dr. H.W. Uh
dr. H.W. Uh
- Julius Center, dept. Data Science & Biostatistics
Research Programs
Biography
Biography
After years of being a concert pianist, Hae-Won Uh studied math as a hobby. She obtained MSc and PhD in Mathematical Statistics from University of Amsterdam. She has been working as a researcher in the multidisciplinary environment, specializing in Statistical Modeling and Data Science. She has been involved in various EU-funded projects: MIMOmics, BigData@Heart, IMforFUTURE, and MSA-Omics.
Her research focuses on the analysis of high-dimensional biological and medical data: specifically, statistical leaning with sparsity. In the era of big data, extracting hidden patterns from noisy heterogeneous data is essential but challenging. She develops methods for integrated analysis of various omics datasets (e.g. genetics, transcriptomics, metabolomics) to obtain more insight into biological mechanisms underlying traits. Such extracted patient-specific molecular profiles from multiple omics datasets will lead to better predictions of health outcomes.
Compositional data describe amounts of components of specimens, when the size of each specimen is constant; relative portions sum up to 100%. Because of this constraint of constant sum, direct applications of multivariate statistical methods may result in spurious conclusions. She develops statistical methods specifically for microbiome study: in particular, longitudinal models to fit the dynamic association among microbiome, environments and host.
A smartphone with a camera can detect heart rhythms, without medical assistance or additional instruments. She investigates the usage of smartphone apps to acquires pulse waveforms via photoplethysmography (PPG). PPG is related to cardiac-induced fluctuations in tissue blood volume using the built-in cameras and LED smartphone flash. She develops an algorithm to reconstruct the sharp spikes of a true ECG from a PPG record. This will lead to an efficient model that well discriminates an irregular pulse during AF from sinus rhythm.
Research Output (56)
el Bouhaddani Said, Uh Hae-Won, Jongbloed Geurt, Houwing-Duistermaat Jeanine 16 Aug 2022, In: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS. 71 , p. 1451-1470 20 p.
Gill Simrat, Bunting Karina V, Sartini Claudio, Cardoso Victor Roth, Ghoreishi Narges, Uh Hae-Won, Williams John A, Suzart-Woischnik Kiliana, Banerjee Amitava, Asselbergs Folkert W, Eijkemans Mjc, Gkoutos Georgios V, Kotecha Dipak 2022, In: Heart. 108 , p. 1600-1607 8 p.
Gu Zhujie, El Bouhaddani Said, Pei Jiayi, Houwing-Duistermaat Jeanine, Uh Hae-Won Dec 2021, In: BMC Bioinformatics. 22 , p. 1-18
Pei J, Schuldt M, Nagyova E, Gu Z, El Bouhaddani S, Yiangou L, Jansen M, Calis J J A, Dorsch L M, Blok C Snijders, van den Dungen N A M, Lansu N, Boukens B J, Efimov I R, Michels M, Verhaar M C, de Weger R, Vink A, van Steenbeek F G, Baas A F, Davis R P, Uh H W, Kuster D W D, Cheng C, Mokry M, van der Velden J, Asselbergs F W, Harakalova M Dec 2021, In: Clinical Epigenetics. 13 , p. 1-20
Dall'Olio Lorenzo, Curti Nico, Remondini Daniel, Safi Harb Yosef, Asselbergs Folkert W, Castellani Gastone, Uh Hae-Won Dec 2020, In: Scientific Reports. 10
Gu Zhujie, el Bouhaddani Said, Harakalova Magdalena, Houwing-Duistermaat Jeanine J., Uh Hae-Won Jul 2020, In: Genetic Epidemiology. 44 , p. 522-522
Houwing-Duistermaat Jeanine J., el Bouhaddani Said, Uh Hae Won Jul 2020, In: Genetic Epidemiology. 44 , p. 489-489
Berbers Roos Marijn, Mohamed Hoesein Firdaus A.A., Ellerbroek Pauline M., van Montfrans Joris M., Dalm Virgil A.S.H., van Hagen P. Martin, Paganelli Fernanda L., Viveen Marco C., Rogers Malbert R.C., de Jong Pim A., Uh Hae Won, Willems Rob J.L., Leavis Helen L. 19 Jun 2020, In: Frontiers in Immunology. 11 11 p.
Uh Hae-Won, Klarić Lucija, Ugrina Ivo, Lauc Gordan, Smilde Age K, Houwing-Duistermaat Jeanine J 25 Mar 2020, In: Molecular omics. 16 , p. 231-242 12 p.
Klarić Lucija, Tsepilov Yakov A, Stanton Chloe M, Mangino Massimo, Sikka Timo Tõnis, Esko Tõnu, Pakhomov Eugene, Salo Perttu, Deelen Joris, McGurnaghan Stuart J, Keser Toma, Vučković Frano, Ugrina Ivo, Krištić Jasminka, Gudelj Ivan, Štambuk Jerko, Plomp Rosina, Pučić-Baković Maja, Pavić Tamara, Vilaj Marija, Trbojević-Akmačić Irena, Drake Camilla, Dobrinić Paula, Mlinarec Jelena, Jelušić Barbara, Richmond Anne, Timofeeva Maria, Grishchenko Alexander K, Dmitrieva Julia, Bermingham Mairead L, Sharapov Sodbo Zh, Farrington Susan M, Theodoratou Evropi, Uh Hae-Won, Beekman Marian, Slagboom Eline P, Louis Edouard, Georges Michel, Wuhrer Manfred, Colhoun Helen M, Dunlop Malcolm G, Perola Markus, Fischer Krista, Polasek Ozren, Campbell Harry, Rudan Igor, Wilson James F, Zoldoš Vlatka, Vitart Veronique, Spector Tim, Aulchenko Yurii S, Lauc Gordan, Hayward Caroline 19 Feb 2020, In: Science advances. 6 18 p.