dr. Y.M. (Ynte) Ruigrok
dr. Y.M. (Ynte) Ruigrok
- Neurologen
Research Programs
Biography
Biography
My name is Ynte Ruigrok and I work as a stroke neurologist and an associate professor at the department of Neurology and Neurosurgery. Both in my clinical work and my research I focus on intracranial aneurysms. Intracranial aneurysms are present in 3% of the population and usually go undetected until rupture occurs leading to an often fatal aneurysmal subarachnoid hemorrhage (ASAH). The overall aim of my research is to identify the patients who are at high risk of developing aneurysms and a subsequent ASAH. It is my ambition to increase insight in underlying disease processes, improve detection of aneurysms in high risk patients and optimize treatment. My research has a strong translational view in which I combine genetics, epidemiology and imaging of intracranial aneurysms.
For my research I have received several prestigious grants, including an ERC starting grant in 2019 for my research project PRYSM: Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage. This project concerns translational research in which I integrate genetic and environmental risk factors with imaging markers and combine these factors in an aneurysm prediction risk model. This will lead to precision medicine in early aneurysm detection to reduce the burden of ASAH.
To advance aneurysm genetic research I have initiated the intracranial aneurysm working group within the international stroke genetics consortium. This cohort enables me to provide insight in which genetic variants and/or genes are associated with intracranial aneurysms and thus make a major contribution to unravelling the genetic architecture of the disease. Recently a large scale genome wide association study (GWAS) on intracranial aneurysms was performed. Based on its findings now more than half of the disease heritability can be explained (Bakker et al, Nature Genetics 2020). Currently my group is performing translational research studies for understanding the biological mechanisms of genetic variants for intracranial aneurysms identified and for exploiting genetics for drug discovery. In addition, observational clinical studies are being performed which provide important insights into causality, mechanisms and consequences of genetic findings.
Research line
Genetic riks of stroke
Most recent key publications
1. Zuurbier CC, ... , Ruigrok YM. Difference in Rupture Risk Between Familial and Sporadic Intracranial Aneurysms: An Individual Patient Data Meta-analysis. Neurology. 2021 Oct 20:10.1212/WNL.0000000000012885. doi: 10.1212/WNL.0000000000012885
2. Bakker MK, Ruigrok YM. Genetics of Intracranial Aneurysms. Stroke. 2021 Aug;52(9):3004-3012. doi: 10.1161/STROKEAHA.120.032621. Epub 2021 Aug 17.
3. Bakker MK, … , Ruigrok YM. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. Nat Genet. 2020 Dec;52(12):1303-1313. doi: 10.1038/s41588-020-00725-7. Epub 2020 Nov 16.PMID: 33199917
4. Bakker MK, Ettema RA, Klostermann M, Rinkel GJE, Veldink JH, Ruigrok YM. Role of Rare Genetic Variants Found in Families With Intracranial Aneurysms in the General Dutch and UK Population. Stroke. 2021 Aug;52(9):e540-e541. doi: 10.1161/STROKEAHA.121.035492. Epub 2021 Jun 25.PMID: 34167329
5. van 't Hof FNG, Lai D, van Setten J, Bots ML, Vaartjes I, Broderick J, Woo D, Foroud T, Rinkel GJE, de Bakker PIW, Ruigrok YM.Exome-chip association analysis of intracranial aneurysms. Neurology. 2020 Feb 4;94(5):e481-e488. doi: 10.1212/WNL.0000000000008665. Epub 2019 Nov 15.PMID: 31732565
Fellowship and Awards
2020 Michele Sale award for Women in Stroke Genetics, an internationally competitive mid-career award of the Internation Stroke Genetics Consortium (ISGC)
2019 ERC starting grant from the European Research Council for the research project ‘Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid haemorrhage (PRYSM)
2014 ZonMW Clinical Fellowship for the research project ‘Towards therapeutic strategies for intracranial aneurysms through deep re-sequencing of genetic risk loci and comprehensive functional characterisation’
2010 Rudolf Magnus Young Talent Fellowship from the Rudolf Magnus Institute of the University Medical Center Utrecht
2009 ‘Vernieuwingsimpuls Veni’ grant from the Netherlands Organization for Scientific Research (NWO) for the research project entitled ‘Genetic variation and the risk of developing intracranial aneurysms’
2008 ‘Amsterdamse Neurologenvereeniging’ prize for thesis (cum laude)
2007 Girard de Mielet van Coehoorn prize for thesis (cum laude) (University Medical Center Utrecht)
2005 personal grant from the Dr. E. Dekker program of the Duth Heart Foundation for the research project 'The role of the extracellular matrix in intracranial aneurysms’
2000 personal grant from the program ‘AGIKO-stipendia’ of NWO for the PhD project on the genetic background of intracranial aneurysms and aneurysmal subarachnoid hemorrhage
Research Output (162)
Mensing Liselore A., van Tuijl Rick J., Greving Jacoba P., Velthuis Birgitta K., van der Schaaf Irene C., Wermer Marieke J.H., Verbaan Dagmar, Vandertop W. Peter, Zuithoff Nicolaas P.A., Rinkel Gabriël J.E., Ruigrok Ynte M. 29 Aug 2023, In: Neurology. 101 , p. e904-e912
Galea Ian, Bandyopadhyay Soham, Bulters Diederik, Humar Rok, Hugelshofer Michael, Schaer Dominik J., Abdulazim Amr, Alalade Andrew F., Alexander Sheila A., Amaro Sergi, Amin-Hanjani Sepideh, Andersen Christopher R., Anderson Craig, Anstey Matthew H., Balla József, Bankole Nourou Dine Adeniran, Bellapart Judith, Bhagat Hemant, Blackburn Spiros L., Brechmann Markus, Buehler P. W., Burkhardt Jan Karl, Chen Yujie, Cohen Jeremy, Cooper P. David, Coulthard Liam G., Cuadrado-Godia Elisa, Dalton Joan, Delaney Anthony, Doré Sylvain, Downer Jonathan, Dye Justin, Fernandez-Perez Isabel, Flower Oliver, Fülesdi Béla, Gaastra Ben, Gaberel Thomas, Galea James, Gankpe Gbetoho Fortuné, Garland Patrick, Gentinetta Thomas, Gram Magnus, Graversen Jonas Heilskov, Grover Patrick J., Guisado-Alonso Daniel, Hasan David, Helmy Adel, Regli Luca, Ruigrok Ynte Marije, Vergouwen Mervyn D.I. 1 Jul 2023, In: Stroke. 54 , p. 1930-1942 13 p.
Bonekamp Nadia E, May Anne M, Halle Martin, Dorresteijn Jannick A N, van der Meer Manon G, Ruigrok Ynte M, de Borst Gert J, Geleijnse Johanna M, Visseren Frank L J, Koopal Charlotte 13 Jun 2023, In: European heart journal open. 3
Vos Iris, Bhat Ishaan, Velthuis Birgitta, Ruigrok Ynte, Kuijf Hugo 5 Apr 2023,
van Os Hendrikus J.A., Kanning Jos P., Bonten Tobias N., Rakers Margot M., Putter Hein, Numans Mattijs E., Ruigrok Ynte M., Groenwold Rolf H.H., Wermer Marieke J.H. 4 Apr 2023, In: Journal of the American Heart Association. 12 32 p.
Zuurbier Charlotte C.M., Bourcier Romain, Constant Dit Beaufils Pacôme, Redon Richard, Desal Hubert, Bor Anne S.E., Rinkel Gabriel J.E., Greving Jacoba P., Ruigrok Ynte M., 1 Apr 2023, In: Stroke. 54 , p. 1015-1020 6 p.
Bakker Mark K., Kanning Jos P., Abraham Gad, Martinsen Amy E., Winsvold Bendik S., Zwart John Anker, Bourcier Romain, Sawada Tomonobu, Koido Masaru, Kamatani Yoichiro, Morel Sandrine, Amouyel Philippe, Debette Stéphanie, Bijlenga Philippe, Berrandou Takiy, Ganesh Santhi K., Bouatia-Naji Nabila, Jones Gregory, Bown Matthew, Rinkel Gabriel J.E., Veldink Jan H., Ruigrok Ynte M., 1 Mar 2023, In: Stroke. 54 , p. 810-818 9 p.
Mensing Liselore A., Kappelle L. Jaap, Koffijberg Hendrik, Ruigrok Ynte M. 3 Jan 2023, In: BMJ Open. 13
Bakker Mark K., Van Straten Tijmen, Chong Michael, Paré Guillaume, Gill Dipender, Ruigrok Ynte M. 1 Jan 2023, In: Stroke. 54 , p. 208-216 9 p.
Ranjan Redoy, Ken-Dror Gie, Martinelli Ida, Grandone Elvira, Hiltunen Sini, Lindgren Erik, Margaglione Maurizio, Le Cam Duchez Veronique, Bagan Triquenot Aude, Zedde Marialuisa, Mancuso Michelangelo, Ruigrok Ynte M., Worrall Brad, Majersik Jennifer J., Putaala Jukka, Haapaniemi Elena, Zuurbier Susanna M., Brouwer Matthijs C., Passamonti Serena M., Abbattista Maria, Bucciarelli Paolo, Lemmens Robin, Pappalardo Emanuela, Costa Paolo, Colombi Marina, Aguiar de Sousa Diana, Rodrigues Sofia, Canhao Patrícia, Tkach Aleksander, Santacroce Rosa, Favuzzi Giovanni, Arauz Antonio, Colaizzo Donatella, Spengos Kostas, Hodge Amanda, Ditta Reina, Han Thang S., Pezzini Alessandro, Coutinho Jonathan M., Thijs Vincent, Jood Katarina, Tatlisumak Turgut, Ferro José M., Sharma Pankaj 2023, In: European Stroke Journal. 8 , p. 344-350 7 p.