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dr. P. (Pieter) Vader

dr. P. (Pieter) Vader

Associate Professor
dr. P. (Pieter) Vader
  • Central Diagnostic Laboratory

Research Programs

Circulatory Health

Biography

Biography

Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.

From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.

In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Associate Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO Veni Grant (2014), ERC Starting Grant (2019), Dutch Heart Foundation Dekker Senior Scientist Grant (2019), and NWO Vidi Grant (2020). In 2021, Pieter was awarded the Prix Galien Research Award for his work on drug delivery.

Fellowship and Awards

  • 2020 NWO Vidi grant for the project: "Molecular drivers of extracellular vesicle targeting and RNA transfer – towards improved delivery"
  • 2019 ERC Starting grant for the project: "Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles" 
  • 2019 Dutch Heart Foundation Dekker Senior Scientist grant for the project: "Therapeutic mRNA delivery to the myocardium for cardiac regeneration"
  • 2014 NWO Veni grant for the project: “Inspired by nature: Extracellular vesicles as potent RNA delivery platforms” 
  • 2011 NWO Rubicon grant for the project: "Cell-derived microvesicles for delivery of small RNAs to tumours"

Research Output (74)

Identification of storage conditions stabilizing extracellular vesicles preparations

Görgens André, Corso Giulia, Hagey Daniel W., Jawad Wiklander Rim, Gustafsson Manuela O., Felldin Ulrika, Lee Yi, Bostancioglu R. Beklem, Sork Helena, Liang Xiuming, Zheng Wenyi, Mohammad Dara K., van de Wakker Simonides I., Vader Pieter, Zickler Antje M., Mamand Doste R., Ma Li, Holme Margaret N., Stevens Molly M., Wiklander Oscar P.B., EL Andaloussi Samir Jun 2022, In: Journal of Extracellular Vesicles. 11 , p. 1-27

Extracellular Vesicles and Their Emerging Roles as Cellular Messengers in Endocrinology:An Endocrine Society Scientific Statement

Salomon Carlos, Das Saumya, Erdbrügger Uta, Kalluri Raghu, Kiang Lim Sai, Olefsky Jerrold M., Rice Gregory E., Sahoo Susmita, Andy Tao W., Vader Pieter, Wang Qun, Weaver Alissa M. Jun 2022, In: Endocrine reviews. 43 , p. 441-468 28 p.

Challenges and directions in studying cell–cell communication by extracellular vesicles

van Niel Guillaume, Carter David R.F., Clayton Aled, Lambert Daniel W., Raposo Graça, Vader Pieter May 2022, In: Nature reviews molecular cell biology. 23 , p. 369-382 14 p.

Extracellular Vesicle-Based Hybrid Systems for Advanced Drug Delivery

Rodríguez Diego A., Vader Pieter Feb 2022, In: Pharmaceutics. 14

Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles

Evers Martijn J W, Du Wenjuan, Yang Qiangbing, Kooijmans Sander A A, Vink Arjan, van Steenbergen Mies, Vader Pieter, de Jager Saskia C A, Fuchs Sabine A, Mastrobattista Enrico, Sluijter Joost P G, Lei Zhiyong, Schiffelers Raymond 22 Jan 2022, In: Journal of controlled release : official journal of the Controlled Release Society. 343 , p. 207-216 10 p.

Isolation methods of large and small extracellular vesicles derived from cardiovascular progenitors:A comparative study

Saludas Laura, Garbayo Elisa, Ruiz-Villalba Adrián, Hernández Silvia, Vader Pieter, Prósper Felipe, Blanco-Prieto María J. Jan 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 170 , p. 187-196 10 p.

Influence of short term storage conditions, concentration methods and excipients on extracellular vesicle recovery and function

van de Wakker S. I., van Oudheusden J., Mol E. A., Roefs M. T., Zheng W., Görgens A., El Andaloussi S., Sluijter J. P.G., Vader P. Jan 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 170 , p. 59-69 11 p.

Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering

Raes Laurens, Pille Melissa, Harizaj Aranit, Goetgeluk Glenn, Van Hoeck Jelter, Stremersch Stephan, Fraire Juan C., Brans Toon, de Jong Olivier Gerrit, Maas-Bakker Roel, Mastrobattista Enrico, Vader Pieter, De Smedt Stefaan C., Vandekerckhove Bart, Raemdonck Koen, Braeckmans Kevin 3 Sep 2021, In: Molecular Therapy - Nucleic Acids. 25 , p. 696-707 12 p.

Illuminating RNA trafficking and functional delivery by extracellular vesicles

de Voogt Willemijn S., Tanenbaum Marvin E., Vader Pieter Jul 2021, In: Advanced Drug Delivery Reviews. 174 , p. 250-264 15 p.

Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion

Sork Helena, Conceicao Mariana, Corso Giulia, Nordin Joel, Lee Yi Xin Fiona, Krjutskov Kaarel, Orzechowski Westholm Jakub, Vader Pieter, Pauwels Marie, Vandenbroucke Roosmarijn E., Wood Matthew Ja, El Andaloussi Samir, Mäger Imre 18 Jun 2021, In: Cells. 10 , p. 1-17

All research output

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