dr. M.A.G. van der Heyden

dr. M.A.G. van der Heyden

Associate Professor
dr. M.A.G. van der Heyden
  • Department of Medical Physiology

Research Programs

Circulatory Health



Marcel is associate professor in the department of Medical Physiology at the University Medical Center Utrecht, The Netherlands. He obtained his PhD in the field of cancer research at the Utrecht University in 1995. Thereafter he performed two post-docs on stem cell biology and connexins at the Netherlands Institute of Developmental Biology. He entered the field of cardiac arrhythmias in 2000.
Currently, his focus is on cardiac potassium ion channel pharmacology and ion channel trafficking. His research group combines functional electrophysiological methods with cellular and molecular biology, and biochemical methods. He authored more than 120 peer reviewed papers, most of which deal with membrane protein biology and pharmacology including ion channels. 

Marcel teaches and writes on scientific integrity and is member of several advisory panels on this subject. Marcel is associate editor on four peer review physiology journals and was secretary of the Dutch Society of Physiology for five years. In 2017/18 he worked as guest-professor at the Department of Pharmacology and Toxicology at Vienna University. Marcel is a passionate teacher of physiology. He obtained his Senior Teaching Qualification in 2018 and is currently coordinator and examiner in the Medical curriculum in the course Circulation 1 and the bachelor Honours Program for medical students.



Cardiac physiology

Potassium ion channels

Cardiac arrhythmia

Ion channel trafficking

Scientific integrity

Research Output (138)

Towards the Development of AgoKirs:New Pharmacological Activators to Study Kir2.x Channel and Target Cardiac Disease

van der Schoor Laura, van Hattum Emma J, de Wilde Sophie M, Harlianto Netanja I, van Weert Aart-Jan, Bloothooft Meye, van der Heyden Marcel A G 11 aug 2020, In: International journal of molecular sciences. 21 , p. 1-13 13 p.

LUF7244 plus Dofetilide Rescues Aberrant Kv11.1 Trafficking and Produces Functional IKv11.1

Qile Muge, Ji Yuan, Golden Tyona D, Houtman Marien J C, Romunde Fee, Fransen Doreth, van Ham Willem B, IJzerman Ad P, January Craig T, Heitman Laura H, Stary-Weinzinger Anna, Delisle Brian P, van der Heyden Marcel A G jun 2020, In: Molecular Pharmacology. 97 , p. 355-364 10 p.

Drug-likeness of linear pentamidine analogues and their impact on the hERG K+ channel - correlation with structural features

Zolek Teresa, Qile M, Kazmierczak Pawel, Bloothooft Meye, van der Heyden MAG, Maciejewska Dorota 25 nov 2019, In: Royal Society of Chemistry. 9 , p. 38355-38371 17 p.

Disease Associated Mutations in KIR Proteins Linked to Aberrant Inward Rectifier Channel Trafficking

Zangerl-Plessl Eva-Maria, Bloothooft Meye, Stary-Weinzinger Anna, van der Heyden Marcel A G, Qile M 25 okt 2019, In: Biomolecules. 9

Glibenclamide and HMR1098 normalize Cantú syndrome-associated gain-of-function currents

Houtman Marien J C, Chen Xingyu, Qile Muge, Duran Karen, van Haaften Gijs, Stary-Weinzinger Anna, van der Heyden Marcel A G 1 aug 2019, In: Journal of Cellular and Molecular Medicine. 23 , p. 4962-4969 8 p.

LUF7244, an allosteric modulator/activator of K <sub>v</sub>11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

Qile Muge, Beekman Henriette D M, Sprenkeler David J, Houtman Marien J C, van Ham W B, Stary-Weinzinger Anna, Beyl Stanislav, Hering Steffen, van den Berg Dirk-Jan, de Lange Elizabeth C M, Heitman Laura H, IJzerman Ad P, Vos Marc A, van der Heyden Marcel A G 24 jul 2019, In: British Journal of Pharmacology. 176 , p. 3871-3885 15 p.

Nicotine intoxication by e-cigarette liquids:a study of case reports and pathophysiology

Maessen Gerdinique C, Wijnhoven Anjali M, Neijzen Rosalie L, Paulus Michelle C, van Heel Dayna A M, Bomers Bart H A, Boersma Lucie E, Konya Burak, van der Heyden Marcel A G 9 jul 2019, In: Clinical Toxicology . 58 , p. 1-8 8 p.

Identification of a PEST Sequence in Vertebrate KIR2.1 That Modifies Rectification

Qile Muge, Ji Yuan, Houtman Marien J C, Veldhuis Marlieke, Romunde Fee, Kok Bart, van der Heyden Marcel A G 5 jul 2019, In: Frontiers in Physiology. 10

Sex hormones and jumping heart beats

van der Heyden Marcel A G, Vos Marc A jun 2019, In: Journal of Cardiovascular Electrophysiology. 30 , p. 950-951 2 p.

All research output

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