prof. dr. P. (Pim) van der Harst

prof. dr. P. (Pim) van der Harst

Full Professor
prof. dr. P. (Pim) van der Harst
  • Department of Cardiology

Research Programs

Circulatory Health



I am an interventional cardiologist and scientist and head of the department of cardiology of the University Medical Center Utrecht. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction. My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website:  In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/m Health to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies. Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Side Activities

2020- honorary appointment Departmentof Cardiology, University Medical Center Groningen

2020- National member of Scientific Advisory Board LifeLiens Cohort Study

2019- Member of Science & Innovation Committee, Dutch Society of Cardiology

2019- Member of the Scientific Counsel of the Dutch Heart Registration (NHR)

2019- Nucleus member of the Council on Cardiovascular Genomics, European Society of Cardiology

2018- Member of the Workgroup Acute Coronary Syndrome, Dutch Society of Cardiology

2020-2021 Member of the Supervisory Board Netherlands Heart Institute

2017-2021 Co-founder and manager non-medical affairs Mijnhuisarts B.V. (primary care facility province of Groningen)

2017- Director and owner of the holding Generalis Procuratio B.V. 

2016-2020 Local member of Scientific Advisory Board LifeLines Cohort Study, LifeLines B.V.

2015-2018 co-organizer & member of the Programing Committee  Netherlands Heart Days

2015-2015 Member of the Scientific Sessions Programing Committee, American Heart Association

2014- Member of the Workgroup Interventional Cardiology, Dutch Society of Cardiology

2010-2015 Associate Editor European Journal of Heart Failure

2010-2016 Associate Editor BMC Medical Genetics

2010-2012 member of grant committee Netherlands Heart Foundation

2009-2018 Honorary appointment Department of Cardiovascular Sciences, University of Leicester, UK

2008-2008 Academic Editor of medical journal PLoS Medicine

2008-2012 Editorial Advisory Panel of medical journal Clinical Science

20??-? Associate Editor Netherlands Heart Journal

Ad-hoc reviewer for medical journals (including, but not limited to Lancet, Nat Genet, JAMA, PLoS Med, Circulation, Circ Res, J Am Coll Cardiol, Arterioscler Thromb Vasc Biol, Hypertension, Eur Heart J, Hum Mol Genet)

Ad-hoc grant reviewer (including but not limited to; Netherlands Heart Foundation; Netherlands Organisation for Scientific Research (NWO, Netherlands); The Research Foundation Flanders (FWO, Belgium); Medical Research Councel (MRC, South Africa); Danish Councel for Independent Research (FI, Denmark);  National Center of Science and Technology Evaluation (Ministry of Education and Science, Republic of Kazakhstan); Heart Research UK (UK). 

Fellowship and Awards



Winner of Humanimal – One Health Innovation Challenge 2015 with the Durrer Center (of which I was Chief Scientific Officer). Price for “Best Professional Idea Flevoland” for our Open One Health Biobank proposal (€ 50,000.--)

2013Scientific Excellence Award from the Board of the UMCG (€ 100,000.--)
2010 Excellence Award from the Netherlands Foundation for Cardiovascular Excellence for Scientific, Clinical and Presenting Excellence (€ 50,000.--)


2012NWO Clinical Fellowship (90.700.441); Systems and functional genomics strategies to identify novel vulnerability genes for heart failure. €160,000.--
2007VENI Fellowship (916.76.170) of the Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research (NWO); Telomere length in cardiovascular disease; differential expression and prognostic value (€ 248,000.--)
2008ICIN Fellowship (€ 45,000.--) of the Interuniversity Cardiology Institute of the Netherlands



Research Output (496)

Author Correction:The power of genetic diversity in genome-wide association studies of lipids (Nature, (2021), 600, 7890, (675-679), 10.1038/s41586-021-04064-3)

Graham Sarah E, Clarke Shoa L, Wu Kuan-Han H, Kanoni Stavroula, Zajac Greg J M, Ramdas Shweta, Surakka Ida, Ntalla Ioanna, Vedantam Sailaja, Winkler Thomas W, Locke Adam E, Marouli Eirini, Hwang Mi Yeong, Han Sohee, Narita Akira, Choudhury Ananyo, Bentley Amy R, Ekoru Kenneth, Verma Anurag, Trivedi Bhavi, Martin Hilary C, Hunt Karen A, Hui Qin, Klarin Derek, Zhu Xiang, Thorleifsson Gudmar, Helgadottir Anna, Gudbjartsson Daniel F, Holm Hilma, Olafsson Isleifur, Akiyama Masato, Sakaue Saori, Terao Chikashi, Kanai Masahiro, Zhou Wei, Brumpton Ben M, Rasheed Humaira, Ruotsalainen Sanni E, Havulinna Aki S, van der Laan Sander W, van Setten Jessica, de Kleijn Dominique, de Borst Gert J, Asselbergs Folkert W, Kraaijeveld Adriaan O, Beulens Joline W J, Pasterkamp Gerard, Hoefer Imo E, van der Harst Pim, Holmes Michael V, 26 May 2023, In: Nature. 618 , p. E19-E20

Druggable proteins influencing cardiac structure and function:Implications for heart failure therapies and cancer cardiotoxicity

Schmidt Amand F, Bourfiss Mimount, Alasiri Abdulrahman, Puyol-Anton Esther, Chopade Sandesh, van Vugt Marion, van der Laan Sander W, Gross Christian, Clarkson Chris, Henry Albert, Lumbers Tom R, van der Harst Pim, Franceschini Nora, Bis Joshua C, Velthuis Birgitta K, Te Riele Anneline S J M, Hingorani Aroon D, Ruijsink Bram, Asselbergs Folkert W, van Setten Jessica, Finan Chris 28 Apr 2023, In: Science advances. 9 17 p.

Long-term follow-up of contemporary drug-eluting stent implantation in diabetic patients:Subanalysis of a randomized controlled trial

van Hemert Nicole D., Voskuil Michiel, Rozemeijer Rik, Kraaijeveld Adriaan O., Rittersma Saskia Z., Leenders Geert E.H., Stein Mèra, Frambach Peter, van der Harst Pim, Agostoni Pierfrancesco, Stella Pieter R., 18 Jan 2023, In: Catheterization and Cardiovascular Interventions. 101 , p. 505-510 6 p.

High bleeding risk in patients undergoing percutaneous coronary intervention with drug-eluting stent implantation:ReCre8 subanalysis

van Hemert Nicole D., Stella Pieter R., Rozemeijer Rik, Stein Mèra, Frambach Peter, Kraaijeveld Adriaan O., Rittersma Saskia Z., Meijs Timion A., Leenders Geert E.H., van der Harst Pim, Agostoni Pierfrancesco, Voskuil Michiel, Dec 2022, In: American Heart Journal Plus: Cardiology Research and Practice. 24 7 p.

Electrocardiogram-based deep learning improves outcome prediction following cardiac resynchronization therapy

Wouters Philippe C., van de Leur Rutger R., Vessies Melle B., van Stipdonk Antonius M.W., Ghossein Mohammed A., Hassink Rutger J., Doevendans Pieter A., van der Harst Pim, Maass Alexander H., Prinzen Frits W., Vernooy Kevin, Meine Mathias, van Es René 7 Nov 2022, In: European heart journal. 44 , p. 680-692 13 p.

A saturated map of common genetic variants associated with human height

Yengo Loïc, Vedantam Sailaja, Marouli Eirini, Sidorenko Julia, Bartell Eric, Sakaue Saori, Graff Marielisa, Eliasen Anders U, Jiang Yunxuan, Raghavan Sridharan, Miao Jenkai, Arias Joshua D, Graham Sarah E, Mukamel Ronen E, Spracklen Cassandra N, Yin Xianyong, Chen Shyh-Huei, Ferreira Teresa, Highland Heather H, Ji Yingjie, Karaderi Tugce, Lin Kuang, Lüll Kreete, Malden Deborah E, Medina-Gomez Carolina, Machado Moara, Moore Amy, Rüeger Sina, Sim Xueling, Vrieze Scott, Ahluwalia Tarunveer S, Akiyama Masato, Allison Matthew A, Alvarez Marcus, Andersen Mette K, Ani Alireza, Appadurai Vivek, Arbeeva Liubov, Bhaskar Seema, Bielak Lawrence F, Bollepalli Sailalitha, Bonnycastle Lori L, Bork-Jensen Jette, van der Laan Sander W, van Setten Jessica, Asselbergs Folkert W, de Borst Gert J, de Kleijn Dominique P V, Kraaijeveld Adriaan, van der Harst Pim, 27 Oct 2022, In: Nature. 610 , p. 704-712 9 p.

Clonal haematopoiesis of indeterminate potential:associations with heart failure incidence, clinical parameters and biomarkers

Shi Canxia, Aboumsallem Joseph Pierre, Suthahar Navin, de Graaf Aniek O, Jansen Joop H, van Zeventer Isabelle A, Bracun Valentina, de Wit Sanne, Screever Elles M, van den Berg Pieter F, Meijers Wouter C, Gansevoort Ron T, Bakker Stephan J L, van der Harst Pim, Silljé Herman H W, Huls Gerwin, de Boer Rudolf A 11 Oct 2022, In: European Journal of Heart Failure. 25 , p. 4-13 10 p.

Variants in the GPR146 Gene Are Associated With a Favorable Cardiometabolic Risk Profile.

Rimbert Antoine, Yeung Ming W, Dalila Nawar, Thio Chris H L, Yu Haojie, Loaiza Natalia, Oldoni Federico, van der Graaf Adriaan, Wang Siqi, Said M Abdullah, Blauw Lisanne L, Girardeau Aurore, Bray Lise, Caillaud Amandine, Bloks Vincent W, Marrec Marie, Moulin Philippe, Rensen Patrick C N, van de Sluis Bart, Snieder Harold, Di Filippo Mathilde, van der Harst Pim, Tybjaerg-Hansen Anne, Zimmerman Philip, Cariou Bertrand, Kuivenhoven Jan Albert Oct 2022, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 42 , p. 1262-1271 10 p.

All research output

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