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dr. W.M. (Wim) Otte

dr. W.M. (Wim) Otte

Associate Professor
dr. W.M. (Wim) Otte
  • Projectafdeling KIND

Research Programs

Brain

Side Activities

Co-founder RCTAlert

Fellowship and Awards

Research
Wim Otte is clinical epidemiologist at the UMC Utrecht Brain Center, and specialized in predictive modeling research. He advocates open science and Bayesian inference. His recent work is dedicated to epilepsy-related clinical questions with sidesteps in the field of AI, clinical trial publication bias, and meta-research.

Grants
2021 - EWUU AI for Health
2019 - NWA-Ideeëngenerator (NWO)
2019 - Bridging the epilepsy diagnostic gap (EU-ATTRACT)
2017 - Fostering Responsible Research Practices (ZonMw)
2015 - VENI (NWO)
2014 - Van Leersumfonds (KNAW)

Grants (co-PI)
2022 - Medicinale cannabis als behandeling bij kinderepilepsie (ZonMw) 
2021 - TKI N-of-1 Trials (Health~Holland)
2020 - Brain@Home (ZonMw, Stichting Proefdiervrij)
2019 - Programma Translationeel Onderzoek 2 (ZonMw, Epilepsiefonds)
2014 - National Priorities Research Program grant (Qatar National Research Fund)

Fellowships
2019 - Rudolf Magnus Young Talent Fellowship (UMC Utrecht)
2014 - Fellowship (Netherlands Brain Foundation)
2013 - Visiting Fellowship (Utrecht University)

Awards
2019 - Outreach prijs (UMC Utrecht Hersencentrum)
2015 - Young scientist of the year (Netherlands eScience Center)

Research Output (102)

Clinical Outcome, Cognition, and Cerebrovascular Reactivity after Surgical Treatment for Moyamoya Vasculopathy:A Dutch Prospective, Single-Center Cohort Study

Deckers Pieter Thomas, Kronenburg Annick, van den Berg Esther, van Schooneveld Monique M, Vonken Evert-Jan P A, Otte Willem M, van Berckel Bart N M, Yaqub Maqsood, Klijn Catharina J M, van der Zwan Albert, Braun Kees P J 2 Dec 2022, In: Journal of Clinical medicine. 11 , p. 1-23

Indicators of questionable research practices were identified in 163,129 randomized controlled trials

Damen Johanna A, Heus Pauline, Lamberink Herm J, Tijdink Joeri K, Bouter Lex, Glasziou Paul, Moher David, Otte Willem M, Vinkers Christiaan H, Hooft Lotty 2 Dec 2022, In: Journal of Clinical Epidemiology. 154 , p. 23-32 10 p.

Yield and risk associated with prolonged presurgical video-EEG monitoring:a systematic review

van Griethuysen Renate, van Asch Charlotte J.J., Otte Wim M., Sander Josemir W., Braun Kees P.J. 1 Dec 2022, In: Epileptic disorders : international epilepsy journal with videotape. 24 , p. 1033-1045 13 p.

Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy:A systematic review and individual participant data meta-analysis

Stevelink Remi, Al-Toma Dania, Jansen Floor E., Lamberink Herm J., Asadi-Pooya Ali A., Farazdaghi Mohsen, Cação Gonçalo, Jayalakshmi Sita, Patil Anuja, Özkara Çiğdem, Aydın Şenay, Gesche Joanna, Beier Christoph P., Stephen Linda J., Brodie Martin J., Unnithan Gopeekrishnan, Radhakrishnan Ashalatha, Höfler Julia, Trinka Eugen, Krause Roland, Irelli Emanuele Cerulli, Di Bonaventura Carlo, Szaflarski Jerzy P., Hernández-Vanegas Laura E., Moya-Alfaro Monica L., Zhang Yingying, Zhou Dong, Pietrafusa Nicola, Specchio Nicola, Japaridze Giorgi, Beniczky Sándor, Janmohamed Mubeen, Kwan Patrick, Syvertsen Marte, Selmer Kaja K., Vorderwülbecke Bernd J., Holtkamp Martin, Viswanathan Lakshminarayanapuram G., Sinha Sanjib, Baykan Betül, Altindag Ebru, von Podewils Felix, Schulz Juliane, Seneviratne Udaya, Viloria-Alebesque Alejandro, Karakis Ioannis, D'Souza Wendyl J., Koeleman Bobby P.C., Otte Willem M., Braun Kees P.J., Nov 2022, In: EClinicalMedicine. 53

Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial):a randomised, single-blind, adaptive non-inferiority trial

Zweiphenning Willemiek, Klooster Maryse A.van t., van Klink Nicole E.C., Leijten Frans S.S., Ferrier Cyrille H., Gebbink Tineke, Huiskamp Geertjan, van Zandvoort Martine J.E., van Schooneveld Monique M.J., Bourez M., Goemans Sophie, Straumann Sven, van Rijen Peter C., Gosselaar Peter H., van Eijsden Pieter, Otte Willem M., van Diessen Eric, Braun Kees P.J., Zijlmans Maeike, Bloemen-Carlier Eltje M., Cibulková Veronika, de Munnink Renee, van der Salm Sandra, Eijkemans Martinus J.C., Ophorst-van Eck Janine M., Velders Anouk, van Asch Charlotte J.J., Zwemmer Jack, van Regteren-van Griethuysen Renate, Smeding Henriette, van der Berg Lydia, de Bresser Jeroen, de Kort Gérard A.P., Dankbaar Jan Willem, Nov 2022, In: The Lancet. Neurology. 21 , p. 982-993 12 p.

Cumulative effects of antiseizure medication on intelligence in children with focal epilepsy

Stevering Carmen H., Lamberink Herm J., Woodfield Julie, van Schooneveld Monique, Otte Willem M., Chin Richard F.M., Bastin Mark E., Geleijns Karin, Braun Kees P.J. 1 Oct 2022, In: Epileptic disorders : international epilepsy journal with videotape. 24 , p. 877-888 12 p.

Incidence of and predictors for antiseizure medication gaps in Medicare beneficiaries with epilepsy:a retrospective cohort study

Terman Samuel W., Niznik Joshua D., Slinger Geertruida, Otte Willem M., Braun Kees P.J., Aubert Carole E., Kerr Wesley T., Boyd Cynthia M., Burke James F. 1 Sep 2022, In: BMC Neurology. 22 , p. 1-14

Tailored epilepsy surgery with high frequency oscillations versus spikes in intra-operative electrocorticography: Results of the RCT HFO trial

Klooster M. Van ' T., Zweiphenning W., Van Klink N., Leijten F., Ferrier C., Gebbink T., Huiskamp G., Van Zandvoort M., Van Schooneveld M., Bourez M., Goemans S., Straumann S., Van Rijen P., Gosselaar P., Van Eijsden P., Otte W., Van Diessen E., Braun K., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 19-20

The spatial relationship between the MRI lesion and intraoperative electrocorticography in focal epilepsy surgery

Straumann S., Schaft E., Noordmans H. J., Dankbaar J. W., Otte W., Steenis J. Van, Smits P., Zweiphenning W., Eijsden P. Van, Gebbink T., Mariani L., Klooseter M. Van't, Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 177-177

Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior

Straathof Milou, Blezer Erwin L.A., Smeele Christel E., van Heijningen Caroline, van der Toorn Annette, Buitelaar Jan, Glennon Jeffrey, Otte Willem M., Dijkhuizen Rick, Buitelaar Jan, de Ruiter Saskia, Naaijen Jilly, Akkermans Sophie, Mennes Maarten, Zwiers Marcel, Ilbegi Shahrzad, Hennissen Leonie, Glennon Jeffrey, van de Vondervoort Ilse, Kapusta Katarzyna, Bielczyk Natalia, Amiri Houshang, Havenith Martha, Franke Barbara, Poelmans Geert, Bralten Janita, Heskes Tom, Sokolova Elena, Groot Perry, Williams Steven, Murphy Declan, Lythgoe David, Bruchhage Muriel, Dud Iulia, Voinescu Bogdan, Dittmann Ralf, Banaschewski Tobias, Brandeis Daniel, Mechler Konstantin, Berg Ruth, Wolf Isabella, Dijkhuizen Rick, Blezer Erwin L.A., Straathof Milou, Mol Wouter, Otte Willem, Durston Sarah, Mensen Vincent, Oranje Bob, Mandl René, Aug 2022, In: Psychopharmacology. 239 , p. 2457-2470 14 p.

All research output

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