dr. P. (Pieter) Vader

dr. P. (Pieter) Vader

Associate Professor
dr. P. (Pieter) Vader
  • Department of Clinical Chemistry and Haematology

Research Programs

Circulatory Health



Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.

From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.

In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Associate Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO Veni Grant (2014), ERC Starting Grant (2019), Dutch Heart Foundation Dekker Senior Scientist Grant (2019), and NWO Vidi Grant (2020). In 2021, Pieter was award the Prix Galien Research Award for his work on drug delivery.

Fellowship and Awards

  • 2020 NWO Vidi grant for the project: "Molecular drivers of extracellular vesicle targeting and RNA transfer – towards improved delivery"
  • 2019 ERC Starting grant for the project: "Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles" 
  • 2019 Dutch Heart Foundation Dekker Senior Scientist grant for the project: "Therapeutic mRNA delivery to the myocardium for cardiac regeneration"
  • 2014 NWO Veni grant for the project: “Inspired by nature: Extracellular vesicles as potent RNA delivery platforms” 
  • 2011 NWO Rubicon grant for the project: "Cell-derived microvesicles for delivery of small RNAs to tumours"

Research Output (63)

Illuminating RNA trafficking and functional delivery by extracellular vesicles

de Voogt Willemijn S., Tanenbaum Marvin E., Vader Pieter jul 2021, In: Advanced Drug Delivery Reviews. 174 , p. 250-264 15 p.

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

Rankin-Turner Stephanie, Vader Pieter, O'Driscoll Lorraine, Giebel Bernd, Heaney Liam M., Davies Owen G. jun 2021, In: Advanced Drug Delivery Reviews. 173 , p. 479-491 13 p.

Approaches to surface engineering of extracellular vesicles

Richter Maximilian, Vader Pieter, Fuhrmann Gregor jun 2021, In: Advanced Drug Delivery Reviews. 173 , p. 416-426 11 p.

Natural or Synthetic RNA Delivery:A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Murphy Daniel E, de Jong Olivier G, Evers Martijn J W, Nurazizah Maratussholikhah, Schiffelers Raymond M, Vader Pieter 11 feb 2021, In: Nano letters. 21 , p. 1888-1895 8 p.

Extracellular Vesicle-Associated Proteins in Tissue Repair

Roefs Marieke T, Sluijter Joost P G, Vader Pieter dec 2020, In: Trends in Cell Biology. 30 , p. 990-1013 24 p.

Normoxic Tumour Extracellular Vesicles Modulate the Response of Hypoxic Cancer and Stromal Cells to Doxorubicin In Vitro

Patras Laura, Fens Marcel H A M, Vader Pieter, Barendrecht Arjan, Sesarman Alina, Banciu Manuela, Schiffelers Raymond 1 sep 2020, In: International journal of molecular sciences. 21 21 p.

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

de Jong Olivier G., Murphy Daniel E., Mäger Imre, Willms Eduard, Garcia-Guerra Antonio, Gitz-Francois Jerney J., Lefferts Juliet, Gupta Dhanu, Steenbeek Sander C., van Rheenen Jacco, El Andaloussi Samir, Schiffelers Raymond M., Wood Matthew J.A., Vader Pieter 28 feb 2020, In: Nature Communications. 11 , p. 1-13

Extracellular vesicles as drug delivery systems:Why and how?

Elsharkasy Omnia M., Nordin Joel Z., Hagey Daniel W., de Jong Olivier G., Schiffelers Raymond M., Andaloussi Samir EL, Vader Pieter 1 jan 2020, In: Advanced Drug Delivery Reviews. 159 , p. 332-343 12 p.

A post-insertion strategy for surface functionalization of bacterial and mammalian cell-derived extracellular vesicles

Jiang Linglei, Luirink Joen, Kooijmans Sander A A, van Kessel Kok P M, Jong Wouter, van Essen Max, Seinen Cor W, de Maat Steven, de Jong Olivier G, Gitz-François Jerney F F, Hennink Wim E, Vader Pieter, Schiffelers Raymond M 2020, In: Biochimica et biophysica acta-General subjects. 1865

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer:an ISEV position paper arising from the ISEV membranes and EVs workshop

Russell Ashley E., Sneider Alexandra, Witwer Kenneth W., Bergese Paolo, Bhattacharyya Suvendra N., Cocks Alexander, Cocucci Emanuele, Erdbrügger Uta, Falcon-Perez Juan M., Freeman David W., Gallagher Thomas M., Hu Shuaishuai, Huang Yiyao, Jay Steven M., Kano Shin ichi, Lavieu Gregory, Leszczynska Aleksandra, Llorente Alicia M., Lu Quan, Mahairaki Vasiliki, Muth Dillon C., Hooten Nicole Noren, Ostrowski Matias, Prada Ilaria, Sahoo Susmita, Schøyen Tine Hiorth, Sheng Lifu, Tesch Deanna, Van Niel Guillaume, Vandenbroucke Roosmarijn E., Verweij Frederik J., Villar Ana V., Wauben Marca, Wehman Ann M., Yin Hang, Carter David Raul Francisco, Vader Pieter 1 dec 2019, In: Journal of Extracellular Vesicles. 8

All research output

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