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prof. dr. P. (Pim) van der Harst

Full Professor

  • Department of Cardiology

Research Programs

Biography

I am an interventional cardiologist and scientist and head of the department of cardiology of the University Medical Center Utrecht. My clinical work includes the percutaneous treatment of obstructive coronary artery disease, including acute myocardial infarction. My translational research focusses on the analysis of big and complex data (e.g. genetic, ehr, imaging), including the use of machine learning and cloud computing, to improve our understanding and the early detection of coronary artery disease and heart failure. To this end we use large population based cohorts, including the Dutch PREVEND and LifeLine cohorts and the UK Biobank. Data on my "omics" research can be found our my website: www.cardiomics.net  In my clinical translational research I am also working on advanced image analysis, device interventions, machine learning, deep learning, and e/m Health to further improve and personalize care for our patients. Currently ongoing diagnostic imaging studies in include the REPLACE-IT (replacement of invasive coronary angiography) and the EARLY-SYNERGY (early detection of obstructive coronary artery disease; www.early-synergy.nl) studies. Currently interventional studies include the GIPS-IV, AXES and MRI-MC studies. Many of my projects based on collaborations with the most influential and creative individuals and research groups in the world.

Side Activities

    • Member of the Supervisory Board Netherlands Heart Institute

Fellowship and Awards

  • Awards

    2015

    Winner of Humanimal – One Health Innovation Challenge 2015 with the Durrer Center (of which I was Chief Scientific Officer). Price for “Best Professional Idea Flevoland” for our Open One Health Biobank proposal (€ 50,000.--)

    2013Scientific Excellence Award from the Board of the UMCG (€ 100,000.--)
    2010 Excellence Award from the Netherlands Foundation for Cardiovascular Excellence for Scientific, Clinical and Presenting Excellence (€ 50,000.--)

    Fellowships

    2012NWO Clinical Fellowship (90.700.441); Systems and functional genomics strategies to identify novel vulnerability genes for heart failure. €160,000.--
    2007VENI Fellowship (916.76.170) of the Innovational Research Incentives Scheme of the Netherlands Organization for Scientific Research (NWO); Telomere length in cardiovascular disease; differential expression and prognostic value (€ 248,000.--)
    2008ICIN Fellowship (€ 45,000.--) of the Interuniversity Cardiology Institute of the Netherlands

             

     

Research Output (9)

Sex-Based Differences in Unrecognized Myocardial Infarction

van der Ende M Yldau, Juarez-Orozco Luis Eduardo, Waardenburg Ingmar, Lipsic Erik, Schurer Remco A J, van der Werf Hindrik W, Benjamin Emelia J, van Veldhuisen Dirk Jan, Snieder Harold, van der Harst Pim 7 jul 2020, In: Journal of the American Heart Association. 9 15 p.

Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure

Huang Yisong, Ollikainen Miina, Muniandy Maheswary, Zhang Tao, van Dongen Jenny, Hao Guang, van der Most Peter J, Pan Yue, Pervjakova Natalia, Sun Yan V, Hui Qin, Lahti Jari, Fraszczyk Eliza, Lu Xueling, Sun Dianjianyi, Richard Melissa A, Willemsen Gonneke, Heikkila Kauko, Mateo Leach Irene, Mononen Nina, Kähönen Mika, Hurme Mikko A, Raitakari Olli T, Drake Amanda J, Perola Markus, Nuotio Marja-Liisa, Huang Yunfeng, Khulan Batbayar, Räikkönen Katri, Wolffenbuttel Bruce H R, Zhernakova Alexandra, Fu Jingyuan, Zhu Haidong, Dong Yanbin, van Vliet-Ostaptchouk Jana V, Franke Lude, Eriksson Johan G, Fornage Myriam, Milani Lili, Lehtimäki Terho, Vaccarino Viola, Boomsma Dorret I, van der Harst Pim, de Geus Eco J C, Salomaa Veikko, Li Shengxu, Chen Wei, Su Shaoyong, Wilson James, Snieder Harold, Kaprio Jaakko, Wang Xiaoling jul 2020, In: Hypertension (Dallas, Tex. : 1979). 76 , p. 195-205 11 p.

Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours

van de Vegte Yordi J, Said M Abdullah, Rienstra Michiel, van der Harst Pim, Verweij Niek 21 apr 2020, In: Nature Communications. 11 10 p.

High-frequency metabolite profiling and the incidence of recurrent cardiac events in patients with post-acute coronary syndrome

Vroegindewey Maxime M., van den Berg Victor J., Oemrawsingh Rohit M., Kardys Isabella, Asselbergs Folkert W., van der Harst Pim, Kietselaer Bas, Lenderink Timo, Akkerhuis K. Martijn, Boersma Eric 2 apr 2020, In: Biomarkers. 25 , p. 235-240

Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation

Nijenhuis Vincent J, Brouwer Jorn, Delewi Ronak, Hermanides Renicus S, Holvoet Wouter, Dubois Christophe L F, Frambach Peter, De Bruyne Bernard, van Houwelingen Gert K, Van Der Heyden Jan A S, Toušek Petr, van der Kley Frank, Buysschaert Ian, Schotborgh Carl E, Ferdinande Bert, van der Harst Pim, Roosen John, Peper Joyce, Thielen Frederick W F, Veenstra Leo, Chan Pin Yin Dean R P P, Swaans Martin J, Rensing Benno J W M, van 't Hof Arnoud W J, Timmers Leo, Kelder Johannes C, Stella Pieter R, Baan Jan, Ten Berg Jurriën M 29 mrt 2020, In: The New England journal of medicine. 382 , p. 1696-1707 12 p.

One Year Outcomes of Coronary Angiography After Cardiac Arrest

Lemkes Jorrit, Janssens Gladys, van der Hoeven Nina, Jewbali Lucia, Dubois Eric, Meuwissen Martijn, Rijpstra Tom, Bosker Hans, Blans Michiel, Bleeker Gabe, Baak Remon, Vlachojannis Georgios, Eikemans Bob, van der Harst Pim, van der Horst Iwan, Voskuil Michiel, van der Heijden Joris, Beishuizen Albertus, Stoel Martin, Camaro Cyril, van der Hoeven Hans, Henriques Jose, Vlaar Alexander, Vink Maarten, Heestermans Ton, Delnoij Thijs, Jessurun Gillian, Oemrawsingh Pranobe, Gosselink Marcel, Plomp Koos, Magro Michael, Elbers Paul, van de Ven Peter, Oudemans-van Straaten Heleen, van Royen Niels 17 dec 2019, In: Circulation. 140 , p. E983-E983

A genotype-guided strategy for oral P2Y<sub>12</sub> inhibitors in primary PCI

Claassens Daniel M.F., Vos Gerrit J.A., Bergmeijer Thomas O., Hermanides Renicus S., Van’t Hof Arnoud W.J., Van Der Harst Pim, Barbato Emanuele, Morisco Carmine, Tjon Joe Gin Richard M., Asselbergs Folkert W., Mosterd Arend, Herrman Jean Paul R., Dewilde Willem J.M., Janssen Paul W.A., Kelder Johannes C., Postma Maarten J., De Boer Anthonius, Boersma Cornelis, Deneer Vera H.M., ten Berg Jurriën M. 24 okt 2019, In: New England Journal of Medicine. 381 , p. 1621-1631 11 p.

Enhancing cardiovascular artificial intelligence (AI) research in the Netherlands:CVON-AI consortium

Benjamins J. W., van Leeuwen K., Hofstra L., Rienstra M., Appelman Y., Nijhof W., Verlaat B., Everts I., den Ruijter H. M., Isgum I., Leiner T., Vliegenthart R., Asselbergs F. W., Juarez-Orozco L. E., van der Harst P. 1 sep 2019, In: Netherlands Heart Journal. 27 , p. 414-425 12 p.

The diagnostic accuracy of clinical examination for estimating cardiac index in critically ill patients:the Simple Intensive Care Studies-I

Hiemstra Bart, Koster Geert, Wiersema Renske, Hummel Yoran M., van der Harst Pim, Snieder Harold, Eck Ruben J., Kaufmann Thomas, Scheeren Thomas W.L., Perner Anders, Wetterslev Jørn, de Smet Anne Marie G.A., Keus Frederik, van der Horst Iwan C.C., Koster Geert, Keus Frederik, van der Horst Iwan C.C., Dieperink Willem, Bleijendaal Roos, Cawale Yasmin F., Clement Ramon P., Dijkhuizen Devon, Eck Ruben J., Hiemstra Bart, Haker Anja, Hilbink Casper D.H., Kaufmann Thomas, Klasen Martiene, Klaver Manon, Schokking Laura J., Sikkens Victor W., Vos Madelon, Woerlee Justin, Wiersema Renske, 27 feb 2019, In: Intensive Care Medicine. 45 , p. 190-200 11 p.