dr. M. (Michal) Mokry

dr. M. (Michal) Mokry

Associate Professor
dr. M. (Michal) Mokry
  • CDL Research
  • Departement of Experimental Cardiology

Research Programs



In my research, I unravel the biological mechanisms behind atherosclerosis. I employ a combination of bulk and single-cell transcriptomics, epigenetics, and bioinformatics, and integrate these approaches with clinical datasets and in vitro experiments.

My work leverages the largest biobank of well-characterized atherosclerotic plaques from over 4,000 patients, known as the Athero-Express study. We generate a variety of complex “-omics” datasets, which include genotyping, transcriptomics (bulk, single-cell, and spatially resolved), DNA methylation (both bulk and single-cell), and proteomics. These datasets are integrated with histological and clinical data to decode the mechanisms of plaque pathogenesis. This integration enables us to pinpoint specific processes that lead to severe manifestations of atherosclerotic disease, such as stroke and myocardial infarction. Alongside computational tools, we utilize primary in vitro model systems derived from vascular and plaque cells, as well as molecular biology techniques, for validation and mechanistic studies."

Research Output (131)

Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated With Endothelial-to-Mesenchymal Transition in Humans

Benavente Ernest Diez, Hartman Robin J G, Sakkers Tim R, Wesseling Marian, Sloots Yannicke, Slenders Lotte, Boltjes Arjan, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Prange Koen H M, de Winther Menno P J, Kuiper Johan, Civelek Mete, van der Laan Sander W, Horvath Steve, Onland-Moret Charlotte, Mokry Michal, Pasterkamp Gerard, den Ruijter Hester M 18 Apr 2024, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 44 , p. 1419-1431

A critical appreciation of pathway analysis in atherosclerotic disease. Cellular phenotypic plasticity as an illustrative example

Wesseling M, Diez-Benavente E, Mokry M, den Ruijter H M, Pasterkamp G 24 Feb 2024, In: Vascular Pharmacology. 154 , p. 1-5 5 p.

IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration

Cutilli Alessandro, Jansen Suze A, Paolucci Francesca, Mokry Michal, Mocholi Enric, Lindemans Caroline A, Coffer Paul J 7 Feb 2024,

Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species

Fang Juntao, Yang Qiangbing, Maas Renée G C, Buono Michele, Meijlink Bram, Lotgerink Bruinenberg Dyonne, Benavente Ernest Diez, Mokry Michal, van Mil Alain, Qian Li, Goumans Marie-José, Schiffelers Raymond, Lei Zhiyong, Sluijter Joost P G 17 Jan 2024, In: Stem Cell Research & Therapy [E]. 15 , p. 19

The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms

Mekke Joost M, Sakkers Tim R, Verwer Maarten C, van den Dungen Noortje A M, Song Yipei, Miller Clint L, Finn Aloke V, Pasterkamp Gerard, Mokry Michal, den Ruijter Hester M, Vink Aryan, de Kleijn Dominique P V, de Borst Gert J, Haitjema Saskia, van der Laan Sander W Dec 2023, In: Scientific Reports. 13 15 p.

Airway and Blood Monocyte Transcriptomic Profiling Reveals an Antiviral Phenotype in Infants With Severe Respiratory Syncytial Virus Infection

Chappin K, Besteman S B, Hennus M P, Wildenbeest J G, Mokry M, Bont L J, van der Vlist M, Calis J J A, 6 Nov 2023, In: The Journal of infectious diseases. 229 , p. S100-S111 12 p.

Human Plaque Myofibroblasts to Study Mechanisms of Atherosclerosis

Buono Michele F, Benavente Ernest Diez, Slenders Lotte, Methorst Daisey, Tessels Daniëlle, Mili Eloi, Finger Roxy, Kapteijn Daniek, Daniels Mark, van den Dungen Noortje A M, Calis Jorg J A, Mol Barend M, de Borst Gert J, de Kleijn Dominique P V, Pasterkamp Gerard, den Ruijter Hester M, Mokry Michal 27 Oct 2023, In: Journal of the American Heart Association. 12

Clonal Proliferation Within Smooth Muscle Cells in Unstable Human Atherosclerotic Lesions

Kawai Kenji, Sakamoto Atsushi, Mokry Michal, Ghosh Saikat Kumar B, Kawakami Rika, Xu Weili, Guo Liang, Fuller Daniela, Tanaka Takamasa, Shah Palak, Cornelissen Anne, Sato Yu, Mori Masayuki, Konishi Takao, Vozenilek Aimee E, Dhingra Roma, Virmani Renu, Pasterkamp Gerard, Finn Aloke V 26 Oct 2023, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 43 , p. 2333-2347 15 p.

Sex differences in the genetic and molecular mechanisms of coronary artery disease

Sakkers Tim R, Mokry Michal, Civelek Mete, Erdmann Jeanette, Pasterkamp Gerard, Diez Benavente Ernest, den Ruijter Hester M 5 Oct 2023, In: Atherosclerosis. 384

Colchicine promotes atherosclerotic plaque stability independently of inflammation

Li Weizhen, Lin Alexander, Hutton Michael, Dhaliwal Harkirat, Nadel James, Rodor Julie, Tumanov Sergey, Örd Tiit, Hadden Matthew, Mokry Michal, Mol Barend M, Pasterkamp Gerard, Padula Matthew P, Geczy Carolyn L, Ramaswamy Yogambha, Sluimer Judith C, Kaikkonen Minna U, Stocker Roland, Baker Andrew H, Fisher Edward A, Patel Sanjay, Misra Ashish 3 Oct 2023, 22 p.

All research output

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