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prof. dr. L. (Linde) Meyaard

Full Professor

  • Laboratory for Translational Immunology (LTI)

prof. dr. L. (Linde) Meyaard

Biography

Linde Meyaard obtained her PhD in 1995 (cum laude) at Sanquin in Amsterdam studying mechanism of immune dysfunction in HIV infection. In 1996 she entered the immune inhibitory receptor field as a post-doc at DNAX Research Institute in California. She identified a novel inhibitory immune receptor, LAIR-1, and continued her work on this receptor in as a fellow of the Royal Academy of Sciences (KNAW) in the UMC Utrecht.
Since 2000 she leads her own research group embedded in the Laboratory of Translational Immunology, supported by multiple grants such as the NWO Vidi and Vici. Meyaard was the first to identify collagens and collagen-like proteins as the natural ligands for LAIR-1.

She extended her research towards other inhibitory receptors and discovered SIRL-1 as a novel receptor able to regulate the function of neutrophils and monocytes.
Currently, Meyaard focuses on studying the control of immune-mediated collateral tissue damage through inhibitory receptors in human disease. She formes a translational research team with clinician Professor Louis Bont, studying regulation of neutrophilic airway inflammation and the potential to therapeutically exploit inhibitory receptors. The growing global interest in targeting inhibitory receptors therapeutically opens up possibilities for clinical application of her work.

 

 

Side Activities

  • Visiting Scientist, Yale Medical School, Dept Immunobiology Aug 201631 Jul 2017

    Secretary general of the Dutch Society of Immunology

    Member of review panel NWO/ALW Open Program

    Associate Editor Frontiers in Molecular Innate Immunity

    Review Editor Frontiers in NK Cell Biology

    Member of the ZonMW TOP program review committee

    Member of the Scientific Advisory Board of the Dutch Arthritis Foundation

Fellowship and Awards

  • 1999-2001      Fellow of the Royal Dutch Academy of Science (KNAW)

    2001                NWO Vidi

    2002                NWO Aspasia

    2014                NWO Vici

Research Output (103)

Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on lung monocytes, but absent on mononuclear phagocytes in skin and colon

von Richthofen Helen J., Gollnast Doron, van Capel Toni M.M., Giovannone Barbara, Westerlaken Geertje H.A., Lutter Lisanne, Oldenburg Bas, Hijnen Dirk Jan, van der Vlist Michiel, de Jong Esther C., Meyaard Linde nov 2020, In: Cellular Immunology. 357

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

Carvalheiro Tiago, Garcia Samuel, Pascoal Ramos M. Inês, Giovannone Barbara, Radstake Timothy R.D.J., Marut Wioleta, Meyaard Linde 19 aug 2020, In: Frontiers in Immunology. 11

Long-term expanding human airway organoids for disease modeling

Sachs Norman, Papaspyropoulos Angelos, Zomer-van Ommen Domenique D., Heo Inha, Böttinger Lena, Klay Dymph, Weeber Fleur, Huelsz-Prince Guizela, Iakobachvili Nino, Amatngalim Gimano D., de Ligt Joep, van Hoeck Arne, Proost Natalie, Viveen Marco C., Lyubimova Anna, Teeven Luc, Derakhshan Sepideh, Korving Jeroen, Begthel Harry, Dekkers Johanna F., Kumawat Kuldeep, Ramos Emilio, van Oosterhout Matthijs F.M., Offerhaus G. Johan, Wiener Dominique J., Olimpio Eduardo P., Dijkstra Krijn K., Smit Egbert F., van der Linden Maarten, Jaksani Sridevi, van de Ven Marieke, Jonkers Jos, Rios Anne C., Voest Emile E., van Moorsel Coline H.M., van der Ent Cornelis K., Cuppen Edwin, van Oudenaarden Alexander, Coenjaerts Frank E., Meyaard Linde, Bont Louis J., Peters Peter J., Tans Sander J., van Zon Jeroen S., Boj Sylvia F., Vries Robert G., Beekman Jeffrey M., Clevers Hans 1 jan 2019, In: EMBO Journal. 38

The pro-tumor effect of CD200 expression is not mimicked by agonistic CD200R antibodies

Pilch Zofia, Tonecka Katarzyna, Skorzynski Marcin, Sas Zuzanna, Braniewska Agata, Kryczka Tomasz, Boon Louis, Golab Jakub, Meyaard Linde, Rygiel Tomasz P. 1 jan 2019, In: PLoS ONE. 14

LAIR-1 limits neutrophilic airway inflammation

Kumawat Kuldeep, Geerdink Ruben J., Hennus Marije P., Roda Mojtaba Abdul, Van Ark Ingrid, Leusink-Muis Thea, Folkerts Gert, Van Oort-Jansen Anita, Mazharian Alexandra, Watson Steve P., Coenjaerts Frank E., Bont Louis, Meyaard Linde 1 jan 2019, In: Frontiers in Immunology. 10 9 p.

Antitumor activity of TLR7 is potentiated by CD200R antibody leading to changes in the tumor microenvironment

Pilch Zofia, Tonecka Katarzyna, Braniewska Agata, Sas Zuzanna, Skorzynski Marcin, Boon Louis, Golab Jakub, Meyaard Linde, Rygiel Tomasz P. 1 aug 2018, In: Cancer Immunology Research. 6 , p. 930-940 11 p.

Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome

van der Linden Maarten, van den Hoogen Lucas L., Westerlaken Geertje H.A., Fritsch-Stork Ruth D.E., Fritsch-Stork Ruth D.E., van Roon Joël A.G., Radstake Timothy R.D.J., Meyaard Linde 1 jul 2018, In: Rheumatology (United Kingdom). 57 , p. 1228-1234 7 p.

Neutrophil-mediated suppression of influenza-induced pathology requires CD11b/CD18 (MAC-1)

Tak Tamar, Rygiel Tomasz P., Karnam Guruswamy, Bastian Okan W., Boon Louis, Viveen Marco, Coenjaerts Frank E., Meyaard Linde, Koenderman Leo, Pillay Janesh 1 apr 2018, In: American Journal of Respiratory Cell and Molecular Biology. 58 , p. 492-499 8 p.

LAIR-1 limits neutrophil extracellular trap formation in viral bronchiolitis

Geerdink Ruben J., Hennus Marije P., Westerlaken Geertje H.A., Abrahams Alferso C., Albers Kim I., Walk Jona, Wesselink Esther, Janssen Riny, Bont Louis, Meyaard Linde feb 2018, In: Journal of Allergy and Clinical Immunology. 141 , p. 811-814 4 p.

Differential Signalling and Kinetics of Neutrophil Extracellular Trap Release Revealed by Quantitative Live Imaging

Van Der Linden Maarten, Westerlaken Geertje H.A., Van Der Vlist Michiel, Van Montfrans Joris, Meyaard Linde 1 dec 2017, In: Scientific Reports. 7

All Research Output (103)