prof. dr. A.J.C. (Arjen) Slooter

Full Professor
prof. dr. A.J.C. (Arjen) Slooter
  • Intensive Care Medicine

Research Programs




Arjen Slooter studied Medicine at the Vrije Universiteit, Amsterdam (1986-1994) and worked subsequently as a resident in Neurology in Sint Lucas Hospital, Amsterdam (1994). He was research fellow in Neuro-Epidemiology at the G.H. Sergievsky Center, Columbia University, New York (1996) and received a PhD in Epidemiology from Erasmus University, Rotterdam (1998), on a thesis on dementia. During his residency in Neurology in the UMC Utrecht (1999-2004), he became enthusiastic for Neurocritical Care. After a fellowship in Intensive Care Medicine (AMC Amsterdam, 2004-2006), he rejoined the UMC Utrecht where he is currently working as consultant neurologist-intensivist at the Department of Intensive Care Medicine. In 2016, he was appointed as Professor in Intensive Care Neuropsychiatry at Utrecht University.

The research focus of Arjen Slooter is on delirium and on neuropsychiatric outcome after anesthesia/surgery or critical illness. He currently works on an EEG-based device to detect delirium, functional connectivity in delirium, drug side-effects and delirium, postoperative delirium, and long-term outcome after ICU admission. He is President of the European Delirium Association and was chairman of the delirium section of the Society of Critical Care Medicine (SCCM) 2018 guideline on pain, agitation, delirium, early mobilization and sleep.

The clinical focus of Arjen Slooter is on Intensive Care of neurological- and neurosurgical patients, and on neurological complications of critical illness. He is responsible for training of ICU nurses, residents and fellows in Neuro-Intensive Care in the UMC Utrecht. Arjen lives with wife Barbara, daughter Pien (2001) and son Bas (2004) in beautiful Utrecht.

Research line

Delirium and (neuropsychiatric) outcome of critical illness

Most recent key publications

1. Van den Boogaard M, Slooter AJC, Brüggemann RJM, Schoonhoven L, Beishuizen A, Vermeijden JW, Pretorius D, de Koning J, Simons KS, Dennesen PJW, Van der Voort PHJ, Houterman S, van der Hoeven JG, Pickkers P; REDUCE Study Investigators. Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial. JAMA 2018;319:680-90 (IF=47.7).

2. Klein Klouwenberg PMC, Zaal IJ, Spitoni C, Ong DSY, van der Kooi AW, Bonten MJM, Slooter AJC, Cremer OL. The attributable mortality of delirium in critically ill patients. BMJ 2014;349:g6652 (IF=23.6).

3. Slooter AJC. Critical illness, delirium and cognitive impairment. Nature Rev Neurol 2013;9:666-7 (IF=20.3). 

4. Van den Boogaard M, Pickkers P, Slooter AJ, Kuiper MA, Spronk PE, van der Voort PH, van der Hoeven JG, Donders R, van Achterberg T, Schoonhoven L. Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study. BMJ 2012;344:e420 (IF=23.6).

5. Van Eijk MMJ, Roes KCB, Honing MLH, Kuiper MA, Karakus A, van der Jagt M, Spronk PE, van Gool WA, van der Mast RC, Kesecioglu J, Slooter AJC. Rivastigmine does not decrease duration of delirium and may increase mortality in critically ill patients: a multicentre, double-blind, randomized, placebo-controlled add-on trial. Lancet 2010;376:1829-37 (IF=53.3).

Fellowship and Awards

‘Public private partnership to revolutionize delirium care in hospitals’. European Union (H2020-EIC-FTI-2018-2020-820555, co-applicant and principal clinical investigator, principal investigator).

‘Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: a prospective randomised multicentre double-blind placebo-controlled clinical trial’. ZonMW GGG (80-84800-98-41 023, co-applicant).

‘Delirium Monitor: reducing the burden of delirium’. Technology Foundation STW, Take-off phase 2 (14066; co-applicant).

‘Objective delirium detection with an innovative EEG-based spot monitor’. European Union (H2020-PHC-12-2014-672974; co-applicant).

‘Delirium Monitor: reducing the burden of delirium’. Technology Foundation STW (2015-14066, principal investigator).

‘Objective delirium monitoring for routine critical care’. European Society of Intensive Care Medicine, Clinical Research Award (2014, principal investigator).

Annual Scientific Award, Society of Critical Care Medicine (2014, principal investigator).

EU-FP7 grant: ‘Biomarker development for postoperative cognitive impairment in the elderly’ (FP7-HEALTH-2013-Innovation-1, co-applicant).

Netherlands Heart Foundation: ‘Induced hypertension for treatment of delayed cerebral ischemia after aneurysmatic subarachnoid haemorrhage’ (2009, principal investigator).

Netherlands Brain Foundation: ‘Induced hypertension for treatment of delayed cerebral ischemia after aneurysmatic subarachnoid haemorrhage’ (2008, principal investigator).

ZonMW doelmatigheid: ‘Rivastigmine for delirium in Intensive Care patients, a multicentre, double-blind, randomised placebo-controlled add-on trial’ (ZonMW 170881003, principal investigator).

Research Output (232)

Preoperative MRI brain phenotypes are related to postoperative delirium in older individuals

Kant Ilse M J, Slooter Arjen J C, Jaarsma-Coes Myriam, van Montfort Simone J T, Witkamp Theo D, Pasma Wietze, Hendrikse Jeroen, de Bresser Jeroen, mei 2021, In: Neurobiology of Aging. 101 , p. 247-255 9 p.

Large-scale ICU data sharing for global collaboration:the first 1633 critically ill COVID-19 patients in the Dutch Data Warehouse

Fleuren Lucas M, de Bruin Daan P, Tonutti Michele, Lalisang Robbert C A, Elbers Paul W G, , Cremer Olaf, Rademaker E, Slooter AJ 2021, In: Intensive Care Medicine. 47 , p. 478-481 4 p.

Publisher Correction:Delirium (Nature Reviews Disease Primers, (2020), 6, 1, (90), 10.1038/s41572-020-00223-4)

Wilson Jo Ellen, Mart Matthew F, Cunningham Colm, Shehabi Yahya, Girard Timothy D, MacLullich Alasdair M J, Slooter Arjen J C, Ely E Wesley 1 dec 2020, In: Nature Reviews Disease Primers. 6


Wilson Jo Ellen, Mart Matthew F, Cunningham Colm, Shehabi Yahya, Girard Timothy D, MacLullich Alasdair M J, Slooter Arjen J C, Ely E Wesley dec 2020, In: Nature Reviews Disease Primers. 6

Family participation in physiotherapy-related tasks of critically ill patients:A mixed methods systematic review

utrecht umc, Valkenet K, Slooter A J C, Veenhof C 24 nov 2020, In: Journal of Critical Care. 62 , p. 49-57 9 p.

Preoperative brain MRI features and occurrence of postoperative delirium

Kant Ilse M J, van Montfort Simone J T, Mutsaerts Henri J M M, Witkamp Theo D, Buijsrogge Marc, Spies Claudia, Hendrikse Jeroen, Slooter Arjen J C, de Bresser Jeroen 16 nov 2020, In: Journal of Psychosomatic Research. 140 , p. 1-6

Characterising neuropsychiatric disorders in patients with COVID-19

Oldham Mark A, Slooter Arjen J C, Cunningham Colm, Rahman Shibley, Davis Daniel, Vardy Emma R L C, Garcez Flavia B, Neufeld Karin J, de Castro Roberta Esteves Vieira, Ely E Wesley, MacLullich Alasdair nov 2020, In: The Lancet Psychiatry. 7 , p. 932-933 2 p.

Hallucinations and other psychotic experiences across diagnoses:A comparison of phenomenological features

Schutte Maya J L, Linszen Mascha M J, Marschall Theresa M, Ffytche Dominic H, Koops Sanne, van Dellen Edwin, Heringa Sophie M, Slooter Arjen J C, Teunisse Rob, van den Heuvel Odile A, Lemstra Afina W, Foncke Elisabeth M J, Slotema Christina Wilhelmina, de Jong Joop, Rossell Susan L, Sommer Iris E C okt 2020, In: Psychiatry Research. 292

Plasma leptin, but not adiponectin, is associated with cognitive impairment in older adults

Feinkohl Insa, Janke Jürgen, Slooter Arjen J C, Winterer Georg, Spies Claudia, Pischon Tobias okt 2020, In: Psychoneuroendocrinology. 120

Psychotropic medication use in former ICU patients with mental health problems:A prospective observational follow-up study

Janssen Debbie G A, Jonker Joep, van Dijk Diederik, Heerdink Eibert R, Egberts Toine C G, Slooter Arjen J C okt 2020, In: Journal of Critical Care. 59 , p. 112-117 6 p.

All research output

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