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dr. Y.M. (Ynte) Ruigrok

Associate Professor - medical
dr. Y.M. (Ynte) Ruigrok
  • Neurologen

Research Programs

Biography

Biography

Ynte Ruigrok obtained her medical degree in Utrecht in 1999. After that she started working as a resident in Neurology at the Department of Neurology and Neurosurgery of the University Medical Center Utrecht. She combined her residency with a PhD project on the genetics of intracranial aneurysm and aneurysmal subarachnoid hemorrhage. She has contributed to the identification of genetic risk factors of intracranial aneurysms using different approaches such as candidate gene studies, linkage studies, genome wide association studies (GWAS) and genome wide expression (GWE) studies. She has participated in three GWAS on intracranial aneurysms published in Nature Genetics. In 2006 she obtained her PhD degree cum laude. In 2010 she registered as a neurologist and continued working as a neurologist at the Department of Neurology and Neurosurgery of the University Medical Center Utrecht. 

Her current research focuses on the identification of 1) genetic determinants and biomarkers in the development and rupture of intracranial aneurysms and 2) first-degree relatives of aneurysm patients who are at high risk of developing aneurysms.  Her research interest is on the identification of 1) genetic determinants and biomarkers in the development and rupture of intracranial aneurysms and 2) first-degree relatives of aneurysm patients who are at high risk of developing aneurysms. Her ambition is to increase insight in underlying disease processes, improve detection of aneurysms in high risk patients and optimize treatment. She aspires to translate findings in her research to clinical applications. Her expertise receives international recognition which has allowed her to establish international collaborations. Among others, she has initiated a consortium on the genetics of IAs of the international stroke genetics consortium (ISGC).

Research line

Genetic riks of stroke

Most recent key publications

1: van 't Hof FN, Vaucher J, Holmes MV, de Wilde A, Baas AF, Blankensteijn JD, Hofman A, Kiemeney LA, Rivadeneira F, Uitterlinden AG, Vermeulen SH, Rinkel GJ, de Bakker PI, Ruigrok YM. Genetic variants associated with type 2 diabetes and adiposity and risk of intracranial and abdominal aortic aneurysms. Eur J Hum Genet. 2017 Jun;25(6):758-762. 

2: van 't Hof FN, Ruigrok YM, et al. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. J Am Heart Assoc. 2016 Jul 14;5(7). pii: e002603.

3: Kleinloog R, Verweij BH, van der Vlies P, Deelen P, Swertz MA, de Muynck L, Van Damme P, Giuliani F, Regli L, van der Zwan A, Berkelbach van der Sprenkel JW, Han KS, Gosselaar P, van Rijen PC, Korkmaz E, Post JA, Rinkel GJ, Veldink JH, Ruigrok YM. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture. Stroke. 2016 May;47(5):1286-93.

4: Rasing I, Ruigrok YM, Greebe P, Velthuis BK, Witkamp TD, Wermer MJ, Roos YB, Vandertop WP, Rinkel GJ. Long-term risk of aneurysmal subarachnoid hemorrhage after a negative aneurysm screen. Neurology. 2015 Mar 3;84(9):912-7.

5: Sijtsma LC, Rinkel GJ, Ruigrok YM. Sex-related clustering of intracranial aneurysms within families. Stroke. 2015 Apr;46(4):1107-9.

Fellowship and Awards

  • 1: 2014 Clinical fellowship, Netherlands Organization for Scientific Research (NWO)
    2: 2010 Rudolf Magnus Young Talent Fellowship from the Rudolf Magnus Institute of the University Medical Center Utrecht
    3: 2009 ‘Vernieuwingsimpuls Veni’ grant from the Netherlands Organization for Scientific Research (NWO) for the research project entitled ‘Genetic variation and the risk of developing intracranial aneurysms’ (project no. 91610016)
    4: 2008 ‘Amsterdamse Neurologenvereeniging’ prize for thesis (cum laude)
    5: 2007 Girard de Mielet van Coehoorn prize for thesis (cum laude) (University Medical Center Utrecht)
    5: 2005 grant from the Netherlands Brain Foundation for the research project entitled 'the role of the extracellular matrix in intracranial aneurysms' (project no. 13F05.13)

Research Output (109)

Variational Autoencoders with a Structural Similarity Loss in Time of Flight MRAs

Timmins Kimberley, van der Schaaf Irene, Velthuis BK, Ruigrok Ynte, Kuijf Hugo 15 feb 2021, 11596

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Bakker Mark K., van der Spek Rick A.A., van Rheenen Wouter, Morel Sandrine, Bourcier Romain, Hostettler Isabel C., Alg Varinder S., van Eijk Kristel R., Koido Masaru, Akiyama Masato, Terao Chikashi, Matsuda Koichi, Walters Robin, Lin Kuang, Li Liming, Millwood Iona Y., Chen Zhengming, Rouleau Guy A., Zhou Sirui, Rannikmäe Kristiina, Sudlow Cathie L.M., Houlden Henry, van den Berg Leonard H., Dina Christian, Naggara Olivier, Gentric Jean Christophe, Shotar Eimad, Eugène François, Desal Hubert, Winsvold Bendik S., Børte Sigrid, Johnsen Marianne Bakke, Brumpton Ben M., Sandvei Marie Søfteland, Willer Cristen J., Hveem Kristian, Zwart John Anker, Verschuren W. M.Monique, Friedrich Christoph M., Hirsch Sven, Schilling Sabine, Dauvillier Jérôme, Martin Olivier, Bian Zheng, Chen Junshi, Klijn Catharina J.M., Rinkel Gabriel J.E., Lindgren Antti, Veldink Jan H., Ruigrok Ynte M., , , , , , , dec 2020, In: Nature Genetics. 52 , p. 1303-1313 11 p.

Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in Patients With a History of Migraine

van Os Hendrikus J A, Ruigrok Ynte M, Verbaan Dagmar, Dennesen Paul, Müller Marcella C A, Coert Bert A, Algra Ale, Vergouwen Mervyn D I, Wermer Marieke J H 1 sep 2020, In: Stroke. 51 , p. 3039-3044 6 p.

Velocity Pulsatility and Arterial Distensibility Along the Internal Carotid Artery

van Tuijl Rick J., Ruigrok Ynte M., Velthuis Birgitta K., van der Schaaf Irene C., Rinkel Gabriël J.E., Zwanenburg Jaco J.M. 18 aug 2020, In: Journal of the American Heart Association. 9 , p. e016883 11 p.

Heritability of territory of ruptured and unruptured intracranial aneurysms in families

van Kammen Mayte Sánchez, Bourcier Romain, Moomaw Charles J., Broderick Joseph P., Woo Daniel, Papagiannaki Chrysanthi, Levrier Olivier, Lindgren Antti E., Koivisto Timo, Jääskeläinen Juha E., Rinkel Gabriël J.E., Ruigrok Ynte M. aug 2020, In: PLoS ONE. 15

Management of Unruptured Cerebral Aneurysms and Arteriovenous Malformations

Ruigrok Ynte M. 1 apr 2020, In: Continuum (Minneapolis, Minn.). 26 , p. 478-498 21 p.

Distribution of Cardioembolic Stroke:A Cohort Study

Pierik Ramon, Algra Ale, van Dijk Ewoud, Erasmus Michiel E, van Gelder Isabella C, Koudstaal Peter J, Luijckx Gert-Jan R, Nederkoorn Paul J, van Oostenbrugge Robert J, Ruigrok Ynte M, Scheeren Thomas W L, Uyttenboogaart Maarten, Visser Marieke C, Wermer Marieke J H, van den Bergh Walter M, 21 jan 2020, In: Cerebrovascular Diseases. 49 , p. 97-104 8 p.

RNA-Sequencing Highlights Inflammation and Impaired Integrity of the Vascular Wall in Brain Arteriovenous Malformations

Hauer Allard J, Kleinloog Rachel, Giuliani Fabrizio, Rinkel Gabriël J E, de Kort Gerard A, Berkelbach van der Sprenkel Jan Willem, van der Zwan Albert, Gosselaar Peter H, van Rijen Peter C, de Boer-Bergsma Jelkje J, Deelen Patrick, Swertz Morris A, De Muynck Louis, Van Damme Philip, Veldink Jan H, Ruigrok Ynte M, Klijn Catharina J M 1 jan 2020, In: Stroke. 51 , p. 268-274 7 p.

Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage

van Dijk Bart J, Meijers Joost C M, Kloek Anne T, Knaup Veronique L, Rinkel Gabriel J E, Morgan B Paul, van der Kamp Marije J, Osuka Koji, Aronica Eleonora, Ruigrok Ynte M, van de Beek Diederik, Brouwer Matthijs, Pekna Marcela, Hol Elly M, Vergouwen Mervyn D I 6 dec 2019, In: Translational Stroke Research. 11 , p. 678-688 11 p.

Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis:The SMART-MR Study

Zwartbol M. H. T., Geerlings M. I., Ghaznawi R., Hendrikse J., van der Kolk A. G., Asselbergs F. W., Nathoe H. M., de Borst G. J., Bots M. L., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren F. L. J., Westerink J., 5 dec 2019, In: American Journal of Neuroradiology. 40 , p. 2016-2022 7 p.

All research output