dr. S. (Stefan) Nierkens

Associate Professor - medical
dr. S. (Stefan) Nierkens
  • Laboratory for Translational Immunology (LTI)
  • Laboratory for Translational Immunology (LTI)



Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

Dr. Nierkens is head of the Central Immune Monitoring Platform (8 fte) of the UMC Utrecht. He facilitates translational research in clinically well-defined (sub)cohorts of patients suffering from cancer, inflammatory and immune-mediated diseases.

Side Activities

  • None

Fellowship and Awards

  • KWF fellowship





Research Output (124)

EASI p-EASI: Predicting disease severity in atopic dermatitis patients treated with dupilumab using a combination of serum biomarkers

Bakker Daphne S, Ariens Lieneke F M, Giovannone Barbara, Hijnen DirkJan, Delemarre Eveline M, Knol Edward, Nierkens Stefan, de Bruin-Weller Marjolein S, Thijs Judith L, Drylewicz Julia dec 2020, In: Allergy. 75 , p. 3287-3289 3 p.

Quantifying lymphocyte vacuolization serves as a measure of CLN3 disease severity

Kuper Willemijn F E, Oostendorp Marlies, van den Broek Brigitte T A, van Veghel Karin, Nonkes Lourens J P, Nieuwenhuis Edward E S, Fuchs Sabine A, Veenendaal Tineke, Klumperman Judith, Huisman Albert, Nierkens Stefan, van Hasselt Peter M jul 2020, In: JIMD Reports. 54 , p. 87-97 11 p.

Hurdles in treating Hurler disease:potential routes to achieve a "real" cure

van den Broek Brigitte T A, van Doorn Jaap, Hegeman Charlotte V, Nierkens Stefan, Lindemans Caroline A, Verhoeven-Duif Nanda, Boelens Jaap Jan, van Hasselt Peter M 23 jun 2020, In: Blood Advances. 4 , p. 2837-2849 13 p.

Development of Mucosal PNAd+ and MAdCAM-1+ Venules during Disease Course in Ulcerative Colitis

Roosenboom Britt, Lochem Ellen G van, Meijer Jos, Smids Carolijn, Nierkens Stefan, Brand Eelco C, Erp Liselot W van, Kemperman Larissa G J M, Groenen Marcel J M, Horje Carmen S Horjus Talabur, Wahab Peter J 6 apr 2020, In: Cells. 9 20 p.

Quantification of T Cell Binding Polyclonal Rabbit Anti-thymocyte Globulin in Human Plasma with Liquid Chromatography Tandem-Mass Spectrometry

Amrani Mohsin El, Admiraal Rick, Willaert Lobke, Ebskamp-van Raaij Lysette J C, Lacna Amelia M, Hack C Erik, Huitema Alwin D R, Nierkens Stefan, van Maarseveen Erik M 1 mrt 2020, In: AAPS Journal. 22 8 p.

Clinical trial simulation to optimize trial design for fludarabine dosing strategies in allogeneic hematopoietic cell transplantation

Langenhorst Jurgen B, Dorlo Thomas P C, van Kesteren Charlotte, van Maarseveen Erik M, Nierkens Stefan, de Witte Moniek A, Jan Boelens Jaap, Huitema Alwin D R 19 jan 2020, In: CPT: Pharmacometrics and Systems Pharmacology. 9 , p. 272-281 10 p.

Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry

Ariens Lieneke F. M., van der Schaft Jorien, Bakker Daphne S., Balak Deepak, Romeijn Margreet L. E., Kouwenhoven Tessa, Kamsteeg Marijke, Giovannone Barbara, Drylewicz Julia, van Amerongen Cynthia Catalina Aurora, Delemarre Evelien M., Knol Edward F., van Wijk Femke, Nierkens Stefan, Thijs Judith L., Schuttelaar Marie L. A., de Bruin-Weller Marjolein S. 1 jan 2020, In: Allergy. 75 , p. 116-126 11 p.

Confirmation of multiple endotypes in atopic dermatitis based on serum biomarkers

Bakker Daphne S, Nierkens Stefan, Knol Edward F, Giovannone Barbara, Delemarre Eveline M, van der Schaft Jorien, van Wijk Femke, de Bruin-Weller Marjolein S, Drylewicz Julia, Thijs Judith L 2020, In: The Journal of Allergy and Clinical Immunology. 147 , p. 189-198 10 p.

A "No-Touch" Antibody-Staining Method of Adherent Cells for High-Throughput Flow Cytometry in 384-Well Microplate Format for Cell-Based Drug Library Screening

Cornel Annelisa, Szanto Celina, van Velzen Jeroen, Boelens Jaap-Jan, Nierkens Stefan 26 dec 2019, In: Cytometry Part A. 97 , p. 845-851 7 p.

Phenotypic variability including Behçet's disease-like manifestations in DADA2 patients due to a homozygous c.973-2A>G splice site mutation.

van Well G.T.J., Kant Benjamin, Nisterlrooij A, Ekmekci S, Henriet Stefanie, Hoppenreijs E.P.A.H., van Deuren M., van Montfrans JM, Nierkens Stefan, Gul A, van Gijn Marielle 9 dec 2019, In: Clinical and Experimental Rheumatology. 37 , p. 142-146

All research output