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prof. dr. G. (Gerard) Pasterkamp

Full Professor

  • Department of Clinical Chemistry and Haematology

prof. dr. G. (Gerard) Pasterkamp

Research Programs

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and scientific medical manager of the division LAB. UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

  • Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

    Board member of Dutch Atherosclerosis Society

    Review board LS7 EU-ERC advanced grants

     

Research Output (565)

Intrinsic transcriptomic sex differences in human endothelial cells at birth and in adults are associated with coronary artery disease targets

Hartman Robin J G, Kapteijn Daniek M C, Haitjema Saskia, Bekker Mireille N, Mokry Michal, Pasterkamp Gerard, Civelek Mete, den Ruijter Hester M 23 jul 2020, In: Scientific Reports. 10 12 p.

Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain

Dekker Mirthe, Waissi Farahnaz, van Bennekom Joelle, Silvis Max J M, Timmerman Nathalie, Bank Ingrid E M, Walter Joan E, Mueller Christian, Schoneveld A H, Schiffelers Raymond M, Pasterkamp Gerard, Grobbee Diederick E, de Winter Robbert J, Mosterd A, de Kleijn Dominique P V, Timmers Leo 23 jul 2020, In: Scientific Reports. 10

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

Wang Ying, Nanda Vivek, Direnzo Daniel, Ye Jianqin, Xiao Sophia, Kojima Yoko, Howe Kathryn L., Jarr Kai Uwe, Flores Alyssa M., Tsantilas Pavlos, Tsao Noah, Rao Abhiram, Newman Alexandra A.C., Eberhard Anne V., Priest James R., Ruusalepp Arno, Pasterkamp Gerard, Maegdefessel Lars, Miller Clint L., Lind Lars, Koplev Simon, Björkegren Johan L.M., Owens Gary K., Ingelsson Erik, Weissman Irving L., Leeper Nicholas J. 7 jul 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117 , p. 15818-15826 9 p.

Cerebral Small Vessel Disease in Standard Pre-operative Imaging Reports Is Independently Associated with Increased Risk of Cardiovascular Death Following Carotid Endarterectomy

Timmerman Nathalie, Rots Marjolijn L, van Koeverden Ian D, Haitjema Saskia, van Laarhoven Constance J H C M, Vuurens Annemiek M, den Ruijter Hester M, Pasterkamp Gerard, Kappelle L Jaap, de Kleijn Dominique P V, de Borst Gert J jun 2020, In: European Journal of Vascular and Endovascular Surgery. 59 , p. 872-880 9 p.

Validation of randomized controlled trial-derived models for the prediction of postintervention outcomes in chronic limb-threatening ischemia

Wijnand Joep G J, van Koeverden Ian D, Teraa Martin, Spreen Marlon I, Mali Willem P T M, van Overhagen Hans, Pasterkamp Gerard, de Borst Gert J, Conte Michael S, Gremmels Hendrik, Verhaar Marianne C 1 mrt 2020, In: Journal of Vascular Surgery. 71 , p. 869-879 11 p.

Automated calcium scores collected during myocardial perfusion imaging improve identification of obstructive coronary artery disease

Dekker Mirthe, Waissi Farahnaz, Bank Ingrid E.M., Lessmann Nikolas, Išgum Ivana, Velthuis Birgitta K., Scholtens Asbjørn M., Leenders Geert E., Pasterkamp Gerard, de Kleijn Dominique P.V., Timmers Leo, Mosterd Arend 1 feb 2020, In: IJC Heart and Vasculature. 26 6 p.

The therapeutic potential of targeting CD40-TRAF6 pathway in cardiovascular Diseases

Bosch Lena, de Haan Judith J., Seijkens Tom T.P., van Tiel Claudia M., Brans Maike A.D., Pasterkamp Gerard, Lutgens Esther, de Jager Saskia C.A. 1 feb 2020, In: International Journal of Cardiology. 300 , p. 220-220 1 p.

Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac:the Aneurysm-Express Biobank Cohort

van Laarhoven Constance J.H.C.M., van Setten Jessica, van Herwaarden Joost A., Pasterkamp Gerard, de Kleijn Dominique P.V., de Borst Gert J., van der Laan Sander W. 27 dec 2019, In: Scientific Reports. 9

Magnetic Resonance Imaging Identified Brain Ischaemia in Symptomatic Patients Undergoing Carotid Endarterectomy Is Related to Histologically Apparent Intraplaque Haemorrhage

Rots Marjolijn L., Timmerman Nathalie, de Kleijn Dominique P.V., Pasterkamp Gerard, Brown Martin M., Bonati Leo H., de Borst Gert J. 1 dec 2019, In: European Journal of Vascular and Endovascular Surgery. 58 , p. 796-804 9 p.

All Research Output (565)