dr. M. (Michal) Mokry
dr. M. (Michal) Mokry
- CDL Research
- Departement of Experimental Cardiology
Research Programs
Biography
Biography
In my research, I unravel the biological mechanisms behind atherosclerosis. I employ a combination of bulk and single-cell transcriptomics, epigenetics, and bioinformatics, and integrate these approaches with clinical datasets and in vitro experiments.
My work leverages the largest biobank of well-characterized atherosclerotic plaques from over 4,000 patients, known as the Athero-Express study. We generate a variety of complex “-omics” datasets, which include genotyping, transcriptomics (bulk, single-cell, and spatially resolved), DNA methylation (both bulk and single-cell), and proteomics. These datasets are integrated with histological and clinical data to decode the mechanisms of plaque pathogenesis. This integration enables us to pinpoint specific processes that lead to severe manifestations of atherosclerotic disease, such as stroke and myocardial infarction. Alongside computational tools, we utilize primary in vitro model systems derived from vascular and plaque cells, as well as molecular biology techniques, for validation and mechanistic studies."
Research Output (121)
Kavousi Maryam et al. 28 Sep 2023, In: Nature Genetics. 55 , p. 1651-1664 14 p.
Benavente Ernest Diez, Karnewar Santosh, Buono Michele, Mili Eloi, Hartman Robin J G, Kapteijn Daniek, Slenders Lotte, Daniels Mark, Aherrahrou Redouane, Reinberger Tobias, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Prange Koen H M, Depuydt Marie A C, de Winther Menno P J, Kuiper Johan, Björkegren Johan L M, Erdmann Jeanette, Civelek Mete, Mokry Michal, Owens Gary K, Pasterkamp Gerard, den Ruijter Hester M 17 Aug 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43 , p. 1836-1850 15 p.
Spanjersberg Talitha C F, Oosterhoff Loes A, Kruitwagen Hedwig S, van den Dungen Noortje A M, Vernooij Johannes C M, Asselbergs Folkert W, Mokry Michal, Spee Bart, Harakalova Magdalena, van Steenbeek Frank G 10 Aug 2023, In: Scientific Reports. 13
Zhang Yujiao, Vandestienne Marie, Lavillegrand Jean Rémi, Joffre Jeremie, Santos-Zas Icia, Lavelle Aonghus, Zhong Xiaodan, Le Goff Wilfried, Guérin Maryse, Al-Rifai Rida, Laurans Ludivine, Bruneval Patrick, Guérin Coralie, Diedisheim Marc, Migaud Melanie, Puel Anne, Lanternier Fanny, Casanova Jean Laurent, Cochain Clément, Zernecke Alma, Saliba Antoine Emmanuel, Mokry Michal, Silvestre Jean Sebastien, Tedgui Alain, Mallat Ziad, Taleb Soraya, Lenoir Olivia, Vindis Cécile, Camus Stéphane M., Sokol Harry, Ait-Oufella Hafid Aug 2023, In: Nature Communications. 14 17 p.
von Scheidt Moritz, Bauer Sabine, Ma Angela, Hao Ke, Kessler Thorsten, Vilne Baiba, Wang Ying, Hodonsky Chani J, Ghosh Saikat K B, Mokry Michal, Gao Hua, Kawai Kenji, Sakamoto Atsushi, Kaiser Juliane, Bongiovanni Dario, Fleig Julia, Oldenbuettel Lilith, Chen Zhifen, Moggio Aldo, Sager Hendrik B, Hecker Judith S, Bassermann Florian, Maegdefessel Lars, Miller Clint L, Koenig Wolfgang, Zeiher Andreas M, Dimmeler Stefanie, Graw Matthias, Braun Christian, Ruusalepp Arno, Leeper Nicholas J, Kovacic Jason C, Björkegren Johan L M, Schunkert Heribert 26 Jul 2023, 34 p.
Buono Michele F, Benavente Ernest Diez, Daniels Mark, Mol Barend M, Mekke Joost M, de Borst Gert J, de Kleijn Dominique P V, van der Laan Sander W, Pasterkamp Gerard, Onland-Moret Charlotte, Mokry Michal, den Ruijter Hester M 5 Jul 2023, In: Biology of Sex Differences. 14 12 p.
van Vroonhoven Ellen C.N., Picavet Lucas W., Scholman Rianne C., van den Dungen Noortje A.M., Mokry Michal, Evers Anouk, Lebbink Robert J., Calis Jorg J.A., Vastert Sebastiaan J., van Loosdregt Jorg Jul 2023, In: Biology. 12 11 p.
Mocholi Enric, Russo Laura, Gopal Keshav, Ramstead Andrew G, Hochrein Sophia M, Vos Harmjan R, Geeven Geert, Adegoke Adeolu O, Hoekstra Anna, van Es Robert M, Pittol Jose Ramos, Vastert Sebastian, Rutter Jared, Radstake Timothy, van Loosdregt Jorg, Berkers Celia, Mokry Michal, Anderson Colin C, O'Connell Ryan M, Vaeth Martin, Ussher John, Burgering Boudewijn M T, Coffer Paul J 1 Jun 2023, In: Cell Reports. 42 , p. 1-24
Jansen Suze A, Cutilli Alessandro, de Koning Coco, van Hoesel Marliek, Sierra Leire Saiz, Nierkens Stefan, Mokry Michal, Nieuwenhuis Edward E S, Hanash Alan M, Mocholi Enric, Coffer Paul J, Lindemans Caroline A 30 Apr 2023,
Benavente Ernest Diez, Karnewar Santosh, Buono Michele, Mili Eloi, Hartman Robin J G, Kapteijn Daniek, Slenders Lotte, Daniels Mark, Aherrahrou Redouane, Reinberger Tobias, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Prange Koen H M, Depuydt Marie A C, de Winther Menno P J, Kuiper Johan, Bj Rkegren Johan L M, Erdmann Jeanette, Civelek Mete, Mokry Michal, Owens Gary K, Pasterkamp Gerard, den Ruijter Hester M 9 Feb 2023,