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prof. dr. M.C. (Monique) Minnema

Full Professor
prof. dr. M.C. (Monique) Minnema
  • Department of Medical Oncology

Biography

Biography

Prof Dr Monique Minnema was trained as internist and hematologist at Academic Medical Center, Amsterdam and the University Medical Center, Utrecht. She started working as a hematologist in 2005 at the department of hematology, UMC Utrecht and specialized in the diagnosis and treatment of B cell malignancies, especially plasma cell dyscrasis  like Multiple Myeloma and AL amyloidosis, and Waldenstrom Macroglobulinemia.
She is the medical head of the hematology research team which supervises more
than 20 clinical studies. Her main focus of clinical research is the
development of novel therapies (both cellular and drug) developments for plasma
cell dyscrasias and she was appointed full professor of hematology in 2019.

Prof Dr Minnema is an active member of the HOVON working parties for Multiple
Myeloma, Lymphoma and the vice president of the Lunenburg Lymphoma consortium (LLPC) for phase I/II studies. Examples of her work are the HOVON 104 trial for
patients with AL amyloidosis first line treatment and the clinical studies with
the monoclonal antibody Daratumumab in relapsed Multiple Myeloma and anti CD19 CAR T cells in relapsed Lymphoma. Her translational research focuses on the immunotherapy for multiple myeloma, bone remodeling after successful anti myeloma treatment and the possibilities of personalized cancer treatment in this bone marrow cancer. She was a member of the organizing committee of the Waldenström workshop in Amsterdam in 2016.

Research Output (135)

Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis

Kastritis Efstathios, Palladini Giovanni, Minnema Monique C, Wechalekar Ashutosh D, Jaccard Arnaud, Lee Hans C, Sanchorawala Vaishali, Gibbs Simon, Mollee Peter, Venner Christopher P, Lu Jin, Schönland Stefan, Gatt Moshe E, Suzuki Kenshi, Kim Kihyun, Cibeira M Teresa, Beksac Meral, Libby Edward, Valent Jason, Hungria Vania, Wong Sandy W, Rosenzweig Michael, Bumma Naresh, Huart Antoine, Dimopoulos Meletios A, Bhutani Divaya, Waxman Adam J, Goodman Stacey A, Zonder Jeffrey A, Lam Selay, Song Kevin, Hansen Timon, Manier Salomon, Roeloffzen Wilfried, Jamroziak Krzysztof, Kwok Fiona, Shimazaki Chihiro, Kim Jin-Seok, Crusoe Edvan, Ahmadi Tahamtan, Tran NamPhuong, Qin Xiang, Vasey Sandra Y, Tromp Brenda, Schecter Jordan M, Weiss Brendan M, Zhuang Sen H, Vermeulen Jessica, Merlini Giampaolo, Comenzo Raymond L, 1 jul 2021, In: The New England journal of medicine. 385 , p. 46-58 13 p.

Direct P70S6K1 inhibition to replace dexamethasone in synergistic combination with MCL-1 inhibition in multiple myeloma

Spaan Ingrid, Timmerman Laura M, Kimman Thomas, Slomp Anne, Cuenca Marta, van Nieuwenhuijzen Niels, Moesbergen Laura M, Minnema Monique C, Raymakers Reinier A, Peperzak Victor 22 jun 2021, In: Blood Advances. 5 , p. 2593-2607 15 p.

Endomyocardial biopsy with co-localization of a lymphoplasmacytic lymphoma and AL amyloidosis

Leguit Roos J, Vink Aryan, de Jonge Nicolaas, Minnema Monique C, Oerlemans Marish I F 23 mei 2021, In: Cardiovascular Pathology. 53 , p. 1-4

Belantamab mafodotin in combination with novel agents in relapsed/refractory multiple myeloma:DREAMM-5 study design

Nooka Ajay K, Weisel Katja, van de Donk Niels Wcj, Routledge David, Otero Paula Rodriguez, Song Kevin, Quach Hang, Callander Natalie, Minnema Monique C, Trudel Suzanne, Jackson Nicola A, Ahlers Christoph M, Im Ellie, Cheng Shinta, Smith L, Hareth Nahi, Ferron-Brady Geraldine, Brouch Maria, de Oca Rocio Montes, Paul Sofia, Holkova Beata, Gupta Ira, Kremer Brandon E, Richardson Paul 8 mrt 2021, In: Future Oncology. 17 , p. 1987-2003 17 p.

Phosphatase PP2A enhances MCL-1 protein half-life in multiple myeloma cells

Slomp Anne, Moesbergen Laura M, Eldering Eric, Kersten Marie José, Minnema Monique C, Peperzak Victor 3 mrt 2021, In: Cell death & disease. 12

Extent of radiological response does not reflect survival in primary central nervous system lymphoma

van der Meulen Matthijs, Postma Alida A, Smits Marion, Bakunina Katerina, Minnema Monique C, Seute Tatjana, Cull Gavin, Enting Roelien H, van der Poel Marjolein, Stevens Wendy B C, Brandsma Dieta, Beeker Aart, Doorduijn Jeanette K, Issa Samar, van den Bent Martin J, Bromberg Jacoline E C 23 feb 2021, In: Neuro-oncology advances. 3

αβ T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies

De Witte Moniek A., Janssen Anke, Nijssen Klaartje, Karaiskaki Froso, Swanenberg Luuk, van Rhenen Anna, Admiraal Rick, van der Wagen Lotte, Minnema Monique C., Petersen Eefke, Raymakers Reinier A.P., Westinga Kasper, Straetemans Trudy, Halkes Constantijn J.M., Boelens Jaap Jan, Kuball Jurgen 12 jan 2021, In: Blood Advances. 5 , p. 240-249 10 p.

EBV-related lymphoma after long-term daratumumab treatment:a case report

Verpoorte-Botden Ilse P G, Minnema Monique C, Raymakers Reinier A P 1 nov 2020, In: Blood cancer journal. 10

Consensus treatment recommendations from the tenth International Workshop for Waldenström Macroglobulinaemia

Castillo Jorge J, Advani Ranjana H, Branagan Andrew R, Buske Christian, Dimopoulos Meletios A, D'Sa Shirley, Kersten Marie José, Leblond Veronique, Minnema Monique C, Owen Roger G, Palomba M Lia, Talaulikar Dipti, Tedeschi Alessandra, Trotman Judith, Varettoni Marzia, Vos Josephine M, Treon Steven P, Kastritis Efstathios nov 2020, In: Lancet haematology. 7 , p. e827-e837

Consensus Statement on the Management of Waldenström Macroglobulinemia Patients During the COVID-19 Pandemic

Talaulikar Dipti, Advani Ranjana H, Branagan Andrew R, Buske Christian, Dimopoulos Meletios A, D'Sa Shirley, Kersten Maria J, Leblond Veronique, Minnema Monique C, Owen Roger G, Palomba Maria Lia, Tedeschi Alessandra, Trotman Judith, Varettoni Marzia, Vos Josephine M, Treon Steven P, Kastritis Efstathios, Castillo Jorge J aug 2020, In: HemaSphere. 4 4 p.

All research output

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