prof. dr. G.J.E. (Gabriël) Rinkel

prof. dr. G.J.E. (Gabriël) Rinkel

Full Professor
prof. dr. G.J.E. (Gabriël) Rinkel
  • Neurologen

Research Programs




Gabriel Rinkel is professor of Neurology at the University Medical Centre Utrecht, the Netherlands. During his medical study he did 6 months extracurricular research at the Rudolf Magnus Institute in Utrecht on the effect of neuropeptides on behaviour, and was elected for an exchange program to study at the Addiction Research Foundation, University of Toronto, Canada. In 1991 he finished his clinical training in neurology and defended his PhD thesis on perimesencephalic subarachnoid haemorrhage.

Gabriel Rinkel is a clinician, teacher and researcher and has fulfilled and fulfils many managerial roles, including chair of the department. In 1997 he received the award “Teacher of the year” of the Faculty of medicine, and has supervised numerous master students and more than 35 PhD students.

Gabriel Rinkel is considered a world leading authority on subarachnoid haemorrhage and intracranial aneurysms. On this topic he has published more than 400 papers in international peer reviewed journals and has given lectures at more than 30 universities in 4 continents. He gives invited lectures and organises symposia at international conferences such as the World Congress of Neurology, the European Neurological Society, the World Stroke Congress, the International Stroke Congress, the European Stroke Organisation Congress, and he is a regular teacher at the European Stroke Organisation and European Association of Neurological Surgeons. He has written invited reviews for journals as the Lancet, Brain, and Stroke. He was principal investigator of the Magnesium in Aneurysmal Subarachnoid Haemorrhage trial, an international investigator driven trial that is up to now the largest drug trial ever performed in patients with subarachnoid haemorrhage.

Gabriel Rinkel has long lasting international collaborations with the University of Edinburgh, has been visiting professor at the University of Toronto, and is member of the guidelines committee for subarachnoid haemorrhage and chair of the guideline committee for unruptured intracranial aneurysms of the European Stroke Organisation. He has been awarded many scientific awards, has given the Stanley Davidson Lecture and the Honyman Gillespie lecture both at the University of Edinburgh, and the Karel Terbrugge lecture at the University of Toronto. In 2013 he was elected as Fellow of the Royal College of Physicians of Edinburgh, and in 2020 he received an honorary doctorate at the University of East-Finland.

Research line

Stroke: subarachnoid haemorrhage and intracranial aneurysms

Most recent key publications

1: Etminan N, Chang HS, Hackenberg K, de Rooij NK, Vergouwen MDI, Rinkel GJE, Algra A. Worldwide Incidence of Aneurysmal Subarachnoid Hemorrhage According to Region, Time Period, Blood Pressure, and Smoking Prevalence in the Population: A  Systematic Review and Meta-analysis. JAMA Neurol. 2019 May 1;76(5):588-597

2: Etminan N, Rinkel GJ. Unruptured intracranial aneurysms: development, rupture and preventive management. Nat Rev Neurol. 2016 Dec;12(12):699-713.

3: Bor AS, Rinkel GJ, van Norden J, Wermer MJ. Long-term, serial screening for intracranial aneurysms in individuals with a family history of aneurysmal subarachnoid haemorrhage: a cohort study. Lancet Neurol. 2014 Apr;13(4):385-92.

4: Greving JP, Wermer MJ, Brown RD Jr, Morita A, Juvela S, Yonekura M, Ishibashi  T, Torner JC, Nakayama T, Rinkel GJ, Algra A. Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol. 2014 Jan;13(1):59-66.

5: Dorhout Mees SM, Algra A, Vandertop WP, van Kooten F, Kuijsten HA, Boiten J, van Oostenbrugge RJ, Al-Shahi Salman R, Lavados PM, Rinkel GJ, van den Bergh WM; MASH-2 Study Group. Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet. 2012 Jul 7;380(9836):44-9.

Side Activities

Chair guideline committee 'unruptured intracranial aneurysms' of the European Stroke Organisation

Visiting professor University Hospital Mannheim, University of Heidelberg, Germany

Fellowship and Awards

1: 1998 European Stroke Research Award
2: 1999-2004 Clinical Established Investigator from the Netherlands Heart Foundation
3: 2006 Stanley Davidson Lecture
4: 2013 Elected as Fellow of the Royal College of Physicians of Edinburgh
5: 2016 Honyman Gillespie Lecture, University of Edinburgh, United Kingdom 
6: 2017 Karel G terBrugge Lectureship, University of Toronto, Canada
7: 2020 Honorary Doctorate University of East-Finland

Research Output (633)

Aneurysm Prevalence and Quality of Life During Screening in Relatives of Patients With Unruptured Intracranial Aneurysms:A Prospective Study

Mensing Liselore A., van Tuijl Rick J., Greving Jacoba P., Velthuis Birgitta K., van der Schaaf Irene C., Wermer Marieke J.H., Verbaan Dagmar, Vandertop W. Peter, Zuithoff Nicolaas P.A., Rinkel Gabriël J.E., Ruigrok Ynte M. 29 Aug 2023, In: Neurology. 101 , p. e904-e912

Risk Prediction of New Intracranial Aneurysms at Follow-Up Screening in People With a Positive Family History

Zuurbier Charlotte C.M., Bourcier Romain, Constant Dit Beaufils Pacôme, Redon Richard, Desal Hubert, Bor Anne S.E., Rinkel Gabriel J.E., Greving Jacoba P., Ruigrok Ynte M., 1 Apr 2023, In: Stroke. 54 , p. 1015-1020 6 p.

Lumbar puncture for treating acute hydrocephalus after aneurysmal subarachnoid haemorrhage

Tack R. W.P., Lindgren A., Vergouwen M. D.I., van der Zwan A., van der Schaaf I., Rinkel G. J.E. 15 Mar 2023, In: Journal of the Neurological Sciences. 446

Genetic Risk Score for Intracranial Aneurysms:Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Bakker Mark K., Kanning Jos P., Abraham Gad, Martinsen Amy E., Winsvold Bendik S., Zwart John Anker, Bourcier Romain, Sawada Tomonobu, Koido Masaru, Kamatani Yoichiro, Morel Sandrine, Amouyel Philippe, Debette Stéphanie, Bijlenga Philippe, Berrandou Takiy, Ganesh Santhi K., Bouatia-Naji Nabila, Jones Gregory, Bown Matthew, Rinkel Gabriel J.E., Veldink Jan H., Ruigrok Ynte M., 1 Mar 2023, In: Stroke. 54 , p. 810-818 9 p.

Clinical response following hypertension induction for clinical delayed cerebral ischemia following subarachnoid hemorrhage:A retrospective, multicenter, cohort study

Tjerkstra Maud A, Müller Marcella C A, Coert Bert A, Hoefnagels Friso W A, Vergouwen Mervyn D I, van Vliet Peter, Ooms Lizzy, Rinkel Gabriël J E, Slooter Arjen J C, Moojen Wouter A, Jellema Korné, Vandertop W Peter, Verbaan Dagmar 2023, In: European Journal of Neurology. 30 , p. 2278-2287 10 p.

In reply

Etminan Nima, Vergouwen Mervyn D.I., Rinkel Gabriel J.E. 2023, In: European Stroke Journal. 8 , p. 602-603 2 p.

Slow recruitment in the HIMALAIA study:lessons for future clinical trials in patients with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage based on feasibility data

Gathier Celine S, van der Jagt Mathieu, van den Bergh Walter M, Dankbaar Jan Willem, Rinkel Gabriel J E, Slooter Arjen J C, Dec 2022, In: Pilot and feasibility studies. 8 , p. 193

Tranexamic Acid After Aneurysmal Subarachnoid Hemorrhage:Post-Hoc Analysis of the ULTRA Trial

Tjerkstra Maud A, Post Rene, Germans Menno R, Vergouwen Mervyn D I, Jellema Korné, Koot Radboud W, Kruyt Nyika D, Willems Peter W A, Wolfs Jasper F C, de Beer Frits C, Kieft Hans, Nanda Dharmin, van der Pol Bram, Roks Gerwin, de Beer Frank, Halkes Patricia H A, Reichman Loes J A, Brouwers Paul J A M, Van den Berg-Vos Renske M, Kwa Vincent I H, van der Ree Taco C, Bronner Irene, Bienfait Henri P, Boogaarts Hieronymus, Klijn Catharina Jm, van den Berg René, Coert Bert A, Horn Janneke, Majoie Charles B L M, Rinkel Gabriël J E, Roos Yvo B W M, Vandertop William, Verbaan Dagmar 20 Oct 2022, In: Neurology. 99 , p. E2605-E2614

Devastating delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Koopman Inez, van Wijngaarden Philippine B., Rinkel Gabriel J.E., Vergouwen Mervyn D.I. 13 Oct 2022, In: Frontiers in Neurology. 13 , p. 1016111

Blood pressure and the risk of rebleeding and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Gathier Celine S, Zijlstra IJsbrand A J, Rinkel Gabriel J E, Groenhof T Katrien J, Verbaan Dagmar, Coert Bert A, Müller Marcella C A, van den Bergh Walter M, Slooter Arjen J C, Eijkemans Marinus J C 5 Oct 2022, In: Journal of Critical Care. 72

All research output

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