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prof. dr. J.P.G. (Joost P.G.) Sluijter

prof. dr. J.P.G. (Joost P.G.) Sluijter

Full Professor
prof. dr. J.P.G. (Joost P.G.) Sluijter
  • Onderzoek Cardiovasculair Reg. Med.

Biography

Biography

Prof Joost Sluijter is a Medical Biologist and got his PhD in 2004 at the University Utrecht on “Collagen turnover in arterial disease”. After being a postdoctoral research fellow at Indiana University-Purdue University (IUPUI), he returned to the University Medical Centre Utrecht (the Netherlands) in 2006.  In his research group, they focus on stimulating cardiac regeneration, thereby using approaches that can lead to improved recovery of cardiac tissue upon injury. In recent years, they identified miRNAs that can push cell lineage specifications and how they could improve progenitor cell transplantation, specifically improving local delivery and cell retention. In this work, they have started to use 3D-bioprinting and advanced technologies of cardiac tissue engineering. His group substantially improved cell delivery to the myocardium, from which they also realized that most of the injected cell action was due to the potential paracrine actions. They therefore started to study the use of secreted vesicles by these cells as a novel approach to induce cardiac repair.

Prof Joost Sluijter is heading the Experimental Cardiology Laboratory and is nucleus member of the Regenerative Medicine program of the UMCU, he is nucleus member of the ESC working groups Cellular Biology of the Heart and Cardiovascular Regenerative & Reparative Medicine, has several editorial roles for journals, published >200 papers, and is awardee of an ERC consolidator grant.

Side Activities

  • Nucleus member working group on Cellular Biology of the Heart (European Society of Cardiology) 2010 - current

  • Chair working group on Cellular Biology of the Heart (European Society of Cardiology) 2016-2018
  • Immediate past-Chair working group on Cellular Biology of the Heart (European Society of Cardiology) 2018-2020

  • Nucleus member working group on Cardiovascular Regenerative & Reparative Medicine (European Society of Cardiology) 2020 - current

  • Board member of the Council on Basic Cardiovascular Science (European Society of Cardiology) 2018-2020

  • Associate editor of Journal of Cardiovascular Translational Research 2016 - current

  • Associate Editor Discovery Biology and Medicine 2012-2014

  • Editorial Board memeber of Clinical and Translational Physiology (Frontiers in Physiology)   2020 - current                                

  • Editorial Board member of Non-coding RNA Investigation 2018 - current

  • Scientific reviewer for journal (selected): Arterioslerosis, Thrombosis and Vascular biology (ATVB),   American Journal of Physiology, British Journal of Pharmacology, Cardiovascular research (Card Res), Circulation (Circ), Circulation research (Circ Res), Clinical Science, Current Pharmaceutical Design, European Heart Journal (EHJ), Journal of the American College of Cardiology (JACC), Journal of Cellular and Molecular Medicine (JCMM), New England Journal of Medicine (NEJoM), Physiological Genomics, Plos One, Stem Cells International, Science.

  • Scientific reviewer for grant providers (selected): Dutch Heart Foundation, NWO, Foundation de Cooperation Scientifique Campus Paris Saclay (FCS, France), Health and Medical Research Fund (China), Danish Council for Independent Research, National Center of Science and Technology Evaluation (Kazachstan), Medical Research Council (UK), Sir Henry Dale Fellowship (UK), Science foundation of Ireland

  • Member of the evaluation team for Ludwig Boltzman Institute for Cardiovascular Research, Vienna, September 2019.
  • Lecturer teaching program of undergraduate students at the Faculty of Medicine, Utrecht University.

  • University Utrecht - advisory board for ERC Starting and consolidator Grant-candidates

  • Advisory Board van de Graduate School of Life Sciences University Utrecht

Fellowship and Awards

  • 2004-2005 Interuniversity Institute of the Netherlands (ICIN)-fellowship

  • 2007-2009 Novartis Foundation for Cardiovascular Excellence Grant

  • 2008-2009 van Ruyvenstichting: 

  • 2009-2012 UMC Utrecht focus and mass area “cardiovascular research”

  • 2010-2014 BMM-YIC

  • 2011-2015 Translationeel Adult Stamcelonderzoek:

  • 2012-2017 HUMAN STem cells for CArdiac REpair (HUSTCARE)

  • 2014-2018 LSH Impuls: MIGRATE

  • 2015-2017: BMM Smartcare2 – Smart microtissues for cardiac regeneration

  • 2015-2019: Horizon 2020 – TECHNOBEAT (PHC-16-2015)

  • 2015-2018: CAS-NWO Program; Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathy

  • 2017-2022: Horizon 2020 - ERC-2016-CoG – 725229:  EVICARE: Extracellular Vesicle-Inspired CArdiac Repair

  • 2017-2019: Vrienden UMCU: “Innovatieve directe medicijnafgifte in het hart”

  • 2018-2022 – Horizon 2020 Marie S. Curie, COFUND programme RESCUE: Local Training Network on REgenerative medicine and Stem Cell technology in UtrEcht 

  • 2018-2021: Technology Of Protein delivery through Extracellular Vesicles to target PCSK9 (TOP-EV), Dutch Heart Foundation 

  • 2019-2024: RegMed XB Cardiovascular Moonshot 

  • 2019-2024: Horizon 2020 BRAV3 (SC1-BHC-07-2019)

  • 2020-2021: NL-PET - Next Level genome editing - efficient and precise correction of PLN/R14del using Prime Editing Technology. PLN foundation.

  • 2021-2024: NWO-OTP - HARVEY; Heart vector-mediated gene therapy: towards a clinically applicable cure for inherited cardiomyopathies.

  • 2021-2024: ZonMw - PSIDER - Multi-disciplimaire Consortia: From pluripotent stem cells to prime editing gene therapy for inherited cardiomyopathies.

  • 2022-2026: Horizon-HLTH-2021-TOOL-06-02; HEAL - HLA-homozygous IPSC-cardiomyocyte aggregate manufacturing technologies for allogenic cell therapy to the heart.

 

Research Output (299)

Small molecule-mediated rapid maturation of human induced pluripotent stem cell-derived cardiomyocytes

Chirico Nino, Kessler Elise L, Maas Renée G C, Fang Juntao, Qin Jiabin, Dokter Inge, Daniels Mark, Šarić Tomo, Neef Klaus, Buikema Jan-Willem, Lei Zhiyong, Doevendans Pieter A, Sluijter Joost P G, van Mil Alain 27 Dec 2022, In: Stem Cell Research & Therapy [E]. 13 , p. 1-18

METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury

Wang Lijun, Wang Jiaqi, Yu Pujiao, Feng Jingyi, Xu Gui e., Zhao Xuan, Wang Tianhui, Lehmann H. Immo, Li Guoping, Sluijter Joost P.G., Xiao Junjie Dec 2022, In: Nature Communications. 13

Gut microbiome mediates the protective effects of exercise after myocardial infarction

Zhou Qiulian, Deng Jiali, Pan Xue, Meng Danni, Zhu Yujiao, Bai Yuzheng, Shi Chao, Duan Yi, Wang Tianhui, Li Xinli, Sluijter Joost Pg, Xiao Junjie Dec 2022, In: Microbiome. 10

Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling

Zhou Qiulian, Meng Danni, Li Feng, Zhang Xiao, Liu Li, Zhu Yujiao, Liu Shuqin, Xu Minjun, Deng Jiali, Lei Zhiyong, Sluijter Joost P.G., Xiao Junjie Nov 2022, In: EBioMedicine. 85

Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes

Peters Marijn C., Maas Renee G.C., van Adrichem Iris, Doevendans Pieter A.M., Mercola Mark, Šarić Tomo, Buikema Jan W., van Mil Alain, Chamuleau Steven A.J., Sluijter Joost P.G., Hnatiuk Anna P., Neef Klaus 21 Oct 2022, In: Stem cells translational medicine. 11 , p. 1040-1051 12 p.

Circadian rhythms in ischaemic heart disease:key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart

Lecour Sandrine, Du PrCrossed D Sign© Bastiaan C., Bøtker Hans Erik, Brundel Bianca J.J.M., Daiber Andreas, Davidson Sean M., Ferdinandy Peter, Girao Henrique, Gollmann-Tepeköylü Can, Gyöngyösi Mariann, Hausenloy Derek J., Madonna Rosalinda, Marber Michael, Perrino Cinzia, Pesce Maurizio, Schulz Rainer, Sluijter Joost P.G., Steffens Sabine, Van Linthout Sophie, Young Martin E., Van Laake Linda W. 1 Aug 2022, In: Cardiovascular research. 118 , p. 2566-2581 16 p.

Clinical Phenotypes of Heart Failure With Preserved Ejection Fraction to Select Preclinical Animal Models

van Ham Willem B, Kessler Elise L, Oerlemans Marish I F J, Handoko M Louis, Sluijter Joost P G, van Veen Toon A B, den Ruijter Hester M, de Jager Saskia C A Aug 2022, In: JACC: Basic to Translational Science. 7 , p. 844-857 14 p.

Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts

Peters Marijn C., Di Martino Sofia, Boelens Thomas, Qin Jiabin, van Mil Alain, Doevendans Pieter A., Chamuleau Steven A.J., Sluijter Joost P.G., Neef Klaus 9 Jun 2022, In: Molecular Therapy - Methods and Clinical Development. 25 , p. 3-16 14 p.

Circadian Dependence of the Acute Immune Response to Myocardial Infarction

Kilgallen Aoife B, van den Akker Frederieke, Feyen Dries A M, Crnko Sandra, Snijders Blok Christian J B, Gremmels Hendrik, du Pré Bastiaan C, Reijers Robin, Doevendans Pieter A, de Jager Saskia C A, Sluijter Joost P G, Sampaio-Pinto Vasco, van Laake Linda W 25 May 2022, In: Frontiers in Pharmacology. 13 , p. 1-13

Elevated Serotonin and NT-proBNP Levels Predict and Detect Carcinoid Heart Disease in a Large Validation Study

Levy Sonja, Kilgallen Aoife B, Korse Catharina M, Oerlemans Marish I F J, Sluijter Joost P G, van Laake Linda W, Valk Gerlof D, Tesselaar Margot E T 1 May 2022, In: Cancers. 14 , p. 1-13

All research output

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