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dr. H.J.G. Snippert

Associate Professor
  • Group Snippert, section Molecular Cancer Research

Research Programs

Strategic Program Cancer

Research Output (38)

Intestinal Regeneration:Regulation by the Microenvironment

Hageman Joris H., Heinz Maria C., Kretzschmar Kai, van der Vaart Jelte, Clevers Hans, Snippert Hugo J.G. 24 aug 2020, In: Developmental Cell. 54 , p. 435-446 12 p.

Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

Bruens Lotte, Ellenbroek Saskia Inge Johanna, Suijkerbuijk Saskia Jacoba Elisabeth, Azkanaz Maria, Hale Alexander James, Toonen Pim, Flanagan Dustin James, Sansom Owen James, Snippert Hugo Johannes, van Rheenen Jacco 21 jul 2020, In: Cell Reports. 32 , p. 1-10

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

Beumer Joep, Puschhof Jens, Bauzá-Martinez Julia, Martínez-Silgado Adriana, Elmentaite Rasa, James Kylie R, Ross Alexander, Hendriks Delilah, Artegiani Benedetta, Busslinger Georg A, Ponsioen Bas, Andersson-Rolf Amanda, Saftien Aurelia, Boot Charelle, Kretzschmar Kai, Geurts Maarten H, Bar-Ephraim Yotam E, Pleguezuelos-Manzano Cayetano, Post Yorick, Begthel Harry, van der Linden Franka, Lopez-Iglesias Carmen, van de Wetering Willine J, van der Linden Reinier, Peters Peter J, Heck Albert J R, Goedhart Joachim, Snippert Hugo, Zilbauer Matthias, Teichmann Sarah A, Wu Wei, Clevers Hans 11 jun 2020, In: Cell. 181 , p. 1291-1306.e19

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Fumagalli Arianna, Oost Koen C., Kester Lennart, Morgner Jessica, Bornes Laura, Bruens Lotte, Spaargaren Lisa, Azkanaz Maria, Schelfhorst Tim, Beerling Evelyne, Heinz Maria C., Postrach Daniel, Seinstra Danielle, Sieuwerts Anieta M., Martens John W.M., van der Elst Stefan, van Baalen Martijn, Bhowmick Debajit, Vrisekoop Nienke, Ellenbroek Saskia I.J., Suijkerbuijk Saskia J.E., Snippert Hugo J., van Rheenen Jacco 2 apr 2020, In: Cell stem cell. 26 , p. 569-578.e7

Colorectal Cancer Modeling with Organoids:Discriminating between Oncogenic RAS and BRAF Variants

Post Jasmin B, Roodhart Jeanine M L, Snippert Hugo J G feb 2020, In: Trends in Cancer. 6 , p. 111-129 19 p.

Snake Venom Gland Organoids

Post Yorick, Puschhof Jens, Beumer Joep, Kerkkamp Harald M., de Bakker Merijn A.G., Slagboom Julien, de Barbanson Buys, Wevers Nienke R., Spijkers Xandor M., Olivier Thomas, Kazandjian Taline D., Ainsworth Stuart, Iglesias Carmen Lopez, van de Wetering Willine J., Heinz Maria C., van Ineveld Ravian L., van Kleef Regina G.D.M., Begthel Harry, Korving Jeroen, Bar-Ephraim Yotam E., Getreuer Walter, Rios Anne C., Westerink Remco H.S., Snippert Hugo J.G., van Oudenaarden Alexander, Peters Peter J., Vonk Freek J., Kool Jeroen, Richardson Michael K., Casewell Nicholas R., Clevers Hans 23 jan 2020, In: Cell. 180 , p. 233-247.e21

High-resolution 3D imaging of fixed and cleared organoids

Dekkers Johanna F., Alieva Maria, Wellens Lianne M., Ariese Hendrikus C.R., Jamieson Paul R., Vonk Annelotte M., Amatngalim Gimano D., Hu Huili, Oost Koen C., Snippert Hugo J.G., Beekman Jeffrey M., Wehrens Ellen J., Visvader Jane E., Clevers Hans, Rios Anne C. 1 jun 2019, In: Nature Protocols. 14 , p. 1756-1771 16 p.

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Kopper Oded, de Witte Chris J, Lõhmussaar Kadi, Valle-Inclan Jose Espejo, Hami Nizar, Kester Lennart, Balgobind Anjali Vanita, Korving Jeroen, Proost Natalie, Begthel Harry, van Wijk Lise M, Revilla Sonia Aristín, Theeuwsen Rebecca, van de Ven Marieke, van Roosmalen Markus J, Ponsioen Bas, Ho Victor W H, Neel Benjamin G, Bosse Tjalling, Gaarenstroom Katja N, Vrieling Harry, Vreeswijk Maaike P G, van Diest Paul J, Witteveen Petronella O, Jonges Trudy, Bos Johannes L, van Oudenaarden Alexander, Zweemer Ronald P, Snippert Hugo J G, Kloosterman Wigard P, Clevers Hans mei 2019, In: Nature Medicine. 25 , p. 838-849 12 p.

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Bolhaqueiro Ana C F, Ponsioen Bas, Bakker Bjorn, Klaasen Sjoerd J, Kucukkose Emre, van Jaarsveld Richard H, Vivié Judith, Verlaan-Klink Ingrid, Hami Nizar, Spierings Diana C J, Sasaki Nobuo, Dutta Devanjali, Boj Sylvia F, Vries Robert G J, Lansdorp Peter M, van de Wetering Marc, van Oudenaarden Alexander, Clevers Hans, Kranenburg Onno, Foijer Floris, Snippert Hugo J G, Kops Geert J P L mei 2019, In: Nature Genetics. 51 , p. 824-834 11 p.

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Huels D. J., Bruens L., Hodder M. C., Cammareri P., Campbell A. D., Ridgway R. A., Gay D. M., Solar-Abboud M., Faller W. J., Nixon C., Zeiger L. B., McLaughlin M. E., Morrissey E., Winton D. J., Snippert H. J., Van Rheenen J., Sansom O. J. 1 dec 2018, In: Nature Communications. 9

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