Back

dr. M. (Michal) Mokry

dr. M. (Michal) Mokry

Associate Professor
dr. M. (Michal) Mokry
  • Department of Clinical Chemistry and Haematology
  • Departement of Experimental Cardiology

Research Programs

Biography

Biography

In my research, I focus on uncovering the biological mechanisms of atherosclerosis and heart failure. I utilize bulk and single-cell transcriptomics, epigenetics, bioinformatics and combine those with clinical data sets and in vitro experiments. 

My research utilizes the largest biobank of well-characterized atherosclerotic plaques with more than 4000 included patients – the Athero-Express study. We generate various types of complex “-omics” datasets, including genotyping, transcriptomics (bulk, single-cell and spatially resolved), DNA methylation (bulk and single-cell) and proteomics. These datasets are integrated with histological and clinical data to unravel mechanisms in plaque pathogenesis and allow us to identify specific processes that lead to the severe manifestation of atherosclerotic disease like stroke and myocardial infarction. Next to computational tools, we use primary in vitro model systems derived from vascular and plaque cells and molecular biology techniques for validation and mechanistic studies.

Research Output (97)

CCN2 Aggravates the Immediate Oxidative Stress–DNA Damage Response following Renal Ischemia–Reperfusion Injury

Valentijn Floris, Goldschmeding Roel, Marquez Exposito Laura, Broekhuizen R., Nguyen Tri Q., Knoppert Sebastiaan, Falke LL, Kester Lennart, Mokry Michal, Ruiz-Ortega Marta, Rodrigues-Diez Raúl R. 20 dec 2021, In: Antioxidants. 10 , p. 1-16

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Mijnheer Gerdien, Lutter Lisanne, Mokry Michal, van der Wal Marlot, Scholman Rianne, Fleskens Veerle, Pandit Aridaman, Tao Weiyang, Wekking Mark, Vervoort Stephin, Roberts Ceri, Petrelli Alessandra, Peeters Janneke G C, Knijff Marthe, de Roock Sytze, Vastert Sebastiaan, Taams Leonie S, van Loosdregt Jorg, van Wijk Femke dec 2021, In: Nature Communications. 12 , p. 1-16

The changing landscape of the vulnerable plaque:a call for fine-tuning of preclinical models

Buono Michele F, Slenders Lotte, Wesseling Marian, Hartman Robin J G, Monaco Claudia, den Ruijter Hester M, Pasterkamp Gerard, Mokry Michal dec 2021, In: Vascular Pharmacology. 141 , p. 1-10

Sex-dependent gene co-expression in the human body

Hartman Robin J G, Mokry Michal, Pasterkamp Gerard, den Ruijter Hester M 21 sep 2021, In: Scientific Reports. 11

Activin-A Induces Early Differential Gene Expression Exclusively in Periodontal Ligament Fibroblasts from Fibrodysplasia Ossificans Progressiva Patients

Schoenmaker Ton, Mokry Michal, Micha Dimitra, Netelenbos Coen, Bravenboer Nathalie, Gilijamse Marjolijn, Eekhoff E Marelise W, de Vries Teun J 1 jun 2021, In: Biomedicines. 9 , p. 1-16

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

Hartman Robin J G, Owsiany Katie, Ma Lijiang, Koplev Simon, Hao Ke, Slenders Lotte, Civelek Mete, Mokry Michal, Kovacic Jason C, Pasterkamp Gerard, Owens Gary, Björkegren Johan L M, den Ruijter Hester M 16 feb 2021, In: Circulation. 143 , p. 713-726 14 p.

Sex-dependent gene regulation of human atherosclerotic plaques by DNA methylation and transcriptome integration points to smooth muscle cell involvement in women

Hartman R., Siemelink M., Haitjema S., Dekkers K. F., Slenders L., Boltjes A., Mokry M., Timmerman N., De Borst G. J., Heijmans B. T., Asselbergs F. W., Pasterkamp G., Van der Laan S. W., Den Ruijter H. M. 29 jan 2021, In: bioRxiv. p. E217-E217

Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation

Roukens M Guy, Frederiks Cynthia L, Seinstra Danielle, Braccioli Luca, Khalil Antoine A, Pals Cornelieke, De Neck Simon, Bornes Laura, Beerling Evelyne, Mokry Michal, de Bruin Alain, Westendorp Bart, van Rheenen Jacco, Coffer Paul J 2021, In: Oncogene. 40 , p. 6343-6353 11 p.

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

Schuldt Maike, Pei Jiayi, Harakalova Magdalena, Dorsch Larissa M, Schlossarek Saskia, Mokry Michal, Knol Jaco C, Pham Thang V, Schelfhorst Tim, Piersma Sander R, Dos Remedios Cris, Dalinghaus Michiel, Michels Michelle, Asselbergs Folkert W, Moutin Marie-Jo, Carrier Lucie, Jimenez Connie R, van der Velden Jolanda, Kuster Diederik W D 2021, In: Circulation. Heart Failure. 14 , p. 39-55

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht

Contact

Emergency?

Directions

Appointments

Practical

umcutrecht.nl maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet