dr. P.A.M. (Paul) Smeets

dr. P.A.M. (Paul) Smeets

Associate Professor
dr. P.A.M. (Paul) Smeets
  • Image Sciences Institute

Research Programs




Paul Smeets is associate professor at the UMC Utrecht and has a background in Behavioral Biology. His PhD work, at the Image Sciences Institute (ISI), aimed at finding biomarkers of satiety in the human brain, using functional MRI. Currently, he works at ISI / UMC Utrecht and at the Division of Human Nutrition and Health of Wageningen University. The central theme in his research is the decision to eat, which is taken in the brain on the basis of multiple neural as well as hormonal signals. Research topics include the neural correlates of taste, satiety and (un)healthy food choice, gut-brain interactions, effects of personality characteristics on food-induced brain responses and functional neuroimaging in anorexia nervosa. In recent years he has been using MRI techniques to study (gastric) digestion.

Research line

Nutritional and Translational Neuroscience

Most recent key publications

1: Smeets, P., Deng, R., Van Eijnatten, E., & Mayar, M. (2021). Monitoring food digestion with magnetic resonance techniques. Proceedings of the Nutrition Society, 80(2), 148-158. doi:10.1017/S0029665120007867

2: Smeets PAM, Dagher A, Hare TA, Kullmann S, van der Laan LN, Poldrack RA, Preissl H, Small D, Stice E, Veldhuizen MG. Good practice in food-related neuroimaging. Am J Clin Nutr. 2019 Mar 1;109(3):491-503. doi: 10.1093/ajcn/nqy344.

3: van Meer F, van der Laan LN, Viergever MA, Adan RAH, Smeets PAM; I.Family Consortium. Considering healthiness promotes healthier choices but modulates medial prefrontal cortex differently in children compared with adults. Neuroimage. 2017 Oct 1;159:325-333. doi: 10.1016/j.neuroimage.2017.08.007.

4: van Meer F, van der Laan LN, Charbonnier L, Viergever MA, Adan RA, Smeets PA; I.Family Consortium. Developmental differences in the brain response to unhealthy food cues: an fMRI study of children and adults. Am J Clin Nutr. 2016 Dec;104(6):1515-1522.

5: Camps G, Mars M, de Graaf C, Smeets PA. Empty calories and phantom fullness: a randomized trial studying the relative effects of energy density and viscosity on gastric emptying determined by MRI and satiety. Am J Clin Nutr. 2016 Jul;104(1):73-80. doi:10.3945/ajcn.115.129064.

6: van Meer F, van der Laan LN, Adan RA, Viergever MA, Smeets PA. What you see is what you eat: an ALE meta-analysis of the neural correlates of food viewing in children and adolescents. Neuroimage. 2015 Jan 1;104:35-43. doi:10.1016/j.neuroimage.2014.09.069.

Research Output (91)

A guide for authors and readers of the American Society for Nutrition Journals on the proper use of P values and strategies that promote transparency and improve research reproducibility

Sorkin John D, Manary Mark, Smeets Paul A M, MacFarlane Amanda J, Astrup Arne, Prigeon Ronald L, Hogans Beth B, Odle Jack, Davis Teresa A, Tucker Katherine L, Duggan Christopher P, Tobias Deirdre K 13 jul 2021, In: American Journal of Clinical Nutrition. 114 , p. 1280-1285 6 p.

Associations between ghrelin and leptin and neural food cue reactivity in a fasted and sated state

Wever Mirjam C M, van Meer Floor, Charbonnier Lisette, Crabtree Daniel R, Buosi William, Giannopoulou Angeliki, Androutsos Odysseas, Johnstone Alexandra M, Manios Yannis, Meek Claire L, Holst Jens J, Smeets Paul A M, 7 jul 2021, In: NeuroImage. 240 , p. 1-11 11 p.

Investigating morphological changes in the brain in relation to etiology and duration of olfactory dysfunction with voxel-based morphometry

Postma E. M., Smeets P. A.M., Boek W. M., Boesveldt S. 16 jun 2021, In: Scientific Reports. 11 , p. 12704 8 p.

Corrigendum to “Effects of hunger state on the brain responses to food cues across the life span” [NeuroImage 171 (2018) 246-255](S1053811918300144)(10.1016/j.neuroimage.2018.01.012)

Charbonnier L, van Meer F, Johnstone A M, Crabtree D, Buosi W, Manios Y, Androutsos O, Giannopoulou A, Viergever M A, Smeets P A M, 16 mrt 2021, In: NeuroImage. 233

The influence of acute partial sleep deprivation on liking, choosing and consuming high- and low-energy foods

Benjamins Jeroen S., Hooge Ignace T.C., Benedict Christian, Smeets Paul A.M., van der Laan Laura N. mrt 2021, In: Food Quality and Preference. 88

Automatic segmentation of the olfactory bulbs in MRI

Noothout Julia M.H., Postma Elbrich M., Boesveldt Sanne, De Vos Bob D., Smeets Paul A.M., Išgum Ivana 2021,

Distraction decreases rIFG-putamen connectivity during goal-directed effort for food rewards

Duif Iris, Wegman Joost, de Graaf Kees, Smeets Paul A M, Aarts Esther 1 dec 2020, In: Scientific Reports. 10

The importance of swelling for in vitro gastric digestion of whey protein gels

Deng Ruoxuan, Mars Monica, Van Der Sman Ruud G.M., Smeets Paul A.M., Janssen Anja E.M. 15 nov 2020, In: Food chemistry. 330 7 p.

Deep Learning-Based Regression and Classification for Automatic Landmark Localization in Medical Images

Noothout Julia M H, De Vos Bob D, Wolterink Jelmer M, Postma Elbrich M, Smeets Paul A M, Takx Richard A P, Leiner Tim, Viergever Max A, Isgum Ivana 13 jul 2020, In: IEEE transactions on medical imaging. 39 , p. 4011-4022 12 p.

Endocrine Cephalic Phase Responses to Food Cues:A Systematic Review

Lasschuijt Marlou P, Mars Monica, de Graaf Cees, Smeets Paul A M 9 jun 2020, In: Advances in nutrition (Bethesda, Md.). 11 , p. 1364-1383 20 p.

All research output

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