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prof. dr. E.E.S. Nieuwenhuis

Full Professor
prof. dr. E.E.S. Nieuwenhuis
  • Gastroenterology & Hepatology research 1
  • Onderzoek

Biography

Biography

Edward Nieuwenhuis, pediatrician, obtained a PhD in mucosal immunology (Prof. Blumberg, Harvard University and Prof. Heijnen, Utrecht University). He became a paediatric gastroenterologist, focusing     on the innate immunesystem in Inflammatory Bowel Disease. His work includes the development of a enterocolitis model in Zebrafish. His current research focuses on IBD, somatic stemcells, epithelial biology and genetics.

In 2009, Edward Nieuwenhuis was appointed as Chairman of the Paediatrics Division of the Wilhelmina Children’s Hospital Utrecht , The Netherlands. In 2010, he was also appointed as Chairman of the    leading program (speerpunt) Child Health of  the University Medical Center Utrecht.

During this period, the Hospital has established strong alliances with medical centers and research institutes in the Netherlands (e.g. Maxima, national center for pediatric oncology, Hubrecht institute for developmental biology & stem cell research) and abroad (e.g. Boston Children’s, The Hospital for Sick Children, Toronto, Hospital Pablo Tobon Uribe, Medellin).

His goal is to build an integrated academic Children’s Hospital which provides health care, medical training and science of excellent standards.

Side Activities

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    2003 Chair CD1-NKT session 12th International Congress of Mucosal Immunology, Boston, USA

    2004-2009 Research Committee Erasmus MC-Sophia Children’s Hospital, Rotterdam

    2005-2009 Working Group Pediatric Allergic Diseases

    2006-2009 Chairman Committee on Clinical Nutrition Erasmus MC-Sophia Children’s Hospital

    2006-2009 Consultant for the International Immunity Advisory Board of Royal Numico

    2006-2009 Member Steering Committee for the Masters of Science program ‘Infection and Immunity’, Erasmus University, Rotterdam

    2007-2011 Scientific Advisor Committee for primary child care in the Netherlands

    2008-2009 Board member, MRACE, Erasmus University advisory committee

    2008-2014 Founder, CEO & CSO LipImmune

    2010- Member of the Board, Wilhelmina Research Fund, Utrecht

    2009- Member of the Local Board, Ronald McDonald Huis, Utrecht

    2010- Scientific Advisor Nutricia

    2010- Scientific Advisor Friso

    2011- Scientific Advisor International Congress of Mucosal Immunology, Paris, France,

    2011- Medical Advisor Health Council of the Netherlands (RGO)

    2011-2015 Editor-in-Chief Pediatric Journal 'Kinderarts&Wetenschap'

    2015- Cheif Editor 'Leerboek Kindergeneeskunde'

    Member, Society of Mucosal Immunology (SMI)

    Member, Dutch Society of Pediatrics (NVK)

    Board member, Dutch Society of Immunology (NVVI)

    Member, European Society of Ped Gastroenterology Hepatology and Nutrition (ESPGHAN)

     

     

Research Output (130)

Prime editing for functional repair in patient-derived disease models

Schene Imre F, Joore Indi P, Oka Rurika, Mokry Michal, van Vugt Anke H M, van Boxtel Ruben, van der Doef Hubert P J, van der Laan Luc J W, Verstegen Monique M A, van Hasselt Peter M, Nieuwenhuis Edward E S, Fuchs Sabine A 1 dec 2020, In: Nature Communications. 11

Enhanced Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy

van Rijn Jorik M, Werner Lael, Aydemir Yusuf, Spronck Joey M A, Pode-Shakked Ben, van Hoesel Marliek, Shimshoni Elee, Polak-Charcon Sylvie, Talmi Liron, Eren Makbule, Weiss Batia, H J Houwen Roderick, Barshack Iris, Somech Raz, Nieuwenhuis Edward E S, Sagi Irit, Raas-Rothschild Annick, Middendorp Sabine, Shouval Dror S 1 nov 2020, In: International journal of molecular sciences. 21 , p. 1-18 18 p.

Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency

Van Dooijeweert Birgit, Broeks Melissa H, Verhoeven-Duif Nanda M, Van Beers Eduard J, Nieuwenhuis Edward E S, Van Solinge Wouter W, Bartels Marije, Jans Judith J, Van Wijk Richard 10 sep 2020, In: Haematologica. Online ahead of print , p. 1-20

Ethical challenges for pediatric liver organoid transplantation

Schneemann Sarah A, Boers Sarah N, van Delden Johannes J M, Nieuwenhuis Edward E S, Fuchs Sabine A, Bredenoord Annelien L 15 jul 2020, In: Science translational medicine. 12 , p. 1-3

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

Quantifying lymphocyte vacuolization serves as a measure of CLN3 disease severity

Kuper Willemijn F E, Oostendorp Marlies, van den Broek Brigitte T A, van Veghel Karin, Nonkes Lourens J P, Nieuwenhuis Edward E S, Fuchs Sabine A, Veenendaal Tineke, Klumperman Judith, Huisman Albert, Nierkens Stefan, van Hasselt Peter M jul 2020, In: JIMD Reports. 54 , p. 87-97 11 p.

Very Early Onset Inflammatory Bowel Disease:A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

Ouahed Jodie, Spencer Elizabeth, Kotlarz Daniel, Shouval Dror S, Kowalik Matthew, Peng Kaiyue, Field Michael, Grushkin-Lerner Leslie, Pai Sung-Yun, Bousvaros Athos, Cho Judy, Argmann Carmen, Schadt Eric, Mcgovern Dermot P B, Mokry Michal, Nieuwenhuis Edward, Clevers Hans, Powrie Fiona, Uhlig Holm, Klein Christoph, Muise Aleixo, Dubinsky Marla, Snapper Scott B 3 dec 2019, In: Inflammatory bowel diseases. 26 , p. 820-842 23 p.

AML Subtype Is a Major Determinant of the Association between Prognostic Gene Expression Signatures and Their Clinical Significance

Wiggers Caroline R M, Baak Mirna L, Sonneveld Edwin, Nieuwenhuis Edward E S, Bartels Marije, Creyghton Menno P 10 sep 2019, In: Cell Reports. 28 , p. 2866-2877.e5

Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development

Govers Anita M A P, Wiggers Caroline R M, van Boxtel Ruben, Mokry Michal, Nieuwenhuis Edward E S, Creyghton Menno P, Bartels Marije, Coffer Paul J aug 2019, In: HemaSphere. 3

DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells[S]

van Rijn Jorik M, van Hoesel Marliek, de Heus Cecilia, van Vugt Anke H M, Klumperman Judith, Nieuwenhuis Edward, Houwen Roderick H J, Middendorp Sabine 17 jul 2019, In: Journal of Lipid Research. 60 , p. 1787-1800 14 p.

All research output