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dr. P.G.J. (Peter) Nikkels

Assistant Professor - medical
dr. P.G.J. (Peter) Nikkels
  • Department of Pathology

Research Programs

Strategic Program Cancer

Biography

Biography

Pathologist, consultant for pediatric and perinatal pathology.

MD exam July 1982, Erasmus Uni­versity Rotter­dam, the Netherlands

PhD thesis: The hemopoietic micro-environment, effects of chemotherapy and irradiation, March 22 1989, Erasmus Uni­versity Rotter­dam, the Netherlands

Pathology training: January 1987 until January 1992, University Hospital Groningen, the Netherlands

1992-december 1996: staff member department of pathology University Hospital Groningen, the Netherlands and responsible for the perinatal pathology

December 1996- : staff member department of pathology, University Hospital Utrecht, the Netherlands. Responsible for pediatric and perinatal pathology including training of residents and performing / supervising 120-140 perinatal and pediatric autopsies annually, 700-800 placentas annually and approximately 1200-1500 surgical biopsies including solid pediatric tumors from October 2014.

Research Output (280)

Interaction between KDELR2 and HSP47 as a Key Determinant in Osteogenesis Imperfecta Caused by Bi-allelic Variants in KDELR2

van Dijk Fleur S., Semler Oliver, Etich Julia, Köhler Anna, Jimenez-Estrada Juan A., Bravenboer Nathalie, Claeys Lauria, Riesebos Elise, Gegic Sejla, Piersma Sander R., Jimenez Connie R., Waisfisz Quinten, Flores Carmen Lisset, Nevado Julian, Harsevoort Arjan J., Janus Guus J.M., Franken Anton A.M., van der Sar Astrid M., Meijers-Heijboer Hanne, Heath Karen E., Lapunzina Pablo, Nikkels Peter G.J., Santen Gijs W.E., Nüchel Julian, Plomann Markus, Wagener Raimund, Rehberg Mirko, Hoyer-Kuhn Heike, Eekhoff Elisabeth M.W., Pals Gerard, Mörgelin Matthias, Newstead Simon, Wilson Brian T., Ruiz-Perez Victor L., Maugeri Alessandra, Netzer Christian, Zaucke Frank, Micha Dimitra 5 nov 2020, In: American Journal of Human Genetics. 107 , p. 989-999 11 p.

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

Wienke Judith, Brouwers Laura, van der Burg Leone M, Mokry Michal, Scholman Rianne C, Nikkels Peter G J, van Rijn Bas B, van Wijk Femke 18 aug 2020, In: JCI Insight. 5

Prophylaxis of implant-related infections by local release of vancomycin from a hydrogel in rabbits

Boot W, Vogely H C, Nikkels P G, Pouran B, van Rijen M H, Ekkelenkamp M B, Hänsch G M, Dhert W J, Gawlitta D 19 feb 2020, In: European Cells & Materials. 39 , p. 108-120 13 p.

Clinical outcomes in chronic intervillositis of unknown etiology

Bos M., Harris-Mostert E. T.M.S., van der Meeren L. E., Baelde J. J., Williams D. J., Nikkels P. G.J., Bloemenkamp K. W.M., van der Hoorn M. L.P. 1 feb 2020, In: Placenta. 91 , p. 19-23 5 p.

Acardius anceps with neck cyst and cleft palate:Three dimensional skeletal computed tomography reconstruction with discussion of the literature

van Gemert Martin J.C., Streekstra Geert J., Vandenbussche Frank P.H.A., Nikkels Peter G.J., van den Wijngaard Jeroen P.H.M. 15 jan 2020, In: Birth Defects Research. 112 , p. 137-140 4 p.

Homozygous damaging SOD2 variant causes lethal neonatal dilated cardiomyopathy

Almomani Rowida, Herkert Johanna C., Posafalvi Anna, Post Jan G., Boven Ludolf G., Van Der Zwaag Paul A., Willems Peter H.G.M., Van Veen-Hof Ingrid H., Verhagen Judith M.A., Wessels Marja W., Nikkels Peter G.J., Wintjes Liesbeth T., Van Den Berg Maarten P., Sinke Richard J., Rodenburg Richard J., Niezen-Koning Klary E., Van Tintelen J. Peter, Jongbloed Jan D.H. 1 jan 2020, In: Journal of Medical Genetics. 57 , p. 23-30 8 p.

Biallelic variants in POLR3GL cause endosteal hyperostosis and oligodontia

Terhal Paulien A, Vlaar Judith M, Middelkamp Sjors, Nievelstein Rutger A J, Nikkels Peter G J, Ross Jamila, Créton Marijn, Bos Jeroen W, Voskuil-Kerkhof Elsbeth S M, Cuppen Edwin, Knoers Nine, van Gassen Koen L I jan 2020, In: European Journal of Human Genetics. 28 , p. 31-39 9 p.

Correction:Aminoacyl-tRNA synthetase deficiencies in search of common themes

Fuchs Sabine A, Schene Imre F, Kok Gautam, Jansen Jurriaan M, Nikkels Peter G J, van Gassen Koen L I, Terheggen-Lagro Suzanne W J, van der Crabben Saskia N, Hoeks Sanne E, Niers Laetitia E M, Wolf Nicole I, de Vries Maaike C, Koolen David A, Houwen Roderick H J, Mulder Margot F, van Hasselt Peter M 2020, In: Genetics in Medicine. p. 1-1

TMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities

Vandervore Laura V, Schot Rachel, Milanese Chiara, Smits Daphne J, Kasteleijn Esmee, Fry Andrew E, Pilz Daniela T, Brock Stefanie, Börklü-Yücel Esra, Post Marco, Bahi-Buisson Nadia, Sánchez-Soler María José, van Slegtenhorst Marjon, Keren Boris, Afenjar Alexandra, Coury Stephanie A, Tan Wen-Hann, Oegema Renske, de Vries Linda S, Fawcett Katherine A, Nikkels Peter G J, Bertoli-Avella Aida, Al Hashem Amal, Alwabel Abdulmalik A, Tlili-Graiess Kalthoum, Efthymiou Stephanie, Zafar Faisal, Rana Nuzhat, Bibi Farah, Houlden Henry, Maroofian Reza, Person Richard E, Crunk Amy, Savatt Juliann M, Turner Lisbeth, Doosti Mohammad, Karimiani Ehsan Ghayoor, Saadi Nebal Waill, Akhondian Javad, Lequin Maarten H, Kayserili Hülya, van der Spek Peter J, Jansen Anna C, Kros Johan M, Verdijk Robert M, Milošević Nataša Jovanov, Fornerod Maarten, Mastroberardino Pier Giorgio, Mancini Grazia M S 5 dec 2019, In: American Journal of Human Genetics. 105 , p. 1126-1147 22 p.

Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism

Lezzerini Marco, Penzo Marianna, O'Donohue Marie-Françoise, Marques Dos Santos Vieira Carolina, Saby Manon, Elfrink Hyung L, Diets Illja J, Hesse Anne-Marie, Couté Yohann, Gastou Marc, Nin-Velez Alexandra, Nikkels Peter G J, Olson Alexandra N, Zonneveld-Huijssoon Evelien, Jongmans Marjolijn C J, Zhang GuangJun, van Weeghel Michel, Houtkooper Riekelt H, Wlodarski Marcin W, Kuiper Roland P, Bierings Marc B, van der Werff Ten Bosch Jutte, Leblanc Thierry, Montanaro Lorenzo, Dinman Jonathan D, Da Costa Lydie, Gleizes Pierre-Emmanuel, MacInnes Alyson W 4 dec 2019, In: Nucleic Acids Research. 48 , p. 770-787 18 p.

All research output