prof. dr. C.K. (Cornelis) van der Ent

prof. dr. C.K. (Cornelis) van der Ent

Full Professor
prof. dr. C.K. (Cornelis) van der Ent
  • Pulmonology patient care
  • Strategic theme Child Health



The research interests of professor Kors van der Ent focus on the themes Cystic Fibrosis and other bronchusobstructive diseseases in young children. He is the leader of the national HIT-CF program which focuses on the development and personalised application of new drugs influencing the basis genetic defect in patients with CF. This program includes both mechanistic studies in collaboration with the Hubrecht lab and the Byvoet Center as well as studies into host pathogen interaction in collaboration with the veterinary faculty of the Utrecht University. Clinical studies are performed in close collaboration with other CF-centres throughout Europe. Furthermore, he was the founder of the Whistler birth cohort, in which thousands of children are followed from birth to study determinants of the development of respiratory diseases. These cohorts mirror normal development to understand mechanisms in disease.

Kors van der Ent has special interest in innovation and valorisation in medical care and believes in creation of hospital networks to build the future medical care system for children. He successfully developed new devices to measure neonatal lung function, which were launched to the market. He also developed the Luchtwegportaal, an interactive web-based system to collect patient data regarding respiratory diseases in many hospitals in The Netherlands.

Side Activities

Chairman of Cystic Fibrosis Center Utrecht

Chairman of Dutch Cystic Fibrosis Research Network

Member of Medical Advisory Board Dutch Cystic Fibrosis Committee

Member of Research committee Wilhelmina Children’s Hospital Utrecht

Member of Medical Ethical Committee University Medical Center Utrecht

Medical advisor of Sioux CCM

Board Member of Malawi Mission Work Team

Chair of CoreNetwork CF of European Refence Network of Excellence for rare lung diseases (ERN-LUNG) 2015-now

Member steering committee Clinical Trial Office UMC Utrecht 2017-now

Coordinator of European HIT-CF program 2018-now

Board member of Lung Alliance Netherlands (LAN) 2020-now

Reviewer for Am J Resp Crit Care Med, European Respir J and many others

Reviewer for the expertise centra voor zeldzame ziekte voor de NFU 2021 - heden

Chair of therapeutic foundation 2021 - heden


Potential Conflicts of Interest

Dr. van der Ent reports grants from GSK, grants from Nutricia, grants from TEVA, grants from Gilead, grants from Vertex, grants from ProQR, grants from Proteostasis, grants from Galapagos NV, grants from Eloxx and grants from Santhera, all paid to UMCU; In addition, Dr. van der Ent has a patent 10006904 with royalties paid.

Fellowship and Awards

European CF young investigator meeting award 2011. A functional CFTR assay using primary cystic fibrosis organoids

European CF basic science meeting award 2011. Treatment with VX809 and VX770 in rectal CF organoids expressing  uncommon CFTR genotypes

European CF basic science meeting award 2012. Characterizing altered inflammatory signaling in CFTR-defective

bronchial epithelial cells

National symposium Dutch CF foundation award 2011. Complement mediated phagocytosis is reduced in CF monocytes.

Research Output (555)

Lung function decline preceding chronic respiratory failure in spinal muscular atrophy:a national prospective cohort study

Veldhoen Esther S, Wijngaarde Camiel A, van Eijk Ruben P A, Asselman Fay-Lynn, Seddiqi Negina, Otto Louise A M, Stam Marloes, Cuppen Inge, Wadman Renske I, van Asperen Roelie M Wösten, Hulzebos Erik H J, van den Oudenrijn Laura P Verweij, Bartels Bart, Boezer Jasmijn, Gaytant M, van der Ent Cornelis K, van der Pol W Ludo 23 Feb 2023, In: Orphanet Journal of Rare Diseases. 18 10 p.

Paediatric short fatigue questionnaire, a 4-item fatigue questionnaire for children

Nap-van der Vlist Merel M., Vroegindeweij Anouk, Hoefnagels Johanna W., van der Ent Cornelis K., Swart Joost F., van de Putte Elise M., Nijhof Sanne L. Feb 2023, In: Journal of Psychosomatic Research. 165

Is Measuring Physical Literacy in School-Aged Children With Cystic Fibrosis or Congenital Heart Disease Needed?

Noordstar Johannes J., Sprong Maaike C.A., Slieker Martijn G., Takken Tim, van Brussel Marco, van der Ent Cornelis K., Hulzebos Erik H.J. 1 Jan 2023, In: Pediatric Physical Therapy. 35 , p. 43-47 5 p.

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

Amatngalim Gimano D, Rodenburg Lisa W, Aalbers Bente L, Raeven Henriette Hm, Aarts Ellen M, Sarhane Dounia, Spelier Sacha, Lefferts Juliet W, Silva Iris Al, Nijenhuis Wilco, Vrendenbarg Sacha, Kruisselbrink Evelien, Brunsveld Jesse E, van Drunen Cornelis M, Michel Sabine, de Winter-de Groot Karin M, Heijerman Harry G, Kapitein Lukas C, Amaral Magarida D, van der Ent Cornelis K, Beekman Jeffrey M Dec 2022, In: Life Science Alliance. 5 , p. 1-14

Drug Repurposing for Cystic Fibrosis:Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids

Rodenburg Lisa W., Delpiano Livia, Railean Violeta, Centeio Raquel, Pinto Madalena C., Smits Shannon M.A., van der Windt Isabelle S., van Hugten Casper F.J., van Beuningen Sam F.B., Rodenburg Remco N.P., van der Ent Cornelis K., Amaral Margarida D., Kunzelmann Karl, Gray Michael A., Beekman Jeffrey M., Amatngalim Gimano D. 21 Oct 2022, In: International Journal of Molecular Sciences. 23

Preclinical Aortic Atherosclerosis in Adolescents With Chronic Disease

Ververs Francesca A, Eikendal Anouk L M, Kofink Daniel, Nuboer Roos, Westenberg Jos J M, Hovenkamp Gijs T, Kemps Jitske J A, Coenen Iris C J, Daems Joëlle J N, Claus Laura R, Ju Yillie, Wulffraat Nico M, van der Ent Cornelis K, Monaco Claudia, Boes Marianne, Leiner Tim, Grotenhuis Heynric B, Schipper Henk S 19 Jul 2022, In: Journal of the American Heart Association. 11 , p. 1-18

Development and outcomes of a patient driven cystic fibrosis quality of care improvement project

Noordhoek Jacquelien J, Jeyaratnam Joshena, Zomer Domenique, Gulmans Vincent A M, van der Ent Cornelis K, Heijerman Harry G M 13 Jul 2022, In: Journal of Cystic Fibrosis. 22 , p. 172-178 7 p.

Oscillometry:a substitute of spirometry in children with neuromuscular diseases?

Veldhoen Esther S, Roos Johan H, Bekkema Rolien, Ludo van der Pol W, Tinnevelt Marcel H B, Verweij-van den Oudenrijn Laura P, Wösten-van Asperen Roelie M, Hulzebos Erik H J, Wijngaarde Camiel A, Kors van der Ent C 26 Apr 2022, In: Pediatric Pulmonology. 57 , p. 1618-1624 7 p.

Short-term effect of air stacking and mechanical insufflation-exsufflation on lung function in patients with neuromuscular diseases

Veldhoen Esther S, Vercoelen Femke, Ros Leandra, Verweij-van den Oudenrijn Laura P, Wösten-van Asperen Roelie M, Hulzebos Erik Hj, Bartels Bart, Gaytant Michael A, van der Ent Kors, Ludo van der Pol W 21 Apr 2022, In: Chronic Respiratory Disease. 19

The Impact of the COVID-19 Outbreak on Mental Wellbeing in Children with a Chronic Condition Compared to Healthy Peers

Hoefnagels Johanna W, Schoen Annelieke B, van der Laan Sabine E I, Rodijk Lyan H, van der Ent Cornelis K, van de Putte Elise M, Dalmeijer Geertje W, Nijhof Sanne L 3 Mar 2022, In: International journal of environmental research and public health. 19

All research output

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