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prof. dr. G.J.E. (Gabriël) Rinkel Full Professor

  • Neurology & Neurosurgery

G.J.E. Rinkel

Contact

Research Programs

Biography

Gabriel Rinkel (1961) studied medicine in Utrecht. During medical study he did 6 months research at the Rudolf Magnus Institute for pharmacology in Utrecht on the effect of neuropeptides on behaviour. Later during medical study he did research at the Addiction Research Foundation, University of Toronto, Canada. After graduating in 1987 he started his residency in neurology and in the meantime research for his thesis on perimesencephalic subarachnoid haemorrhage; both were completed in 1991. For his thesis he received in 1992 the Synthélabo Research Award from the ‘Société de Ciculation et Métabolism du Cerveau’ at the CHU Lariboisière-Saint Louis in Paris. In 1997 he received the award “Teacher of the year” of the Faculty of medicine, and in 1998 the Stroke Research Award at the annual European Stroke Conference in Edinburgh. From 1999 to 2004 he was Clinical Established Investigator of the Netherlands Heart foundation. In 2002 he was appointed as Professor of Neurology. From 2003 through 2009 he chaired the Medical Ethics Committee of the University Medical Centre Utrecht. Since 2011 he is Chairman of Neurology at  the University Medical Center Utrecht. He also is vice-director of the Rudolf Magnus Institute of Neuroscience. His research focuses on subarachnoid haemorrhage and intracranial aneurysms. He is (co-)author of more than 300 papers on subarachnoid haemorrhage and intracranial aneurysms in international peer reviewed journals and has given invited lectures at more than 25 universities in 4 continents, and at international conferences such as the World Congress of Neurology, the European Neurological Society, the World Stroke Congress, the International Stroke Congress, the European Stroke Congress and the World Federation of Interventional and Therapeutical Neuroradiology. In 2006 he gave the Stanley Davidson Lecture at the Neurology Symposium of the Royal College of Physicians of Edinburgh.

Research line

Stroke: subarachnoid haemorrhage and intracranial aneurysms

Most recent key publications

1: Etminan N, Chang HS, Hackenberg K, de Rooij NK, Vergouwen MDI, Rinkel GJE, Algra A. Worldwide Incidence of Aneurysmal Subarachnoid Hemorrhage According to Region, Time Period, Blood Pressure, and Smoking Prevalence in the Population: A  Systematic Review and Meta-analysis. JAMA Neurol. 2019 May 1;76(5):588-597

2: Etminan N, Rinkel GJ. Unruptured intracranial aneurysms: development, rupture and preventive management. Nat Rev Neurol. 2016 Dec;12(12):699-713.

3: Bor AS, Rinkel GJ, van Norden J, Wermer MJ. Long-term, serial screening for intracranial aneurysms in individuals with a family history of aneurysmal subarachnoid haemorrhage: a cohort study. Lancet Neurol. 2014 Apr;13(4):385-92.

4: Greving JP, Wermer MJ, Brown RD Jr, Morita A, Juvela S, Yonekura M, Ishibashi  T, Torner JC, Nakayama T, Rinkel GJ, Algra A. Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol. 2014 Jan;13(1):59-66.

5: Dorhout Mees SM, Algra A, Vandertop WP, van Kooten F, Kuijsten HA, Boiten J, van Oostenbrugge RJ, Al-Shahi Salman R, Lavados PM, Rinkel GJ, van den Bergh WM; MASH-2 Study Group. Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet. 2012 Jul 7;380(9836):44-9.

Side Activities

  • Chair guideline committee 'unruptured intracranial aneurysms' of the European Stroke Organisation

    Visiting professor University of Toronto

Fellowship and Awards

  • 1: 1998 European Stroke Research Award
    2: 1999-2004 Clinical Established Investigator from the Netherlands Heart Foundation
    3: 2006 Stanley Davidson Lecture
    4: 2013 Elected as Fellow of the Royal College of Physicians of Edinburgh
    5: 2016 Honyman Gillespie Lecture, University of Edinburgh, United Kingdom 
    6: 2017 Karel G terBrugge Lectureship, University of Toronto, Canada

Research Output (477)

Contrast leakage distant from the hematoma in patients with spontaneous ICH:A 7 T MRI study

Jolink Wilmar MT, Lindenholz Arjen, van Etten Ellis S, van Nieuwenhuizen Koen M, Schreuder Floris Hbm, Kuijf Hugo J, van Osch Matthias Jp, Hendrikse Jeroen, Rinkel Gabriel Je, Wermer Marieke JH, Klijn Catharina JM mei 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40 , p. 1002-1011 10 p.

External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Kammen Mayte Sánchez van, Greving Jacoba P, Kuroda Satoshi, Kashiwazaki Daina, Morita Akio, Shiokawa Yoshiaki, Kimura Toshikazu, Cognard Christophe, Januel Anne C, Lindgren Antti, Koivisto Timo, Jääskeläinen Juha E, Ronkainen Antti, Pyysalo Liisa, Öhman Juha, Rahi Melissa, Kuhmonen Johanna, Rinne Jaakko, Leemans Eva L, Majoie Charles B, Vandertop W Peter, Verbaan Dagmar, Roos Yvo B W E M, Berg René van den, Boogaarts Hieronymus D, Moudrous Walid, Wijngaard Ido R van den, Hove Laura Ten, Teo Mario, George Edward J St, Hackenberg Katharina A M, Abdulazim Amr, Etminan Nima, Rinkel Gabriël J E, Vergouwen Mervyn D I sep 2019, In: Stroke. 21 , p. 340-346 7 p.

Gadolinium Enhancement of the Aneurysm Wall in Unruptured Intracranial Aneurysms Is Associated with an Increased Risk of Aneurysm Instability:A Follow-Up Study

Vergouwen M D I, Backes D, van der Schaaf I C, Hendrikse J, Kleinloog R, Algra A, Rinkel G J E jul 2019, In: American Journal of Neuroradiology. 40 , p. 1112-1116 5 p.

Common Data Elements for Unruptured Intracranial Aneurysms and Subarachnoid Hemorrhage Clinical Research:A National Institute for Neurological Disorders and Stroke and National Library of Medicine Project

Suarez Jose I, Sheikh Muniza K, Macdonald R Loch, Amin-Hanjani Sepideh, Brown Robert D, de Oliveira Manoel Airton Leonardo, Derdeyn Colin P, Etminan Nima, Keller Emanuela, Leroux Peter D, Mayer Stephan A, Morita Akio, Rinkel Gabriel, Rufennacht Daniel, Stienen Martin N, Torner James, Vergouwen Mervyn D I, Wong George K C, 16 jun 2019, In: Neurocritical Care. 30 , p. 4-19 16 p.

Common Data Elements for Radiological Imaging of Patients with Subarachnoid Hemorrhage:Proposal of a Multidisciplinary Research Group

Hackenberg Katharina A M, Etminan Nima, Wintermark Max, Meyers Philip M, Lanzino Giuseppe, Rüfenacht Daniel, Krings Timo, Huston John, Rinkel Gabriel, Derdeyn Colin, , Vergouwen Mervyn 16 jun 2019, In: Neurocritical Care. 30 , p. 60-78 19 p.

Definition and Prioritization of Data Elements for Cohort Studies and Clinical Trials on Patients with Unruptured Intracranial Aneurysms: Proposal of a Multidisciplinary Research Group

Hackenberg Katharina A. M., Algra Ale, Salman Rustam Al-Shahi, Frosen Juhana, Hasan David, Juvela Seppo, Langer David, Meyers Philip, Morita Akio, Rinkel Gabriel, Etminan Nima, Suarez Jose I., Macdonald R. Loch, Amin-Hanjani Sepideh, Brown Robert D., Jr., Manoel Airton Leonardo de Oliveira, Derdeyn Colin P., Etminan Nima, Keller Emanuela, LeRoux Peter D., Mayer Stephan, Morita Akio, Rinkel Gabriel, Rufennacht Daniel, Stienen Martin N., Torner James, Vergouwen Mervyn D. I., Wong George K. C., Bijlenga Philippe, Ko Nerissa, McDougall Cameron G., Mocco J., Murayama Yuuichi, Werner Marieke J. H., Mayer Stephan, Suarez Jose I., Damani Rahul, Broderick Joseph, Dhar Raj, Jauch Edward C., Kirkpatrick Peter J., Martin Renee H., Mocco J., Vergouwen Mervyn D. I., Ruigrok Ynte, Rinkel Gabriel, Rinkel Gabriel, Algra Ale, Vergouwen Mervyn D. I., Visser-Meily Johanna, 16 jun 2019, In: Neurocritical Care. 30 , p. 87-101 15 p.

In Reply:Outcome After Clipping and Coiling for Aneurysmal Subarachnoid Hemorrhage in Clinical Practice in Europe, USA, and Australia

Lindgren Antti, Koivisto Timo, Jääskeläinen Juha E., Vergouwen Mervyn D.I., Rinkel Gabriel J.E. 1 jun 2019, In: Neurosurgery. 84 , p. E447-E447

Aneurysm characteristics and risk of rebleeding after subarachnoid haemorrhage

Koopman Inez, Greving Jacoba P, van der Schaaf Irene C, van der Zwan Albert, Rinkel Gabriel Je, Vergouwen Mervyn DI 1 jun 2019, In: European Stroke Journal. 4 , p. 153-159 7 p.

Comparison of Rupture Risk of Intracranial Aneurysms Between Familial and Sporadic Patients

Mensing Liselore A, Greving Jacoba P, Verhoeff Tessa A, Rinkel Gabriel J E, Ruigrok Ynte M jun 2019, In: Stroke. 50 , p. 1380-1383 4 p.

All Research Output (477)
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