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dr. S. (Stefan) Nierkens

dr. S. (Stefan) Nierkens

Associate Professor - medical
dr. S. (Stefan) Nierkens
  • Laboratory for Translational Immunology (LTI)
  • Laboratory for Translational Immunology (LTI)

Biography

Biography

Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

Dr. Nierkens is head of the Central Immune Monitoring Platform (8 fte) of the UMC Utrecht. He facilitates translational research in clinically well-defined (sub)cohorts of patients suffering from cancer, inflammatory and immune-mediated diseases.

Side Activities

None

Fellowship and Awards

KWF fellowship

Kika

ZonMW-TAS

VillaJoep

Ammodo

Research Output (139)

Efficient lentiviral transduction method to gene modify cord blood CD8<sup>+</sup> T cells for cancer therapy applications

Lo Presti Vania, Cornel Annelisa M., Plantinga Maud, Dünnebach Ester, Kuball Jurgen, Boelens Jaap Jan, Nierkens Stefan, van Til Niek P. 11 jun 2021, In: Molecular Therapy - Methods and Clinical Development. 21 , p. 357-368 12 p.

Immune Monitoring during Therapy Reveals Activitory and Regulatory Immune Responses in High-Risk Neuroblastoma

Szanto Celina L, Cornel Annelisa M, Tamminga Sara M, Delemarre Eveline M, de Koning Coco C H, van den Beemt Denise A M H, Dunnebach Ester, Tas Michelle L, Dierselhuis Miranda P, Tytgat Lieve G A M, van Noesel Max M, Kraal Kathelijne C J M, Boelens Jaap-Jan, Huitema Alwin D R, Nierkens Stefan 1 mei 2021, In: Cancers. 13 18 p.

CD4+ T-cell reconstitution predicts survival outcomes after acute graft-versus-host-disease:a dual-center validation

de Koning Coco, Prockop Susan, van Roessel Ichelle, Kernan Nancy, Klein Elizabeth, Langenhorst Jurgen, Szanto Celina, Belderbos Mirjam, Bierings Marc, Boulad Farid, Bresters Dorine, Cancio Maria, Curran Kevin, Kollen Wouter, O'Reilly Richard, Scaradavou Andromachi, Spitzer Barbara, Versluijs Birgitta, Huitema Alwin, Lindemans Caroline, Nierkens Stefan, Boelens Jaap Jan 11 feb 2021, In: Blood. 137 , p. 848-855 8 p.

The immune landscape of neuroblastoma:Challenges and opportunities for novel therapeutic strategies in pediatric oncology

Wienke Judith, Dierselhuis Miranda P, Tytgat Godelieve A M, Künkele Annette, Nierkens Stefan, Molenaar Jan J feb 2021, In: European Journal of Cancer. 144 , p. 123-150 28 p.

Automated identification of leukocyte subsets improves standardization of database-guided expert-supervised diagnostic orientation in acute leukemia:a EuroFlow study

Lhermitte Ludovic, Barreau Sylvain, Morf Daniela, Fernandez Paula, Grigore Georgiana, Barrena Susana, de Bie Maaike, Flores-Montero Juan, Brüggemann Monika, Mejstrikova Ester, Nierkens Stefan, Burgos Leire, Caetano Joana, Gaipa Giuseppe, Buracchi Chiara, da Costa Elaine Sobral, Sedek Lukasz, Szczepański Tomasz, Aanei Carmen-Mariana, van der Sluijs-Gelling Alita, Delgado Alejandro Hernández, Fluxa Rafael, Lecrevisse Quentin, Pedreira Carlos E, van Dongen Jacques J M, Orfao Alberto, van der Velden Vincent H J, jan 2021, In: Modern Pathology. 34 , p. 59-69 11 p.

Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation:A normal response to an abnormal situation

Spijkerman Roy, Bongers Suzanne H, Bindels Bas J J, Tinnevelt Gerjen H, Giustarini Giulio, Jorritsma Nikita K N, Buitenwerf Wiebe, van Spengler Daan E J, Delemarre Eveline M, Nierkens Stefan, van Goor Harriët M R, Jansen Jeroen J, Vrisekoop Nienke, Hietbrink Falco, Leenen Luke P H, Kaasjager Karin A H, Koenderman Leo, jan 2021, In: Journal of Leukocyte Biology. 109 , p. 99-114 16 p.

Gene Augmentation and Editing to Improve TCR Engineered T Cell Therapy against Solid Tumors

Lo Presti Vania, Buitenwerf Frank, van Til Niek P, Nierkens Stefan 3 dec 2020, In: Vaccines. 8 , p. 1-22 22 p.

EASI p-EASI: Predicting disease severity in atopic dermatitis patients treated with dupilumab using a combination of serum biomarkers

Bakker Daphne S, Ariens Lieneke F M, Giovannone Barbara, Hijnen DirkJan, Delemarre Eveline M, Knol Edward, Nierkens Stefan, de Bruin-Weller Marjolein S, Thijs Judith L, Drylewicz Julia dec 2020, In: Allergy. 75 , p. 3287-3289 3 p.

Clinical Grade Production of Wilms' Tumor-1 Loaded Cord Blood-Derived Dendritic Cells to Prevent Relapse in Pediatric AML After Cord Blood Transplantation

Plantinga Maud, Lo Presti Vania, de Haar Colin G, Dünnebach Ester, Madrigal Alejandro, Lindemans Caroline A, Boelens Jaap Jan, Nierkens Stefan 25 sep 2020, In: Frontiers in Immunology. 11 , p. 1-13

FACSCanto II and LSRFortessa flow cytometer instruments can be synchronized utilizing single-fluorochrome-conjugated surface-dyed beads for standardized immunophenotyping

Cornel Annelisa M, van der Burght Christine A J, Nierkens Stefan, van Velzen Jeroen F 1 sep 2020, In: Journal of Clinical Laboratory Analysis. 34 , p. 1-7

All research output

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