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prof. dr. G. (Gerard) Pasterkamp

Full Professor
prof. dr. G. (Gerard) Pasterkamp
  • Department of Clinical Chemistry and Haematology

Research Programs

Circulatory Health

Biography

Biography

Gerard Pasterkamp, MD, is professor Experimental Cardiology and scientific medical manager of the division LAB. UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

Board member of Dutch Atherosclerosis Society

Review board LS7 EU-ERC advanced grants

 

Research Output (610)

Mildly Increased Renin Expression in the Absence of Kidney Injury in the Murine Transverse Aortic Constriction Model

Wesseling Marian, Mulder Eva, Brans Maike A D, Kapteijn Daniek M C, Bulthuis Marian, Pasterkamp Gerard, Verhaar Marianne C, Danser A H Jan, van Goor Harry, Joles Jaap A, de Jager Saskia C A 15 jun 2021, In: Frontiers in Pharmacology. 12 , p. 1-11

Monocyte-chemoattractant protein-1 levels in human atherosclerotic lesions associate with plaque vulnerability

Georgakis Marios K., van der Laan Sander W., Asare Yaw, Mekke Joost M., Haitjema Saskia, Schoneveld Arjan H., de Jager Saskia C.A., Nurmohamed Nick S., Kroon Jeffrey, Stroes Erik S.G., de Kleijn Dominique P.V., de Borst Gert J., Maegdefessel Lars, Soehnlein Oliver, Pasterkamp Gerard, Dichgans Martin 8 apr 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41 , p. 2038-2048 11 p.

Prosaposin mediates inflammation in atherosclerosis

van Leent Mandy M T, Beldman Thijs J, Toner Yohana C, Lameijer Marnix A, Rother Nils, Bekkering Siroon, Teunissen Abraham J P, Zhou Xianxiao, van der Meel Roy, Malkus Joost, Nauta Sheqouia A, Klein Emma D, Fay Francois, Sanchez-Gaytan Brenda L, Pérez-Medina Carlos, Kluza Ewelina, Ye Yu-Xiang, Wojtkiewicz Gregory, Fisher Edward A, Swirski Filip K, Nahrendorf Matthias, Zhang Bin, Li Yang, Zhang Bowen, Joosten Leo A B, Pasterkamp Gerard, Boltjes Arjan, Fayad Zahi A, Lutgens Esther, Netea Mihai G, Riksen Niels P, Mulder Willem J M, Duivenvoorden Raphaël 10 mrt 2021, In: Science translational medicine. 13 , p. 1-13

Sex-Stratified Gene Regulatory Networks Reveal Female Key Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching

Hartman Robin J G, Owsiany Katie, Ma Lijiang, Koplev Simon, Hao Ke, Slenders Lotte, Civelek Mete, Mokry Michal, Kovacic Jason C, Pasterkamp Gerard, Owens Gary, Björkegren Johan L M, den Ruijter Hester M 16 feb 2021, In: Circulation. 143 , p. 713-726 14 p.

The hypoxia-sensor carbonic anhydrase IX affects macrophage metabolism, but is not a suitable biomarker for human cardiovascular disease

Demandt J A F, Dubois L J, van Kuijk K, Zaťovičová M, Jin H, Parkkila S, van der Laan S W, Jelenska L, Mees B M E, Reutelingsperger C P M, Cleutjens K B J M, van der Kallen C J H, Schalkwijk C G, van Greevenbroek M M J, Biessen E A L, Pasterkamp G, Pastoreková S, Stehouwer C D A, Sluimer J C 11 jan 2021, In: Scientific Reports. 11 14 p.

The prognostic value of automated coronary calcium derived by a deep learning approach on non-ECG gated CT images from 82Rb-PET/CT myocardial perfusion imaging

Dekker Mirthe, Waissi Farahnaz, Bank Ingrid E M, Isgum Ivana, Scholtens Asbjørn M, Velthuis Birgitta K, Pasterkamp Gerard, de Winter Robbert J, Mosterd Arend, Timmers Leo, de Kleijn Dominique P V 2021, In: International Journal of Cardiology. 329 , p. 9-15 7 p.

Preclinical Feasibility and Patency Analyses of a New Distal Coronary Connector:The ELANA Heart Bypass

Stecher David, Hoogewerf Marieke, Bronkers Glenn, van Putte Bart P, Doevendans Pieter A, Tulleken Cornelis A F, van Herwerden Lex, Pasterkamp Gerard, Buijsrogge Marc P 2021, In: Innovations (Philadelphia, Pa.). 16 , p. 163-168 6 p.

Cardiovascular imaging of women and men visiting the outpatient clinic with chest pain or discomfort:design and rationale of the ARGUS Study

Groepenhoff Floor, Eikendal Anouk L M, Bots Sophie Heleen, van Ommen Anne-Mar, Overmars L M, Kapteijn Daniek, Pasterkamp Gerard, Reiber Johan H C, Hautemann David, Menken Roxana, Wittekoek Marianne E, Hofstra Leonard, Onland-Moret N Charlotte, Haitjema Saskia, Hoefer Imo, Leiner Tim, den Ruijter Hester M 15 dec 2020, In: BMJ Open. 10 , p. 1-7

Preemptive Stenting of the Vulnerable Plaque:Fixing a Dogma?

Pasterkamp Gerard, van der Harst Pim, den Ruijter Hester M 17 nov 2020, In: Journal of the American College of Cardiology. 76 , p. 2302-2304 3 p.

Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells

Aherrahrou Rédouane, Guo Liang, Nagraj Vijay Peter, Aguhob Aaron Andrew, Hinkle Jameson, Chen Lisa, Soh Joon Yuhl, Lue Dillon, Alencar Gabriel F, Boltjes Arjan, van der Laan Sander W, Farber Emily, Fuller Daniela, Anane-Wae Rita, Akingbesote Ngozi D, Manichaikul Ani W, Ma Lijiang, Kaikkonen Minna U, Björkegren Johan Lm, Onengut-Gumuscu Suna, Pasterkamp Gerard, Miller Clint L, Owens Gary K, Finn Aloke V, Navab Mohamad, Fogelman Alan M, Berliner Judith A, Civelek Mete 12 okt 2020, In: Circulation research. 127 , p. 1552-1565 14 p.

All research output

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