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prof. dr. K.G.M. (K. (Carl) G.M. ) Moons

prof. dr. K.G.M. (K. (Carl) G.M. ) Moons

Full Professor
prof. dr. K.G.M. (K. (Carl) G.M.  ) Moons
  • Department of Epidemiology
  • Julius Center Research Program Methodology

Research Programs

Strategic Program Cancer

Biography

Biography

K.G.M. (Carl) Moons is Professor of Clinical Epidemiology at the Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, Utrecht, The Netherlands. He is Director of Research of the Julius Center (550 Employees). He headed the research program ‘Research Methodology’ until 2019. 

Education:

- MSc in Biomedical Sciences (Radboud University Nijmegen, 1992);

- MSc in Clinical Epidemiology (Erasmus University Rotterdam, 1994)

- PhD in Medicine (Erasmus University Rotterdam, 1996).

Since 2005 full Professor of Clinical Epidemiology at the Julius Center,UMC Utrecht, Utrecht University, Utrecht, The Netherlands.

He was a visiting Professor at the University of Virginia, USA (2002) and at Tokai University, Japan (2005-2010).

He has been a member of various committees, e.g. Netherlands Organization for Scientific Research, Royal Dutch Academy of Sciences, Dutch Health Council, Cochrane Collaboration, and Medical Ethical Committees.

He is principal investigator in numerous international clinical (epidemiology) studies funded by various organisations (EU, NHS, NIH). His experience covers the full range of conduct, data analysis, reporting and dissemination of such studies, varying from studies on the evaluation of medical devices and tests for diagnosis, prognosis, screening and monitoring, to etiological studies and randomised therapeutic trials, to meta-epidemiological studies, both on aggregate and individual participant data. His main focus concerns improving the methods and approaches for evaluation and implementation of medical devices, (bio)markers and prediction models. His major expertise is introducing innovations for the design, conducting, analysis and reporting of evaluations of diagnostic and prognostic tests, devices, (bio)markers and prediction models. Clinical topics include cancer, deep vein thrombosis, stroke, heart failure and peri-operative risk assessment. He teaches graduate and postgraduate students in all aspects of clinical (epidemiological) research design, conducting, analysis and reporting, throughout the world.

Indicators of Research Excellence

Over his career Professor Moons has published over 480 peer-reviewed publications (including scientific papers and book chapters) with >22,000 citations (H index 72, Scopus). He has obtained numerous (methodological and applied) research grants, including large prestigious personal grants (in summary over 10 million euro as co-PI). The (societal) impact of his research record has also been recognised by membership of the Dutch Health Council, Chair of Committee of the Royal Netherlands Academy of Arts and Sciences, membership of numerous committees of Dutch Scientific Organisations, and interviews for national and internal news magazines. He also teaches bachelor, master, post doctoral students in clinical research across the world, including Asia and Africa.

 

Side Activities

Adjunct Professor of Clinical Epidemiology, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, USA. (since 2005)

Adjunct Professor of Clinical Epidemiology, Center of Statistics in Medicine, Oxford University, Oxford, UK (since 2017)

Staff Cochrane Netherlands.

Member of Cochrane Collaboration; Convenor Cochrane's Prognosis Methods Group; Member of IPD Meta-analysis group and Diagnostic Test Accuracy Group.

Editor-in-chief BMC Diagnostic and Prognostic Research.

Member of the Dutch Health Council

Chair of The Netherlands Implant Side-effects Expertise Center

Initiator and ambassador of Health Innovation Initiative Holland (Hii Holland)

Fellowship and Awards

2003 VIDI Award        The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, “Diagnostic Prediction Rules; innovative methods to improve their applicability”.

2008 TOP Grant         The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, "Clinical prediction rules: towards a framework for meta-analysis, validation, and updating"

2010 VICI Award        The Netherlands Organisation for Health Research and Development, Role: Principal Investigator “A different view on diagnostic research: a framework for studying the  Differential diagnosis and diseases with an imperfect or missing reference test"

Research Output (680)

Minimal reporting improvement after peer review in reports of COVID-19 prediction models:systematic review

Hudda Mohammed T, Archer Lucinda, van Smeden Maarten, Moons Karel G M, Collins Gary S, Steyerberg Ewout W, Wahlich Charlotte, Reitsma Johannes B, Riley Richard D, Van Calster Ben, Wynants Laure 14 Dec 2022, In: Journal of Clinical Epidemiology. 154 , p. 75-84 10 p.

Head-to-head comparison of the accuracy of saliva and nasal rapid antigen SARS-CoV-2 self-testing:cross-sectional study

Schuit Ewoud, Venekamp Roderick P., Veldhuijzen Irene K., van den Bijllaardt Wouter, Pas Suzan D., Stohr Joep J.J.M., Lodder Esther B., Hellwich Marloes, Molenkamp Richard, Igloi Zsofia, Wijers Constantijn, Vroom Irene H., Nagel-Imming Carla R.S., Han Wanda G.H., Kluytmans Jan A.J.W., van den Hof Susan, van de Wijgert Janneke H.H.M., Moons Karel G.M. 24 Oct 2022, In: BMC Medicine. 20

Diagnostic accuracy of covid-19 rapid antigen tests with unsupervised self-sampling in people with symptoms in the omicron period:cross sectional study

Schuit Ewoud, Venekamp Roderick P., Hooft Lotty, Veldhuijzen Irene K., van den Bijllaardt Wouter, Pas Suzan D., Zwart Vivian F., Lodder Esther B., Hellwich Marloes, Koppelman Marco, Molenkamp Richard, Wijers Constantijn J.H., Vroom Irene H., Smeets Leonard C., Nagel-Imming Carla R.S., Han Wanda G.H., van den Hof Susan, Kluytmans Jan A.J.W., van de Wijgert Janneke H.H.M., Moons Karel G.M. 14 Sep 2022, In: BMJ (Clinical research ed.). 378

Risk of bias of prognostic models developed using machine learning:a systematic review in oncology

Dhiman Paula, Ma Jie, Andaur Navarro Constanza L, Speich Benjamin, Bullock Garrett, Damen Johanna A A, Hooft Lotty, Kirtley Shona, Riley Richard D, Van Calster Ben, Moons Karel G M, Collins Gary S 7 Jul 2022, In: Diagnostic and Prognostic Research. 6

Cochrane corner:Biomarkers to improve preoperative prediction of major cardiac outcomes after non-cardiac surgery

Vernooij Lisette M, van Klei Wilton A, Moons Karel Gm, van Waes Judith Ar, Damen Johanna Aag 5 Jul 2022, In: Heart (British Cardiac Society). 108 , p. 1257-1259 3 p.

Developing, validating, updating and judging the impact of prognostic models for respiratory diseases

van Royen Florien S, Moons Karel G M, Geersing Geert-Jan, van Smeden Maarten 21 Jun 2022, In: The European respiratory journal. 60

Critical appraisal of artificial intelligence-based prediction models for cardiovascular disease

van Smeden Maarten, Heinze Georg, Van Calster Ben, Asselbergs Folkert W, Vardas Panos E, Bruining Nico, de Jaegere Peter, Moore Jason H, Denaxas Spiros, Boulesteix Anne-Laure, Moons Karel G M 26 May 2022, In: European heart journal. 43 , p. 2921-2930 10 p.

Methodological conduct of prognostic prediction models developed using machine learning in oncology:a systematic review

Dhiman Paula, Ma Jie, Andaur Navarro Constanza L., Speich Benjamin, Bullock Garrett, Damen Johanna A.A., Hooft Lotty, Kirtley Shona, Riley Richard D., Van Calster Ben, Moons Karel G.M., Collins Gary S. 8 Apr 2022, In: BMC Medical Research Methodology. 22

Detection of SARS-CoV-2 infection in the general population by three prevailing rapid antigen tests:cross-sectional diagnostic accuracy study

Venekamp Roderick P, Veldhuijzen Irene K, Moons Karel G M, van den Bijllaardt Wouter, Pas Suzan D, Lodder Esther B, Molenkamp Richard, Igloi Zsofi, Wijers Constantijn, Dos Santos Claudy Oliveira, Debast Sylvia B, Bruins Marjan J, Polad Khaled, Nagel-Imming Carla R S, Han Wanda G H, van de Wijgert Janneke H H M, van den Hof Susan, Schuit Ewoud 24 Feb 2022, In: BMC Medicine. 20

Prognostic factors for adverse outcomes in patients with COVID-19:a field-wide systematic review and meta-analysis

Bellou Vanesa, Tzoulaki Ioanna, van Smeden Maarten, Moons Karel G M, Evangelou Evangelos, Belbasis Lazaros 1 Feb 2022, In: The European respiratory journal. 59

All research output

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