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prof. dr. J.G.J. (Jan) van de Winkel

prof. dr. J.G.J. (Jan) van de Winkel

Full Professor

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Research Output (250)

Expression of CD64 (Fc gamma RI) in skin of patients with acute GVHD

van Royen-Kerkhof A., Walraven V., Sanders E.A.M., de Weger R.A., van Wichen D.F., de Koning E., Thepen T., van de Winkel J.G.J., Leusen J.H.W. Dec 2011, In: Bone Marrow Transplantation. 46 , p. 1566-1569 4 p.

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden

Boross P., Jansen J.H.M., de Haij S., Beurskens F.J., van der Poel C.E., Bevaart L., Nederend M., Golay J., van de Winkel J.G.J., Parren P.W.H.I., Leusen J.H.W. 2011, In: Haematologica. 96 , p. 1822-30 9 p.

Functional characteristics of the high affinity IgG receptor, FcγRI

van der Poel C.E., Spaapen R.M., van de Winkel J.G.J., Leusen J.H.W. 2011, In: Journal of Immunology. 186 , p. 2699-2704 6 p.

Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing

Lohse S., Derer S., Beyer T., Klausz K., Peipp M., Leusen J.H.W., van de Winkel J.G.J., Dechant M., Valerius T. 2011, In: Journal of Immunology. 186 , p. 3770-3778 9 p.

Epidermal growth factor receptor (EGFR) antibody-induced antibody-dependent cellular cytotoxicity plays a prominent role in inhibiting tumorigenesis, even of tumor cells insensitive to EGFR signaling inhibition

Overdijk M.B., Verploegen S., van den Brakel J.H., Lammerts van Bueren J.J., Vink T., van de Winkel J.G.J., Parren P.W.H.I., Bleeker W.K. 2011, In: Journal of Immunology. 187 , p. 3383-3390 8 p.

Anti-galactose-α-1,3-galactose IgE from allergic patients does not bind α-galactosylated glycans on intact therapeutic antibody Fc domains

Lammerts van Bueren J.J., Rispens T., Verploegen S., van der Palen-Merkus T., Stapel S., Workman L.J., James H., van Berkel P.H.C., van de Winkel J.G.J., Platts-Mills T.A.E., Parren P.W.H.I. 2011, In: Nature Biotechnology. 29 , p. 574-576 3 p.

Loss of CD20 and bound CD20 antibody from opsonized B cells occurs more rapidly because of trogocytosis mediated by Fc receptor-expressing effector cells than direct internalization by the B cells

Beum P.V., Peek E.M., Lindorfer M.A., Beurskens F.J., Engelberts P.J., Parren P.W.H.I., van de Winkel J.G.J., Taylor R.P. 2011, In: Journal of Immunology. 187 , p. 3438-3447 10 p.

Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength.

Labrijn A.F., Rispens T., Meesters J., Rose R.J., den Bleker T.H., Loverix S., van den Bremer E.T.J., Neijssen J., Vink T., Lasters I., Aalberse R.C., Heck A.J.R., van de Winkel J.G.J., Schuurman J., Parren P.W.H.I. 2011, In: Journal of Immunology. 187 , p. 3238-3246 9 p.

The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19).

Shi J., McIntosh R.S., Adame-Gallegos J., Dehal P.K., van Egmond M., van de Winkel J.G.J., Draper S.J., Forbes E.K., Corran P.H., Holder A.A., Woof J.M., Pleass R.J. 2011, In: BMC Biotechnology [E]. 11 , p. 77 1 p.

Combined Fc-protein- and Fc-glyco-engineering of scFv-Fc fusion proteins synergistically enhances CD16a binding but does not further enhance NK-cell mediated ADCC.

Repp R., Kellner C., Muskulus A., Staudinger M., Mohseni Nodehi S., Glorius P., Akramiene D., Dechant M., Fey G.H., van Berkel P.H.C., van de Winkel J.G.J., Parren P.W.H.I., Valerius T., Gramatzki M., Peipp M. 2011, In: Journal of Immunological Methods. 373 , p. 67-78 12 p.

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