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prof. dr. A.J.C. (Arjen) Slooter

prof. dr. A.J.C. (Arjen) Slooter

Full Professor
prof. dr. A.J.C. (Arjen) Slooter
  • Intensive Care Medicine

Research Programs

Brain

Biography

Biography

Arjen Slooter studied Medicine at the Vrije Universiteit, Amsterdam (1986-1994) and worked subsequently as a resident in Neurology in Sint Lucas Hospital, Amsterdam (1994). He was research fellow in Neuro-Epidemiology at the G.H. Sergievsky Center, Columbia University, New York (1996) and received a PhD in Epidemiology from Erasmus University, Rotterdam (1998), on a thesis on dementia. During his residency in Neurology in the UMC Utrecht (1999-2004), he became enthusiastic for Neurocritical Care. After a fellowship in Intensive Care Medicine (AMC Amsterdam, 2004-2006), he rejoined the UMC Utrecht where he is currently working as consultant neurologist-intensivist at the Department of Intensive Care Medicine. In 2016, he was appointed as Professor in Intensive Care Neuropsychiatry at Utrecht University.

The research focus of Arjen Slooter is on delirium and on neuropsychiatric outcome after anesthesia/surgery or critical illness. He currently works on an EEG-based device to detect delirium, functional connectivity in delirium, drug side-effects and delirium, postoperative delirium, and long-term outcome after ICU admission. He is President of the European Delirium Association and was chairman of the delirium section of the (American) Society of Critical Care Medicine (SCCM) 2018 guideline on pain, agitation, delirium, early mobilization and sleep.

The clinical focus of Arjen Slooter is on Intensive Care of neurological- and neurosurgical patients, and on neurological complications of critical illness. He is responsible for training of ICU nurses, residents and fellows in Neuro-Intensive Care in the UMC Utrecht. Arjen lives with wife Barbara, daughter Pien (2001) and son Bas (2004) in beautiful Utrecht.

Research line

Delirium and (neuropsychiatric) outcome of critical illness

Most recent key publications

1. Klein Klouwenberg PMC, Zaal IJ, Spitoni C, Ong DSY, van der Kooi AW, Bonten MJM, Slooter AJC, Cremer OL. The attributable mortality of delirium in critically ill patients. BMJ 2014;349:g6652.
Impact factor 30.3, top 10% Medicine, General and Internal.

2. Van den Boogaard M, Slooter AJC, Brüggemann RJM, Schoonhoven L, Beishuizen A, Vermeijden JW, Pretorius D, de Koning J, Simons KS, Dennesen PJW, Van der Voort PHJ, Houterman S, van der Hoeven JG, Pickkers P; REDUCE Study Investigators. Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial. JAMA 2018;319:680-90.
Impact factor 45.5, top 10% Medicine, General and Internal.

3. Numan T, van den Boogaard M, Kamper AM, Rood PJT, Peelen LM, Slooter AJC; Dutch Delirium Detection Study Group. Delirium detection using relative delta power based on 1-minute single-channel EEG: a multicentre study. Br J Anaesth 2019;122:60-8.
Impact factor 6.9, top 10% Anesthesiology.

4. Slooter AJC, Otte WM, Devlin JW, Arora RC, Bleck TP, Claassen J, Duprey MS, Ely EW, Kaplan PW, Latronico N, Morandi A, Neufeld KJ, Sharshar T, MacLullich AMJ, Stevens RD. Updated nomenclature of delirium and acute encephalopathy: statement of ten societies. Intensive Care Med 2020;46:1020-2.
Impact factor 17.7, top 10% Critical Care Medicine.

5. Wilson JE, Mart M, Cunningham C, Shehabi Y, Girard T, MacLullich A, Slooter AJC, EW Ely. Delirium. Nat Rev Dis Primers. In press.
Impact factor 40.7, top 10% Medicine, General and Internal.

Fellowship and Awards

‘Public private partnership to revolutionize delirium care in hospitals’. European Union (H2020-EIC-FTI-2018-2020-820555, co-applicant and principal clinical investigator, principal investigator).

‘Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: a prospective randomised multicentre double-blind placebo-controlled clinical trial’. ZonMW GGG (80-84800-98-41 023, co-applicant).

‘Delirium Monitor: reducing the burden of delirium’. Technology Foundation STW, Take-off phase 2 (14066; co-applicant).

‘Objective delirium detection with an innovative EEG-based spot monitor’. European Union (H2020-PHC-12-2014-672974; co-applicant).

‘Delirium Monitor: reducing the burden of delirium’. Technology Foundation STW (2015-14066, principal investigator).

‘Objective delirium monitoring for routine critical care’. European Society of Intensive Care Medicine, Clinical Research Award (2014, principal investigator).

Annual Scientific Award, Society of Critical Care Medicine (2014, principal investigator).

EU-FP7 grant: ‘Biomarker development for postoperative cognitive impairment in the elderly’ (FP7-HEALTH-2013-Innovation-1, co-applicant).

Netherlands Heart Foundation: ‘Induced hypertension for treatment of delayed cerebral ischemia after aneurysmatic subarachnoid haemorrhage’ (2009, principal investigator).

Netherlands Brain Foundation: ‘Induced hypertension for treatment of delayed cerebral ischemia after aneurysmatic subarachnoid haemorrhage’ (2008, principal investigator).

ZonMW doelmatigheid: ‘Rivastigmine for delirium in Intensive Care patients, a multicentre, double-blind, randomised placebo-controlled add-on trial’ (ZonMW 170881003, principal investigator).

Research Output (241)

Factors associated with a persistent delirium in the intensive care unit:A retrospective cohort study

Kooken Rens W J, van den Berg Maarten, Slooter Arjen J C, Pop-Purceleanu Monica, van den Boogaard Mark 18 sep 2021, In: Journal of Critical Care. 66 , p. 132-137 6 p.

Determining preoperative brain MRI features and occurrence of postoperative delirium

Kant Ilse M J, de Bresser Jeroen, Slooter Arjen J C sep 2021, In: Journal of Psychosomatic Research. 148 , p. 110568

Case-control study on the interplay between immunoparalysis and delirium after cardiac surgery

CheheiliSobbi Shokoufeh, Peters van Ton Annemieke M, Wesselink Esther M, Looije Marjolein F, Gerretsen Jelle, Morshuis Wim J, Slooter Arjen J C, Abdo Wilson F, Pickkers Peter, van den Boogaard Mark 23 aug 2021, In: Journal of Cardiothoracic Surgery. 16 , p. 239

EEG and clinical assessment in delirium and acute encephalopathy

Hut Suzanne C A, Dijkstra-Kersten Sandra M A, Numan Tianne, Henriquez Nizare R V R, Teunissen Nico W, van den Boogaard Mark, Leijten Franciscus S, Slooter Arjen J C aug 2021, In: Psychiatry and Clinical Neurosciences. 75 , p. 265-266 2 p.

Non-pharmacological Interventions in Delirium:The Law of the Handicap of a Head Start

Slooter Arjen J C 7 jul 2021, In: American Journal of Respiratory and Critical Care Medicine. 204 , p. 624-626 3 p.

Reply to Murray and Newsome:Opioids for Sedation: Has the Pendulum Swung Too Far?

Duprey Matthew S, Slooter Arjen J C, Devlin John W 7 jun 2021, In: American Journal of Respiratory and Critical Care Medicine. 204 , p. 612 1 p.

Preoperative MRI brain phenotypes are related to postoperative delirium in older individuals

Kant Ilse M J, Slooter Arjen J C, Jaarsma-Coes Myriam, van Montfort Simone J T, Witkamp Theo D, Pasma Wietze, Hendrikse Jeroen, de Bresser Jeroen, mei 2021, In: Neurobiology of Aging. 101 , p. 247-255 9 p.

Opioid Use Increases the Risk of Delirium in Critically Ill Adults Independently of Pain

Duprey Matthew S, Dijkstra-Kersten Sandra M A, Zaal Irene J, Briesacher Becky A, Saczynski Jane S, Griffith John L, Devlin John W, Slooter Arjen J C 9 apr 2021, In: American Journal of Respiratory and Critical Care Medicine. 204 , p. 566-572 7 p.

Preoperative Comparison of Three Anticholinergic Drug Scales in Older Adult Patients and Development of Postoperative Delirium:A Prospective Observational Study

Heinrich Maria, Müller Anika, Cvijan Andela, Mörgeli Rudolf, Kruppa Jochen, Winterer Georg, Slooter Arjen J C, Spies Claudia D, apr 2021, In: Drugs & Aging. 38 , p. 347-354 8 p.

Haloperidol, clonidine and resolution of delirium in critically ill patients:a prospective cohort study

Smit Lisa, Dijkstra-Kersten Sandra M A, Zaal Irene J, van der Jagt Mathieu, Slooter Arjen J C mrt 2021, In: Intensive Care Medicine. 47 , p. 316-324 9 p.

All research output

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