prof. dr. B.W. (Bas W.) Raaymakers Full Professor

Experimental Clinical Physics Radiotherapy

Contact

braaymak@umcutrecht.nl

Research Programs

Cancer

Biography

Bas Raaymakers is working to improve cancer therapy by investigating, as well as developing, new high precision radiotherapy.
Together with prof Jan Lagendijk but also with industrial partners Elekta and Philips he designed and built a hybrid MRI accelerator to facilitate high precision, soft-tissue based image guidance for radiotherapy. This enables better radiotherapy via dose escalation while decreasing toxicity.
At the same time, the translation of this new technology to the clinic is pursued. For instance fast, on-line treatment planning, so that the patient is treated based on the latest state of the anatomy. This improves the current radiotherapy practice and at the same time is a requirement for smooth clinical introduction of the MRI accelerator.
Clinical work flow and procedures for different tumour sites are under investigation. Two major categories can be distinguished: The first is improving the existing radiotherapy patient treatments, so better conform the dose distribution to the tumour shape to minimise harm to the surroundings. The second is enabling radiotherapy as an alternative for surgery for patients currently not eligible for radiotherapy, e.g. highly mobile tumours in the kidney. The motion is too large to safely administer dose with conventional radiotherapy technology, with the on-line MRI guidance the motion uncertainty can be mitigated and radiation can be safely administered, offering a completely non-invasive treatment.

Side Activities

Member of International Advisory Committee of Physics in Medicine and Biology

Fellowship and Awards

VENI grant in 2003, Technical feasibility of the MRI accelerator

Research Output (153)

Target coverage and dose criteria based evaluation of the first clinical 1.5T MR-linac SBRT treatments of lymph node oligometastases compared with conventional CBCT-linac treatment

Winkel Dennis, Bol Gijsbert H., Werensteijn-Honingh Anita M., Intven Martijn P.W., Eppinga Wietse S.C., Hes Jochem, Snoeren Louk M.W., Sikkes Gonda G., Gadellaa-van Hooijdonk Christa G.M., Raaymakers Bas W., Jürgenliemk-Schulz Ina M., Kroon Petra S. 1 mei 2020, In: Radiotherapy and Oncology. 146 , p. 118-125 8 p.

Dosimetric impact of soft-tissue based intrafraction motion from 3D cine-MR in prostate SBRT

de Muinck Keizer D M, Kontaxis C, Kerkmeijer L G W, van der Voort van Zyp J R N, van den Berg C A T, Raaymakers B W, Lagendijk J J W, de Boer J C J 17 jan 2020, In: Physics in Medicine and Biology. 65 10 p.

Biomechanical quality assurance criteria for deformable image registration algorithms used in radiotherapy guidance

Zachiu Cornel, de Senneville Baudouin Denis, Raaymakers Bas W, Ries Mario 10 jan 2020, In: Physics in Medicine and Biology. 65 19 p.

Fast contour propagation for MR-guided prostate radiotherapy using convolutional neural networks

Eppenhof K A J, Maspero M, Savenije M H F, de Boer J C J, van der Voort van Zyp J R N, Raaymakers B W, Raaijmakers A J E, Veta M, van den Berg C A T, Pluim J P W 26 dec 2019, In: Medical Physics. 47 , p. 1238-1248 11 p.

Soft-tissue prostate intrafraction motion tracking in 3D cine-MR for MR-guided radiotherapy

de Muinck Keizer Daan M, Kerkmeijer Linda G W, Maspero Matteo, Andreychenko Anna, van der Voort van Zyp Jochem R N, Van den Berg Cornelis A T, Raaymakers Bas W, Lagendijk Jan J W, de Boer J C J 5 dec 2019, In: Physics in Medicine and Biology. 64 , p. 235008 12 p.

ReconSocket:A low-latency raw data streaming interface for real-time MRI-guided radiotherapy

Borman P. T.S., Raaymakers B. W., Glitzner M. 17 sep 2019, In: Physics in medicine and biology. 64 , p. 185008

Evaluating the benefit of PBS vs. VMAT dose distributions in terms of dosimetric sparing and robustness against inter-fraction anatomical changes for pediatric abdominal tumors

Guerreiro Filipa, Zachiu Cornel, Seravalli Enrica, Ribeiro Cássia O, Janssens Geert O, Ries Mario, de Senneville Baudouin Denis, Maduro John H, Brouwer Charlotte L, Korevaar Erik W, Knopf Antje C, Raaymakers Bas W sep 2019, In: Radiotherapy & Oncology. 138 , p. 158-165 8 p.

Adaptive radiotherapy:The Elekta Unity MR-linac concept

Winkel Dennis, Bol Gijsbert H, Kroon Petra S, van Asselen Bram, Hackett Sara S, Werensteijn-Honingh Anita M, Intven Martijn P W, Eppinga Wietse S C, Tijssen Rob H N, Kerkmeijer Linda G W, de Boer Hans C J, Mook Stella, Meijer Gert J, Hes Jochem, Willemsen-Bosman Mirjam, de Groot-van Breugel Eline N, Jürgenliemk-Schulz Ina M, Raaymakers Bas W sep 2019, In: Clinical and translational radiation oncology. 18 , p. 54-59 6 p.

Individual lymph nodes: "See it and Zap it"

Winkel Dennis, Werensteijn-Honingh Anita M, Kroon Petra S, Eppinga Wietse S C, Bol Gijsbert H, Intven Martijn P W, de Boer Hans C J, Snoeren Louk M W, Hes Jochem, Raaymakers Bas W, Jürgenliemk-Schulz Ina M sep 2019, In: Clinical and translational radiation oncology. 18 , p. 46-53 8 p.

Technical note: MLC racking performance on the Elekta unity MRI-linac:MLC-tracking performance on the Elekta unity MRI-linac

Glitzner M., Woodhead P. L., Borman P. T.S., Lagendijk J. J.W., Raaymakers B. W. 1 aug 2019, In: Physics in medicine and biology. 64 , p. 15NT02

All Research Output (153)