prof. dr. G. (Gerard) Pasterkamp

prof. dr. G. (Gerard) Pasterkamp

Full Professor
prof. dr. G. (Gerard) Pasterkamp
  • Central Diagnostic Laboratory

Research Programs

Circulatory Health



Gerard Pasterkamp, MD, is professor Experimental Cardiology and quarter maker of the Circulatory Health Research Center, UMC Utrecht. His research interests are in the field of cardiovascular biology and more specifically innovation in biomarkers. His research interests are in the field of cardiovascular biology and innovation in biomarkers and drug targets. The research group houses the largest atherosclerotic plaque biobank worldwide: Athero Express including >4000 patients. This biobank has generated new insights into determinants of plaque destabilisation. The laboratory also invests in the excavation of genetic determinants of atherosclerotic plaque characteristics. He coordinates national and EU based consortia with the aim to unravel biomarkers and mechanisms of atherosclerotic disease. His translational profile is noted in the private public consortia he is involved in. He is supervising three public private grants that have been rewarded with the aim to develop novel biomarkers and imaging technology to detect cardiac ischemia and endothelial dysfunction. In 2018 he obtained a LeDucq grant together with Prof G Owens (Virginia University) on the role of smooth muscle cell plasticity in the atherosclerotic plaque. 

Side Activities

Editorial scientific board ATVB, Cardiovascular research, Atherosclerosis, Eur J Cardiovascular Pharmacology

Board member of Dutch Atherosclerosis Society

Review board LS7 EU-ERC advanced grants and Finnish Academy of Sciences


Research Output (638)

The Role of the Vulnerable Carotid Plaque in Embolic Stroke of Unknown Source

Willey Joshua Z, Pasterkamp Gerard 7 Jun 2022, In: Journal of the American College of Cardiology. 79 , p. 2200-2202 3 p.

Increased frequency of proangiogenic tunica intima endothelial kinase 2 (Tie2) expressing monocytes in individuals with type 2 diabetes mellitus

Reijrink M, van Ark J, Lexis C P H, Visser L M, Lodewijk M E, van der Horst I C C, Zeebregts C J, van Goor H, de Jager S C A, Pasterkamp G, Wolffenbuttel B H R, Hillebrands J L 12 May 2022, In: Cardiovascular Diabetology. 21 , p. 1-16

Protective role of chaperone-mediated autophagy against atherosclerosis

Madrigal-Matute Julio, de Bruijn Jenny, van Kuijk Kim, Riascos-Bernal Dario F, Diaz Antonio, Tasset Inmaculada, Martín-Segura Adrián, Gijbels Marion J J, Sander Bianca, Kaushik Susmita, Biessen Erik A L, Tiano Simoni, Bourdenx Mathieu, Krause Gregory J, McCracken Ian, Baker Andrew H, Jin Han, Sibinga Nicholas E S, Bravo-Cordero Jose Javier, Macian Fernando, Singh Rajat, Rensen Patrick C N, Berbée Jimmy F P, Pasterkamp Gerard, Sluimer Judith C, Cuervo Ana Maria 5 Apr 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119 , p. 1-12

Ceramides and phospholipids in plasma extracellular vesicles are associated with high risk of major cardiovascular events after carotid endarterectomy

Timmerman Nathalie, Waissi Farahnaz, Dekker Mirthe, de Borst Gert J., van Bennekom Joelle, de Winter Robbert J., Hilvo Mika, Jylhä Antti, Pasterkamp Gerard, de Kleijn Dominique P.V., Laaksonen Reijo 1 Apr 2022, In: Scientific Reports. 12 , p. 1-13

Preclinical Comparison of Distal Off-Pump Anastomotic Remodeling:Hand-Sewn Versus ELANA Heart Bypass

Stecher David, Hoogewerf Marieke, van Putte Bart P., Osman Shadan, Doevendans Pieter A., Tulleken Cornelis, van Herwerden Lex, Pasterkamp Gerard, Buijsrogge Marc P. 18 Mar 2022, In: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery. 17 , p. 111-118 8 p.

False Utopia of One Unifying Description of the Vulnerable Atherosclerotic Plaque:A Call for Recalibration That Appreciates the Diversity of Mechanisms Leading to Atherosclerotic Disease

Pasterkamp Gerard, den Ruijter Hester M, Giannarelli Chiara 10 Feb 2022, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 42 , p. E86-E95

The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease

Slenders Lotte, Tessels Daniëlle E, van der Laan Sander W, Pasterkamp Gerard, Mokry Michal 8 Feb 2022, In: Frontiers in cardiovascular medicine. 9 , p. 826103

Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis

Slenders Lotte, Landsmeer Lennart P L, Cui Kai, Depuydt Marie A C, Verwer Maarten, Mekke Joost, Timmerman Nathalie, van den Dungen Noortje A M, Kuiper Johan, de Winther Menno P J, Prange Koen H M, Ma Wei Feng, Miller Clint L, Aherrahrou Redouane, Civelek Mete, de Borst Gert J, de Kleijn Dominique P V, Asselbergs Folkert W, den Ruijter Hester M, Boltjes Arjan, Pasterkamp Gerard, van der Laan Sander W, Mokry Michal Jan 2022, In: European heart journal open. 2

The power of genetic diversity in genome-wide association studies of lipids

Graham Sarah E, Clarke Shoa L, Wu Kuan-Han H, Kanoni Stavroula, Zajac Greg J M, Ramdas Shweta, Surakka Ida, Ntalla Ioanna, Vedantam Sailaja, Winkler Thomas W, Locke Adam E, Marouli Eirini, Hwang Mi Yeong, Han Sohee, Narita Akira, Choudhury Ananyo, Bentley Amy R, Ekoru Kenneth, Verma Anurag, Trivedi Bhavi, Martin Hilary C, Hunt Karen A, Hui Qin, Klarin Derek, Zhu Xiang, Thorleifsson Gudmar, Helgadottir Anna, Gudbjartsson Daniel F, Holm Hilma, Olafsson Isleifur, Akiyama Masato, Sakaue Saori, Terao Chikashi, Kanai Masahiro, Zhou Wei, Brumpton Ben M, Rasheed Humaira, Ruotsalainen Sanni E, Havulinna Aki S, van der Laan Sander W, van Setten Jessica, de Kleijn Dominique, de Borst Gert J, Asselbergs Folkert W, Kraaijeveld Adriaan O, Beulens Joline W J, Pasterkamp Gerard, Hoefer Imo E, van der Harst Pim, Holmes Michael V, 9 Dec 2021, In: Nature. 600 , p. 675-679 5 p.

The changing landscape of the vulnerable plaque:a call for fine-tuning of preclinical models

Buono Michele F, Slenders Lotte, Wesseling Marian, Hartman Robin J G, Monaco Claudia, den Ruijter Hester M, Pasterkamp Gerard, Mokry Michal Dec 2021, In: Vascular Pharmacology. 141 , p. 1-10

All research output

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