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dr. S. (Stefan) Nierkens

dr. S. (Stefan) Nierkens

Associate Professor
dr. S. (Stefan) Nierkens
  • Center for Translational Immunology (CTI) Research

Biography

Biography

Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.

Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.

 

Side Activities

Advisory Board / Consultancy / Speaker: Sobi, Medimmune, GamidaCell, Olink

 

Fellowship and Awards

KWF fellowship

Kika

ZonMW-TAS

VillaJoep

Ammodo

Research Output (178)

Identification of circulating monocytes as producers of tuberculosis disease biomarker C1q

Niewold Paula, Dijkstra Douwe J, Cai Yi, Goletti Delia, Palmieri Fabrizio, van Meijgaarden Krista E, Verreck Frank A W, Akkerman Onno W, Hofland Regina W, Delemarre Eveline M, Nierkens Stefan, Verheul Marije K, Pollard Andrew J, van Dissel Jaap T, Ottenhoff Tom H M, Trouw Leendert A, Joosten Simone A 18 Jul 2023, In: Scientific Reports. 13 , p. 1-10

Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function

Jansen Suze A, Cutilli Alessandro, de Koning Coco, van Hoesel Marliek, Sierra Leire Saiz, Nierkens Stefan, Mokry Michal, Nieuwenhuis Edward E S, Hanash Alan M, Mocholi Enric, Coffer Paul J, Lindemans Caroline A 30 Apr 2023,

Soluble Signal Inhibitory Receptor on Leukocytes-1 Is Released from Activated Neutrophils by Proteinase 3 Cleavage

von Richthofen Helen J., Westerlaken Geertje H.A., Gollnast Doron, Besteman Sjanna, Delemarre Eveline M., Rodenburg Karlijn, Moerer Petra, Stapels Daphne A.C., Andiappan Anand K., Rötzschke Olaf, Nierkens Stefan, Leavis Helen L., Bont Louis J., Rooijakkers Suzan H.M., Meyaard Linde 15 Feb 2023, In: Journal of immunology (Baltimore, Md. : 1950). 210 , p. 389-397 9 p.

Conventional dendritic cells type 1 are strongly enriched, quiescent and relatively tolerogenic in local inflammatory arthritis

Boltjes Arjan, Samat Anoushka Ashok Kumar, Plantinga Maud, Mokry Michal, Castelijns Bas, Swart Joost F., Vastert Sebastiaan J., Creyghton Menno, Nierkens Stefan, van Loosdregt Jorg, van Wijk Femke 4 Jan 2023, In: Frontiers in Immunology. 13

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

Strating Esther, Verhagen Mathijs P, Wensink Emerens, Dünnebach Ester, Wijler Liza, Aranguren Itziar, De la Cruz Alberto Sanchez, Peters Niek A, Hageman Joris H, van der Net Mirjam M C, van Schelven Susanne, Laoukili Jamila, Fodde Riccardo, Roodhart Jeanine, Nierkens Stefan, Snippert Hugo, Gloerich Martijn, Rinkes Inne Borel, Elias Sjoerd G, Kranenburg Onno 2023, In: Frontiers in Immunology. 14

Heterozygous Variants in the DNA-binding Domain of c-Myb May Affect Normal B/T Cell Development

Smits Bas M., Hartley Taila, Dünnebach Ester, Bartels Marije, Boycott Kim M., Kernohan Kirstin D., Dyment David A., Giltay Jacques C., Haddad Elie, Jarinova Olga, Van Montfrans Joris, Van Royen-Kerkhof Annet, Van Der Veken Lars T., De Witte Moniek, Nierkens Stefan, Pham-Huy Anne, Leavis Helen L. 21 Oct 2022, In: HemaSphere. 6 , p. E774

Clinical features and immune-related protein patterns of anti-MDA5 positive clinically amyopathic dermatomyositis Dutch patients

Hensgens Marjolein P.M., Delemarre Eveline M., Drylewicz Julia, Voortman Mareye, Krol Roline M., Dalm Virgil A.S.H., Miedema Jelle R., Wiertz Ivo, Grutters Jan, Limper Maarten, Nierkens Stefan, Leavis Helen L. 6 Oct 2022, In: Rheumatology (Oxford, England). 61 , p. 4087-4096 10 p.

Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes

Sengupta Satyaki, Das Sanjukta, Crespo Angela C, Cornel Annelisa M, Patel Anand G, Mahadevan Navin R, Campisi Marco, Ali Alaa K, Sharma Bandana, Rowe Jared H, Huang Hao, Debruyne David N, Cerda Esther D, Krajewska Malgorzata, Dries Ruben, Chen Minyue, Zhang Shupei, Soriano Luigi, Cohen Malkiel A, Versteeg Rogier, Jaenisch Rudolf, Spranger Stefani, Romee Rizwan, Miller Brian C, Barbie David A, Nierkens Stefan, Dyer Michael A, Lieberman Judy, George Rani E 22 Sep 2022, In: Nature Cancer. 3 , p. 1228-1246 19 p.

Uncovering the mode of action of engineered T cells in patient cancer organoids

Dekkers Johanna F., Alieva Maria, Cleven Astrid, Keramati Farid, Wezenaar Amber K.L., van Vliet Esmée J., Puschhof Jens, Brazda Peter, Johanna Inez, Meringa Angelo D., Rebel Heggert G., Buchholz Maj Britt, Barrera Román Mario, Zeeman Amber L., de Blank Sam, Fasci Domenico, Geurts Maarten H., Cornel Annelisa M., Driehuis Else, Millen Rosemary, Straetemans Trudy, Nicolasen Mara J.T., Aarts-Riemens Tineke, Ariese Hendrikus C.R., Johnson Hannah R., van Ineveld Ravian L., Karaiskaki Froso, Kopper Oded, Bar-Ephraim Yotam E., Kretzschmar Kai, Eggermont Alexander M.M., Nierkens Stefan, Wehrens Ellen J., Stunnenberg Henk G., Clevers Hans, Kuball Jürgen, Sebestyen Zsolt, Rios Anne C. 25 Jul 2022, In: Nature Biotechnology. 41 , p. 60-69 10 p.

Naive T Cells in Graft Versus Host Disease and Graft Versus Leukemia:Innocent or Guilty?

Dekker Linde, Sanders Evy, Lindemans Caroline A., de Koning Coco, Nierkens Stefan 20 Jun 2022, In: Frontiers in Immunology. 13 , p. 1-10

All research output

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