prof. dr. C.K. (Cornelis) van der Ent
prof. dr. C.K. (Cornelis) van der Ent
- Pulmonology patient care
- Strategic theme Child Health
Research Programs
Biography
Biography
The research interests of professor Kors van der Ent focus on the themes Cystic Fibrosis and other bronchusobstructive diseseases in young children. He is the leader of the national HIT-CF program which focuses on the development and personalised application of new drugs influencing the basis genetic defect in patients with CF. This program includes both mechanistic studies in collaboration with the Hubrecht lab and the Byvoet Center as well as studies into host pathogen interaction in collaboration with the veterinary faculty of the Utrecht University. Clinical studies are performed in close collaboration with other CF-centres throughout Europe. Furthermore, he was the founder of the Whistler birth cohort, in which thousands of children are followed from birth to study determinants of the development of respiratory diseases. These cohorts mirror normal development to understand mechanisms in disease.
Kors van der Ent has special interest in innovation and valorisation in medical care and believes in creation of hospital networks to build the future medical care system for children. He successfully developed new devices to measure neonatal lung function, which were launched to the market. He also developed the Luchtwegportaal, an interactive web-based system to collect patient data regarding respiratory diseases in many hospitals in The Netherlands.
Side Activities
Chairman of Cystic Fibrosis Center Utrecht
Chairman of Dutch Cystic Fibrosis Research Network
Member of Medical Advisory Board Dutch Cystic Fibrosis Committee
Member of Research committee Wilhelmina Children’s Hospital Utrecht
Member of Medical Ethical Committee University Medical Center Utrecht
Medical advisor of Sioux CCM
Board Member of Malawi Mission Work Team
Chair of CoreNetwork CF of European Refence Network of Excellence for rare lung diseases (ERN-LUNG) 2015-now
Member steering committee Clinical Trial Office UMC Utrecht 2017-now
Coordinator of European HIT-CF program 2018-now
Board member of Lung Alliance Netherlands (LAN) 2020-now
Reviewer for Am J Resp Crit Care Med, European Respir J and many others
Reviewer for the expertise centra voor zeldzame ziekte voor de NFU 2021 - heden
Chair of therapeutic foundation 2021 - heden
Potential Conflicts of Interest
Dr. van der Ent reports grants from GSK, grants from Nutricia, grants from TEVA, grants from Gilead, grants from Vertex, grants from ProQR, grants from Proteostasis, grants from Galapagos NV, grants from Eloxx and grants from Santhera, all paid to UMCU; In addition, Dr. van der Ent has a patent 10006904 with royalties paid.
Fellowship and Awards
European CF young investigator meeting award 2011. A functional CFTR assay using primary cystic fibrosis organoids
European CF basic science meeting award 2011. Treatment with VX809 and VX770 in rectal CF organoids expressing uncommon CFTR genotypes
European CF basic science meeting award 2012. Characterizing altered inflammatory signaling in CFTR-defective
bronchial epithelial cells
National symposium Dutch CF foundation award 2011. Complement mediated phagocytosis is reduced in CF monocytes.
Research Output (555)
Veldhoen Esther S, Wijngaarde Camiel A, van Eijk Ruben P A, Asselman Fay-Lynn, Seddiqi Negina, Otto Louise A M, Stam Marloes, Cuppen Inge, Wadman Renske I, van Asperen Roelie M Wösten, Hulzebos Erik H J, van den Oudenrijn Laura P Verweij, Bartels Bart, Boezer Jasmijn, Gaytant M, van der Ent Cornelis K, van der Pol W Ludo 23 Feb 2023, In: Orphanet Journal of Rare Diseases. 18 10 p.
Nap-van der Vlist Merel M., Vroegindeweij Anouk, Hoefnagels Johanna W., van der Ent Cornelis K., Swart Joost F., van de Putte Elise M., Nijhof Sanne L. Feb 2023, In: Journal of Psychosomatic Research. 165
Noordstar Johannes J., Sprong Maaike C.A., Slieker Martijn G., Takken Tim, van Brussel Marco, van der Ent Cornelis K., Hulzebos Erik H.J. 1 Jan 2023, In: Pediatric Physical Therapy. 35 , p. 43-47 5 p.
Amatngalim Gimano D, Rodenburg Lisa W, Aalbers Bente L, Raeven Henriette Hm, Aarts Ellen M, Sarhane Dounia, Spelier Sacha, Lefferts Juliet W, Silva Iris Al, Nijenhuis Wilco, Vrendenbarg Sacha, Kruisselbrink Evelien, Brunsveld Jesse E, van Drunen Cornelis M, Michel Sabine, de Winter-de Groot Karin M, Heijerman Harry G, Kapitein Lukas C, Amaral Magarida D, van der Ent Cornelis K, Beekman Jeffrey M Dec 2022, In: Life Science Alliance. 5 , p. 1-14
Rodenburg Lisa W., Delpiano Livia, Railean Violeta, Centeio Raquel, Pinto Madalena C., Smits Shannon M.A., van der Windt Isabelle S., van Hugten Casper F.J., van Beuningen Sam F.B., Rodenburg Remco N.P., van der Ent Cornelis K., Amaral Margarida D., Kunzelmann Karl, Gray Michael A., Beekman Jeffrey M., Amatngalim Gimano D. 21 Oct 2022, In: International Journal of Molecular Sciences. 23
Ververs Francesca A, Eikendal Anouk L M, Kofink Daniel, Nuboer Roos, Westenberg Jos J M, Hovenkamp Gijs T, Kemps Jitske J A, Coenen Iris C J, Daems Joëlle J N, Claus Laura R, Ju Yillie, Wulffraat Nico M, van der Ent Cornelis K, Monaco Claudia, Boes Marianne, Leiner Tim, Grotenhuis Heynric B, Schipper Henk S 19 Jul 2022, In: Journal of the American Heart Association. 11 , p. 1-18
Noordhoek Jacquelien J, Jeyaratnam Joshena, Zomer Domenique, Gulmans Vincent A M, van der Ent Cornelis K, Heijerman Harry G M 13 Jul 2022, In: Journal of Cystic Fibrosis. 22 , p. 172-178 7 p.
Veldhoen Esther S, Roos Johan H, Bekkema Rolien, Ludo van der Pol W, Tinnevelt Marcel H B, Verweij-van den Oudenrijn Laura P, Wösten-van Asperen Roelie M, Hulzebos Erik H J, Wijngaarde Camiel A, Kors van der Ent C 26 Apr 2022, In: Pediatric Pulmonology. 57 , p. 1618-1624 7 p.
Veldhoen Esther S, Vercoelen Femke, Ros Leandra, Verweij-van den Oudenrijn Laura P, Wösten-van Asperen Roelie M, Hulzebos Erik Hj, Bartels Bart, Gaytant Michael A, van der Ent Kors, Ludo van der Pol W 21 Apr 2022, In: Chronic Respiratory Disease. 19
Hoefnagels Johanna W, Schoen Annelieke B, van der Laan Sabine E I, Rodijk Lyan H, van der Ent Cornelis K, van de Putte Elise M, Dalmeijer Geertje W, Nijhof Sanne L 3 Mar 2022, In: International journal of environmental research and public health. 19