prof. dr. M.C. (Monique) Minnema

Full Professor
prof. dr. M.C. (Monique) Minnema
  • Department of Medical Oncology



Prof Dr Monique Minnema was trained as internist and hematologist at Academic Medical Center, Amsterdam and the University Medical Center, Utrecht. She started working as a hematologist in 2005 at the department of hematology, UMC Utrecht and specialized in the diagnosis and treatment of B cell malignancies, especially plasma cell dyscrasis  like Multiple Myeloma and AL amyloidosis, and Waldenstrom Macroglobulinemia.
She is the medical head of the hematology research team which supervises more
than 20 clinical studies. Her main focus of clinical research is the
development of novel therapies (both cellular and drug) developments for plasma
cell dyscrasias and she was appointed full professor of hematology in 2019.

Prof Dr Minnema is an active member of the HOVON working parties for Multiple
Myeloma, Lymphoma and the vice president of the Lunenburg Lymphoma consortium (LLPC) for phase I/II studies. Examples of her work are the HOVON 104 trial for
patients with AL amyloidosis first line treatment and the clinical studies with
the monoclonal antibody Daratumumab in relapsed Multiple Myeloma and anti CD19 CAR T cells in relapsed Lymphoma. Her translational research focuses on the immunotherapy for multiple myeloma, bone remodeling after successful anti myeloma treatment and the possibilities of personalized cancer treatment in this bone marrow cancer. She was a member of the organizing committee of the Waldenström workshop in Amsterdam in 2016.

Research Output (130)

Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells

Slomp Anne, Moesbergen Laura M, Eldering Eric, Kersten Marie José, Minnema Monique C, Peperzak Victor 3 mrt 2021, In: Cell death & disease. 12 , p. 229

Extent of radiological response does not reflect survival in primary central nervous system lymphoma

van der Meulen Matthijs, Postma Alida A, Smits Marion, Bakunina Katerina, Minnema Monique C, Seute Tatjana, Cull Gavin, Enting Roelien H, van der Poel Marjolein, Stevens Wendy B C, Brandsma Dieta, Beeker Aart, Doorduijn Jeanette K, Issa Samar, van den Bent Martin J, Bromberg Jacoline E C 23 feb 2021, In: Neuro-oncology advances. 3 , p. vdab007

αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies

De Witte Moniek A., Janssen Anke, Nijssen Klaartje, Karaiskaki Froso, Swanenberg Luuk, van Rhenen Anna, Admiraal Rick, van der Wagen Lotte, Minnema Monique C., Petersen Eefke, Raymakers Reinier A.P., Westinga Kasper, Straetemans Trudy, Halkes Constantijn J.M., Boelens Jaap Jan, Kuball Jurgen 12 jan 2021, In: Blood Advances. 5 , p. 240-249 10 p.

EBV-related lymphoma after long-term daratumumab treatment:a case report

Verpoorte-Botden Ilse P G, Minnema Monique C, Raymakers Reinier A P 1 nov 2020, In: Blood cancer journal. 10

Consensus treatment recommendations from the tenth International Workshop for Waldenström Macroglobulinaemia

Castillo Jorge J, Advani Ranjana H, Branagan Andrew R, Buske Christian, Dimopoulos Meletios A, D'Sa Shirley, Kersten Marie José, Leblond Veronique, Minnema Monique C, Owen Roger G, Palomba M Lia, Talaulikar Dipti, Tedeschi Alessandra, Trotman Judith, Varettoni Marzia, Vos Josephine M, Treon Steven P, Kastritis Efstathios nov 2020, In: Lancet haematology. 7 , p. e827-e837

Consensus Statement on the Management of Waldenström Macroglobulinemia Patients During the COVID-19 Pandemic

Talaulikar Dipti, Advani Ranjana H, Branagan Andrew R, Buske Christian, Dimopoulos Meletios A, D'Sa Shirley, Kersten Maria J, Leblond Veronique, Minnema Monique C, Owen Roger G, Palomba Maria Lia, Tedeschi Alessandra, Trotman Judith, Varettoni Marzia, Vos Josephine M, Treon Steven P, Kastritis Efstathios, Castillo Jorge J aug 2020, In: HemaSphere. 4 4 p.

Carfilzomib Combined With Thalidomide and Low-dose Dexamethasone for Remission Induction and Consolidation in Newly Diagnosed Transplant Eligible Patients With Multiple Myeloma:8 vs 4 Induction Cycles; the Carthadex Trial

Wester Ruth, Zweegman Sonja, van der Holt Bronno, Kersten Marie José, Vellenga Edo, van Marwijk-Kooy Marinus, Asselbergs Emelie, de Weerdt Okke, Minnema Monique C, Lonergan Sarah, Palumbo Antonio, Broijl Annemiek, Sonneveld Pieter aug 2020, In: HemaSphere. 4 3 p.

A randomized phase 3 trial of zanubrutinib vs ibrutinib in symptomatic Waldenström macroglobulinemia:The ASPEN study

Tam Constantine S, Opat Stephen, D'Sa Shirley, Jurczak Wojciech, Lee Hui-Peng, Cull Gavin, Owen Roger G, Marlton Paula, Wahlin Björn Engelbrekt, Garcia-Sanz Ramon, McCarthy Helen, Mulligan Stephen, Tedeschi Alessandra, Castillo Jorge, Czyz Jaroslaw, Fernández de Larrea Carlos, Belada David, Libby Edward, Matous Jeffrey V, Motta Marina, Siddiqi Tanya, Tani Monica, Trneny Marek, Minnema Monique C, Buske Christian, Leblond Veronique, Chan Wai Y, Schneider Jingjing Yan, Ro Sunhee, Cohen Aileen, Huang Jane, Dimopoulos Meletios A 30 jul 2020, In: Blood. 136 , p. 2038-2050 13 p.

Clone-directed therapy for proliferative glomerulonephritis with monoclonal immunoglobulin depositions is it always necessary? ::Two case reports and literature review

van Kruijsdijk Rob C M, Abrahams Alferso C, Nguyen Tri Q, Minnema Monique C, Jacobs Joannes F M, Limper Maarten 1 jun 2020, In: Journal of Nephrology. 33 , p. 611-617 7 p.

Challenges in the Management of patients with systemic light chain (AL) amyloidosis during the COVID-19 pandemic

Kastritis Efstathios, Wechalekar Ashutosh, Schönland Stefan, Sanchorawala Vaishali, Merlini Giampaolo, Palladini Giovanni, Minnema Monique, Roussel Murielle, Jaccard Arnaud, Hegenbart Ute, Kumar Shaji, Cibeira Maria Teresa, Blade Joan, Dimopoulos Meletios A 1 jun 2020, In: British Journal of Haematology. 190 , p. 346-357 12 p.

All research output

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