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dr. ir. G.C.M. (Trudy) Straetemans

dr. ir. G.C.M. (Trudy) Straetemans

Associate Professor

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Research Output (22)

TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice

Johanna Inez, Hernández-López Patricia, Heijhuurs Sabine, Bongiovanni Laura, de Bruin Alain, Beringer Dennis, van Dooremalen Sanne, Shultz Leonard D, Ishikawa Fumihiko, Sebestyen Zsolt, Straetemans Trudy, Kuball Jürgen 5 Feb 2020, In: Journal of Leukocyte Biology. 107 , p. 1069-1079 11 p.

gamma delta T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity

Janssen Anke, Villacorta Hidalgo José, Beringer Dennis X, van Dooremalen Sanne F.J., Fernando Febilla, van Diest Eline, Terrizzi Antonela R, Bronsert Peter, Kock Sylvia, Schmitt-Graeff Annette, Werner Martin, Heise Kerstin, Follo Marie, Straetemans Trudy, Sebestyen Zsolt, Chudakov Dmitriy M, Kasatskaya Sofya A, Frenkel Felix E, Ravens Sarina, Spierings Eric, Prinz Immo, Küppers Ralf, Malkovsky Miroslav, Fisch Paul, Kuball Jurgen 4 Feb 2020, In: Cancer Immunology Research. 8 , p. 530-543 14 p.

TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product

Straetemans Trudy, Janssen Anke, Jansen Koen, Doorn Ruud, Aarts Tineke, van Muyden Anna D D, Simonis Marieke, Bergboer Judith, de Witte Moniek, Sebestyen Zsolt, Kuball Jurgen 14 Dec 2019, In: Molecular Therapy. 28 , p. 561-571 11 p.

Identification of a tumor-specific allo-HLA-restricted γδTCR

Kierkels G J J, Scheper W, Meringa A D, Johanna I, Beringer D X, Janssen A, Schiffler M, Aarts-Riemens T, Kramer L, Straetemans T, Heijhuurs S, Leusen J H W, San José E, Fuchs K, Griffioen M, Falkenburg J H, Bongiovanni L, de Bruin A, Vargas-Diaz D, Altelaar M, Heck A J R, Shultz L D, Ishikawa F, Nishimura M I, Sebestyén Z, Kuball J 8 Oct 2019, In: Blood Advances. 3 , p. 2870-2882 13 p.

Evaluating in vivo efficacy - Toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells

Johanna Inez, Straetemans Trudy, Heijhuurs Sabine, Aarts-Riemens Tineke, Norell Håkan, Bongiovanni Laura, De Bruin Alain, Sebestyen Zsolt, Kuball Jürgen 12 Mar 2019, In: Journal for ImmunoTherapy of Cancer. 7

Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model

Braham Maaike V.J., Minnema Monique C., Aarts Tineke, Sebestyen Zsolt, Straetemans Trudy, Vyborova Anna, Kuball Jurgen, Öner F. Cumhur, Robin Catherine, Alblas Jacqueline 3 Jun 2018, In: OncoImmunology. 7

GMP-grade manufacturing of T cells engineered to express a defined γδTCR

Straetemans Trudy, Kierkels Guido J.J., Doorn Ruud, Jansen Koen, Heijhuurs Sabine, dos Santos Joao M., van Muyden Anna D.D., Vie Henri, Clemenceau Béatrice, Raymakers Reinier, de Witte Moniek, Sebestyén Zsolt, Kuball Jürgen 30 May 2018, In: Frontiers in Immunology [E]. 9

The next step toward GMP-grade production of engineered immune cells

Kierkels Guido J J, Straetemans Trudy, de Witte Moniek A, Kuball Jürgen Feb 2016, In: OncoImmunology. 5

Untouched GMP-ready purified engineered immune cells to treat cancer

Straetemans Trudy, Gründer Cordula, Heijhuurs Sabine, Hol Samantha, Slaper-Cortenbach Ineke, Bönig Halvard, Sebestyen Zsolt, Kuball Jürgen 1 Sep 2015, In: Clinical Cancer Research. 21 , p. 3957-3968 12 p.

Orchestrating an immune response against cancer with engineered immune cells expressing αβTCRs, CARs, and innate immune receptors:an immunological and regulatory challenge

de Witte Moniek A, Kierkels Guido J J, Straetemans Trudy, Britten Cedrik M, Kuball Jürgen Jul 2015, In: Cancer Immunology, Immunotherapy. 64 , p. 893-902 10 p.

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