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prof. dr. G. (Gerard) Pasterkamp

prof. dr. G. (Gerard) Pasterkamp

Full Professor
prof. dr. G. (Gerard) Pasterkamp
  • Central Diagnostic Laboratory

Research Programs

Circulatory Health

Biography

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and scientific medical manager of the division LAB. UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

Board member of Dutch Atherosclerosis Society

Review board LS7 EU-ERC advanced grants

 

Research Output (632)

The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease

Slenders Lotte, Tessels Daniëlle E, van der Laan Sander W, Pasterkamp Gerard, Mokry Michal 8 Feb 2022, In: Frontiers in cardiovascular medicine. 9 , p. 826103

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

Slenders Lotte, Landsmeer Lennart P L, Cui Kai, Depuydt Marie A C, Verwer Maarten, Mekke Joost, Timmerman Nathalie, van den Dungen Noortje A M, Kuiper Johan, de Winther Menno P J, Prange Koen H M, Ma Wei Feng, Miller Clint L, Aherrahrou Redouane, Civelek Mete, de Borst Gert J, de Kleijn Dominique P V, Asselbergs Folkert W, den Ruijter Hester M, Boltjes Arjan, Pasterkamp Gerard, van der Laan Sander W, Mokry Michal Jan 2022, In: European heart journal open. 2 , p. oeab043

The power of genetic diversity in genome-wide association studies of lipids

Graham Sarah E, Clarke Shoa L, Wu Kuan-Han H, Kanoni Stavroula, Zajac Greg J M, Ramdas Shweta, Surakka Ida, Ntalla Ioanna, Vedantam Sailaja, Winkler Thomas W, Locke Adam E, Marouli Eirini, Hwang Mi Yeong, Han Sohee, Narita Akira, Choudhury Ananyo, Bentley Amy R, Ekoru Kenneth, Verma Anurag, Trivedi Bhavi, Martin Hilary C, Hunt Karen A, Hui Qin, Klarin Derek, Zhu Xiang, Thorleifsson Gudmar, Helgadottir Anna, Gudbjartsson Daniel F, Holm Hilma, Olafsson Isleifur, Akiyama Masato, Sakaue Saori, Terao Chikashi, Kanai Masahiro, Zhou Wei, Brumpton Ben M, Rasheed Humaira, Ruotsalainen Sanni E, Havulinna Aki S, van der Laan Sander W, van Setten Jessica, de Kleijn Dominique, de Borst Gert J, Asselbergs Folkert W, Kraaijeveld Adriaan O, Beulens Joline W J, Pasterkamp Gerard, Hoefer Imo E, van der Harst Pim, Holmes Michael V, 9 Dec 2021, In: Nature. 600 , p. 675-679 5 p.

The changing landscape of the vulnerable plaque:a call for fine-tuning of preclinical models

Buono Michele F, Slenders Lotte, Wesseling Marian, Hartman Robin J G, Monaco Claudia, den Ruijter Hester M, Pasterkamp Gerard, Mokry Michal Dec 2021, In: Vascular Pharmacology. 141 , p. 1-10

Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets

Ma Wei Feng, Hodonsky Chani J, Turner Adam W, Wong Doris, Song Yipei, Mosquera Jose Verdezoto, Ligay Alexandra V, Slenders Lotte, Gancayco Christina, Pan Huize, Barrientos Nelson B, Mai David, Alencar Gabriel F, Owsiany Katherine, Owens Gary K, Reilly Muredach P, Li Mingyao, Pasterkamp Gerard, Mokry Michal, van der Laan Sander W, Khomtchouk Bohdan B, Miller Clint L 26 Nov 2021, In: Atherosclerosis. 340 , p. 12-22 11 p.

High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome

Dekker Mirthe, Waissi Farahnaz, Silvis Max J.M., Bennekom Joelle V., Schoneveld Arjan H., de Winter Robbert J., Isgum Ivana, Lessmann Nikolas, Velthuis Birgitta K., Pasterkamp Gerard, Mosterd Arend, Timmers Leo, de Kleijn Dominique P.V. 23 Sep 2021, In: Scientific Reports. 11 10 p.

Sex-dependent gene co-expression in the human body

Hartman Robin J G, Mokry Michal, Pasterkamp Gerard, den Ruijter Hester M 21 Sep 2021, In: Scientific Reports. 11

APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans

Tsiantoulas Dimitrios, Eslami Mahya, Obermayer Georg, Clement Marc, Smeets Diede, Mayer Florian J, Kiss Máté G, Enders Lennart, Weißer Juliane, Göderle Laura, Lambert Jordi, Frommlet Florian, Mueller André, Hendrikx Tim, Ozsvar-Kozma Maria, Porsch Florentina, Willen Laure, Afonyushkin Taras, Murphy Jane E, Fogelstrand Per, Donzé Olivier, Pasterkamp Gerard, Hoke Matthias, Kubicek Stefan, Jørgensen Helle F, Danchin Nicolas, Simon Tabassome, Scharnagl Hubert, März Winfried, Borén Jan, Hess Henry, Mallat Ziad, Schneider Pascal, Binder Christoph J 25 Aug 2021, In: Nature. 597 , p. 92-96 5 p.

Scientists on the Spot:Re-defining atherosclerosis through biobanks

Gladka Monika M, Pasterkamp Gerard 1 Jul 2021, In: Cardiovascular research. 117 , p. e99-e100

Sclerostin Downregulation Globally by Naturally Occurring Genetic Variants, or Locally in Atherosclerotic Plaques, Does Not Associate With Cardiovascular Events in Humans

Holdsworth Gill, Staley James R., Hall Peter, van Koeverden Ian, Vangjeli Ciara, Okoye Remi, Boyce Rogely W., Turk James R., Armstrong Martin, Wolfreys Alison, Pasterkamp Gerard Jul 2021, In: Journal of Bone and Mineral Research. 36 , p. 1326-1339 14 p.

All research output

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