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prof. dr. R.H. (R.H.) Medema

Full Professor

  • Molecular Cancer Research

Research Programs

Research Output (142)

Degree and site of chromosomal instability define its oncogenic potential

Hoevenaar Wilma H.M., Janssen Aniek, Quirindongo Ajit I., Ma Huiying, Klaasen Sjoerd J., Teixeira Antoinette, van Gerwen Bastiaan, Lansu Nico, Morsink Folkert H.M., Offerhaus G. Johan A., Medema René H., Kops Geert J.P.L., Jelluma Nannette 20 mrt 2020, In: Nature Communications. 11 11 p.

Persistent repair intermediates induce senescence

Feringa F. M., Raaijmakers J. A., Hadders M. A., Vaarting C., Macurek L., Heitink L., Krenning L., Medema R. H. 1 dec 2018, In: Nature Communications. 9

Cytokinesis defects and cancer

Lens Susanne M.A., Medema René H. 1 jan 2018, In: Nature Reviews Cancer. 19 , p. 32-45 14 p.

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

Haarhuis Judith H.I., van der Weide Robin H., Blomen Vincent A., Yáñez-Cuna J. Omar, Amendola Mario, van Ruiten Marjon S., Krijger Peter H. L., Teunissen Hans, Medema René H., van Steensel Bas, Brummelkamp Thijn R., de Wit Elzo, Rowland Benjamin D. 4 mei 2017, In: Cell. 169 , p. 693-707.e14

Hypersensitivity to DNA damage in antephase as a safeguard for genome stability

Feringa Femke M., Krenning Lenno, Koch André, Van Den Berg Jeroen, Van Den Broek Bram, Jalink Kees, Medema René H. 26 aug 2016, In: Nature Communications [E]. 7

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

Vecchione Loredana, Gambino Valentina, Raaijmakers Jonne, Schlicker Andreas, Fumagalli Arianna, Russo Mariangela, Villanueva Alberto, Beerling Evelyne, Bartolini Alice, Mollevi David G., El-Murr Nizar, Chiron Marielle, Calvet Loreley, Nicolazzi Céline, Combeau Cécile, Henry Christophe, Simon Iris M., Tian Sun, In 'T Veld Sjors, D'Ario Giovanni, Mainardi Sara, Beijersbergen Roderick L., Lieftink Cor, Linn Sabine, Rumpf-Kienzl Cornelia, Delorenzi Mauro, Wessels Lodewyk, Salazar Ramon, Di Nicolantonio Federica, Bardelli Alberto, Van Rheenen Jacco, Medema René H., Tejpar Sabine, Bernards René 7 apr 2016, In: Cell. 165 , p. 317-330 14 p.

HC StratoMineR:A Web-Based Tool for the Rapid Analysis of High-Content Datasets

Omta Wienand A, van Heesbeen Roy G, Pagliero Romina J, van der Velden Lieke M, Lelieveld Daphne, Nellen Mehdi, Kramer Maik, Yeong Marley, Saeidi Amir M, Medema Rene H, Spruit Marco, Brinkkemper Sjaak, Klumperman Judith, Egan David A 2016, In: Assay and Drug Development Technologies. 14 , p. 439-452 14 p.

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

Maia A. R R, De Man J., Boon U., Janssen A., Song J. Y., Omerzu M., Sterrenburg J. G., Prinsen M. B W, Willemsen-Seegers N., De Roos J. A D M, Van Doornmalen A. M., Uitdehaag J. C M, Kops G. J P L, Jonkers J., Buijsman R. C., Zaman Guido J R, Medema R. H. 1 okt 2015, In: Annals of Oncology. 26 , p. 2180-2192 13 p.

Molecular basis underlying resistance to Mps1/TTK inhibitors

Koch A., Maia A., Janssen A., Medema R. H. 14 sep 2015, In: Oncogene. 35 , p. 2518–2528

The core spliceosome as target and effector of non-canonical ATM signalling

Tresini Maria, Warmerdam Daniël O, Kolovos Petros, Snijder Loes, Vrouwe Mischa G, Demmers Jeroen A A, van IJcken Wilfred F J, Grosveld Frank G, Medema René H, Hoeijmakers Jan H J, Mullenders Leon H F, Vermeulen Wim, Marteijn Jurgen A 2 jul 2015, In: Nature. 523 , p. 53-58 6 p.

All Research Output (142)