dr. P. (Pieter) Vader

Assistant Professor

  • Department of Clinical Chemistry and Haematology

dr. P. (Pieter) Vader

Research Programs


Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.

From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.

In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Assistant Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO VENI fellowship (2014), ERC Starting Grant (2019) and Dutch Heart Foundation Dekker Senior Scientist Grant (2019).

Fellowship and Awards

    • 2019 ERC Starting grant for the project: "Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles" 
    • 2019 Dutch Heart Foundation Dekker Senior Scientist grant for the project: "Therapeutic mRNA delivery to the myocardium for cardiac regeneration"
    • 2014 NWO Veni grant for the project: “Inspired by nature: Extracellular vesicles as potent RNA delivery platforms” 
    • 2011 NWO Rubicon grant for the project: "Cell-derived microvesicles for delivery of small RNAs to tumours"

Research Output (55)

Normoxic Tumour Extracellular Vesicles Modulate the Response of Hypoxic Cancer and Stromal Cells to Doxorubicin In Vitro

Patras Laura, Fens Marcel H A M, Vader Pieter, Barendrecht Arjan, Sesarman Alina, Banciu Manuela, Schiffelers Raymond 19 aug 2020, In: International journal of molecular sciences. 21

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer:an ISEV position paper arising from the ISEV membranes and EVs workshop

Russell Ashley E., Sneider Alexandra, Witwer Kenneth W., Bergese Paolo, Bhattacharyya Suvendra N., Cocks Alexander, Cocucci Emanuele, Erdbrügger Uta, Falcon-Perez Juan M., Freeman David W., Gallagher Thomas M., Hu Shuaishuai, Huang Yiyao, Jay Steven M., Kano Shin ichi, Lavieu Gregory, Leszczynska Aleksandra, Llorente Alicia M., Lu Quan, Mahairaki Vasiliki, Muth Dillon C., Hooten Nicole Noren, Ostrowski Matias, Prada Ilaria, Sahoo Susmita, Schøyen Tine Hiorth, Sheng Lifu, Tesch Deanna, Van Niel Guillaume, Vandenbroucke Roosmarijn E., Verweij Frederik J., Villar Ana V., Wauben Marca, Wehman Ann M., Yin Hang, Carter David Raul Francisco, Vader Pieter 1 dec 2019, In: Journal of Extracellular Vesicles. 8

Biofabrication of Cell-Derived Nanovesicles: A Potential Alternative to Extracellular Vesicles for Regenerative Medicine

Ilahibaks Nazma, Lei Zhiyong, Deshantri AK, Jiang L, Schiffelers Raymond, Vader Pieter, Sluijter Joost P.G., Mol Emma nov 2019, In: Cells. 8

Injectable Supramolecular Ureidopyrimidinone Hydrogels Provide Sustained Release of Extracellular Vesicle Therapeutics

Mol Emma A, Lei Zhiyong, Roefs Marieke T, Bakker Maarten H, Goumans Marie-José, Doevendans Pieter A, Dankers Patricia Y W, Vader Pieter, Sluijter Joost P G okt 2019, In: Advanced Healthcare Materials. 8

Interfering with endolysosomal trafficking enhances release of bioactive exosomes

Ortega Francisco G., Roefs Marieke T., de Miguel Perez Diego, Kooijmans Sander A., de Jong Olivier G., Sluijter Joost P., Schiffelers Raymond M., Vader Pieter 1 aug 2019, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 20

Drug Delivery with Extracellular Vesicles:From Imagination to Innovation

De Jong Olivier G., Kooijmans Sander A.A., Murphy Daniel E., Jiang Linglei, Evers Martijn J.W., Sluijter Joost P.G., Vader Pieter, Schiffelers Raymond M. jul 2019, In: ACCOUNTS OF CHEMICAL RESEARCH. 52 , p. 1761-1770 10 p.

Extracellular vesicle-based therapeutics:natural versus engineered targeting and trafficking

Murphy Daniel E, de Jong Olivier G, Brouwer Maarten, Wood Matthew J, Lavieu Grégory, Schiffelers Raymond M, Vader Pieter 15 mrt 2019, In: Experimental & molecular medicine. 51

State-of-the-Art Design and Rapid-Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Evers Martijn J. W., Kulkarni Jayesh A., van der Meel Roy, Cullis Pieter R., Vader Pieter, Schiffelers Raymond M. 11 sep 2018, In: SMALL METHODS. 2

Extracellular vesicle heterogeneity:Subpopulations, isolation techniques, and diverse functions in cancer progression

Willms Eduard, Cabañas Carlos, Mäger Imre, Wood Matthew J.A., Vader Pieter 30 apr 2018, In: Frontiers in Immunology. 9

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells:a plug-and-play approach

Kooijmans Sander A A, Gitz-Francois Jerney J J M, Schiffelers Raymond M, Vader Pieter 1 feb 2018, In: Nanoscale. 10 , p. 2413-2426 14 p.

All Research Output (55)