dr. J.M.L. (Jeanine) Roodhart

dr. J.M.L. (Jeanine) Roodhart

Associate Professor - medical
dr. J.M.L. (Jeanine) Roodhart
  • Department of Medical Oncology

Research Programs

Strategic Program Cancer

Side Activities

Advisory boards:

Pierre Fabre, Merck, Bayer, Servier, BMS, AMGEN, GSK

Public-private  research collaborations:

HUB organoid technology

Cleara Biotech

BMS pharmaceutical company

Pierre Fabre pharmaceutical company

Servier pharmaceutical company          

GSK pharmaceutical company

Xilis MOS technology

Delphi diagnostics

Other academic activities

  • 2018 - .. Steering committee UPORT
  • 2020 - ..ONCODE clinical advisory board
  • 2020 – .. Editor patient information regarding colorectal cancer on ‘’
  • 2021-.. Member of the TC Bio (ethical committee for the UMC Utrecht biobank)
  • 2021 Reviewer at Medicom Medical Publishers for ASCO GI 2021 Medicom Conference Report.
  • 2021-2022 Editor at Medicom Medical Publishers for Medical Education: developing e-learnings regarding colorectal cancer for medical oncologist.
  • 2022 editor patient information video’s for patië
  • 2023 Framingham selectie colorectal cancer
  • KWF wetenschappelijke raad
  • board member stichting hubrecht organoid biobank

Invited lectures

  • 2023-2 jaarsymposium oncologie (continuum), landelijke nascholing NVMO, annual training course for medical oncologist: update on colorectal cancer
  • 2022-9 MEDTALKS round table discussion regarding updated CRC guideline (main guest)
  • 2022-9 Expert meeting mCRC /ESMO, Innovaties & moleculaire diagnostiek
  • 2022-6 Swedish post-ASCO meeting to discuss CRC update from ASCO 2022 (invited by Karolinska institute for national event).
  • 2022-5 NVMO targeted therapies, organoid technology for every patient!
  • 2021-10 Biocartis user meeting Amsterdam, Netherlands/Scandinavia. Biomarkers in colorectal cancer treatment.
  • 2021-9 ESMO 2021 MEDTALKS colorectal cancer summary of ESMO
  • 2021-9 Summerschool for young medical oncologist, panel discussion session.
  • 2020-11 Annual meeting of the Nederlandse Vereniging voor Oncologie (NVMO, dutch society of medical oncologists), satellite symposium: clinical implications of biomarkers.
  • 2020-10 post-ESMO meeting of the NVMO (dutch society of medical oncologists): ESMO updates on colorectal cancer (Amsterdam)
  • 2020-9 Pre-ESMO colorectal cancer expert meeting: biomarkers and targeted therapy
  • 2019-4 Post-AACR meeting: translational gastro-intestinal updates. (Amsterdam)
  • 2019-3 14e jaarsymposium oncologie (continuum), landelijke nascholing NVMO, annual training course for medical oncologist: update on colorectal cancer


DSMB membership

  1. PelVex-II trial - multicenter trial for recurrent rectal cancer evaluating the additive value of induction chemotherapy before chemoradiation.
  1. RADAR-PANC – TwiC comparing standardized versus non-standardized follow-up after resection of pancreatic adenocarcinoma.

Research Output (58)

ASO Visual Abstract:Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort

Zwart Koen, van der Baan Frederieke H, Punt Cornelis J A, Wensink G Emerens, Bolhuis Karen, Laclé Miangela M, van Grevenstein Wilhelmina M U, Hagendoorn Jeroen, de Hingh Ignace H, Koopman Miriam, Vink Geraldine, Roodhart Jeanine Oct 2023, In: Annals of surgical oncology. 30 , p. 6773-6774 2 p.

A Case of Yellow Airway Secretions and Oral Fluid

Zuidhof Hidde R, van Schelt Martijn, Roodhart Jeanine M L, Ten Berg Maarten J, Kemperman Hans 28 Apr 2023, In: Clinical chemistry. 69 , p. 540-541 2 p.

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Mertens Sander, Huismans Maarten A, Verissimo Carla S, Ponsioen Bas, Overmeer Rene, Proost Natalie, van Tellingen Olaf, van de Ven Marieke, Begthel Harry, Boj Sylvia F, Clevers Hans, Roodhart Jeanine M L, Bos Johannes L, Snippert Hugo J G 30 Mar 2023, In: Cell Reports. 42

Predicting early extrahepatic recurrence after local treatment of colorectal liver metastases

Wensink G. E., Bolhuis Karen, Elferink Marloes A.G., Fijneman Remond J.A., Kranenburg Onno, Borel Rinkes Inne H.M., Koopman Miriam, Swijnenburg Rutger Jan, Vink Geraldine R., Hagendoorn Jeroen, Punt Cornelis J.A., Roodhart Jeanine M.L., Elias Sjoerd G. 1 Mar 2023, In: British Journal of Surgery. 110 , p. 362-371 10 p.

FOxTROT2:innovative trial design to evaluate the role of neoadjuvant chemotherapy for treating locally advanced colon cancer in older adults or those with frailty

Platt J R, Todd O M, Hall P, Craig Z, Quyn A, Seymour M, Braun M, Roodhart J, Punt C, Christou N, Taieb J, Karoui M, Brown J, Cairns D A, Morton D, Gilbert A, Seligmann J F Feb 2023, In: ESMO open. 8 , p. 1-9

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

Strating Esther, Verhagen Mathijs P, Wensink Emerens, Dünnebach Ester, Wijler Liza, Aranguren Itziar, De la Cruz Alberto Sanchez, Peters Niek A, Hageman Joris H, van der Net Mirjam M C, van Schelven Susanne, Laoukili Jamila, Fodde Riccardo, Roodhart Jeanine, Nierkens Stefan, Snippert Hugo, Gloerich Martijn, Rinkes Inne Borel, Elias Sjoerd G, Kranenburg Onno 2023, In: Frontiers in Immunology. 14

Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice

Küçükköse Emre, Heesters Balthasar A, Villaudy Julien, Verheem André, Cercel Madalina, van Hal Susan, Boj Sylvia F, Borel Rinkes Inne H M, Punt Cornelis J A, Roodhart Jeanine M L, Laoukili Jamila, Koopman Miriam, Spits Hergen, Kranenburg Onno Dec 2022, In: Journal for ImmunoTherapy of Cancer. 10

Pre-Diagnostic Circulating Resistin Concentrations Are Not Associated with Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Study

Pham Thu-Thi, Nimptsch Katharina, Aleksandrova Krasimira, Jenab Mazda, Reichmann Robin, Wu Kana, Tjønneland Anne, Kyrø Cecilie, Schulze Matthias B, Kaaks Rudolf, Katzke Verena, Palli Domenico, Pasanisi Fabrizio, Ricceri Fulvio, Tumino Rosario, Krogh Vittorio, Roodhart Jeanine, Castilla Jesús, Sánchez Maria-Jose, Colorado-Yohar Sandra Milena, Harbs Justin, Rutegård Martin, Papier Keren, Aglago Elom K, Dimou Niki, Mayen-Chacon Ana-Lucia, Weiderpass Elisabete, Pischon Tobias 9 Nov 2022, In: Cancers. 14

External Validation of the Colon Life Nomogram for Predicting 12-Week Mortality in Dutch Metastatic Colorectal Cancer Patients Treated with Trifluridine/Tipiracil in Daily Practice

Hamers Patricia A.H., Wensink G. Emerens, van Smeden Maarten, Vink Geraldine R., Smabers Lidwien P., Lunenberg Renee A., Laclé Miangela M., Koopman Miriam, May Anne M., Roodhart Jeanine M.L. 18 Oct 2022, In: Cancers. 14

Correlation of Immunological and Histopathological Features with Gene Expression-Based Classifiers in Colon Cancer Patients

van de Weerd Simone, Smit Marloes A, Roelands Jessica, Mesker Wilma E, Bedognetti Davide, Kuppen Peter J K, Putter Hein, Tollenaar Rob A E M, Roodhart Jeanine M L, Hendrickx Wouter, Medema Jan Paul, van Krieken J Han J M 2 Oct 2022, In: International journal of molecular sciences. 23 , p. 1-16

All research output

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