dr. J.M.L. (Jeanine) Roodhart

dr. J.M.L. (Jeanine) Roodhart

Associate Professor - medical
dr. J.M.L. (Jeanine) Roodhart
  • Dept of Medical Oncology

Research Programs


Side Activities

Advisory boards:

Pierre Fabre, Merck, Bayer, Servier, BMS, AMGEN, GSK

Public-private  research collaborations:

HUB organoid technology

Cleara Biotech

BMS pharmaceutical company

Pierre Fabre pharmaceutical company

Servier pharmaceutical company          

GSK pharmaceutical company

Xilis MOS technology

Delphi diagnostics

Other academic activities

  • 2018 - .. Steering committee UPORT
  • 2020 - ..ONCODE clinical advisory board
  • 2020 – .. Editor patient information regarding colorectal cancer on ‘’
  • 2021-.. Member of the TC Bio (ethical committee for the UMC Utrecht biobank)
  • 2021 Reviewer at Medicom Medical Publishers for ASCO GI 2021 Medicom Conference Report.
  • 2021-2022 Editor at Medicom Medical Publishers for Medical Education: developing e-learnings regarding colorectal cancer for medical oncologist.
  • 2022 editor patient information video’s for patië
  • 2023 Framingham selectie colorectal cancer
  • 2023 KWF wetenschappelijke raad
  • 2023 board member stichting hubrecht organoid biobank

Invited lectures

  • 2023-2 jaarsymposium oncologie (continuum), landelijke nascholing NVMO, annual training course for medical oncologist: update on colorectal cancer
  • 2022-9 MEDTALKS round table discussion regarding updated CRC guideline (main guest)
  • 2022-9 Expert meeting mCRC /ESMO, Innovaties & moleculaire diagnostiek
  • 2022-6 Swedish post-ASCO meeting to discuss CRC update from ASCO 2022 (invited by Karolinska institute for national event).
  • 2022-5 NVMO targeted therapies, organoid technology for every patient!
  • 2021-10 Biocartis user meeting Amsterdam, Netherlands/Scandinavia. Biomarkers in colorectal cancer treatment.
  • 2021-9 ESMO 2021 MEDTALKS colorectal cancer summary of ESMO
  • 2021-9 Summerschool for young medical oncologist, panel discussion session.
  • 2020-11 Annual meeting of the Nederlandse Vereniging voor Oncologie (NVMO, dutch society of medical oncologists), satellite symposium: clinical implications of biomarkers.
  • 2020-10 post-ESMO meeting of the NVMO (dutch society of medical oncologists): ESMO updates on colorectal cancer (Amsterdam)
  • 2020-9 Pre-ESMO colorectal cancer expert meeting: biomarkers and targeted therapy
  • 2019-4 Post-AACR meeting: translational gastro-intestinal updates. (Amsterdam)
  • 2019-3 14e jaarsymposium oncologie (continuum), landelijke nascholing NVMO, annual training course for medical oncologist: update on colorectal cancer


DSMB membership

  1. PelVex-II trial - multicenter trial for recurrent rectal cancer evaluating the additive value of induction chemotherapy before chemoradiation.
  1. RADAR-PANC – TwiC comparing standardized versus non-standardized follow-up after resection of pancreatic adenocarcinoma.

Research Output (62)

ASO Visual Abstract:Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort

Zwart Koen, van der Baan Frederieke H, Punt Cornelis J A, Wensink G Emerens, Bolhuis Karen, Laclé Miangela M, van Grevenstein Wilhelmina M U, Hagendoorn Jeroen, de Hingh Ignace H, Koopman Miriam, Vink Geraldine, Roodhart Jeanine Oct 2023, In: Annals of surgical oncology. 30 , p. 6773-6774 2 p.

Prognostic value of Lynch syndrome, BRAF V600E, and RAS mutational status in dMMR/MSI-H metastatic colorectal cancer in a pooled analysis of Dutch and French cohorts.

Zwart Koen, van der Baan Frederieke H, Cohen Romain, Aparicio Thomas, de la Fouchardiére Christelle, Lecomte Thierry, Punt Cornelis J A, Sefrioui David, Verheijden Rik J, Vink Geraldine R, Wensink G Emerens, Zaanan Aziz, Koopman Miriam, Tougeron David, Roodhart Jeanine M L 16 Jun 2023, In: Cancer Medicine. 12 , p. 15841-15853 13 p.

A Case of Yellow Airway Secretions and Oral Fluid

Zuidhof Hidde R, van Schelt Martijn, Roodhart Jeanine M L, Ten Berg Maarten J, Kemperman Hans 28 Apr 2023, In: Clinical chemistry. 69 , p. 540-541 2 p.

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Mertens Sander, Huismans Maarten A, Verissimo Carla S, Ponsioen Bas, Overmeer Rene, Proost Natalie, van Tellingen Olaf, van de Ven Marieke, Begthel Harry, Boj Sylvia F, Clevers Hans, Roodhart Jeanine M L, Bos Johannes L, Snippert Hugo J G 30 Mar 2023, In: Cell Reports. 42

Lymphatic Invasion of Plakoglobin-Dependent Tumor Cell Clusters Drives Formation of Polyclonal Lung Metastases in Colon Cancer

Küçükköse Emre, Laoukili Jamila, Gorelick Alexander N., Degner Sebastian, Laclé Miangela M., van den Bent Lotte, Peters Niek A., Verheem André, Hung Wei Ting, Frenkel Nicola C., Wassenaar Emma C.E., Lansu Nico, Lenos Kristiaan J., Vermeulen Louis, Koopman Miriam, Roodhart Jeanine M.L., Kops Geert J.P.L., Borel Rinkes Inne H.M., Hagendoorn Jeroen, Naxerova Kamila, Kranenburg Onno 10 Mar 2023, In: Gastroenterology. 165 , p. 429-444.e15

Predicting early extrahepatic recurrence after local treatment of colorectal liver metastases

Wensink G. E., Bolhuis Karen, Elferink Marloes A.G., Fijneman Remond J.A., Kranenburg Onno, Borel Rinkes Inne H.M., Koopman Miriam, Swijnenburg Rutger Jan, Vink Geraldine R., Hagendoorn Jeroen, Punt Cornelis J.A., Roodhart Jeanine M.L., Elias Sjoerd G. 1 Mar 2023, In: British Journal of Surgery. 110 , p. 362-371 10 p.

FOxTROT2:innovative trial design to evaluate the role of neoadjuvant chemotherapy for treating locally advanced colon cancer in older adults or those with frailty

Platt J R, Todd O M, Hall P, Craig Z, Quyn A, Seymour M, Braun M, Roodhart J, Punt C, Christou N, Taieb J, Karoui M, Brown J, Cairns D A, Morton D, Gilbert A, Seligmann J F Feb 2023, In: ESMO open. 8 , p. 1-9

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

Strating Esther, Verhagen Mathijs P, Wensink Emerens, Dünnebach Ester, Wijler Liza, Aranguren Itziar, De la Cruz Alberto Sanchez, Peters Niek A, Hageman Joris H, van der Net Mirjam M C, van Schelven Susanne, Laoukili Jamila, Fodde Riccardo, Roodhart Jeanine, Nierkens Stefan, Snippert Hugo, Gloerich Martijn, Rinkes Inne Borel, Elias Sjoerd G, Kranenburg Onno 2023, In: Frontiers in Immunology. 14

Consensus molecular subtype transition during progression of colorectal cancer

van de Weerd Simone, Torang Arezo, Zwager Liselotte W., Koelink Pim J., Koster Jan, Bastiaansen Barbara A.J., Lammers Veerle, Longobardi Ciro, Roodhart Jeanine M.L., van Krieken J. Han, Farina Sarasqueta Arantza, Dekker Evelien, Medema Jan Paul 2023, In: Journal of Pathology. 261 , p. 298-308 11 p.

All research output

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