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prof. dr. K.G.M. (K. (Carl) G.M. ) Moons

Full Professor
prof. dr. K.G.M. (K. (Carl) G.M.  ) Moons
  • Department of Epidemiology
  • Julius Center Research Program Methodology

Research Programs

Strategic Program Cancer

Biography

Biography

K.G.M. (Carl) Moons is Professor of Clinical Epidemiology at the Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht University, Utrecht, The Netherlands. He is Director of Research of the Julius Center (550 Employees). He headed the research program ‘Research Methodology’ until 2019. 

Education:

- MSc in Biomedical Sciences (Radboud University Nijmegen, 1992);

- MSc in Clinical Epidemiology (Erasmus University Rotterdam, 1994)

- PhD in Medicine (Erasmus University Rotterdam, 1996).

Since 2005 full Professor of Clinical Epidemiology at the Julius Center,UMC Utrecht, Utrecht University, Utrecht, The Netherlands.

He was a visiting Professor at the University of Virginia, USA (2002) and at Tokai University, Japan (2005-2010).

He has been a member of various committees, e.g. Netherlands Organization for Scientific Research, Royal Dutch Academy of Sciences, Dutch Health Council, Cochrane Collaboration, and Medical Ethical Committees.

He is principal investigator in numerous international clinical (epidemiology) studies funded by various organisations (EU, NHS, NIH). His experience covers the full range of conduct, data analysis, reporting and dissemination of such studies, varying from studies on the evaluation of medical devices and tests for diagnosis, prognosis, screening and monitoring, to etiological studies and randomised therapeutic trials, to meta-epidemiological studies, both on aggregate and individual participant data. His main focus concerns improving the methods and approaches for evaluation and implementation of medical devices, (bio)markers and prediction models. His major expertise is introducing innovations for the design, conducting, analysis and reporting of evaluations of diagnostic and prognostic tests, devices, (bio)markers and prediction models. Clinical topics include cancer, deep vein thrombosis, stroke, heart failure and peri-operative risk assessment. He teaches graduate and postgraduate students in all aspects of clinical (epidemiological) research design, conducting, analysis and reporting, throughout the world.

Indicators of Research Excellence

Over his career Professor Moons has published over 480 peer-reviewed publications (including scientific papers and book chapters) with >22,000 citations (H index 72, Scopus). He has obtained numerous (methodological and applied) research grants, including large prestigious personal grants (in summary over 10 million euro as co-PI). The (societal) impact of his research record has also been recognised by membership of the Dutch Health Council, Chair of Committee of the Royal Netherlands Academy of Arts and Sciences, membership of numerous committees of Dutch Scientific Organisations, and interviews for national and internal news magazines. He also teaches bachelor, master, post doctoral students in clinical research across the world, including Asia and Africa.

 

Side Activities

  • Adjunct Professor of Clinical Epidemiology, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, USA. (since 2005)

    Adjunct Professor of Clinical Epidemiology, Center of Statistics in Medicine, Oxford University, Oxford, UK (since 2017)

    Staff Cochrane Netherlands.

    Member of Cochrane Collaboration; Convenor Cochrane's Prognosis Methods Group; Member of IPD Meta-analysis group and Diagnostic Test Accuracy Group.

    Editor-in-chief BMC Diagnostic and Prognostic Research.

    Member of the Dutch Health Council

    Chair of The Netherlands Implant Side-effects Expertise Center

    Initiator and ambassador of Health Innovation Initiative Holland (Hii Holland)

Fellowship and Awards

  • 2003 VIDI Award        The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, “Diagnostic Prediction Rules; innovative methods to improve their applicability”.

    2008 TOP Grant         The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, "Clinical prediction rules: towards a framework for meta-analysis, validation, and updating"

    2010 VICI Award        The Netherlands Organisation for Health Research and Development, Role: Principal Investigator “A different view on diagnostic research: a framework for studying the  Differential diagnosis and diseases with an imperfect or missing reference test"

Research Output (647)

Real-life impact of clinical prediction rules for venous thromboembolism in primary care:a cross-sectional cohort study

van Maanen Rosanne, Kingma Annelieke E C, Oudega Ruud, Rutten Frans H, Moons Karel, Geersing Geert-Jan 28 dec 2020, In: BMJ Open. 10 , p. e039913

The Number of Concomitant Drugs and the Safety of Direct Oral Anticoagulants in Routine Care Patients with Atrial Fibrillation

van den Dries Carline J, van Doorn Sander, Souverein Patrick, Pajouheshnia Romin, Moons Karel G M, Hoes Arno W, Geersing Geert-Jan, van den Ham Hendrika A 23 dec 2020, In: TH open : companion journal to thrombosis and haemostasis. 4 , p. e417-e426

Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia:an individual participant data meta-analysis

Allotey John, Snell Kym Ie, Smuk Melanie, Hooper Richard, Chan Claire L, Ahmed Asif, Chappell Lucy C, von Dadelszen Peter, Dodds Julie, Green Marcus, Kenny Louise, Khalil Asma, Khan Khalid S, Mol Ben W, Myers Jenny, Poston Lucilla, Thilaganathan Basky, Staff Anne C, Smith Gordon Cs, Ganzevoort Wessel, Laivuori Hannele, Odibo Anthony O, Ramírez Javier A, Kingdom John, Daskalakis George, Farrar Diane, Baschat Ahmet A, Seed Paul T, Prefumo Federico, da Silva Costa Fabricio, Groen Henk, Audibert Francois, Masse Jacques, Skråstad Ragnhild B, Salvesen Kjell Å, Haavaldsen Camilla, Nagata Chie, Rumbold Alice R, Heinonen Seppo, Askie Lisa M, Smits Luc Jm, Vinter Christina A, Magnus Per M, Eero Kajantie, Villa Pia M, Jenum Anne K, Andersen Louise B, Norman Jane E, Ohkuchi Akihide, Eskild Anne, Bhattacharya Sohinee, McAuliffe Fionnuala M, Galindo Alberto, Herraiz Ignacio, Carbillon Lionel, Klipstein-Grobusch Kerstin, Yeo SeonAe, Teede Helena J, Browne Joyce L, Moons Karel Gm, Riley Richard D, Thangaratinam Shakila 18 dec 2020, In: Health technology assessment (Winchester, England). 24 , p. 1-290 290 p.

Protocol for a systematic review on the methodological and reporting quality of prediction model studies using machine learning techniques

Andaur Navarro Constanza L, Damen Johanna A A G, Takada Toshihiko, Nijman Steven W J, Dhiman Paula, Ma Jie, Collins Gary S, Bajpai Ram, Riley Richard D, Moons Karel Gm, Hooft Lotty 11 nov 2020, In: BMJ Open. 10 , p. 1-6

External validation of prognostic models predicting pre-eclampsia:individual participant data meta-analysis

Snell Kym I E, Allotey John, Smuk Melanie, Hooper Richard, Chan Claire, Ahmed Asif, Chappell Lucy C, Von Dadelszen Peter, Green Marcus, Kenny Louise, Khalil Asma, Khan Khalid S, Mol Ben W, Myers Jenny, Poston Lucilla, Thilaganathan Basky, Staff Anne C, Smith Gordon C S, Ganzevoort Wessel, Laivuori Hannele, Odibo Anthony O, Arenas Ramírez Javier, Kingdom John, Daskalakis George, Farrar Diane, Baschat Ahmet A, Seed Paul T, Prefumo Federico, da Silva Costa Fabricio, Groen Henk, Audibert Francois, Masse Jacques, Skråstad Ragnhild B, Salvesen Kjell Å, Haavaldsen Camilla, Nagata Chie, Rumbold Alice R, Heinonen Seppo, Askie Lisa M, Smits Luc J M, Vinter Christina A, Magnus Per, Eero Kajantie, Villa Pia M, Jenum Anne K, Andersen Louise B, Norman Jane E, Klipstein-Grobusch Kerstin, Browne Joyce L, Moons Karel G M, 2 nov 2020, In: BMC Medicine. 18

The zika virus individual participant data consortium:A global initiative to estimate the effects of exposure to zika virus during pregnancy on adverse fetal, infant, and child health outcomes

Alger Jackeline, De Alencar Ximenes Ricardo Arraes, Avelino-Silva Vivian I., Bardají Azucena, Mojica Carlos Hernan Becerra, Benedetti Andrea, De Lourdes Benamor Teixeira Maria, Bethencourt Sarah, Aburto Victor Hugo Borja, Brant Fátima, Brasil Patrícia, Brickley Elizabeth B., Broutet Nathalie, Buekens Pierre, Cafferata Mariá Luisa, Calvet Guilherme, Campbell Harlan, Carabali Mabel, Chan Derrick, Costa Federico, Da Costa Ferreira Orlando, Coutinho Conrado Milani, Cunha Antonio Jose, Cure Carlos Cure, Damen Johanna A.A., De Jong Valentijn M.T., Debray Thomas P., DeBiasi Roberta L., Diaz-Martinez Luis Alfonso, Duarte Geraldo, Ferriol Diana Mariá, Ganz Jucelia S., Gérardin Patrick, Gilboa Suzanne M., Gonzalez Maritza, Muñiz Concepción Grajales, Gustafson Paul, Sanchez Luz Angela Gutierrez, Guzmán Mariá G., Hofer Cristina, Holband Natanael, Inwani Irene, Jaenisch Thomas, João Esaú, Juliana Amadu, Kara Edna, Kim Caron, Ko Albert I., Koopmans Marion, Moons Karel G.M., 30 sep 2020, In: Tropical Medicine and Infectious Disease. 5 , p. 152-160 8 p.

TRIPOD statement:a preliminary pre-post analysis of reporting and methods of prediction models

Zamanipoor Najafabadi Amir H, Ramspek Chava L, Dekker Friedo W, Heus Pauline, Hooft Lotty, Moons Karel G M, Peul Wilco C, Collins Gary S, Steyerberg Ewout W, van Diepen Merel 18 sep 2020, In: BMJ Open. 10

Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults:a systematic review and meta-analysis

Kreuzberger Nina, Damen Johanna AAG, Trivella Marialena, Estcourt Lise J, Aldin Angela, Umlauff Lisa, Vazquez-Montes Maria Dla, Wolff Robert, Moons Karel GM, Monsef Ina, Foroutan Farid, Kreuzer Karl-Anton, Skoetz Nicole 31 jul 2020, In: The Cochrane database of systematic reviews. 2020

Transparent Reporting of Multivariable Prediction Models in Journal and Conference Abstracts:TRIPOD for Abstracts

Heus Pauline, Reitsma Johannes B, Collins Gary S, Damen Johanna A A G, Scholten Rob J P M, Altman Douglas G, Moons Karel G M, Hooft Lotty 2 jun 2020, In: Annals of Internal Medicine. 173 , p. 42-47 6 p.

Effect of tailoring anticoagulant treatment duration by applying a recurrence risk prediction model in patients with venous thromboembolism compared to usual care:A randomized controlled trial

Geersing Geert-Jan, Hendriksen Janneke M T, Zuithoff Nicolaas P A, Roes Kit C, Oudega Ruud, Takada Toshihiko, Schutgens Roger E G, Moons Karel G M jun 2020, In: PLoS Medicine. 17 , p. 1-17

All research output