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prof. dr. J.P.G. (Joost P.G.) Sluijter

Full Professor

  • Onderzoek Cardiovasculair Reg. Med.

prof. dr. J.P.G. (Joost P.G.) Sluijter

Biography

Prof Joost Sluijter is a Medical Biologist and got his PhD in 2004 at the University Utrecht on “Collagen turnover in arterial disease”. After being a postdoctoral research fellow at Indiana University-Purdue University (IUPUI), he returned to the University Medical Centre Utrecht (the Netherlands) in 2006.  In his research group, they focus on stimulating cardiac regeneration, thereby using approaches that can lead to improved recovery of cardiac tissue upon injury. In recent years, they identified miRNAs that can push cell lineage specifications and how they could improve progenitor cell transplantation, specifically improving local delivery and cell retention. In this work, they have started to use 3D-bioprinting and advanced technologies of cardiac tissue engineering. His group substantially improved cell delivery to the myocardium, from which they also realized that most of the injected cell action was due to the potential paracrine actions. They therefore started to study the use of secreted vesicles by these cells as a novel approach to induce cardiac repair.

Prof Joost Sluijter is heading the Experimental Cardiology Laboratory and is nucleus member of the Regenerative Medicine program of the UMCU, he is nucleus member of the ESC working groups Cellular Biology of the Heart and Cardiovascular Regenerative & Reparative Medicine, has several editorial roles for journals, published >170 papers, and is awardee of an ERC consolidator grant.

Side Activities

    • Nucleus member working group on Cellular Biology of the Heart (European Society of Cardiology)

    • Immediate past-Chair working group on Cellular Biology of the Heart (European Society of Cardiology)

    • Nucleus member working group on Cardiovascular Regenerative & Reparative Medicine (European Society of Cardiology)

    • Board member of the Council on Basic Cardiovascular Science (European Society of Cardiology)

    • Associate editor of Journal of Cardiovascular Translational Research

    • Associate Editor Discovery Biology and Medicine 

    • Editorial Board memeber of Clinical and Translational Physiology (Frontiers in Physiology)                                   

    • Editorial Board member of Non-coding RNA Investigation

    • Scientific reviewer for journal (selected): Arterioslerosis, Thrombosis and Vascular biology (ATVB),   American Journal of Physiology, British Journal of Pharmacology, Cardiovascular research (Card Res), Circulation (Circ), Circulation research (Circ Res), Clinical Science, Current Pharmaceutical Design, European Heart Journal (EHJ), Journal of the American College of Cardiology (JACC), Journal of Cellular and Molecular Medicine (JCMM), New England Journal of Medicine (NEJoM), Physiological Genomics, Plos One, Stem Cells International, Science.

    • Scientific reviewer for grant providers (selected): Dutch Heart Foundation, NWO, Foundation de Cooperation Scientifique Campus Paris Saclay (FCS, France), Health and Medical Research Fund (China), Danish Council for Independent Research, National Center of Science and Technology Evaluation (Kazachstan), Medical Research Council (UK), Sir Henry Dale Fellowship (UK), Science foundation of Ireland

    •  Lecturer teaching program of undergraduate students at the Faculty of Medicine, Utrecht University.

    • University Utrecht - advisory board for ERC Starting and consolidator Grant-candidates

    • Advisory Board van de Graduate School of Life Sciences University Utrecht

Fellowship and Awards

    • 2004-2005 Interuniversity Institute of the Netherlands (ICIN)-fellowship
    • 2007-2009 Novartis Foundation for Cardiovascular Excellence Grant
    • 2008-2009 van Ruyvenstichting
    • 2009-2012 UMC Utrecht focus and mass area “cardiovascular research”
    • 2010-2014 BMM-YIC
    • 2011-2015 Translationeel Adult Stamcelonderzoek:
    • 2012-2017 HUMAN STem cells for CArdiac REpair (HUSTCARE)
    • 2014-2018 LSH Impuls: MIGRATE
    • 2015-2017: BMM Smartcare2 – Smart microtissues for cardiac regeneration
    • 2015-2019: Horizon 2020 – TECHNOBEAT (PHC-16-2015)
    • 2015-2018: CAS-NWO Program; Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathy
    • 2017-2022: Horizon 2020 - ERC-2016-CoG – 725229:  EVICARE: Extracellular Vesicle-Inspired CArdiac Repair
    • 2017-2019: Vrienden UMCU: “Innovatieve directe medicijnafgifte in het hart”
    • 2018-2022 – Horizon 2020 Marie S. Curie, COFUND programme RESCUE: Local Training Network on REgenerative medicine and Stem Cell technology in UtrEcht 
    • 2018-2021: Technology Of Protein delivery through Extracellular Vesicles to target PCSK9 (TOP-EV), Dutch Heart Foundation 
    • 2019-2024: RegMed XB Cardiovascular Moonshot 
    • 2019-2024: Horizon 2020 BRAV3 (SC1-BHC-07-2019)
    • 2020-2021: NL-PET - Next Level genome editing - efficient and precise correction of PLN/R14del using Prime Editing Technology. PLN foundation

     

Research Output (251)

Minimally Invasive Ways of Determining Circadian Rhythms in Humans

Crnko Sandra, Schutte Hilde, Doevendans Pieter, Sluijter Joost P G, van Laake Linda W 16 dec 2020, In: Physiology (Bethesda, Md.). 36 , p. 7-20 14 p.

Damage-Associated Molecular Patterns in Myocardial Infarction and Heart Transplantation:The Road to Translational Success

Silvis Max J M, Kaffka Genaamd Dengler Selma E, Odille Clémence A, Mishra Mudit, van der Kaaij Niels P, Doevendans Pieter, Sluijter Joost P G, de Kleijn Dominique P V, de Jager Saskia C A, Bosch Lena, van Hout Gerardus P J 8 dec 2020, In: Frontiers in Immunology. 11 , p. 599511

Extracellular Vesicle-Associated Proteins in Tissue Repair

Roefs Marieke T, Sluijter Joost P G, Vader Pieter dec 2020, In: Trends in Cell Biology. 30 , p. 990-1013 24 p.

Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

Martins-Marques Tania, Ribeiro-Rodrigues Teresa, de Jager Saskia C., Zuzarte Monica, Ferreira Cátia, Cruz Pedro, Reis Liliana, Baptista Rui, Gonçalves Lino, Sluijter Joost P.G., Girao Henrique 23 okt 2020, In: Life Science Alliance. 3

Comparing Conventional Chemotherapy to Chronomodulated Chemotherapy for Cancer Treatment:Protocol for a Systematic Review

Kilgallen Aoife B, Štibler Urška, Printezi Markella I, Putker Marrit, Punt Cornelis J A, Sluijter Joost P G, May Anne M, van Laake Linda W 21 okt 2020, In: JMIR Research Protocols. 9 , p. e18023

Induced Pluripotent Stem Cells

van Mil Alain, Neef Klaus, Balk Geerthe Margriet, Buikema Jan Willem, Sluijter Joost P.G., Doevendans PA sep 2020, 2020 , p. 439-455 17 p.

Cellular and Molecular Mechanism of Cardiac Regeneration:A Comparison of Newts, Zebrafish, and Mammals

de Wit Lousanne, Fang Juntao, Neef Klaus, Xiao Junjie, A Doevendans Pieter, Schiffelers Raymond M, Lei Zhiyong, Sluijter Joost P G 19 aug 2020, In: Biomolecules. 10 20 p.

Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes

Buikema Jan W, Lee Soah, Goodyer William R, Maas Renee G, Chirikian Orlando, Li Guang, Miao Yi, Paige Sharon L, Lee Daniel, Wu Haodi, Paik David T, Rhee Siyeon, Tian Lei, Galdos Francisco X, Puluca Nazan, Beyersdorf Benjamin, Hu James, Beck Aimee, Venkamatran Sneha, Swami Srilatha, Wijnker Paul, Schuldt Maike, Dorsch Larissa M, van Mil Alain, Red-Horse Kristy, Wu Joy Y, Geisen Caroline, Hesse Michael, Serpooshan Vahid, Jovinge Stefan, Fleischmann Bernd K, Doevendans Pieter A, van der Velden Jolanda, Garcia K Christopher, Wu Joseph C, Sluijter Joost P G, Wu Sean M 2 jul 2020, In: Cell stem cell. 27 , p. 50-63.e5

Loss of miR-132/212 Has No Long-Term Beneficial Effect on Cardiac Function After Permanent Coronary Occlusion in Mice

Lei Zhiyong, Fang Juntao, Deddens Janine C, Metz Corina H G, van Eeuwijk Esther C M, El Azzouzi Hamid, Doevendans Pieter A, Sluijter Joost P G jun 2020, In: Frontiers in Physiology. 11 9 p.

miR-19a-3p containing exosomes improve function of ischaemic myocardium upon shock wave therapy

Gollmann-Tepeköylü Can, Pölzl Leo, Graber Michael, Hirsch Jakob, Nägele Felix, Lobenwein Daniela, Hess Michael W., Blumer Michael J., Kirchmair Elke, Zipperle Johannes, Hromada Carina, Mühleder Severin, Hackl Hubert, Hermann Martin, Al Khamisi Hemse, Förster Martin, Lichtenauer Michael, Mittermayr Rainer, Paulus Patrick, Fritsch Helga, Bonaros Nikolaos, Kirchmair Rudolf, Sluijter Joost P.G., Davidson Sean, Grimm Michael, Holfeld Johannes 1 mei 2020, In: Cardiovascular research. 116 , p. 1226-1236 11 p.

All Research Output (251)