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prof. dr. P. (Pim) van der Harst

Full Professor
  • Division of Heart & Lungs

Research Programs

Circulatory Health

Biography

Biography

I am an interventional cardiologist and scientist and head of the department of cardiology of the University Medical Center Utrecht. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction. My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website: www.cardiomics.net  In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/m Health to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; www.early-synergy.nl) studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies. Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Side Activities

  • Member of the Supervisory Board Netherlands Heart Institute

Fellowship and Awards

Awards

2015

Winner of Humanimal – One Health Innovation Challenge 2015 with the Durrer Center (of which I was Chief Scientific Officer). Price for “Best Professional Idea Flevoland” for our Open One Health Biobank proposal (€ 50,000.--)

2013Scientific Excellence Award from the Board of the UMCG (€ 100,000.--)
2010 Excellence Award from the Netherlands Foundation for Cardiovascular Excellence for Scientific, Clinical and Presenting Excellence (€ 50,000.--)

Fellowships

2012NWO Clinical Fellowship (90.700.441); Systems and functional genomics strategies to identify novel vulnerability genes for heart failure. €160,000.--
2007VENI Fellowship (916.76.170) of the Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research (NWO); Telomere length in cardiovascular disease; differential expression and prognostic value (€ 248,000.--)
2008ICIN Fellowship (€ 45,000.--) of the Interuniversity Cardiology Institute of the Netherlands

         

 

Research Output (88)

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Lagou Vasiliki, Mägi Reedik, Hottenga Jouke- Jan, Grallert Harald, Perry John R B, Bouatia-Naji Nabila, Marullo Letizia, Rybin Denis, Jansen Rick, Min Josine L, Dimas Antigone S, Ulrich Anna, Zudina Liudmila, Gådin Jesper R, Jiang Longda, Faggian Alessia, Bonnefond Amélie, Fadista Joao, Stathopoulou Maria G, Isaacs Aaron, Willems Sara M, Navarro Pau, Tanaka Toshiko, Jackson Anne U, Montasser May E, O'Connell Jeff R, Bielak Lawrence F, Webster Rebecca J, Saxena Richa, Stafford Jeanette M, Pourcain Beate St, Timpson Nicholas J, Salo Perttu, Shin So-Youn, Amin Najaf, Smith Albert V, Li Guo, Verweij Niek, Goel Anuj, Ford Ian, Johnson Paul C D, Johnson Toby, Kapur Karen, Thorleifsson Gudmar, Strawbridge Rona J, Rasmussen-Torvik Laura J, Esko Tõnu, Mihailov Evelin, Fall Tove, Harst Pim van der, 5 jan 2021, In: Nature Communications. 12 , p. 24

Temporal Evolution of Serum Concentrations of High-Sensitivity Cardiac Troponin During 1 Year After Acute Coronary Syndrome Admission

van den Berg Victor J, Oemrawsingh Rohit M, Umans Victor A W M, Kardys Isabella, Asselbergs Folkert W, van der Harst Pim, Hoefer Imo E, Kietselaer Bas, Lenderink Timo, Oude Ophuis Anton J, van Schaik Ron H, de Winter Robbert J, Akkerhuis K Martijn, Boersma Eric, 5 jan 2021, In: Journal of the American Heart Association. 10 , p. 1-13 13 p.

Sex differences in patients with out-of-hospital cardiac arrest without ST-segment elevation:A COACT trial substudy

Spoormans Eva M, Lemkes Jorrit S, Janssens Gladys N, van der Hoeven Nina W, Jewbali Lucia S D, Dubois Eric A, van de Ven Peter M, Meuwissen Martijn, Rijpstra Tom A, Bosker Hans A, Blans Michiel J, Bleeker Gabe B, Baak Remon, Vlachojannis Georgios J, Eikemans Bob J W, der Harst Pim van, van der Horst Iwan C C, Voskuil Michiel, van der Heijden Joris J, Beishuizen Albertus, Stoel Martin, Camaro Cyril, van der Hoeven Hans, Henriques José P, Vlaar Alexander P J, Vink Maarten A, van den Bogaard Bas, Heestermans Ton A C M, de Ruijter Wouter, Delnoij Thijs S R, Crijns Harry J G M, Jessurun Gillian A J, Oemrawsingh Pranobe V, Gosselink Marcel T M, Plomp Koos, Magro Michael, Elbers Paul W G, Appelman Yolande, van Royen Niels jan 2021, In: Resuscitation. 158 , p. 14-22 9 p.

Discovering and Visualizing Disease-specific Electrocardiogram Features Using Deep Learning:Proof-of-concept in Phospholamban Gene Mutation Carriers

van de Leur Rutger, Taha Karim, Bos Max N, van der Heijden Jeroen F, Gupta Deepak, Cramer Maarten J, Hassink Rutger J, van der Harst Pim, Doevendans Pieter A, Asselbergs Folkert W, van Es René 2021, In: Circulation. Arrhythmia and electrophysiology. 14 , p. 138-147

Cardiac complications in patients hospitalised with COVID-19

Linschoten Marijke, Peters Sanne, van Smeden Maarten, Jewbali Lucia S, Schaap Jeroen, Siebelink Hans-Marc, Smits Peter C, Tieleman Robert G, van der Harst Pim, van Gilst Wiek H, Asselbergs Folkert W, dec 2020, In: European Heart Journal. Acute Cardiovascular Care. 9 , p. 817-823 7 p.

Data on sex differences in one-year outcomes of out-of-hospital cardiac arrest patients without ST-segment elevation

Spoormans Eva M., Lemkes Jorrit S., Janssens Gladys N., van der Hoeven Nina W., Jewbali Lucia S.D., Dubois Eric A., van de Ven Peter M., Meuwissen Martijn, Rijpstra Tom A., Bosker Hans A., Blans Michiel J., Bleeker Gabe B., Baak Remon, Vlachojannis Georgios J., Eikemans Bob J.W., van der Harst Pim, van der Horst Iwan C.C., Voskuil Michiel, van der Heijden Joris J., Beishuizen Albertus, Stoel Martin, Camaro Cyril, van der Hoeven Hans, Henriques José P., Vlaar Alexander P.J., Vink Maarten A., van den Bogaard Bas, Heestermans Ton A.C.M., de Ruijter Wouter, Delnoij Thijs S.R., Crijns Harry J.G.M., Jessurun Gillian A.J., Oemrawsingh Pranobe V., Gosselink Marcel T.M., Plomp Koos, Magro Michael, Elbers Paul W.G., Appelman Yolande, van Royen Niels dec 2020, In: Data in Brief. 33 , p. 1-5

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Surendran Praveen, Feofanova Elena V., Lahrouchi Najim, Ntalla Ioanna, Karthikeyan Savita, Cook James, Chen Lingyan, Mifsud Borbala, Yao Chen, Kraja Aldi T., Cartwright James H., Hellwege Jacklyn N., Giri Ayush, Tragante Vinicius, Thorleifsson Gudmar, Liu Dajiang J., Prins Bram P., Stewart Isobel D., Cabrera Claudia P., Eales James M., Akbarov Artur, Auer Paul L., Bielak Lawrence F., Bis Joshua C., Braithwaite Vickie S., Brody Jennifer A., Daw E. Warwick, Warren Helen R., Drenos Fotios, Nielsen Sune Fallgaard, Faul Jessica D., Fauman Eric B., Fava Cristiano, Ferreira Teresa, Foley Christopher N., Franceschini Nora, Gao He, Giannakopoulou Olga, Giulianini Franco, Gudbjartsson Daniel F., Guo Xiuqing, Harris Sarah E., Havulinna Aki S., Helgadottir Anna, van der Harst Pim, Vaartjes Ilonca, Asselbergs Folkert W., Bots Michiel L., van der Harst Pim, van der Meer Peter, , , , , dec 2020, In: Nature Genetics. 52 , p. 1314-1332 19 p.

Preemptive Stenting of the Vulnerable Plaque:Fixing a Dogma?

Pasterkamp Gerard, van der Harst Pim, den Ruijter Hester M 17 nov 2020, In: Journal of the American College of Cardiology. 76 , p. 2302-2304 3 p.

Effect of Adding Ticagrelor to Standard Aspirin on Saphenous Vein Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting (POPular CABG):A Randomized, Double-Blind, Placebo-Controlled Trial

Willemsen Laura M., Janssen Paul W.A., Peper Joyce, Soliman-Hamad Mohamed A., van Straten Albert H.M., Klein Patrick, Hackeng Chris M., Sonker Uday, Bekker Margreet W.A., von Birgelen Clemens, Brouwer Marc A., van der Harst Pim, Vlot Eline A., Deneer Vera H.M., Chan Pin Yin Dean R.P.P., Gimbel Marieke E., Beukema Kasper F., Daeter Edgar J., Kelder Johannes C., Tijssen Jan G.P., Rensing Benno J.W.M., van Es Hendrik W., Swaans Martin J., Ten Berg Jurrien M. 10 nov 2020, In: Circulation. 142 , p. 1799-1807 9 p.

Big Data and Artificial Intelligence:Opportunities and Threats in Electrophysiology

van de Leur Rutger R, Boonstra Machteld J, Bagheri Ayoub, Roudijk Rob W, Sammani Arjan, Taha Karim, Doevendans Pieter Afm, van der Harst Pim, van Dam Peter M, Hassink Rutger J, van Es René, university Folkert W nov 2020, In: Arrhythmia & electrophysiology review. 9 , p. 146-154 9 p.

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