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prof. dr. C.K. (Cornelis) van der Ent Full Professor

  • Speerpunt Child Health
  • Pulmonology patient care

C.K. van der Ent

Contact

Research Programs

Biography

The research interests of professor Kors van der Ent focus on the themes Cystic Fibrosis and other bronchusobstructive diseseases in young children. He is the leader of the national HIT-CF program which focuses on the development and personalised application of new drugs influencing the basis genetic defect in patients with CF. This program includes both mechanistic studies in collaboration with the Hubrecht lab and the Byvoet Center as well as studies into host pathogen interaction in collaboration with the veterinary faculty of the Utrecht University. Clinical studies are performed in close collaboration with other CF-centres throughout Europe. Furthermore, he was the founder of the Whistler birth cohort, in which thousands of children are followed from birth to study determinants of the development of respiratory diseases. These cohorts mirror normal development to understand mechanisms in disease.

Kors van der Ent has special interest in innovation and valorisation in medical care and believes in creation of hospital networks to build the future medical care system for children. He successfully developed new devices to measure neonatal lung function, which were launched to the market. He also developed the Luchtwegportaal, an interactive web-based system to collect patient data regarding respiratory diseases in many hospitals in The Netherlands.

Side Activities

  • Chairman of Cystic Fibrosis Center Utrecht

    Chairman of Dutch Cystic Fibrosis Research Network

    Member of Medical Advisory Board Dutch Cystic Fibrosis Committee

    Member of Research committee Wilhelmina Children’s Hospital Utrecht

    Member of Medical Ethical Committee University Medical Center Utrecht

    Medical advisor of Sioux CCM

    Board Member of Malawi Mission Work Team

    Reviewer for Am J Resp Crit Care Med, European Respir J and many others

     

Fellowship and Awards

  • European CF young investigator meeting award 2011. A functional CFTR assay using primary cystic fibrosis organoids

    European CF basic science meeting award 2011. Treatment with VX809 and VX770 in rectal CF organoids expressing  uncommon CFTR genotypes

    European CF basic science meeting award 2012. Characterizing altered inflammatory signaling in CFTR-defective

    bronchial epithelial cells

    National symposium Dutch CF foundation award 2011. Complement mediated phagocytosis is reduced in CF monocytes.

Research Output (339)

Excess early postnatal weight gain and blood pressure in healthy young children

Jansen M. A. C., Uiterwaal C. S. P. M., van der Ent C. K., Grobbee D. E., Dalmeijer G. W. 1 okt 2019, In: Journal of Developmental Origins of Health and Disease. 10 , p. 563-569 7 p.

Rapid early increase in BMI is associated with impaired longitudinal growth in children with cystic fibrosis

Hak Sarah F., Arets Hubertus G.M., van der Ent Cornelis K., van der Kamp Hetty J. 1 aug 2019, In: Pediatric Pulmonology. 54 , p. 1209-1215 7 p.

Aligning patients' needs and research priorities towards a comprehensive CF research program

Noordhoek Jacquelien J., Gulmans Vincent A.M., Heijerman Harry G.M., van der Ent Cornelis K. 1 mei 2019, In: Journal of Cystic Fibrosis. 18 , p. 382-384 3 p.

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

Berkers Gitte, van Mourik Peter, Vonk Annelotte M, Kruisselbrink Evelien, Dekkers Johanna F, de Winter-de Groot Karin M, Arets Hubertus G M, Marck-van der Wilt Rozemarijn E P, Dijkema Jasper S, Vanderschuren Maaike M, Houwen Roderick H J, Heijerman Harry G M, van de Graaf Eduard A, Elias Sjoerd G, Majoor Christof J, Koppelman Gerard H, Roukema Jolt, Bakker Marleen, Janssens Hettie M, van der Meer Renske, Vries Robert G J, Clevers Hans C, de Jonge Hugo R, Beekman Jeffrey M, van der Ent Cornelis K 12 feb 2019, In: Cell Reports. 26 , p. 1701-1708.e3

Long-term expanding human airway organoids for disease modeling

Sachs Norman, Papaspyropoulos Angelos, Zomer-van Ommen Domenique D., Heo Inha, Böttinger Lena, Klay Dymph, Weeber Fleur, Huelsz-Prince Guizela, Iakobachvili Nino, Amatngalim Gimano D., de Ligt Joep, van Hoeck Arne, Proost Natalie, Viveen Marco C., Lyubimova Anna, Teeven Luc, Derakhshan Sepideh, Korving Jeroen, Begthel Harry, Dekkers Johanna F., Kumawat Kuldeep, Ramos Emilio, van Oosterhout Matthijs F.M., Offerhaus G. Johan, Wiener Dominique J., Olimpio Eduardo P., Dijkstra Krijn K., Smit Egbert F., van der Linden Maarten, Jaksani Sridevi, van de Ven Marieke, Jonkers Jos, Rios Anne C., Voest Emile E., van Moorsel Coline H.M., van der Ent Cornelis K., Cuppen Edwin, van Oudenaarden Alexander, Coenjaerts Frank E., Meyaard Linde, Bont Louis J., Peters Peter J., Tans Sander J., van Zon Jeroen S., Boj Sylvia F., Vries Robert G., Beekman Jeffrey M., Clevers Hans 1 jan 2019, In: EMBO Journal. 38

Intestinal organoids to model cystic fibrosis

Van Mourik Peter, Beekman Jeffrey M., Van Der Ent Cornelis K. 1 jan 2019, In: European Respiratory Journal. 54

Folding-function relationship of the most common cystic fibrosis-causing CFTR conductance mutants

Van Willigen Marcel, Vonk Annelotte M., Yeoh Hui Ying, Kruisselbrink Evelien, Kleizen Bertrand, Van Der Ent Cornelis K., Egmond Maarten R., De Jonge Hugo R., Braakman Ineke, Beekman Jeffrey M., Van Der Sluijs Peter 1 jan 2019, In: Life Science Alliance. 2

Healthy play, better coping:The importance of play for the development of children in health and disease

Nijhof Sanne L., Vinkers Christiaan H., van Geelen Stefan M., Duijff Sasja N., Achterberg E. J.Marijke, van der Net Janjaap, Veltkamp Remco C., Grootenhuis Martha A., van de Putte Elise M., Hillegers Manon H.J., van der Brug Anneke W., Wierenga Corette J., Benders Manon J.N.L., Engels Rutger C.M.E., van der Ent C. Kors, Vanderschuren Louk J.M.J., Lesscher Heidi M.B. 1 dec 2018, In: Neuroscience and Biobehavioral Reviews. 95 , p. 421-429 9 p.

Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as biomarker of CFTR function

de Winter-de Groot Karin M, Janssens Hettie M, van Uum Rick T, Dekkers Johanna F, Berkers Gitte, Vonk Annelotte, Kruisselbrink Evelien, Oppelaar Hugo, Vries Robert, Clevers Hans, Houwen Roderick H J, Escher Johanna C, Elias Sjoerd G, de Jonge Hugo R, de Rijke Yolanda B, Tiddens Harm A W M, van der Ent Cornelis K, Beekman Jeffrey M 30 aug 2018, In: European Respiratory Journal. 52

The impact of oral food challenges for food allergy on quality of life:a systematic review

Kansen Hannah M, Le Thuy-My, Meijer Yolanda, Flokstra-de Blok Bertine M J, Welsing Paco M J, van der Ent Cornelis K, Knulst André C, van Erp Francine C 1 aug 2018, In: Pediatric Allergy and Immunology. 29 , p. 527-537 11 p.

All Research Output (339)
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