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dr. M. (Michal) Mokry

dr. M. (Michal) Mokry

Associate Professor
dr. M. (Michal) Mokry
  • CDL Research
  • Departement of Experimental Cardiology

Research Programs

Biography

Biography

In my research, I focus on uncovering the biological mechanisms of atherosclerosis and heart failure. I utilize bulk and single-cell transcriptomics, epigenetics, bioinformatics and combine those with clinical data sets and in vitro experiments. 

My research utilizes the largest biobank of well-characterized atherosclerotic plaques with more than 4000 included patients – the Athero-Express study. We generate various types of complex “-omics” datasets, including genotyping, transcriptomics (bulk, single-cell and spatially resolved), DNA methylation (bulk and single-cell) and proteomics. These datasets are integrated with histological and clinical data to unravel mechanisms in plaque pathogenesis and allow us to identify specific processes that lead to the severe manifestation of atherosclerotic disease like stroke and myocardial infarction. Next to computational tools, we use primary in vitro model systems derived from vascular and plaque cells and molecular biology techniques for validation and mechanistic studies.

Research Output (107)

A comprehensive transcriptomic comparison of hepatocyte model systems improves selection of models for experimental use

Ardisasmita Arif Ibrahim, Schene Imre F, Joore Indi P, Kok Gautam, Hendriks Delilah, Artegiani Benedetta, Mokry Michal, Nieuwenhuis Edward E S, Fuchs Sabine A 14 Oct 2022, In: Communications biology. 5

DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages

Cobo Isidoro, Tanaka Tiffany N, Chandra Mangalhara Kailash, Lana Addison, Yeang Calvin, Han Claudia, Schlachetzki Johannes, Challcombe Jean, Fixsen Bethany R, Sakai Mashito, Li Rick Z, Fields Hannah, Mokry Michal, Tsai Randy G, Bejar Rafael, Prange Koen, de Winther Menno, Shadel Gerald S, Glass Christopher K 9 Aug 2022, In: Immunity. 55 , p. 1386-1401.e10

The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease

Slenders Lotte, Tessels Daniëlle E, van der Laan Sander W, Pasterkamp Gerard, Mokry Michal 8 Feb 2022, In: Frontiers in cardiovascular medicine. 9 , p. 1-12

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

Slenders Lotte, Landsmeer Lennart P L, Cui Kai, Depuydt Marie A C, Verwer Maarten, Mekke Joost, Timmerman Nathalie, van den Dungen Noortje A M, Kuiper Johan, de Winther Menno P J, Prange Koen H M, Ma Wei Feng, Miller Clint L, Aherrahrou Redouane, Civelek Mete, de Borst Gert J, de Kleijn Dominique P V, Asselbergs Folkert W, den Ruijter Hester M, Boltjes Arjan, Pasterkamp Gerard, van der Laan Sander W, Mokry Michal Jan 2022, In: European heart journal open. 2

Chromatin Immunoprecipitation Sequencing (ChIP-seq) Protocol for Small Amounts of Frozen Biobanked Cardiac Tissue

Pei Jiayi, van den Dungen Noortje A M, Asselbergs Folkert W, Mokry Michal, Harakalova Magdalena 2022, 2458 , p. 97-111 15 p.

Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation

Mokry Michal, Boltjes Arjan, Slenders Lotte, Bel-Bordes Gemma, Cui Kai, Brouwer Eli, Mekke Joost M., Depuydt Marie A. C., Timmerman Nathalie, Waissi Farahnaz, Verwer Maarten C., Turner Adam W., Khan Mohammad Daud, Hodonsky Chani J., Diez Benavente Ernest, Hartman Robin J. G., van den Dungen Noortje A. M., Lansu Nico, Nagyova Emilia, Prange Koen H. M., Kovacic Jason C., Björkegren Johan L. M., Pavlos Eleftherios, Andreakos Evangelos, Schunkert Heribert, Owens Gary K., Monaco Claudia, Finn Aloke V., Virmani Renu, Leeper Nicholas J., de Winther Menno P. J., Kuiper Johan, de Borst Gert J., Stroes Erik S. G., Civelek Mete, de Kleijn Dominique P. V., den Ruijter Hester M., Asselbergs Folkert W., van der Laan Sander W., Miller Clint L., Pasterkamp Gerard 2022, In: Nature Cardiovascular Research. 1 , p. 1140-1155 16 p.

Transcriptome sequencing reveals two subtypes of cortisol-secreting adrenocortical tumours in dogs and identifies CYP26B1 as a potential new therapeutic target

Sanders Karin, Kooistra Hans S., van den Heuvel Marieke, Mokry Michal, Grinwis Guy C.M., van den Dungen Noortje A.M., van Steenbeek Frank G., Galac Sara 2022, In: Veterinary and comparative oncology.

CCN2 Aggravates the Immediate Oxidative Stress–DNA Damage Response following Renal Ischemia–Reperfusion Injury

Valentijn Floris, Goldschmeding Roel, Marquez Exposito Laura, Broekhuizen R., Nguyen Tri Q., Knoppert Sebastiaan, Falke LL, Kester Lennart, Mokry Michal, Ruiz-Ortega Marta, Rodrigues-Diez Raúl R. 20 Dec 2021, In: Antioxidants. 10 , p. 1-16

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Mijnheer Gerdien, Lutter Lisanne, Mokry Michal, van der Wal Marlot, Scholman Rianne, Fleskens Veerle, Pandit Aridaman, Tao Weiyang, Wekking Mark, Vervoort Stephin, Roberts Ceri, Petrelli Alessandra, Peeters Janneke G C, Knijff Marthe, de Roock Sytze, Vastert Sebastiaan, Taams Leonie S, van Loosdregt Jorg, van Wijk Femke Dec 2021, In: Nature Communications. 12 , p. 1-16

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Pei J, Schuldt M, Nagyova E, Gu Z, El Bouhaddani S, Yiangou L, Jansen M, Calis J J A, Dorsch L M, Blok C Snijders, van den Dungen N A M, Lansu N, Boukens B J, Efimov I R, Michels M, Verhaar M C, de Weger R, Vink A, van Steenbeek F G, Baas A F, Davis R P, Uh H W, Kuster D W D, Cheng C, Mokry M, van der Velden J, Asselbergs F W, Harakalova M Dec 2021, In: Clinical Epigenetics. 13 , p. 1-20

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