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prof. dr. G.J.E. (Gabriël) Rinkel

Full Professor

  • Neurology & Neurosurgery

prof. dr. G.J.E. (Gabriël) Rinkel

Research Programs

Biography

Gabriel Rinkel (1961) studied medicine in Utrecht. During medical study he did 6 months research at the Rudolf Magnus Institute for pharmacology in Utrecht on the effect of neuropeptides on behaviour. Later during medical study he did research at the Addiction Research Foundation, University of Toronto, Canada. After graduating in 1987 he started his residency in neurology and in the meantime research for his thesis on perimesencephalic subarachnoid haemorrhage; both were completed in 1991. For his thesis he received in 1992 the Synthélabo Research Award from the ‘Société de Ciculation et Métabolism du Cerveau’ at the CHU Lariboisière-Saint Louis in Paris. In 1997 he received the award “Teacher of the year” of the Faculty of medicine, and in 1998 the Stroke Research Award at the annual European Stroke Conference in Edinburgh. From 1999 to 2004 he was Clinical Established Investigator of the Netherlands Heart foundation. In 2002 he was appointed as Professor of Neurology. From 2003 through 2009 he chaired the Medical Ethics Committee of the University Medical Centre Utrecht. Since 2011 he is Chairman of Neurology at  the University Medical Center Utrecht. He also is vice-director of the Rudolf Magnus Institute of Neuroscience. His research focuses on subarachnoid haemorrhage and intracranial aneurysms. He is (co-)author of more than 300 papers on subarachnoid haemorrhage and intracranial aneurysms in international peer reviewed journals and has given invited lectures at more than 25 universities in 4 continents, and at international conferences such as the World Congress of Neurology, the European Neurological Society, the World Stroke Congress, the International Stroke Congress, the European Stroke Congress and the World Federation of Interventional and Therapeutical Neuroradiology. In 2006 he gave the Stanley Davidson Lecture at the Neurology Symposium of the Royal College of Physicians of Edinburgh.

Research line

Stroke: subarachnoid haemorrhage and intracranial aneurysms

Most recent key publications

1: Etminan N, Chang HS, Hackenberg K, de Rooij NK, Vergouwen MDI, Rinkel GJE, Algra A. Worldwide Incidence of Aneurysmal Subarachnoid Hemorrhage According to Region, Time Period, Blood Pressure, and Smoking Prevalence in the Population: A  Systematic Review and Meta-analysis. JAMA Neurol. 2019 May 1;76(5):588-597

2: Etminan N, Rinkel GJ. Unruptured intracranial aneurysms: development, rupture and preventive management. Nat Rev Neurol. 2016 Dec;12(12):699-713.

3: Bor AS, Rinkel GJ, van Norden J, Wermer MJ. Long-term, serial screening for intracranial aneurysms in individuals with a family history of aneurysmal subarachnoid haemorrhage: a cohort study. Lancet Neurol. 2014 Apr;13(4):385-92.

4: Greving JP, Wermer MJ, Brown RD Jr, Morita A, Juvela S, Yonekura M, Ishibashi  T, Torner JC, Nakayama T, Rinkel GJ, Algra A. Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol. 2014 Jan;13(1):59-66.

5: Dorhout Mees SM, Algra A, Vandertop WP, van Kooten F, Kuijsten HA, Boiten J, van Oostenbrugge RJ, Al-Shahi Salman R, Lavados PM, Rinkel GJ, van den Bergh WM; MASH-2 Study Group. Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet. 2012 Jul 7;380(9836):44-9.

Side Activities

  • Chair guideline committee 'unruptured intracranial aneurysms' of the European Stroke Organisation

    Visiting professor University of Toronto

Fellowship and Awards

  • 1: 1998 European Stroke Research Award
    2: 1999-2004 Clinical Established Investigator from the Netherlands Heart Foundation
    3: 2006 Stanley Davidson Lecture
    4: 2013 Elected as Fellow of the Royal College of Physicians of Edinburgh
    5: 2016 Honyman Gillespie Lecture, University of Edinburgh, United Kingdom 
    6: 2017 Karel G terBrugge Lectureship, University of Toronto, Canada

Research Output (584)

Velocity Pulsatility and Arterial Distensibility Along the Internal Carotid Artery

van Tuijl Rick J., Ruigrok Ynte M., Velthuis Birgitta K., van der Schaaf Irene C., Rinkel Gabriël J.E., Zwanenburg Jaco J.M. 18 aug 2020, In: Journal of the American Heart Association. 9 11 p.

Contrast leakage distant from the hematoma in patients with spontaneous ICH:A 7 T MRI study

Jolink Wilmar MT, Lindenholz Arjen, van Etten Ellis S, van Nieuwenhuizen Koen M, Schreuder Floris Hbm, Kuijf Hugo J, van Osch Matthias Jp, Hendrikse Jeroen, Rinkel Gabriel Je, Wermer Marieke JH, Klijn Catharina JM 1 mei 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40 , p. 1002-1011 10 p.

Exome-chip association analysis of intracranial aneurysms

van 't Hof Femke N G, Lai Dongbing, van Setten Jessica, Bots Michiel L, Vaartjes Ilonca, Broderick Joseph, Woo Daniel, Foroud Tatiana, Rinkel Gabriel J E, de Bakker Paul I W, Ruigrok Ynte M 15 nov 2019, In: Neurology. 94 , p. e481-e488

Assessment of the Most Optimal Control Tissue for Intracranial Aneurysm Gene Expression Studies

Laarman Melanie D., Kleinloog Rachel, Bakker Mark K., Rinkel Gabriël J.E., Bakkers Jeroen, Ruigrok Ynte M. 1 okt 2019, In: Stroke. 50 , p. 2933-2936 4 p.

External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Kammen Mayte Sánchez van, Greving Jacoba P, Kuroda Satoshi, Kashiwazaki Daina, Morita Akio, Shiokawa Yoshiaki, Kimura Toshikazu, Cognard Christophe, Januel Anne C, Lindgren Antti, Koivisto Timo, Jääskeläinen Juha E, Ronkainen Antti, Pyysalo Liisa, Öhman Juha, Rahi Melissa, Kuhmonen Johanna, Rinne Jaakko, Leemans Eva L, Majoie Charles B, Vandertop W Peter, Verbaan Dagmar, Roos Yvo B W E M, Berg René van den, Boogaarts Hieronymus D, Moudrous Walid, Wijngaard Ido R van den, Hove Laura Ten, Teo Mario, George Edward J St, Hackenberg Katharina A M, Abdulazim Amr, Etminan Nima, Rinkel Gabriël J E, Vergouwen Mervyn D I sep 2019, In: Stroke. 21 , p. 340-346 7 p.

Histological differences of the Vascular wall between sites with high and low prevalence of intracranial aneurysm

Laarman Melanie D., Ruigrok Ynte M., Nierstrasz Renske C.S., Spliet Wim G.M., Van Hecke Wim, Algra Ale, Rinkel Gabriël J.E. 1 jul 2019, In: Journal of Neuropathology and Experimental Neurology. 78 , p. 648-654 7 p.

Gadolinium Enhancement of the Aneurysm Wall in Unruptured Intracranial Aneurysms Is Associated with an Increased Risk of Aneurysm Instability:A Follow-Up Study

Vergouwen M D I, Backes D, van der Schaaf I C, Hendrikse J, Kleinloog R, Algra A, Rinkel G J E jul 2019, In: American Journal of Neuroradiology. 40 , p. 1112-1116 5 p.

Correlation of age at time of aneurysmal subarachnoid hemorrhage within families

Dalemans Diana J.Z., Mensing Liselore A., Bourcier Romain, Aggour Mohamed, Ben Hassen Wagih, Lindgren Antti E., Koivisto Timo, Jääskeläinen Juha E., Rinkel Gabriel J.E., Ruigrok Ynte M. jul 2019, In: International Journal of Stroke. 14 , p. NP15-NP16

Common Data Elements for Unruptured Intracranial Aneurysms and Subarachnoid Hemorrhage Clinical Research:A National Institute for Neurological Disorders and Stroke and National Library of Medicine Project

Suarez Jose I, Sheikh Muniza K, Macdonald R Loch, Amin-Hanjani Sepideh, Brown Robert D, de Oliveira Manoel Airton Leonardo, Derdeyn Colin P, Etminan Nima, Keller Emanuela, Leroux Peter D, Mayer Stephan A, Morita Akio, Rinkel Gabriel, Rufennacht Daniel, Stienen Martin N, Torner James, Vergouwen Mervyn D I, Wong George K C, 16 jun 2019, In: Neurocritical Care. 30 , p. 4-19 16 p.

All Research Output (584)