dr. H.G. (Henny G.) Otten

dr. H.G. (Henny G.) Otten

Associate Professor
dr. H.G. (Henny G.) Otten
  • Laboratory for Translational Immunology (LTI)

Research Programs

Infection & Immunity



Henny Otten is an associate professor with a primary research interest focused on humoral immunity including associated effector mechanisms. He studied medical biology at the University of Amsterdam and obtained his PhD at the Department of Rheumatology of the University Hospital Leiden. In 1992 he started as post-doc at the department of Immunohematology at the University Hospital Utrecht developing molecular HLA-typing and performing research in the field of bone marrow and organ transplantation. Since 1997 he is co-director of the HLA laboratory in the UMCU. Between 1997-2000 he was also interim head of the bone-marrow transplantation laboratory. He is leader of the national PROCARE consortium which studies the impact of humoral allo- and auto-immunity in ~5000 kidney transplants; a study subsidized by Dutch Kidney Foundation. Together with funding from multiple commercial partners, studies are performed on the effector functions of antibodies in relation to complement and FcRgamma polymorphisms,  prediction of (the severity of) food allergy and angio-edema, an biomarkers predicting chronic rejection after lung transplantation. He holds certificates as Medical Immunologist,  European Specialist in Histocompatibility & Immunogenetics, Transplantation Immunologist, and Immunologist. In close collaboration with clinicians, Henny Otten has (co-)authored >100 peer-reviewed papers with translational objectives.

Side Activities

Board member (treasurer) of the Dutch Transplantation Society

Board member of the society of Medical Immunology

Chairman of the SMBWO Immunology Supervision and Assessment Committee (2014-2018)

Member of the Dutch HLA working group

Member of the Dutch Society of Immunology

Research Output (149)

High-resolution mapping identifies HLA class II associations with multifocal motor neuropathy

Bos Jeroen W., Otten Henny G., Herraets Ingrid J.T., Goedee H. Stephan, Cats E. A., de Hoop Talitha, Verduijn Willem, van der Pol W. Ludo, van den Berg Leonard H. mei 2021, In: Neurobiology of Aging. 101 , p. 79-84 6 p.

ARHGDIB and AT1R autoantibodies are differentially related to the development and presence of chronic antibody-mediated rejection and fibrosis in kidney allografts

Betjes Michiel G.H., Sablik Kasia A., Litjens Nicolle H.R., Otten Henny G., de Weerd Annelies E. feb 2021, In: Human Immunology. 82 , p. 89-96 8 p.

Text Mining of Electronic Health Records Can Accurately Identify and Characterize Patients With Systemic Lupus Erythematosus

Brunekreef Tammo E, Otten Henny G, van den Bosch Suzanne C, Hoefer Imo E, van Laar Jacob M, Limper Maarten, Haitjema Saskia feb 2021, In: ACR open rheumatology. 3 , p. 65-71 7 p.

IgE-binding to vicilin-like antimicrobial peptides is associated with systemic reactions to macadamia nut

Ehlers Anna M., Rohwer Stefanie, Otten Henny G., Brix Bettina, Le Thuy My, Suer Waltraud, Knulst André C. 2 dec 2020, In: Clinical and Translational Allergy. 10 , p. 1-5

Detection of specific IgE against linear epitopes from Gal d 1 has additional value in diagnosing hen's egg allergy in adults

Ehlers Anna M, Otten Henny G, Wierzba Eva, Flügge Ulrike, Le Thuy-My, Knulst André C, Suer Waltraud 10 sep 2020, In: Clinical and Experimental Allergy. 50 , p. 1415-1423 9 p.

Biomarker profiles of endothelial activation and dysfunction in rare systemic autoimmune diseases:implications for cardiovascular risk

Wienke Judith, Mertens Jorre S, Garcia Samuel, Lim Johan, Wijngaarde Camiel A, Yeo Joo Guan, Meyer Alain, van den Hoogen Lucas L, Tekstra Janneke, Hoogendijk Jessica E, Otten Henny G, Fritsch-Stork Ruth D E, de Jager Wilco, Seyger Marieke M B, Thurlings Rogier M, de Jong Elke M G J, van der Kooi Anneke J, van der Pol W Ludo, Arkachaisri Thaschawee, Radstake Timothy R D J, van Royen-Kerkhof Annet, van Wijk Femke, 18 aug 2020, In: Rheumatology (Oxford, England). 60 , p. 785-801 17 p.

Response of FcεRI-bearing leucocytes to omalizumab in chronic spontaneous urticaria

Alizadeh Aghdam M, Knol E F, van den Elzen M, den Hartog Jager C, van Os-Medendorp H, Knulst A C, Otten H G, Röckmann H 10 jan 2020, In: Clinical and Experimental Allergy. 50 , p. 364-371 8 p.

Ara h 7 isoforms share many linear epitopes:Are 3D epitopes crucial to elucidate divergent abilities?

Ehlers Anna M., Klinge Marco, Suer Waltraud, Weimann Yvonne, Knulst André C., Besa Frithjof, Le Thuy My, Otten Henny G. 1 nov 2019, In: Clinical and Experimental Allergy. 49 , p. 1512-1519 8 p.

Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Heidt Sebastiaan, Haasnoot Geert W., Witvliet Marian D., van der Linden-van Oevelen Marissa J.H., Kamburova Elena G., Wisse Bram W., Joosten Irma, Allebes Wil A., van der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., van Reekum Franka E., van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, van Duijnhoven Elly M., Gelens Marielle A.C.J., Christiaans Maarten H.L., van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, van der Pant Karlijn A.M.I., van der Weerd Neelke C., ten Berge Ineke J.M., Bemelman Frederike J., Hoitsma Andries, van der Boog Paul J.M., de Fijter Johan W., Betjes Michiel G.H., Otten Henny G., Roelen Dave L., Claas Frans H.J. okt 2019, In: American Journal of Transplantation. 19 , p. 2926-2933 8 p.

A single nucleotide C3 polymorphism associates with clinical outcome after lung transplantation

Kardol-Hoefnagel Tineke, Budding Kevin, van de Graaf Eduard A., Setten Jessica van, van Rossum Oliver A., Oudijk Erik Jan D., Otten Henderikus G. 1 sep 2019, In: Frontiers in Immunology. 10 9 p.

All research output

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