prof. dr. G. (Gerard) Pasterkamp

Full Professor
prof. dr. G. (Gerard) Pasterkamp
  • Department of Clinical Chemistry and Haematology

Research Programs

Circulatory Health



Gerard Pasterkamp, MD, is professor Experimental Cardiology and scientific medical manager of the division LAB. UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

Board member of Dutch Atherosclerosis Society

Review board LS7 EU-ERC advanced grants


Research Output (605)

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

Hartman Robin J G, Owsiany Katie, Ma Lijiang, Koplev Simon, Hao Ke, Slenders Lotte, Civelek Mete, Mokry Michal, Kovacic Jason C, Pasterkamp Gerard, Owens Gary, Björkegren Johan L M, den Ruijter Hester M 16 feb 2021, In: Circulation. 143 , p. 713-726 14 p.

The prognostic value of automated coronary calcium derived by a deep learning approach on non-ECG gated CT images from 82Rb-PET/CT myocardial perfusion imaging

Dekker Mirthe, Waissi Farahnaz, Bank Ingrid E M, Isgum Ivana, Scholtens Asbjørn M, Velthuis Birgitta K, Pasterkamp Gerard, de Winter Robbert J, Mosterd Arend, Timmers Leo, de Kleijn Dominique P V 2021, In: International Journal of Cardiology. 329 , p. 9-15 7 p.

Cardiovascular imaging of women and men visiting the outpatient clinic with chest pain or discomfort:design and rationale of the ARGUS Study

Groepenhoff Floor, Eikendal Anouk L M, Bots Sophie Heleen, van Ommen Anne-Mar, Overmars L M, Kapteijn Daniek, Pasterkamp Gerard, Reiber Johan H C, Hautemann David, Menken Roxana, Wittekoek Marianne E, Hofstra Leonard, Onland-Moret N Charlotte, Haitjema Saskia, Hoefer Imo, Leiner Tim, den Ruijter Hester M 15 dec 2020, In: BMJ Open. 10 , p. 1-7

Preemptive Stenting of the Vulnerable Plaque:Fixing a Dogma?

Pasterkamp Gerard, van der Harst Pim, den Ruijter Hester M 17 nov 2020, In: Journal of the American College of Cardiology. 76 , p. 2302-2304 3 p.

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells

Aherrahrou Rédouane, Guo Liang, Nagraj Vijay Peter, Aguhob Aaron Andrew, Hinkle Jameson, Chen Lisa, Soh Joon Yuhl, Lue Dillon, Alencar Gabriel F, Boltjes Arjan, van der Laan Sander W, Farber Emily, Fuller Daniela, Anane-Wae Rita, Akingbesote Ngozi D, Manichaikul Ani W, Ma Lijiang, Kaikkonen Minna U, Björkegren Johan Lm, Onengut-Gumuscu Suna, Pasterkamp Gerard, Miller Clint L, Owens Gary K, Finn Aloke V, Navab Mohamad, Fogelman Alan M, Berliner Judith A, Civelek Mete 12 okt 2020, In: Circulation research. 127 , p. 1552-1565 14 p.

The age- and sex-specific composition of atherosclerotic plaques in vascular surgery patients

de Bakker Marie, Timmerman Nathalie, van Koeverden Ian D, de Kleijn Dominique P V, de Borst Gert J, Pasterkamp Gerard, Boersma Eric, den Ruijter Hester M okt 2020, In: Atherosclerosis. 310 , p. 1-10 10 p.

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

Depuydt Marie Ac, Prange Koen Hm, Slenders Lotte, Örd Tiit, Elbersen Danny, Boltjes Arjan, de Jager Saskia Ca, Asselbergs Folkert W, de Borst Gert J, Aavik Einari, Lönnberg Tapio, Lutgens Esther, Glass Christopher K, den Ruijter Hester M, Kaikkonen Minna U, Bot Ilze, Slütter Bram, van der Laan Sander W, Yla-Herttuala Seppo, Mokry Michal, Kuiper Johan, de Winther Menno Pj, Pasterkamp Gerard 28 sep 2020, In: Circulation research. 127 , p. 1437-1455 19 p.

The TAXINOMISIS Project:A multidisciplinary approach for the development of a new risk stratification model for patients with asymptomatic carotid artery stenosis

Timmerman Nathalie, Galyfos George, Sigala Fragiska, Thanopoulou Kalliopi, de Borst Gert J, Davidovic Lazar, Eckstein Hans-Henning, Filipovic Nenad, Grugni Roberto, Kallmayer Michael, de Kleijn Dominique P V, Koncar Igor, Mantzaris Michalis D, Marchal Elisabeth, Matsagkas Miltiadis, Mutavdzic Perica, Palombo Domenico, Pasterkamp Gerard, Potsika Vassiliki T, Andreakos Evangelos, Fotiadis Dimitrios I, 20 sep 2020, In: European Journal of Clinical Investigation. 50 , p. 1-12

Plasma extracellular vesicle proteins are associated with stress-induced myocardial ischemia in women presenting with chest pain

Dekker Mirthe, Waissi Farahnaz, van Bennekom Joelle, Silvis Max J M, Timmerman Nathalie, Bank Ingrid E M, Walter Joan E, Mueller Christian, Schoneveld A H, Schiffelers Raymond M, Pasterkamp Gerard, Grobbee Diederick E, de Winter Robbert J, Mosterd A, de Kleijn Dominique P V, Timmers Leo 23 jul 2020, In: Scientific Reports. 10 8 p.

All research output

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