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prof. dr. P. (Pim) van der Harst

prof. dr. P. (Pim) van der Harst

Full Professor
  • Division of Heart & Lungs

Research Programs

Circulatory Health

Biography

Biography

I am an interventional cardiologist and scientist and head of the department of cardiology of the University Medical Center Utrecht. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction. My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website: www.cardiomics.net  In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/m Health to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; www.early-synergy.nl) studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies. Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Side Activities

  • Member of the Supervisory Board Netherlands Heart Institute

Fellowship and Awards

Awards

2015

Winner of Humanimal – One Health Innovation Challenge 2015 with the Durrer Center (of which I was Chief Scientific Officer). Price for “Best Professional Idea Flevoland” for our Open One Health Biobank proposal (€ 50,000.--)

2013Scientific Excellence Award from the Board of the UMCG (€ 100,000.--)
2010 Excellence Award from the Netherlands Foundation for Cardiovascular Excellence for Scientific, Clinical and Presenting Excellence (€ 50,000.--)

Fellowships

2012NWO Clinical Fellowship (90.700.441); Systems and functional genomics strategies to identify novel vulnerability genes for heart failure. €160,000.--
2007VENI Fellowship (916.76.170) of the Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research (NWO); Telomere length in cardiovascular disease; differential expression and prognostic value (€ 248,000.--)
2008ICIN Fellowship (€ 45,000.--) of the Interuniversity Cardiology Institute of the Netherlands

         

 

Research Output (123)

The power of genetic diversity in genome-wide association studies of lipids

Graham Sarah E, Clarke Shoa L, Wu Kuan-Han H, Kanoni Stavroula, Zajac Greg J M, Ramdas Shweta, Surakka Ida, Ntalla Ioanna, Vedantam Sailaja, Winkler Thomas W, Locke Adam E, Marouli Eirini, Hwang Mi Yeong, Han Sohee, Narita Akira, Choudhury Ananyo, Bentley Amy R, Ekoru Kenneth, Verma Anurag, Trivedi Bhavi, Martin Hilary C, Hunt Karen A, Hui Qin, Klarin Derek, Zhu Xiang, Thorleifsson Gudmar, Helgadottir Anna, Gudbjartsson Daniel F, Holm Hilma, Olafsson Isleifur, Akiyama Masato, Sakaue Saori, Terao Chikashi, Kanai Masahiro, Zhou Wei, Brumpton Ben M, Rasheed Humaira, Ruotsalainen Sanni E, Havulinna Aki S, van der Laan Sander W, van Setten Jessica, de Kleijn Dominique, de Borst Gert J, Asselbergs Folkert W, Kraaijeveld Adriaan O, Beulens Joline W J, Pasterkamp Gerard, Hoefer Imo E, van der Harst Pim, Holmes Michael V, 9 dec 2021, In: Nature. 600 , p. 675-679 5 p.

3-Year Clinical Outcomes After Implantation of Permanent-Polymer Versus Polymer-Free Stent:ReCre8 Landmark Analysis

van Hemert Nicole D., Voskuil Michiel, Rozemeijer Rik, Stein Mèra, Frambach Peter, Pereira Bruno, Rittersma Saskia Z., Kraaijeveld Adriaan O., Leenders Geert E.H., Timmers Leo, van der Harst Pim, Agostoni Pierfrancesco, Stella Pieter R., 22 nov 2021, In: JACC: Cardiovascular Interventions. 14 , p. 2477-2486 10 p.

Percutaneous Coronary Intervention in Patients With Complex Lesion Anatomy: A ReCre8 Subanalysis

van Hemert Nicole, Voskuil Michiel, Rozemeijer Rik, Kraaijeveld Adriaan, Rittersma Saskia, Leenders Geert, Stein Mera, Frambach Peter, van der Harst Pim, Agostoni Pierfrancesco, Stella Pieter 9 nov 2021, In: Journal of the American College of Cardiology. 78 , p. B140-B141

Clinical Outcomes in Troponin-Negative Patients Treated With Short DAPT Undergoing Percutaneous Coronary Intervention: A Subanalysis of the ReCre8 Trial

Van Hemert Nicole, Voskuil Michiel, Rozemeijer Rik, Kraaijeveld Adriaan, Rittersma Saskia, Leenders Geert, Stein Mera, Frambach Peter, Van der Harst Pim, Agostoni Pierfrancesco, Stella Pieter 9 nov 2021, In: Journal of the American College of Cardiology. 78 , p. B74-B74

The effect of immediate coronary angiography after cardiac arrest without ST-segment elevation on left ventricular function. A sub-study of the COACT randomised trial

Lemkes Jorrit S, Spoormans Eva M, Demirkiran Ahmet, Leutscher Sophie, Janssens Gladys N, van der Hoeven Nina W, Jewbali Lucia S D, Dubois Eric A, Meuwissen Martijn, Rijpstra Tom A, Bosker Hans A, Blans Michiel J, Bleeker Gabe B, Baak Rémon, Vlachojannis Georgios J, Eikemans Bob J W, van der Harst Pim, van der Horst Iwan C C, Voskuil Michiel, van der Heijden Joris J, Beishuizen Albertus, Stoel Martin, Camaro Cyril, van der Hoeven Hans, Henriques José P, Vlaar Alexander P J, Vink Maarten A, van den Bogaard Bas, Heestermans Ton A C M, de Ruijter Wouter, Delnoij Thijs S R, Crijns Harry J G M, Jessurun Gillian A J, Oemrawsingh Pranobe V, Gosselink Marcel T M, Plomp Koos, Magro Michael, Elbers Paul W G, van de Ven Peter M, van Loon Ramon B, van Royen Niels 28 apr 2021, In: Resuscitation. 164 , p. 93-100 8 p.

Clopidogrel in noncarriers of CYP2C19 loss-of-function alleles versus ticagrelor in elderly patients with acute coronary syndrome:A pre-specified sub analysis from the POPular Genetics and POPular Age trials CYP2C19 alleles in elderly patients

Claassens Daniel M F, Gimbel Marieke E, Bergmeijer Thomas O, Vos Gerrit J A, Hermanides Renicus S, van der Harst Pim, Barbato Emanuele, Morisco Carmine, Tjon Joe Gin Richard M, de Vrey Evelyn A, Heestermans Ton A C M, Jukema J Wouter, von Birgelen Clemens, Waalewijn Reinier A, Hofma Sjoerd H, den Hartog Frank R, Voskuil Michiel, Van't Hof Arnoud W J, Asselbergs Folkert W, Mosterd A, Herrman Jean-Paul R, DeWilde Willem, Mahmoodi Bakhtawar K, Deneer Vera H M, Ten Berg Jurriën M 19 apr 2021, In: International Journal of Cardiology. 334 , p. 10-17 8 p.

Temporal Evolution of Serum Concentrations of High-Sensitivity Cardiac Troponin During 1 Year After Acute Coronary Syndrome Admission

van den Berg Victor J, Oemrawsingh Rohit M, Umans Victor A W M, Kardys Isabella, Asselbergs Folkert W, van der Harst Pim, Hoefer Imo E, Kietselaer Bas, Lenderink Timo, Oude Ophuis Anton J, van Schaik Ron H, de Winter Robbert J, Akkerhuis K Martijn, Boersma Eric, 5 jan 2021, In: Journal of the American Heart Association. 10 , p. 1-13 13 p.

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Lagou Vasiliki, Mägi Reedik, Hottenga Jouke- Jan, Grallert Harald, Perry John R B, Bouatia-Naji Nabila, Marullo Letizia, Rybin Denis, Jansen Rick, Min Josine L, Dimas Antigone S, Ulrich Anna, Zudina Liudmila, Gådin Jesper R, Jiang Longda, Faggian Alessia, Bonnefond Amélie, Fadista Joao, Stathopoulou Maria G, Isaacs Aaron, Willems Sara M, Navarro Pau, Tanaka Toshiko, Jackson Anne U, Montasser May E, O'Connell Jeff R, Bielak Lawrence F, Webster Rebecca J, Saxena Richa, Stafford Jeanette M, Pourcain Beate St, Timpson Nicholas J, Salo Perttu, Shin So-Youn, Amin Najaf, Smith Albert V, Li Guo, Verweij Niek, Goel Anuj, Ford Ian, Johnson Paul C D, Johnson Toby, Kapur Karen, Thorleifsson Gudmar, Strawbridge Rona J, Rasmussen-Torvik Laura J, Esko Tõnu, Mihailov Evelin, Fall Tove, Harst Pim van der, 5 jan 2021, In: Nature Communications. 12 , p. 24

Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation:A COACT trial substudy

Spoormans Eva M, Lemkes Jorrit S, Janssens Gladys N, van der Hoeven Nina W, Jewbali Lucia S D, Dubois Eric A, van de Ven Peter M, Meuwissen Martijn, Rijpstra Tom A, Bosker Hans A, Blans Michiel J, Bleeker Gabe B, Baak Remon, Vlachojannis Georgios J, Eikemans Bob J W, der Harst Pim van, van der Horst Iwan C C, Voskuil Michiel, van der Heijden Joris J, Beishuizen Albertus, Stoel Martin, Camaro Cyril, van der Hoeven Hans, Henriques José P, Vlaar Alexander P J, Vink Maarten A, van den Bogaard Bas, Heestermans Ton A C M, de Ruijter Wouter, Delnoij Thijs S R, Crijns Harry J G M, Jessurun Gillian A J, Oemrawsingh Pranobe V, Gosselink Marcel T M, Plomp Koos, Magro Michael, Elbers Paul W G, Appelman Yolande, van Royen Niels jan 2021, In: Resuscitation. 158 , p. 14-22 9 p.

Discovering and Visualizing Disease-specific Electrocardiogram Features Using Deep Learning:Proof-of-concept in Phospholamban Gene Mutation Carriers

van de Leur Rutger, Taha Karim, Bos Max N, van der Heijden Jeroen F, Gupta Deepak, Cramer Maarten J, Hassink Rutger J, van der Harst Pim, Doevendans Pieter A, Asselbergs Folkert W, van Es René 2021, In: Circulation. Arrhythmia and electrophysiology. 14 , p. 138-147

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