dr. S. (Stefan) Nierkens

Associate Professor - medical
dr. S. (Stefan) Nierkens
  • Laboratory for Translational Immunology (LTI)
  • Laboratory for Translational Immunology (LTI)



Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

Dr. Nierkens is head of the Central Immune Monitoring Platform (8 fte) of the UMC Utrecht. He facilitates translational research in clinically well-defined (sub)cohorts of patients suffering from cancer, inflammatory and immune-mediated diseases.

Side Activities


Fellowship and Awards

KWF fellowship





Research Output (135)

Efficient lentiviral transduction method to gene modify cord blood CD8<sup>+</sup> T cells for cancer therapy applications

Lo Presti Vania, Cornel Annelisa M., Plantinga Maud, Dünnebach Ester, Kuball Jurgen, Boelens Jaap Jan, Nierkens Stefan, van Til Niek P. 11 jun 2021, In: Molecular Therapy - Methods and Clinical Development. 21 , p. 357-368 12 p.

Immune Monitoring during Therapy Reveals Activitory and Regulatory Immune Responses in High-Risk Neuroblastoma

Szanto Celina L, Cornel Annelisa M, Tamminga Sara M, Delemarre Eveline M, de Koning Coco C H, van den Beemt Denise A M H, Dunnebach Ester, Tas Michelle L, Dierselhuis Miranda P, Tytgat Lieve G A M, van Noesel Max M, Kraal Kathelijne C J M, Boelens Jaap-Jan, Huitema Alwin D R, Nierkens Stefan 26 apr 2021, In: Cancers. 13

Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation:A normal response to an abnormal situation

Spijkerman Roy, Bongers Suzanne H, Bindels Bas J J, Tinnevelt Gerjen H, Giustarini Giulio, Jorritsma Nikita K N, Buitenwerf Wiebe, van Spengler Daan E J, Delemarre Eveline M, Nierkens Stefan, van Goor Harriët M R, Jansen Jeroen J, Vrisekoop Nienke, Hietbrink Falco, Leenen Luke P H, Kaasjager Karin A H, Koenderman Leo, jan 2021, In: Journal of Leukocyte Biology. 109 , p. 99-114 16 p.

Gene Augmentation and Editing to Improve TCR Engineered T Cell Therapy against Solid Tumors

Lo Presti Vania, Buitenwerf Frank, van Til Niek P, Nierkens Stefan 3 dec 2020, In: Vaccines. 8 , p. 1-22 22 p.

EASI p-EASI: Predicting disease severity in atopic dermatitis patients treated with dupilumab using a combination of serum biomarkers

Bakker Daphne S, Ariens Lieneke F M, Giovannone Barbara, Hijnen DirkJan, Delemarre Eveline M, Knol Edward, Nierkens Stefan, de Bruin-Weller Marjolein S, Thijs Judith L, Drylewicz Julia dec 2020, In: Allergy. 75 , p. 3287-3289 3 p.

Clinical Grade Production of Wilms' Tumor-1 Loaded Cord Blood-Derived Dendritic Cells to Prevent Relapse in Pediatric AML After Cord Blood Transplantation

Plantinga Maud, Lo Presti Vania, de Haar Colin G, Dünnebach Ester, Madrigal Alejandro, Lindemans Caroline A, Boelens Jaap Jan, Nierkens Stefan 25 sep 2020, In: Frontiers in Immunology. 11 , p. 559152

FACSCanto II and LSRFortessa flow cytometer instruments can be synchronized utilizing single-fluorochrome-conjugated surface-dyed beads for standardized immunophenotyping

Cornel Annelisa M, van der Burght Christine A J, Nierkens Stefan, van Velzen Jeroen F 1 sep 2020, In: Journal of Clinical Laboratory Analysis. 34 , p. e23361

Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation

Dekker Linde, de Koning Coco, Lindemans Caroline, Nierkens Stefan 20 jul 2020, In: Cancers. 12 , p. 1-21 21 p.

MHC Class I Downregulation in Cancer:Underlying Mechanisms and Potential Targets for Cancer Immunotherapy

Cornel Annelisa M, Mimpen Iris L, Nierkens Stefan 2 jul 2020, In: Cancers. 12 , p. 1-33 33 p.

Quantifying lymphocyte vacuolization serves as a measure of CLN3 disease severity

Kuper Willemijn F E, Oostendorp Marlies, van den Broek Brigitte T A, van Veghel Karin, Nonkes Lourens J P, Nieuwenhuis Edward E S, Fuchs Sabine A, Veenendaal Tineke, Klumperman Judith, Huisman Albert, Nierkens Stefan, van Hasselt Peter M jul 2020, In: JIMD Reports. 54 , p. 87-97 11 p.

All research output

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