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prof. dr. G.J.E. (Gabriël) Rinkel

Full Professor
prof. dr. G.J.E. (Gabriël) Rinkel
  • Neurologen

Research Programs

Biography

Biography

Gabriel Rinkel (1961) studied medicine in Utrecht. During medical study he did 6 months research at the Rudolf Magnus Institute for pharmacology in Utrecht on the effect of neuropeptides on behaviour. Later during medical study he did research at the Addiction Research Foundation, University of Toronto, Canada. After graduating in 1987 he started his residency in neurology and in the meantime research for his thesis on perimesencephalic subarachnoid haemorrhage; both were completed in 1991. For his thesis he received in 1992 the Synthélabo Research Award from the ‘Société de Ciculation et Métabolism du Cerveau’ at the CHU Lariboisière-Saint Louis in Paris. In 1997 he received the award “Teacher of the year” of the Faculty of medicine, and in 1998 the Stroke Research Award at the annual European Stroke Conference in Edinburgh. From 1999 to 2004 he was Clinical Established Investigator of the Netherlands Heart foundation. In 2002 he was appointed as Professor of Neurology. From 2003 through 2009 he chaired the Medical Ethics Committee of the University Medical Centre Utrecht. Since 2011 he is Chairman of Neurology at  the University Medical Center Utrecht. He also is vice-director of the Rudolf Magnus Institute of Neuroscience. His research focuses on subarachnoid haemorrhage and intracranial aneurysms. He is (co-)author of more than 300 papers on subarachnoid haemorrhage and intracranial aneurysms in international peer reviewed journals and has given invited lectures at more than 25 universities in 4 continents, and at international conferences such as the World Congress of Neurology, the European Neurological Society, the World Stroke Congress, the International Stroke Congress, the European Stroke Congress and the World Federation of Interventional and Therapeutical Neuroradiology. In 2006 he gave the Stanley Davidson Lecture at the Neurology Symposium of the Royal College of Physicians of Edinburgh.

Research line

Stroke: subarachnoid haemorrhage and intracranial aneurysms

Most recent key publications

1: Etminan N, Chang HS, Hackenberg K, de Rooij NK, Vergouwen MDI, Rinkel GJE, Algra A. Worldwide Incidence of Aneurysmal Subarachnoid Hemorrhage According to Region, Time Period, Blood Pressure, and Smoking Prevalence in the Population: A  Systematic Review and Meta-analysis. JAMA Neurol. 2019 May 1;76(5):588-597

2: Etminan N, Rinkel GJ. Unruptured intracranial aneurysms: development, rupture and preventive management. Nat Rev Neurol. 2016 Dec;12(12):699-713.

3: Bor AS, Rinkel GJ, van Norden J, Wermer MJ. Long-term, serial screening for intracranial aneurysms in individuals with a family history of aneurysmal subarachnoid haemorrhage: a cohort study. Lancet Neurol. 2014 Apr;13(4):385-92.

4: Greving JP, Wermer MJ, Brown RD Jr, Morita A, Juvela S, Yonekura M, Ishibashi  T, Torner JC, Nakayama T, Rinkel GJ, Algra A. Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol. 2014 Jan;13(1):59-66.

5: Dorhout Mees SM, Algra A, Vandertop WP, van Kooten F, Kuijsten HA, Boiten J, van Oostenbrugge RJ, Al-Shahi Salman R, Lavados PM, Rinkel GJ, van den Bergh WM; MASH-2 Study Group. Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet. 2012 Jul 7;380(9836):44-9.

Side Activities

  • Chair guideline committee 'unruptured intracranial aneurysms' of the European Stroke Organisation

    Visiting professor University of Toronto

Fellowship and Awards

  • 1: 1998 European Stroke Research Award
    2: 1999-2004 Clinical Established Investigator from the Netherlands Heart Foundation
    3: 2006 Stanley Davidson Lecture
    4: 2013 Elected as Fellow of the Royal College of Physicians of Edinburgh
    5: 2016 Honyman Gillespie Lecture, University of Edinburgh, United Kingdom 
    6: 2017 Karel G terBrugge Lectureship, University of Toronto, Canada

Research Output (596)

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Bakker Mark K., van der Spek Rick A.A., van Rheenen Wouter, Morel Sandrine, Bourcier Romain, Hostettler Isabel C., Alg Varinder S., van Eijk Kristel R., Koido Masaru, Akiyama Masato, Terao Chikashi, Matsuda Koichi, Walters Robin, Lin Kuang, Li Liming, Millwood Iona Y., Chen Zhengming, Rouleau Guy A., Zhou Sirui, Rannikmäe Kristiina, Sudlow Cathie L.M., Houlden Henry, van den Berg Leonard H., Dina Christian, Naggara Olivier, Gentric Jean Christophe, Shotar Eimad, Eugène François, Desal Hubert, Winsvold Bendik S., Børte Sigrid, Johnsen Marianne Bakke, Brumpton Ben M., Sandvei Marie Søfteland, Willer Cristen J., Hveem Kristian, Zwart John Anker, Verschuren W. M.Monique, Friedrich Christoph M., Hirsch Sven, Schilling Sabine, Dauvillier Jérôme, Martin Olivier, Bian Zheng, Chen Junshi, Klijn Catharina J.M., Rinkel Gabriel J.E., Lindgren Antti, Veldink Jan H., Ruigrok Ynte M., , , , , , , dec 2020, In: Nature Genetics. 52 , p. 1303-1313 11 p.

Velocity Pulsatility and Arterial Distensibility Along the Internal Carotid Artery

van Tuijl Rick J., Ruigrok Ynte M., Velthuis Birgitta K., van der Schaaf Irene C., Rinkel Gabriël J.E., Zwanenburg Jaco J.M. 18 aug 2020, In: Journal of the American Heart Association. 9 , p. e016883 11 p.

Heritability of territory of ruptured and unruptured intracranial aneurysms in families

van Kammen Mayte Sánchez, Bourcier Romain, Moomaw Charles J., Broderick Joseph P., Woo Daniel, Papagiannaki Chrysanthi, Levrier Olivier, Lindgren Antti E., Koivisto Timo, Jääskeläinen Juha E., Rinkel Gabriël J.E., Ruigrok Ynte M. aug 2020, In: PLoS ONE. 15

Location specific risk factors for intracerebral hemorrhage:Systematic review and meta-analysis

Jolink Wilmar M T, Wiegertjes Kim, Rinkel Gabriël J E, Algra Ale, de Leeuw Frank-Erik, Klijn Catharina J M 20 jul 2020, In: Neurology. 95 , p. e1807-e1818

Prediction of Outcome Using Quantified Blood Volume in Aneurysmal SAH

van der Steen W. E., Marquering H. A., Ramos L. A., van den Berg R., Coert B. A., Boers A. M.M., Vergouwen M. D.I., Rinkel G. J.E., Velthuis B. K., Roos Y. B.W.E.M., Majoie C. B.L.M., Vandertop W. P., Verbaan D. 1 jun 2020, In: AJNR. American journal of neuroradiology. 41 , p. 1015-1021 7 p.

The course of cerebrospinal fluid parameters ≤ 20 days after aneurysmal subarachnoid hemorrhage

Koopman Inez, Zuithoff Nicolaas P A, Rinkel Gabriel J E, Vergouwen Mervyn D I 19 mei 2020, In: Journal of the Neurological Sciences. 415

Contrast leakage distant from the hematoma in patients with spontaneous ICH:A 7 T MRI study

Jolink Wilmar MT, Lindenholz Arjen, van Etten Ellis S, van Nieuwenhuizen Koen M, Schreuder Floris Hbm, Kuijf Hugo J, van Osch Matthias Jp, Hendrikse Jeroen, Rinkel Gabriel Je, Wermer Marieke JH, Klijn Catharina JM 1 mei 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40 , p. 1002-1011 10 p.

RNA-Sequencing Highlights Inflammation and Impaired Integrity of the Vascular Wall in Brain Arteriovenous Malformations

Hauer Allard J, Kleinloog Rachel, Giuliani Fabrizio, Rinkel Gabriël J E, de Kort Gerard A, Berkelbach van der Sprenkel Jan Willem, van der Zwan Albert, Gosselaar Peter H, van Rijen Peter C, de Boer-Bergsma Jelkje J, Deelen Patrick, Swertz Morris A, De Muynck Louis, Van Damme Philip, Veldink Jan H, Ruigrok Ynte M, Klijn Catharina J M 1 jan 2020, In: Stroke. 51 , p. 268-274 7 p.

Effects of dobutamine and phenylephrine on cerebral perfusion in patients undergoing cerebral bypass surgery:a randomised crossover trial

Akkermans Annemarie, van Waes Judith A.R., van Doormaal Tristan P.C., de Waal Eric E.C., Rinkel Gabriël J.E., van der Zwan Albert, Kalkman Cor J., van Klei Wilton A. 1 jan 2020, In: British Journal of Anaesthesia. 125 , p. 539-547 9 p.

All research output