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prof. dr. E.E.S. Nieuwenhuis

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Research Output (130)

Prime editing for functional repair in patient-derived disease models

Schene Imre F, Joore Indi P, Oka Rurika, Mokry Michal, van Vugt Anke H M, van Boxtel Ruben, van der Doef Hubert P J, van der Laan Luc J W, Verstegen Monique M A, van Hasselt Peter M, Nieuwenhuis Edward E S, Fuchs Sabine A 1 dec 2020, In: Nature Communications. 11

Enhanced Collagen Deposition in the Duodenum of Patients with Hyaline Fibromatosis Syndrome and Protein Losing Enteropathy

van Rijn Jorik M, Werner Lael, Aydemir Yusuf, Spronck Joey M A, Pode-Shakked Ben, van Hoesel Marliek, Shimshoni Elee, Polak-Charcon Sylvie, Talmi Liron, Eren Makbule, Weiss Batia, H J Houwen Roderick, Barshack Iris, Somech Raz, Nieuwenhuis Edward E S, Sagi Irit, Raas-Rothschild Annick, Middendorp Sabine, Shouval Dror S 1 nov 2020, In: International journal of molecular sciences. 21 , p. 1-16 16 p.

Untargeted metabolic profiling in dried blood spots identifies disease fingerprint for pyruvate kinase deficiency

Van Dooijeweert Birgit, Broeks Melissa H, Verhoeven-Duif Nanda M, Van Beers Eduard J, Nieuwenhuis Edward E S, Van Solinge Wouter W, Bartels Marije, Jans Judith J, Van Wijk Richard 10 sep 2020, In: Haematologica. Online ahead of print

Ethical challenges for pediatric liver organoid transplantation

Schneemann Sarah A, Boers Sarah N, van Delden Johannes J M, Nieuwenhuis Edward E S, Fuchs Sabine A, Bredenoord Annelien L 15 jul 2020, In: Science translational medicine. 12

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

Quantifying lymphocyte vacuolization serves as a measure of CLN3 disease severity

Kuper Willemijn F E, Oostendorp Marlies, van den Broek Brigitte T A, van Veghel Karin, Nonkes Lourens J P, Nieuwenhuis Edward E S, Fuchs Sabine A, Veenendaal Tineke, Klumperman Judith, Huisman Albert, Nierkens Stefan, van Hasselt Peter M jul 2020, In: JIMD Reports. 54 , p. 87-97 11 p.

Very Early Onset Inflammatory Bowel Disease:A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

Ouahed Jodie, Spencer Elizabeth, Kotlarz Daniel, Shouval Dror S, Kowalik Matthew, Peng Kaiyue, Field Michael, Grushkin-Lerner Leslie, Pai Sung-Yun, Bousvaros Athos, Cho Judy, Argmann Carmen, Schadt Eric, Mcgovern Dermot P B, Mokry Michal, Nieuwenhuis Edward, Clevers Hans, Powrie Fiona, Uhlig Holm, Klein Christoph, Muise Aleixo, Dubinsky Marla, Snapper Scott B 3 dec 2019, In: Inflammatory bowel diseases. 26 , p. 820-842 23 p.

AML Subtype Is a Major Determinant of the Association between Prognostic Gene Expression Signatures and Their Clinical Significance

Wiggers Caroline R M, Baak Mirna L, Sonneveld Edwin, Nieuwenhuis Edward E S, Bartels Marije, Creyghton Menno P 10 sep 2019, In: Cell Reports. 28 , p. 2866-2877.e5

Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development

Govers Anita M A P, Wiggers Caroline R M, van Boxtel Ruben, Mokry Michal, Nieuwenhuis Edward E S, Creyghton Menno P, Bartels Marije, Coffer Paul J aug 2019, In: HemaSphere. 3

DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells[S]

van Rijn Jorik M, van Hoesel Marliek, de Heus Cecilia, van Vugt Anke H M, Klumperman Judith, Nieuwenhuis Edward, Houwen Roderick H J, Middendorp Sabine 17 jul 2019, In: Journal of Lipid Research. 60 , p. 1787-1800 14 p.