legind CS, Broberg BV, Mandl RCW, et al. Heritability of cerebral glutamate levels and their association with schizophrenia spectrum disorders: a (1)[H]-spectroscopy twin study. Neuropsychopharmacology. 2019;44(3):581-589. doi:10.1038/s41386-018-0236-0

3.        Gangadin SS, Nasib LG, Sommer IEC, Mandl RCW. MRI investigation of immune dysregulation in schizophrenia. Curr Opin Psychiatry. 2019. doi:10.1097/yco.0000000000000498

4.        Ferguson B, Petridou N, Fracasso A, et al. Detailed T1-Weighted Profiles from the Human Cortex Measured in Vivo at 3 Tesla MRI. Neuroinformatics. 2018:1-16.

5.        Jessen K, Mandl RCW, Fagerlund B, et al. Patterns of Cortical Structures and Cognition in Antipsychotic-Naïve Patients With First-Episode Schizophrenia: A Partial Least Squares Correlation Analysis. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2018.

Research Output (99)

The YOUth study:Rationale, design, and study procedures

Onland-Moret N. Charlotte, Buizer-Voskamp Jacobine E., Albers Maria E.W.A., Brouwer Rachel M., Buimer Elizabeth E.L., Hessels Roy S., de Heus Roel, Huijding Jorg, Junge Caroline M.M., Mandl René C.W., Pas Pascal, Vink Matthijs, van der Wal Juliëtte J.M., Hulshoff Pol Hilleke E., Kemner Chantal 7 okt 2020, In: Developmental Cognitive Neuroscience. 46

The YOUth cohort study:MRI protocol and test-retest reliability in adults

Buimer Elizabeth E.L., Pas Pascal, Brouwer Rachel M., Froeling Martijn, Hoogduin Hans, Leemans Alexander, Luijten Peter, van Nierop Bastiaan J., Raemaekers Mathijs, Schnack Hugo G., Teeuw Jalmar, Vink Matthijs, Visser Fredy, Hulshoff Pol Hilleke E., Mandl René C.W. okt 2020, In: Developmental Cognitive Neuroscience. 45 , p. 1-15

Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis

van Dellen Edwin, Börner Corinna, Schutte Maya, van Montfort Simone, Abramovic Lucija, Boks Marco P., Cahn Wiepke, van Haren Neeltje, Mandl René, Stam Cornelis J., Sommer Iris 2 sep 2020, In: npj Schizophrenia. 6

Vasogenic edema versus neuroplasticity as neural correlates of hippocampal volume increase following electroconvulsive therapy

Nuninga Jasper O., Mandl René C.W., Froeling Martijn, Siero Jeroen C.W., Somers Metten, Boks Marco P., Nieuwdorp Wendy, Heringa Sophie, Sommer Iris E.C. 1 jul 2020, In: Brain Stimulation. 13 , p. 1080-1086 7 p.

Language in schizophrenia:relation with diagnosis, symptomatology and white matter tracts

de Boer J N, van Hoogdalem M, Mandl R C W, Brummelman J, Voppel A E, Begemann M J H, van Dellen E, Wijnen F N K, Sommer I E C 20 apr 2020, In: npj Schizophrenia. 6 , p. 10

Structural and functional MRI of altered brain development in a novel adolescent rat model of quinpirole-induced compulsive checking behavior

Straathof Milou, Blezer Erwin L.A., van Heijningen Caroline, Smeele Christel E., van der Toorn Annette, Buitelaar Jan K., de Ruiter Saskia, Naaijen Jilly, Akkermans Sophie, Mennes Maarten, Zwiers Marcel, Ilbegi Shahrzad, Hennissen Leonie, Glennon Jeffrey C., van de Vondervoort Ilse, Kapusta Katarzyna, Bielczyk Na AAtalia, Amiri Houshang, Havenith Martha, Franke Barbara, Poelmans Geert, Bralten Janita, Heskes Tom, Sokolova Elena, Groot Perry, Williams Steven, Murphy De AAclan, Lythgoe David, Bruchhage Muriel, Dud Iulia, Voinescu Bogdan, Dittmann Ralf, Banaschewski Tobias, Brandeis Daniel, Mechler Konstantin, Berg Ruth, Wolf Isabella, Häge Alexander, Landauer Michael, Hohmann Sarah, Schlier Regina Boecker, Ruff Matthias, Mandl René, Dijkhuizen Rick, Blezer Erwin, Mol Wouter, Otte Willem, Durston Sarah, Oranje Bob, Dijkhuizen Rick, 1 apr 2020, In: European Neuropsychopharmacology. 33 , p. 58-70 13 p.

Structural methods in gray matter

Mandl René C.W., Schnack Hugo G., Brouwer Rachel M., Hulshoff Pol Hilleke E. 1 jan 2020, p. 3-26 24 p.

No Effects of Cognitive Remediation on Cerebral White Matter in Individuals at Ultra-High Risk for Psychosis-A Randomized Clinical Trial

Kristensen Tina D, Ebdrup Bjørn H, Hjorthøj Carsten, Mandl René C W, Raghava Jayachandra M, Jepsen Jens Richardt M, Fagerlund Birgitte, Glenthøj Louise B, Wenneberg Christina, Krakauer Kristine, Pantelis Christos, Glenthøj Birte Y, Nordentoft Merete 2020, In: Frontiers in Psychiatry. 11 , p. 873

MRI investigation of immune dysregulation in schizophrenia

Gangadin Shiral S, Nasib Lyliana G, Sommer Iris E C, Mandl René C W mei 2019, In: Current Opinion in Psychiatry. 32 , p. 164-169 6 p.

SLEEP MEASURES AND THEIR INFLAMMATORY AND CLINICAL CORRELATES IN INDIVIDUALS WITH SCHIZOPHRENIA

Legind Christian, Broberg Brian, Brouwer Rachel, Mandl Rene, Ebdrup Bjorn H., Anhoj Simon, Jensen Maria H., Hilker Rikke Prime, Fagerlund Birgitte, Pol Hilleke Hulshoff, Glenthoj Birte, Rostrup Egill apr 2019, In: Schizophrenia Bulletin. 45 , p. S311-S311

All research output