dr. B. (Bob) Oranje

Associate Professor
dr. B. (Bob) Oranje
  • Psychiatry

Research Programs




Bob Oranje is vice director of NICHE, University Medical Center Utrecht (UMC-U), Holland, as well as senior researcher and head of the psychophysiological department of the Center for Neuropsychiatric Schizophrenia Research [CNSR], Glostrup, Denmark. Since 2009 he is lector at the Faculty of Health and Medical Sciences, Dept. of Neurology, Psychiatry, and Sensory Sciences, Copenhagen University, Denmark. Furthermore, since 2012 he is UHD at the department of Psychiatry, UMC-U, Holland, where he opened a new electrophysiological and neurocognitive lab in 2017. BO has developed a psychophysiological test-battery, the Copenhagen Psychophysiological Test Battery [CPTB]. The CPTB consists of five psychophysiological paradigms specifically designed for research on psychiatric disorders and plays a central role in the projects that he has initiated. His research primarily focusses on improving/developing medical treatment for patients with schizophrenia, autism and ADHD. Secondary goals are developing animal models for schizophrenia and determining vulnerability indicators (endophenotypes) for psychosis, schizophrenia and autism in children and adolescents, in order to try and prevent these individuals from developing these disorders later in life. As such, BO has initiated several projects, including pharmacological challenge studies in healthy volunteers, treatment studies in patients with schizophrenia, studies in children and  adolescents with developmental disorders, translational studies in animals, and a project using concurrent EEG and fMRI methodology. In addition, BO collaborates in many national and international projects. Currently, his research has been sponsored by a large number of major and minor research grants, both in Denmark and in Holland. He has been promotor, co-promotor and project-leader of a large number of preclinical and clinical projects in both Holland and Denmark.

Research line

Electrophysiologically mediated improvement of treatment for psychotic as well as developmental disorders

Most recent key publications

1: B. Oranje, B. Aggernaes, H. Rasmussen, B. H. Ebdrup, and B. Y. Glenthoj. Selective attention and mismatch negativity in antipsychotic-naive, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy. Psychol.Med.:1-11, 2017.

2: C. Vlaskamp, B. Oranje, G. F. Madsen, J. R. Mollegaard Jepsen, S. Durston, C. Cantio, B. Glenthoj, and N. Bilenberg. Auditory processing in autism spectrum disorder: Mismatch negativity deficits. Autism Res., 2017.

3: G. F. Madsen, N. Bilenberg, J. R. Jepsen, B. Y. Glenthøj, C. Cantio, and B. Oranje. Normal P50 gating in children with autism, yet attenuated P50 amplitude in the Asperger subcategory. Autism Res. Epub, 2015.

4: L. Witten, J. F. Bastlund, B. Y. Glenthoj, C. Bundgaard, B. Steiniger-Brach, A. Mork, and B. Oranje. Comparing Pharmacological Modulation of Sensory Gating in Healthy Humans and Rats: The Effects of Reboxetine and Haloperidol. Neuropsychopharmacology, 2015.

5: N. Bak and B. Oranje. Psychophysiology-Informed (Multimodal) Imaging. Curr.Top.Behav.Neurosci. 21:371-385, 2014.

Fellowship and Awards

1: ZonMW Goed Gebruik Geneesmiddelen (GGG, 2013 & 2015)

2: Lundbeck foundation grants (main applicant personal salary 2009, 2010)

3: Lundbeck Foundation Center for Neurovascular signaling

4: Førskningsrådet for Sundhed of Sygdom (FSS) (co-applicant for postdoctoral researcher)

5: The Capital region of Psychiatry 2012

Research Output (105)

"Include me if you can"-reasons for low enrollment of pediatric patients in a psychopharmacological trial

Niemeyer Larissa, Mechler Konstantin, Buitelaar Jan, Durston Sarah, Gooskens Bram, Oranje Bob, Banaschewski Tobias, Dittmann Ralf W, Häge Alexander 1 mrt 2021, In: Trials. 22 , p. 178

Genetic underpinnings of schizophrenia-related electroencephalographical intermediate phenotypes:A systematic review and meta-analysis

Hederih Jure, Nuninga Jasper O., van Eijk Kristel, van Dellen Edwin, Smit Dirk J.A., Oranje Bob, Luykx Jurjen J. 10 jan 2021, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 104 , p. 110001

Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders:Findings From the ENIGMA ADHD, ASD, and OCD Working Groups

Boedhoe Premika S W, van Rooij Daan, Hoogman Martine, Twisk Jos W R, Schmaal Lianne, Abe Yoshinari, Alonso Pino, Ameis Stephanie H, Anikin Anatoly, Anticevic Alan, Arango Celso, Arnold Paul D, Asherson Philip, Assogna Francesca, Auzias Guillaume, Banaschewski Tobias, Baranov Alexander, Batistuzzo Marcelo C, Baumeister Sarah, Baur-Streubel Ramona, Behrmann Marlene, Bellgrove Mark A, Benedetti Francesco, Beucke Jan C, Biederman Joseph, Bollettini Irene, Bose Anushree, Bralten Janita, Bramati Ivanei E, Brandeis Daniel, Brem Silvia, Brennan Brian P, Busatto Geraldo F, Calderoni Sara, Calvo Anna, Calvo Rosa, Castellanos Francisco X, Cercignani Mara, Chaim-Avancini Tiffany M, Chantiluke Kaylita C, Cheng Yuqi, Cho Kang Ik K, Christakou Anastasia, Coghill David, Conzelmann Annette, Cubillo Ana I, Durston Sarah, Janssen Joost, Oranje Bob, Shook Devon, 16 jun 2020, In: American Journal of Psychiatry. 177 , p. 834-843 10 p.

Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex:An open-label pilot study

Van Andel Dorinde M., Sprengers Jan J., Oranje Bob, Scheepers Floortje E., Jansen Floor E., Bruining Hilgo 7 mei 2020, In: Molecular Autism. 11 14 p.

Structural and functional MRI of altered brain development in a novel adolescent rat model of quinpirole-induced compulsive checking behavior

Straathof Milou, Blezer Erwin L.A., van Heijningen Caroline, Smeele Christel E., van der Toorn Annette, Buitelaar Jan K., de Ruiter Saskia, Naaijen Jilly, Akkermans Sophie, Mennes Maarten, Zwiers Marcel, Ilbegi Shahrzad, Hennissen Leonie, Glennon Jeffrey C., van de Vondervoort Ilse, Kapusta Katarzyna, Bielczyk Na AAtalia, Amiri Houshang, Havenith Martha, Franke Barbara, Poelmans Geert, Bralten Janita, Heskes Tom, Sokolova Elena, Groot Perry, Williams Steven, Murphy De AAclan, Lythgoe David, Bruchhage Muriel, Dud Iulia, Voinescu Bogdan, Dittmann Ralf, Banaschewski Tobias, Brandeis Daniel, Mechler Konstantin, Berg Ruth, Wolf Isabella, Häge Alexander, Landauer Michael, Hohmann Sarah, Schlier Regina Boecker, Ruff Matthias, Mandl René, Dijkhuizen Rick, Blezer Erwin, Mol Wouter, Otte Willem, Durston Sarah, Oranje Bob, Dijkhuizen Rick, 1 apr 2020, In: European Neuropsychopharmacology. 33 , p. 58-70 13 p.

Serious Games as Potential Therapies:A Validation Study of a Neurofeedback Game

Coenen Femke, Scheepers Floortje E., Palmen Saskia J. M., de Jonge Maretha, V, Oranje Bob 1 mrt 2020, In: Clinical EEG and neuroscience. 51 , p. 87-93 7 p.

Include me if you can!: Reasons for low enrollment of pediatric patients in a psychopharmacological trial

Haege A., Mechler K., Niemeyer L., Buitelaar J., Durston S., Gooskens B. R., Oranje B., Banaschewski T., Dittmann R. W. mrt 2020, In: Pharmacopsychiatry. 53 , p. 96-96

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Postema Merel C., van Rooij Daan, Anagnostou Evdokia, Arango Celso, Auzias Guillaume, Behrmann Marlene, Filho Geraldo Busatto, Calderoni Sara, Calvo Rosa, Daly Eileen, Deruelle Christine, Di Martino Adriana, Dinstein Ilan, Duran Fabio Luis S., Durston Sarah, Ecker Christine, Ehrlich Stefan, Fair Damien, Fedor Jennifer, Feng Xin, Fitzgerald Jackie, Floris Dorothea L., Freitag Christine M., Gallagher Louise, Glahn David C., Gori Ilaria, Haar Shlomi, Hoekstra Liesbeth, Jahanshad Neda, Jalbrzikowski Maria, Janssen Joost, King Joseph A., Kong Xiang Zhen, Lazaro Luisa, Lerch Jason P., Luna Beatriz, Martinho Mauricio M., McGrath Jane, Medland Sarah E., Muratori Filippo, Murphy Clodagh M., Murphy Declan G.M., O’Hearn Kirsten, Oranje Bob, Parellada Mara, Puig Olga, Retico Alessandra, Rosa Pedro, Rubia Katya, Shook Devon, 31 okt 2019, In: Nature Communications. 10

10Kin1day: A Bottom-Up Neuroimaging Initiative

van den Heuvel Martijn P. et al. 9 mei 2019, In: Frontiers in Neurology. 10 , p. 425 7 p.

Brain Imaging of the Cortex in ADHD:A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples

Hoogman Martine et al. 24 apr 2019, In: American Journal of Psychiatry. 176 , p. 531-542 12 p.

All research output

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