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prof. dr. G. (Gerard) Pasterkamp

prof. dr. G. (Gerard) Pasterkamp

Full Professor
prof. dr. G. (Gerard) Pasterkamp
  • Department of Clinical Chemistry and Haematology

Research Programs

Circulatory Health

Biography

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and scientific medical manager of the division LAB. UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

Board member of Dutch Atherosclerosis Society

Review board LS7 EU-ERC advanced grants

 

Research Output (615)

High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome

Dekker Mirthe, Waissi Farahnaz, Silvis Max J.M., Bennekom Joelle V., Schoneveld Arjan H., de Winter Robbert J., Isgum Ivana, Lessmann Nikolas, Velthuis Birgitta K., Pasterkamp Gerard, Mosterd Arend, Timmers Leo, de Kleijn Dominique P.V. 23 sep 2021, In: Scientific Reports. 11 10 p.

APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans

Tsiantoulas Dimitrios, Eslami Mahya, Obermayer Georg, Clement Marc, Smeets Diede, Mayer Florian J, Kiss Máté G, Enders Lennart, Weißer Juliane, Göderle Laura, Lambert Jordi, Frommlet Florian, Mueller André, Hendrikx Tim, Ozsvar-Kozma Maria, Porsch Florentina, Willen Laure, Afonyushkin Taras, Murphy Jane E, Fogelstrand Per, Donzé Olivier, Pasterkamp Gerard, Hoke Matthias, Kubicek Stefan, Jørgensen Helle F, Danchin Nicolas, Simon Tabassome, Scharnagl Hubert, März Winfried, Borén Jan, Hess Henry, Mallat Ziad, Schneider Pascal, Binder Christoph J 25 aug 2021, In: Nature. 597 , p. 92-96 5 p.

Mildly Increased Renin Expression in the Absence of Kidney Injury in the Murine Transverse Aortic Constriction Model

Wesseling Marian, Mulder Eva, Brans Maike A D, Kapteijn Daniek M C, Bulthuis Marian, Pasterkamp Gerard, Verhaar Marianne C, Danser A H Jan, van Goor Harry, Joles Jaap A, de Jager Saskia C A 15 jun 2021, In: Frontiers in Pharmacology. 12 , p. 1-11

Monocyte-chemoattractant protein-1 levels in human atherosclerotic lesions associate with plaque vulnerability

Georgakis Marios K., van der Laan Sander W., Asare Yaw, Mekke Joost M., Haitjema Saskia, Schoneveld Arjan H., de Jager Saskia C.A., Nurmohamed Nick S., Kroon Jeffrey, Stroes Erik S.G., de Kleijn Dominique P.V., de Borst Gert J., Maegdefessel Lars, Soehnlein Oliver, Pasterkamp Gerard, Dichgans Martin 8 apr 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41 , p. 2038-2048 11 p.

Prosaposin mediates inflammation in atherosclerosis

van Leent Mandy M T, Beldman Thijs J, Toner Yohana C, Lameijer Marnix A, Rother Nils, Bekkering Siroon, Teunissen Abraham J P, Zhou Xianxiao, van der Meel Roy, Malkus Joost, Nauta Sheqouia A, Klein Emma D, Fay Francois, Sanchez-Gaytan Brenda L, Pérez-Medina Carlos, Kluza Ewelina, Ye Yu-Xiang, Wojtkiewicz Gregory, Fisher Edward A, Swirski Filip K, Nahrendorf Matthias, Zhang Bin, Li Yang, Zhang Bowen, Joosten Leo A B, Pasterkamp Gerard, Boltjes Arjan, Fayad Zahi A, Lutgens Esther, Netea Mihai G, Riksen Niels P, Mulder Willem J M, Duivenvoorden Raphaël 10 mrt 2021, In: Science translational medicine. 13 , p. 1-13

Decreased activity and stability of pyruvate kinase in sickle cell disease:a novel target for mitapivat therapy

Rab Minke A E, Bos Jennifer, van Oirschot Brigitte, Straaten Stephanie van, Kosinski Penelope A, Chubukov Victor, Kim Hyeryun, Mangus Heidi, Schutgens Roger E G, Pasterkamp Gerard, Dang Lenny, Kung Charles, van Beers Eduard J, van Wijk Richard 10 mrt 2021, In: Blood. 137 , p. 2997-3001 5 p.

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

Hartman Robin J G, Owsiany Katie, Ma Lijiang, Koplev Simon, Hao Ke, Slenders Lotte, Civelek Mete, Mokry Michal, Kovacic Jason C, Pasterkamp Gerard, Owens Gary, Björkegren Johan L M, den Ruijter Hester M 16 feb 2021, In: Circulation. 143 , p. 713-726 14 p.

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

Demandt J A F, Dubois L J, van Kuijk K, Zaťovičová M, Jin H, Parkkila S, van der Laan S W, Jelenska L, Mees B M E, Reutelingsperger C P M, Cleutjens K B J M, van der Kallen C J H, Schalkwijk C G, van Greevenbroek M M J, Biessen E A L, Pasterkamp G, Pastoreková S, Stehouwer C D A, Sluimer J C 11 jan 2021, In: Scientific Reports. 11 14 p.

Preclinical Feasibility and Patency Analyses of a New Distal Coronary Connector:The ELANA Heart Bypass

Stecher David, Hoogewerf Marieke, Bronkers Glenn, van Putte Bart P, Doevendans Pieter A, Tulleken Cornelis A F, van Herwerden Lex, Pasterkamp Gerard, Buijsrogge Marc P 2021, In: Innovations (Philadelphia, Pa.). 16 , p. 163-168 6 p.

The prognostic value of automated coronary calcium derived by a deep learning approach on non-ECG gated CT images from 82Rb-PET/CT myocardial perfusion imaging

Dekker Mirthe, Waissi Farahnaz, Bank Ingrid E M, Isgum Ivana, Scholtens Asbjørn M, Velthuis Birgitta K, Pasterkamp Gerard, de Winter Robbert J, Mosterd Arend, Timmers Leo, de Kleijn Dominique P V 2021, In: International Journal of Cardiology. 329 , p. 9-15 7 p.

All research output

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