dr. E.M. (Evelyn) Monninkhof

Assistant Professor

  • Department of Epidemiology
  • Julius Center Research Program Cancer

dr. E.M. (Evelyn) Monninkhof

Research Programs


Evelyn Monninkhof studied Biomedical Health Sciences at the Catholic University Nijmegen. In 1998, she obtained her Master’s degree in Epidemiology. In 1999, she started a PhD project at Medisch Spectrum Twente hospital in Enschede and the Department of Epidemiology at the University Medical Center Nijmegen. In February 2004, she completed her thesis on ‘Medical and behavioural interventions in COPD: the COPE study’. Since October 2003, she is working at the Julius Center for Health Sciences and Primary care as a postdoc researcher in the field of cancer epidemiology, obesity and physical activity. Furthermore, she is a teacher in Epidemiology & Evidence Based Medicine and methodological consultant for the department of Radiotherapy.

Interests and Focus

Main research interest of Evelyn Monninkhof is directed towards physical activity, obesity and (breast) cancer risk. She has been coordinating/ involved in several randomised controlled trials studying the effect of exercise on breast cancer risk or outcome after breast cancer diagnosis:

  • The SHAPE-1 study examined the effects of a 1-year exercise programme on endogenous hormone levels (associated with breast cancer among 189 sedentary postmenopausal women.
  • The SHAPE-2 study examined the effect of weight loss mainly driven by exercise compared to equivalent weight loss due to a calorie restricted diet only on sex hormone levels. In addition, the role of total body fat and intra-abdominal fat was explored.
  • The UMBRELLA- Fit trial: a trial investigating the effects of physical activity in breast cancer patients applying a new study design (the cmRCT design)
  • The PAM (Physical Activity & Exercise) study. This study investigates the effects of exercise on cognitive function in breast cancer patients with complaints in this area after chemotherapy treatment.

Besides above mentioned trials, Evelyn is also involved in the DENSE trial: a very large trial studying the cost-effectiveness of biennial screening with MRI + mammography compared to mammography alone in women aged 50-75 years with extremely dense breasts. At the radiotherapy department, she is involved in the FLAME trial. This trial invetsigates standard fractionated external beam radiotherapy (EBRT) with and without an additional integrated boost to the macroscopically visible tumour in patients with localized prostate cancer on disease-free survival and side effects.

Side Activities

  • -         Member (methodologist) of the Medical Ethical Committee of the UMC Utrecht

    -         Member of the tracer pool of the UMC Utrecht

    -         Consultant at the Julius Support office

Fellowship and Awards

  • None

Research Output (124)

Meerwaarde van MRI-screening bij zeer dicht borstweefsel in het bevolkingsonderzoek borstkanker

de Lange Stéphanie V., Bakker Marije F., Pijnappel Ruud M., Mann Ritse M., Peeters Petra H.M., Monninkhof Evelyn M., Emaus Marleen J., Loo Claudette E., Bisschops Robertus H.C., Lobbes Marc B.I., de Jong Mathijn D.F., Duvivier Katya M., Veltman Jeroen, Karssemeijer Nico, de Koning Harry J., van Diest Paul J., Mali Willem P.T.M., van den Bosch Maurice A.A.J., Veldhuis Wouter B., van Gils Carla H. apr 2020, In: Nederlands Tijdschrift voor Geneeskunde. 164 10 p.

Theoretical potential for endometrial cancer prevention through primary risk factor modification:Estimates from the EPIC cohort

Fortner Renée T, Hüsing Anika, Dossus Laure, Tjønneland Anne, Overvad Kim, Dahm Christina C, Arveux Patrick, Fournier Agnès, Kvaskoff Marina, Schulze Matthias B, Bergmann Manuela, Trichopoulou Antonia, Karakatsani Anna, La Vecchia Carlo, Masala Giovanna, Pala Valeria, Mattiello Amalia, Tumino Rosario, Ricceri Fulvio, van Gils Carla H, Monninkhof Evelyn M, Bonet Catalina, Quirós José Ramón, Sanchez Maria-Jose, Rodríguez-Palacios Daniel-Ángel, Gurrea Aurelio B, Amiano Pilar, Allen Naomi E, Travis Ruth C, Gunter Marc J, Viallon Vivian, Weiderpass Elisabete, Riboli Elio, Kaaks Rudolf 3 feb 2020, In: International Journal of Cancer. 147 , p. 1325-1333 9 p.

Physical activity and risks of breast and colorectal cancer:a Mendelian randomisation analysis

Papadimitriou Nikos et al. 30 jan 2020, In: Nature Communications. 11 10 p.

Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases:a multinational cohort study

Freisling Heinz, Viallon Vivian, Lennon Hannah, Bagnardi Vincenzo, Ricci Cristian, Butterworth Adam S, Sweeting Michael, Muller David, Romieu Isabelle, Bazelle Pauline, Kvaskoff Marina, Arveux Patrick, Severi Gianluca, Bamia Christina, Kühn Tilman, Kaaks Rudolf, Bergmann Manuela, Boeing Heiner, Tjønneland Anne, Olsen Anja, Overvad Kim, Dahm Christina C, Menéndez Virginia, Agudo Antonio, Sánchez Maria-Jose, Amiano Pilar, Santiuste Carmen, Gurrea Aurelio Barricarte, Tong Tammy Y N, Schmidt Julie A, Tzoulaki Ioanna, Tsilidis Konstantinos K, Ward Heather, Palli Domenico, Agnoli Claudia, Tumino Rosario, Ricceri Fulvio, Panico Salvatore, Picavet H Susan J, Bakker Marije, Monninkhof Evelyn, Nilsson Peter, Manjer Jonas, Rolandsson Olov, Thysell Elin, Weiderpass Elisabete, Jenab Mazda, Riboli Elio, Vineis Paolo, Danesh John, Wareham Nick J, Gunter Marc J, Ferrari Pietro 10 jan 2020, In: BMC Medicine. 18 11 p.

Supplemental MRI Screening for Women with Extremely Dense Breast Tissue

Bakker Marije F, de Lange Stéphanie V, Pijnappel Ruud M, Mann Ritse M, Peeters Petra H M, Monninkhof Evelyn M, Emaus Marleen J, Loo Claudette E, Bisschops Robertus H C, Lobbes Marc B I, de Jong Matthijn D F, Duvivier Katya M, Veltman Jeroen, Karssemeijer Nico, de Koning Harry J, van Diest Paul J, Mali Willem P T M, van den Bosch Maurice A A J, Veldhuis Wouter B, van Gils Carla H, 28 nov 2019, In: The New England journal of medicine. 381 , p. 2091-2102 12 p.

The Trials within Cohorts design faced methodological advantages and disadvantages in the exercise oncology setting

Gal Roxanne, Monninkhof Evelyn M, van Gils Carla H, Groenwold Rolf H H, van den Bongard Desirée H J G, Peeters Petra H M, Verkooijen Helena M, May Anne M sep 2019, In: Journal of Clinical Epidemiology. 113 , p. 137-146 10 p.

Effect of physical exercise on cognitive function and brain measures after chemotherapy in patients with breast cancer (PAM study):protocol of a randomised controlled trial

Witlox Lenja, Schagen Sanne B, de Ruiter Michiel B, Geerlings Mirjam I, Peeters Petra H M, Koevoets Emmie W, van der Wall Elsken, Stuiver Martijn, Sonke Gabe, Velthuis Miranda J, Palen Job A M van der, Jobsen Jan J, May Anne M, Monninkhof E M 1 jun 2019, In: BMJ Open. 9

Physical activity levels of women with breast cancer during and after treatment, a comparison with the Dutch female population

Gal R., Monninkhof E. M., Peeters P. H.M., van Gils C. H., van den Bongard D. H.J.G., Wendel-Vos G. C.W., Zuithoff N. P.A., Verkooijen H. M., May A. M. 4 mei 2019, In: Acta Oncologica. 58 , p. 673-681 9 p.

Breast Cancer Survivors' Experiences With an Activity Tracker Integrated Into a Supervised Exercise Program:Qualitative Study

Wu Hoi San, Gal Roxanne, van Sleeuwen Niek C, Brombacher Aarnout C, IJsselsteijn Wijnand A, May Anne M, Monninkhof Evelyn M 21 feb 2019, In: JMIR mHealth and uHealth. 7

Effect of diet with or without exercise on abdominal fat in postmenopausal women - a randomised trial

van Gemert Willemijn A, Peeters Petra H, May Anne M, Doornbos Adriaan J H, Elias Sjoerd G, van der Palen Job, Veldhuis Wouter, Stapper Maaike, Schuit Jantine A, Monninkhof Evelyn M 11 feb 2019, In: BMC Public Health. 19 , p. 174

All Research Output (124)