dr. P. (Pieter) Vader

dr. P. (Pieter) Vader

Associate Professor
dr. P. (Pieter) Vader
  • Central Diagnostic Laboratory

Research Programs

Circulatory Health



Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.

From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.

In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Associate Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO Veni Grant (2014), ERC Starting Grant (2019), Dutch Heart Foundation Dekker Senior Scientist Grant (2019), NWO Vidi Grant (2020) and ERC Consolidator Grant (2023). In 2021, Pieter was awarded the Prix Galien Research Award for his work on drug delivery.

Fellowship and Awards

  • 2023 ERC Consolidator Grant for the project: "Unravelling extracellular vesicle heterogeneity to inspire improved therapeutic RNA delivery systems"
  • 2020 NWO Vidi grant for the project: "Molecular drivers of extracellular vesicle targeting and RNA transfer – towards improved delivery"
  • 2019 ERC Starting grant for the project: "Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles" 
  • 2019 Dutch Heart Foundation Dekker Senior Scientist grant for the project: "Therapeutic mRNA delivery to the myocardium for cardiac regeneration"
  • 2014 NWO Veni grant for the project: “Inspired by nature: Extracellular vesicles as potent RNA delivery platforms” 
  • 2011 NWO Rubicon grant for the project: "Cell-derived microvesicles for delivery of small RNAs to tumours"

Research Output (84)

Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses

van de Wakker Simon, Bauzá-Martinez Julia, Rios Arceo Carla , Manjikian Herak, Snijders Blok Christian J.B., Roefs Marieke, Maas Renee G, Willms Eduard, Pronker Matti F., de Jong Olivier, Wu Wei, Görgens André, Andaloussi Samir E L, Sluijter Joost, Vader Pieter 13 Jan 2024, In: Journal of Extracellular Vesicles. 13 21 p.

Extracellular vesicle-mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin-kexin type 9 (Pcsk9) in primary mouse hepatocytes

Ilahibaks Nazma F, Kluiver Thomas A, de Jong Olivier G, de Jager Saskia C A, Schiffelers Raymond M, Vader Pieter, Peng Weng Chuan, Lei Zhiyong, Sluijter Joost P G Jan 2024, In: Journal of Extracellular Vesicles. 13

Heparin interferes with the uptake of liposomes in glioma

van Solinge Thomas S, Friis Kristina Pagh, O'Brien Killian, Verschoor Romy L, van Aarle Jeroen, Koekman Arnold, Breakefield Xandra O, Vader Pieter, Schiffelers Raymond, Broekman Marike 15 Dec 2023, In: International Journal of Pharmaceutics: X. 6 , p. 1-8

Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration

Zeng Ye, Estapé Senti Mariona, Labonia M. Clara I., Papadopoulou Panagiota, Brans Maike A.D., Dokter Inge, Fens Marcel H., van Mil Alain, Sluijter Joost P.G., Schiffelers Raymond M., Vader Pieter, Kros Alexander 12 Dec 2023, In: ACS Nano. 17 , p. 23466-23477 12 p.

Extracellular vesicle heterogeneity and its impact for regenerative medicine applications

Van De Wakker Simonides Immanuel, Meijers Fleur Michelle, Sluijter Joost Petrus Gerardus, Vader Pieter Sep 2023, In: Pharmacological Reviews. 75 , p. 1043-1061 19 p.

Cardiac progenitor cell-derived extracellular vesicles promote angiogenesis through both associated- and co-isolated proteins

Roefs Marieke Theodora, Bauzá-Martinez Julia, van de Wakker Simonides Immanuel, Qin Jiabin, Olijve Willem Theodoor, Tuinte Robin, Rozeboom Marjolein, Snijders Blok Christian, Mol Emma Alise, Wu Wei, Vader Pieter, Sluijter Joost Petrus Gerardus 1 Aug 2023, In: Communications biology. 6

TOP-EVs:Technology of Protein delivery through Extracellular Vesicles is a versatile platform for intracellular protein delivery

Ilahibaks Nazma F., Ardisasmita Arif I., Xie Songpu, Gunnarsson Anders, Brealey Joseph, Vader Pieter, de Jong Olivier G., de Jager Saskia, Dekker Niek, Peacock Ben, Schiffelers Raymond M., Sluijter Joost P.G., Lei Zhiyong Mar 2023, In: Journal of Controlled Release. 355 , p. 579-592 14 p.

Methods for the identification and characterization of extracellular vesicles in cardiovascular studies:from exosomes to microvesicles

Davidson Sean M., Boulanger Chantal M., Aikawa Elena, Badimon Lina, Barile Lucio, Binder Christoph J., Brisson Alain, Buzas Edit, Emanueli Costanza, Jansen Felix, Katsur Miroslava, Lacroix Romaric, Lim Sai Kiang, Mackman Nigel, Mayr Manuel, Menasché Philippe, Nieuwland Rienk, Sahoo Susmita, Takov Kaloyan, Thum Thomas, Vader Pieter, Wauben Marca H.M., Witwer Kenneth, Sluijter Joost P.G. 1 Jan 2023, In: Cardiovascular research. 119 , p. 45-63 19 p.

Enabling Precision Medicine with CRISPR-Cas Genome Editing Technology:A Translational Perspective

Ilahibaks Nazma F., Hulsbos Maike J., Lei Zhiyong, Vader Pieter, Sluijter Joost P.G. 2023, p. 315-339 25 p.

Evaluation and manipulation of tissue and cellular distribution of cardiac progenitor cell-derived extracellular vesicles

Roefs Marieke T., Heusermann Wolf, Brans Maike A.D., Snijders Blok Christian, Lei Zhiyong, Vader Pieter, Sluijter Joost P.G. 24 Nov 2022, In: Frontiers in Pharmacology. 13

All research output

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