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dr. H.J.G. Snippert

dr. H.J.G. Snippert

Associate Professor
  • Group Snippert, section Molecular Cancer Research

Research Programs

Strategic Program Cancer

Research Output (43)

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

Heinz Maria C, Peters Niek A, Oost Koen C, Lindeboom Rik G H, van Voorthuijsen Lisa, Fumagalli Arianna, van der Net Mirjam C, de Medeiros Gustavo, Hageman Joris H, Verlaan-Klink Ingrid, Borel Rinkes Inne H M, Liberali Prisca, Gloerich Martijn, van Rheenen Jacco, Vermeulen Michiel, Kranenburg Onno, Snippert Hugo J G 15 May 2022, In: Cancer Research. 82 , p. 1953-1968 16 p.

Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

Bollen Yannik, Hageman Joris H, van Leenen Petra, Derks Lucca L M, Ponsioen Bas, Buissant des Amorie Julian R, Verlaan-Klink Ingrid, van den Bos Myrna, Terstappen Leon W M M, van Boxtel Ruben, Snippert Hugo J G 28 Jan 2022, In: PLoS Biology. 20 , p. 1-16

Chromosomal copy number heterogeneity predicts survival rates across cancers

van Dijk Erik, van den Bosch Tom, Lenos Kristiaan J, El Makrini Khalid, Nijman Lisanne E, van Essen Hendrik F B, Lansu Nico, Boekhout Michiel, Hageman Joris H, Fitzgerald Rebecca C, Punt Cornelis J A, Tuynman Jurriaan B, Snippert Hugo J G, Kops Geert J P L, Medema Jan Paul, Ylstra Bauke, Vermeulen Louis, Miedema Daniël M Dec 2021, In: Nature Communications. 12 , p. 1-12

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Ponsioen Bas, Post Jasmin B, Buissant des Amorie Julian R, Laskaris Dimitrios, van Ineveld Ravian L, Kersten Simone, Bertotti Andrea, Sassi Francesco, Sipieter François, Cappe Benjamin, Mertens Sander, Verlaan-Klink Ingrid, Boj Sylvia F, Vries Rob G J, Rehmann Holger, Vandenabeele Peter, Riquet Franck B, Trusolino Livio, Bos Johannes L, Snippert Hugo J G 1 Apr 2021, In: Nature Cell Biology. 23 , p. 377-390 14 p.

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Bollen Yannik, Stelloo Ellen, van Leenen Petra, van den Bos Myrna, Ponsioen Bas, Lu Bingxin, van Roosmalen Markus J., Bolhaqueiro Ana C.F., Kimberley Christopher, Mossner Maximilian, Cross William C.H., Besselink Nicolle J.M., van der Roest Bastiaan, Boymans Sander, Oost Koen C., de Vries Sippe G., Rehmann Holger, Cuppen Edwin, Lens Susanne M.A., Kops Geert J.P.L., Kloosterman Wigard P., Terstappen Leon W.M.M., Barnes Chris P., Sottoriva Andrea, Graham Trevor A., Snippert Hugo J.G. 2021, In: Nature Genetics. 53 , p. 1187-1195 9 p.

Intestinal Regeneration:Regulation by the Microenvironment

Hageman Joris H., Heinz Maria C., Kretzschmar Kai, van der Vaart Jelte, Clevers Hans, Snippert Hugo J.G. 24 Aug 2020, In: Developmental Cell. 54 , p. 435-446 12 p.

Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

Bruens Lotte, Ellenbroek Saskia Inge Johanna, Suijkerbuijk Saskia Jacoba Elisabeth, Azkanaz Maria, Hale Alexander James, Toonen Pim, Flanagan Dustin James, Sansom Owen James, Snippert Hugo Johannes, van Rheenen Jacco 21 Jul 2020, In: Cell Reports. 32 , p. 1-10

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

Beumer Joep, Puschhof Jens, Bauzá-Martinez Julia, Martínez-Silgado Adriana, Elmentaite Rasa, James Kylie R, Ross Alexander, Hendriks Delilah, Artegiani Benedetta, Busslinger Georg A, Ponsioen Bas, Andersson-Rolf Amanda, Saftien Aurelia, Boot Charelle, Kretzschmar Kai, Geurts Maarten H, Bar-Ephraim Yotam E, Pleguezuelos-Manzano Cayetano, Post Yorick, Begthel Harry, van der Linden Franka, Lopez-Iglesias Carmen, van de Wetering Willine J, van der Linden Reinier, Peters Peter J, Heck Albert J R, Goedhart Joachim, Snippert Hugo, Zilbauer Matthias, Teichmann Sarah A, Wu Wei, Clevers Hans 11 Jun 2020, In: Cell. 181 , p. 1291-1306.e19

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Fumagalli Arianna, Oost Koen C., Kester Lennart, Morgner Jessica, Bornes Laura, Bruens Lotte, Spaargaren Lisa, Azkanaz Maria, Schelfhorst Tim, Beerling Evelyne, Heinz Maria C., Postrach Daniel, Seinstra Danielle, Sieuwerts Anieta M., Martens John W.M., van der Elst Stefan, van Baalen Martijn, Bhowmick Debajit, Vrisekoop Nienke, Ellenbroek Saskia I.J., Suijkerbuijk Saskia J.E., Snippert Hugo J., van Rheenen Jacco 2 Apr 2020, In: Cell stem cell. 26 , p. 569-578.e7

Colorectal Cancer Modeling with Organoids:Discriminating between Oncogenic RAS and BRAF Variants

Post Jasmin B, Roodhart Jeanine M L, Snippert Hugo J G Feb 2020, In: Trends in Cancer. 6 , p. 111-129 19 p.

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