prof. dr. L. (Linde) Meyaard

Full Professor
prof. dr. L. (Linde) Meyaard
  • Laboratory for Translational Immunology (LTI)



Linde Meyaard obtained her PhD in 1995 (cum laude) at Sanquin in Amsterdam studying mechanism of immune dysfunction in HIV infection. In 1996 she entered the immune inhibitory receptor field as a post-doc at DNAX Research Institute in California. She identified a novel inhibitory immune receptor, LAIR-1, and continued her work on this receptor in as a fellow of the Royal Academy of Sciences (KNAW) in the UMC Utrecht.
Since 2000 she leads her own research group embedded in the Laboratory of Translational Immunology, supported by multiple grants such as the NWO Vidi and Vici. Meyaard was the first to identify collagens and collagen-like proteins as the natural ligands for LAIR-1.

She extended her research towards other inhibitory receptors and discovered SIRL-1 as a novel receptor able to regulate the function of neutrophils and monocytes.
Currently, Meyaard focuses on studying the control of immune-mediated collateral tissue damage through inhibitory receptors in human disease. She formes a translational research team with clinician Professor Louis Bont, studying regulation of neutrophilic airway inflammation and the potential to therapeutically exploit inhibitory receptors. The growing global interest in targeting inhibitory receptors therapeutically opens up possibilities for clinical application of her work.



Side Activities

Visiting Scientist, Yale Medical School, Dept Immunobiology Aug 201631 Jul 2017

Secretary general of the Dutch Society of Immunology

Member of review panel NWO/ALW Open Program

Associate Editor Frontiers in Molecular Innate Immunity

Review Editor Frontiers in NK Cell Biology

Member of the ZonMW TOP program review committee

Member of the Scientific Advisory Board of the Dutch Arthritis Foundation

Fellowship and Awards

1999-2001      Fellow of the Royal Dutch Academy of Science (KNAW)

2001                NWO Vidi

2002                NWO Aspasia

2014                NWO Vici

Research Output (107)

Transcriptome of airway neutrophils reveals an interferon response in life-threatening respiratory syncytial virus infection

Besteman Sjanna B., Callaghan Amie, Langedijk Annefleur C., Hennus Marije P., Meyaard Linde, Mokry Michal, Bont Louis J., Calis Jorg J.A. nov 2020, In: Clinical Immunology. 220 , p. 1-10

Signal Inhibitory Receptor on Leukocytes-1 is highly expressed on lung monocytes, but absent on mononuclear phagocytes in skin and colon

von Richthofen Helen J., Gollnast Doron, van Capel Toni M.M., Giovannone Barbara, Westerlaken Geertje H.A., Lutter Lisanne, Oldenburg Bas, Hijnen Dirk Jan, van der Vlist Michiel, de Jong Esther C., Meyaard Linde 28 aug 2020, In: Cellular Immunology. 357

Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation

Carvalheiro Tiago, Garcia Samuel, Pascoal Ramos M. Inês, Giovannone Barbara, Radstake Timothy R.D.J., Marut Wioleta, Meyaard Linde 19 aug 2020, In: Frontiers in Immunology. 11 13 p.

Functional categories of immune inhibitory receptors

Rumpret Matevž, Drylewicz Julia, Ackermans Laura J.E., Borghans José A.M., Medzhitov Ruslan, Meyaard Linde 1 jan 2020, In: Nature Reviews. Immunology. 20 , p. 771-780 10 p.

Signal inhibitory receptor on leukocytes (SIRL)-1 and leukocyte- associated immunoglobulin-like receptor (LAIR)-1 regulate neutrophil function in infants

Besteman Sjanna B., Callaghan Amie, Hennus Marije P., Westerlaken Geertje H.A., Meyaard Linde, Bont Louis L. 13 dec 2019, In: Clinical Immunology. 211 , p. 1-9

Neutrophil extracellular traps and low-density granulocytes are associated with the interferon signature in systemic lupus erythematosus, but not in antiphospholipid syndrome

Van Den Hoogen Lucas L., Van Der Linden Maarten, Meyaard Linde, Fritsch-Stork Ruth D.E., Van Roon Joel A., Radstake Timothy R.D.J. 1 jan 2019, In: Annals of the Rheumatic Diseases. 79

Long-term expanding human airway organoids for disease modeling

Sachs Norman, Papaspyropoulos Angelos, Zomer-van Ommen Domenique D., Heo Inha, Böttinger Lena, Klay Dymph, Weeber Fleur, Huelsz-Prince Guizela, Iakobachvili Nino, Amatngalim Gimano D., de Ligt Joep, van Hoeck Arne, Proost Natalie, Viveen Marco C., Lyubimova Anna, Teeven Luc, Derakhshan Sepideh, Korving Jeroen, Begthel Harry, Dekkers Johanna F., Kumawat Kuldeep, Ramos Emilio, van Oosterhout Matthijs F.M., Offerhaus G. Johan, Wiener Dominique J., Olimpio Eduardo P., Dijkstra Krijn K., Smit Egbert F., van der Linden Maarten, Jaksani Sridevi, van de Ven Marieke, Jonkers Jos, Rios Anne C., Voest Emile E., van Moorsel Coline H.M., van der Ent Cornelis K., Cuppen Edwin, van Oudenaarden Alexander, Coenjaerts Frank E., Meyaard Linde, Bont Louis J., Peters Peter J., Tans Sander J., van Zon Jeroen S., Boj Sylvia F., Vries Robert G., Beekman Jeffrey M., Clevers Hans 1 jan 2019, In: EMBO Journal. 38

The pro-tumor effect of CD200 expression is not mimicked by agonistic CD200R antibodies

Pilch Zofia, Tonecka Katarzyna, Skorzynski Marcin, Sas Zuzanna, Braniewska Agata, Kryczka Tomasz, Boon Louis, Golab Jakub, Meyaard Linde, Rygiel Tomasz P. 1 jan 2019, In: PLoS ONE. 14

LAIR-1 limits neutrophilic airway inflammation

Kumawat Kuldeep, Geerdink Ruben J., Hennus Marije P., Roda Mojtaba Abdul, Van Ark Ingrid, Leusink-Muis Thea, Folkerts Gert, Van Oort-Jansen Anita, Mazharian Alexandra, Watson Steve P., Coenjaerts Frank E., Bont Louis, Meyaard Linde 1 jan 2019, In: Frontiers in Immunology. 10 9 p.

Antitumor activity of TLR7 is potentiated by CD200R antibody leading to changes in the tumor microenvironment

Pilch Zofia, Tonecka Katarzyna, Braniewska Agata, Sas Zuzanna, Skorzynski Marcin, Boon Louis, Golab Jakub, Meyaard Linde, Rygiel Tomasz P. 1 aug 2018, In: Cancer Immunology Research. 6 , p. 930-940 11 p.

All research output

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