prof. dr. R.H. (R.H.) Medema

prof. dr. R.H. (R.H.) Medema

Full Professor

Show full profile

Research Output (145)

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

Maia A. R R, De Man J., Boon U., Janssen A., Song J. Y., Omerzu M., Sterrenburg J. G., Prinsen M. B W, Willemsen-Seegers N., De Roos J. A D M, Van Doornmalen A. M., Uitdehaag J. C M, Kops G. J P L, Jonkers J., Buijsman R. C., Zaman Guido J R, Medema R. H. 1 Oct 2015, In: Annals of Oncology. 26 , p. 2180-2192 13 p.

Molecular basis underlying resistance to Mps1/TTK inhibitors

Koch A., Maia A., Janssen A., Medema R. H. 14 Sep 2015, In: Oncogene. 35 , p. 2518–2528 11 p.

The core spliceosome as target and effector of non-canonical ATM signalling

Tresini Maria, Warmerdam Daniël O, Kolovos Petros, Snijder Loes, Vrouwe Mischa G, Demmers Jeroen A A, van IJcken Wilfred F J, Grosveld Frank G, Medema René H, Hoeijmakers Jan H J, Mullenders Leon H F, Vermeulen Wim, Marteijn Jurgen A 2 Jul 2015, In: Nature. 523 , p. 53-58 6 p.

Spatial separation of Plk1 phosphorylation and activity

Bruinsma Wytse, Aprelia Melinda, Kool Jolanda, Macurek Libor, Lindqvist Arne, Medema René H. Jun 2015, In: Frontiers in oncology. 5

Delaying mitotic exit downregulates FLIP expression and strongly sensitizes tumor cells to TRAIL

Sánchez-Pérez T., Medema R. H., López-Rivas A. 29 Jan 2015, In: Oncogene. 34 , p. 661-669 9 p.

The same, only different - DNA damage checkpoints and their reversal throughout the cell cycle

Shaltiel Indra A., Krenning Lenno, Bruinsma Wytse, Medema René H. 2015, In: Journal of Cell Science. 128 , p. 607-620 14 p.

Genome-wide RNAi screen for synthetic lethal interactions with the C. elegans kinesin-5 homolog BMK-1

Maia André F, Tanenbaum Marvin E, Galli Matilde, Lelieveld Daphne, Egan David A, Gassmann Reto, Sunkel Claudio E, van den Heuvel Sander, Medema René H 2015, In: Scientific data. 2

USP17- and SCFβTrCP--regulated degradation of DEC1 controls the DNA damage response

Kim J., D'Annibale S., Magliozzi R., Low T.Y., Jansen P., Shaltiel I.A., Mohammed S., Heck A.I., Medema R.H., Guardavaccaro D. 15 Nov 2014, In: Molecular and Cellular Biology. 34 , p. 4177-4185 9 p.

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

Shaltiël I.A., Aprelia M., Saurin A.T., Chowdhury D., Kops G.J.P.L., Voest E.E., Medema R.H. 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111 , p. 7313-7318 6 p.

Cancer Core Europe:A consortium to address the cancer care - Cancer research continuum challenge

Eggermont Alexander M M, Caldas Carlos, Ringborg Ulrik, Medema René, Tabernero Josep, Wiestler Otmar 2014, In: European Journal of Cancer. 50 , p. 2745-2746 2 p.

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet