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prof. dr. J.P.G. (Joost P.G.) Sluijter

Full Professor

  • Onderzoek Cardiovasculair Reg. Med.

prof. dr. J.P.G. (Joost P.G.) Sluijter

Biography

Prof Joost Sluijter is a Medical Biologist and got his PhD in 2004 at the University Utrecht on “Collagen turnover in arterial disease”. After being a postdoctoral research fellow at Indiana University-Purdue University (IUPUI), he returned to the University Medical Centre Utrecht (the Netherlands) in 2006.  In his research group, they focus on stimulating cardiac regeneration, thereby using approaches that can lead to improved recovery of cardiac tissue upon injury. In recent years, they identified miRNAs that can push cell lineage specifications and how they could improve progenitor cell transplantation, specifically improving local delivery and cell retention. In this work, they have started to use 3D-bioprinting and advanced technologies of cardiac tissue engineering. His group substantially improved cell delivery to the myocardium, from which they also realized that most of the injected cell action was due to the potential paracrine actions. They therefore started to study the use of secreted vesicles by these cells as a novel approach to induce cardiac repair.

Prof Joost Sluijter is heading the Experimental Cardiology Laboratory and is nucleus member of the Regenerative Medicine program of the UMCU, he is the current past-chair of the ESC working group Cellular Biology of the Heart, has several editorial roles for journals, published >170 papers, and is awardee of an ERC consolidator grant.

Side Activities

  • -Nucleus member working group on Cellular Biology of the Heart (European Society of Cardiology)

    - Immediate past-Chair working group on Cellular Biology of the Heart (European Society of Cardiology)

    - Board member of the Council on Basic Cardiovascular Science (European Society of Cardiology)

    - Associate editor of Journal of Cardiovascular Translational Research

    - Associate Editor Discovery Biology and Medicine 

    - Editorial Board memeber of Clinical and Translational Physiology (Frontiers in Physiology)                                   

    - Editorial Board member of Non-coding RNA Investigation

    - Scientific reviewer for journal (selected): Arterioslerosis, Thrombosis and Vascular biology (ATVB),   American Journal of Physiology, British Journal of Pharmacology, Cardiovascular research (Card Res), Circulation (Circ), Circulation research (Circ Res), Clinical Science, Current Pharmaceutical Design, European Heart Journal (EHJ), Journal of the American College of Cardiology (JACC), Journal of Cellular and Molecular Medicine (JCMM), New England Journal of Medicine (NEJoM), Physiological Genomics, Plos One, Stem Cells International, Science.

    - Scientific reviewer for grant providers (selected): Dutch Heart Foundation, NWO, Foundation de Cooperation Scientifique Campus Paris Saclay (FCS, France), Health and Medical Research Fund (China), Danish Council for Independent Research, National Center of Science and Technology Evaluation (Kazachstan), Medical Research Council (UK), Sir Henry Dale Fellowship (UK), Science foundation of Ireland

     - Lecturer teaching program of undergraduate students at the Faculty of Medicine, Utrecht University.

    - University Utrecht - advisory board for ERC Starting and consolidator Grant-candidates

    - Advisory Board van de Graduate School of Life Sciences University Utrecht

Fellowship and Awards

  • 2004-2005 Interuniversity Institute of the Netherlands (ICIN)-fellowship
    2007-2009 Novartis Foundation for Cardiovascular Excellence Grant
    2008-2009 van Ruyvenstichting
    2009-2012 UMC Utrecht focus and mass area “cardiovascular research”
    2010-2014 BMM-YIC
    2011-2015 Translationeel Adult Stamcelonderzoek:
    2012-2017 HUMAN STem cells for CArdiac REpair (HUSTCARE)
    2014-2018 LSH Impuls: MIGRATE
    2015-2017: BMM Smartcare2 – Smart microtissues for cardiac regeneration
    2015-2019: Horizon 2020 – TECHNOBEAT (PHC-16-2015)
    2015-2018: CAS-NWO Program; Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathy
    2017-2022: Horizon 2020 - ERC-2016-CoG – 725229:  EVICARE: Extracellular Vesicle-Inspired CArdiac Repair
    2017-2019: Vrienden UMCU: “Innovatieve directe medicijnafgifte in het hart”
    2018-2022 – Horizon 2020 Marie S. Curie, COFUND programme RESCUE: Local Training Network on REgenerative medicine and Stem Cell technology in UtrEcht 
    2018-2021: Technology Of Protein delivery through Extracellular Vesicles to target PCSK9 (TOP-EV), Dutch Heart Foundation 
    2019-2024: RegMed XB Cardiovascular Moonshot 
    2019-2024: Horizon 2020 BRAV3 (SC1-BHC-07-2019)
    2020-2021: NL-PET - Next Level genome editing - efficient and precise correction of PLN/R14del using Prime Editing Technology. PLN foundation

     

Research Output (243)

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

Buikema Jan W, Lee Soah, Goodyer William R, Maas Renee G, Chirikian Orlando, Li Guang, Miao Yi, Paige Sharon L, Lee Daniel, Wu Haodi, Paik David T, Rhee Siyeon, Tian Lei, Galdos Francisco X, Puluca Nazan, Beyersdorf Benjamin, Hu James, Beck Aimee, Venkamatran Sneha, Swami Srilatha, Wijnker Paul, Schuldt Maike, Dorsch Larissa M, van Mil Alain, Red-Horse Kristy, Wu Joy Y, Geisen Caroline, Hesse Michael, Serpooshan Vahid, Jovinge Stefan, Fleischmann Bernd K, Doevendans Pieter A, van der Velden Jolanda, Garcia K Christopher, Wu Joseph C, Sluijter Joost P G, Wu Sean M 2 jul 2020, In: Cell stem cell. 27 , p. 50-63.e5

Loss of miR-132/212 Has No Long-Term Beneficial Effect on Cardiac Function After Permanent Coronary Occlusion in Mice

Lei Zhiyong, Fang Juntao, Deddens Janine C, Metz Corina H G, van Eeuwijk Esther C M, El Azzouzi Hamid, Doevendans Pieter A, Sluijter Joost P G jun 2020, In: Frontiers in Physiology. 11 9 p.

miR-19a-3p containing exosomes improve function of ischaemic myocardium upon shock wave therapy

Gollmann-Tepeköylü Can, Pölzl Leo, Graber Michael, Hirsch Jakob, Nägele Felix, Lobenwein Daniela, Hess Michael W., Blumer Michael J., Kirchmair Elke, Zipperle Johannes, Hromada Carina, Mühleder Severin, Hackl Hubert, Hermann Martin, Al Khamisi Hemse, Förster Martin, Lichtenauer Michael, Mittermayr Rainer, Paulus Patrick, Fritsch Helga, Bonaros Nikolaos, Kirchmair Rudolf, Sluijter Joost P.G., Davidson Sean, Grimm Michael, Holfeld Johannes 1 mei 2020, In: Cardiovascular research. 116 , p. 1226-1236 11 p.

Control of Angiogenesis via a VHL/miR-212/132 Axis

Lei Zhiyong, Klasson Timothy D., Brandt Maarten M., van de Hoek Glenn, Logister Ive, Cheng Caroline, Doevendans Pieter A., Sluijter Joost P.G., Giles Rachel H. 19 apr 2020, In: Cells. 9 11 p.

Plasma Immunoglobulin Levels Prior to Cardiac Transplantation are Associated with Post-Transplantation Survival

van den Hoogen P., Huibers M. M., van den Dolder F. W., de Weger R. A., Siera E., de Jonge N., Doevendans P. A., Sluijter J. P., de Jager S. C., Vink A. apr 2020, In: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 39 , p. S500-S501

Prognostic biomarker soluble ST2 exhibits diurnal variation in chronic heart failure patients

Crnko Sandra, Printezi Markella I, Jansen Tijn P J, Leiteris Laurynas, van der Meer Manon G, Schutte Hilde, van Faassen Martijn, du Pré Bastiaan C, de Jonge Nicolaas, Asselbergs Folkert W, Gaillard Carlo A J M, Kemperman Hans, Doevendans Pieter A, Sluijter Joost P G, van Laake Linda W 31 mrt 2020, In: ESC heart failure. 7 , p. 1224-1233 10 p.

Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality

El Azzouzi Hamid, Vilaça Andreia P, Feyen Dries A M, Gommans Willemijn M, de Weger Roel A, Doevendans Pieter A F, Sluijter Joost P G 18 mrt 2020, In: Frontiers in cardiovascular medicine. 7 16 p.

Non-coding RNAs in Cardiac Regeneration

van der Ven C. F.T., Hogewoning B. C.R., van Mil A., Sluijter Joost P.G. 2020, p. 163-180 18 p.

Polymeric siRNA gene delivery- transfection efficiency versus cytotoxicity

Sluijter Joost P.G., Kargaard A, Klumperman B. 28 dec 2019, In: Journal of Controlled Release. 316 , p. 263-291 29 p.

Biofabrication of Cell-Derived Nanovesicles: A Potential Alternative to Extracellular Vesicles for Regenerative Medicine

Ilahibaks Nazma, Lei Zhiyong, Deshantri AK, Jiang L, Schiffelers Raymond, Vader Pieter, Sluijter Joost P.G., Mol Emma nov 2019, In: Cells. 8

All Research Output (243)