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prof. dr. P.J. (Paul J.) van Diest

prof. dr. P.J. (Paul J.) van Diest

Full Professor
prof. dr. P.J. (Paul J.) van Diest
  • Department of Pathology

Research Programs

Strategic Program Cancer

Biography

Biography

Paul J van Diest has been a dedicated cancer researcher since the start of his career, obtaining numerous grants a.o. from the NIH and the Dutch Cancer Society. He studied Medicine, did his PhD and pathology residency at the VU University medical center (VUMC) in Amsterdam. After obtaining his Board certification in Pathology in 1996, he became Consultant Pathologist at the Department of Pathology of the VUMC. In 1999 he was appointed Associate Professor and in 2001 to full Professor. In 2003 he moved to Utrecht to become Head of the Department of Pathology at the University Medical Center Utrecht (UMCU) where he is currently still working. He is Adjunct Professor of Oncology at the Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, USA. He serves on the editorial board of >20 international journals. He has been active in the board as secretary and president of several international societies. He has published >700 papers in peer reviewed journals, personally supervised 70 PhD theses, and has an H-index of 66. The main theme of his research is finding ways for prevention, optimized diagnosis and cure of breast cancer, both the male and female forms. He is also active in the field of implementing digital pathology.

Side Activities

From all these activitites for the UMC Utrecht  there never is personal income, or - if there is a fee - it is for the department of pathology of Utrecht.

Adjunct Professor of Oncology, Sidney Kimmel Oncology Center at Johns Hopkins, Baltimore, USA

Member of the Digital Pathology advisory board of PAIGE.

Editorial board activities

World Journal of Surgical Procedures      

Member of the Editorial Board of Recent Patents on Biomarkers

Member of the Editorial Board of the Chinese Journal of Clinicians

Associate editor of BMC Cancer

Member of the Editorial Board of Pathology Research International

Member of the Editorial Board of The Open Plastic Surgery Journal

Member of the Editorial Board of The Open Prostate Journal

Member of the Editorial Board of Laboratory Investigation

Member of the Editorial Board of the Journal of Experimental & Clinical Cancer Research

Member of the Editorial Board of Biotechnic and Histochemistry

Member of the Editorial Board of Analytical and Quantitative Cytology and Histology

Academic Editor of PlosOne

Associate editor of the Journal of Case Reports in Medicine

Member of the Editorial Board of World Journal of Medical Genetics

Member of the Editorial Board of World Journal of Clinical Urology

Member of the Editorial Board of World Journal of Surgical Procedures

Member of the Editorial Board of Current Biomarker Findings

 

Advisory boards

 

2005-               Member of the breast cancer advisory board of Astra Zenica

2008-               Member of the Digital Pathology advisory board of Philips.

2013-               Member of the Advisory Council of the Breast Cancer Society Netherlands (BVN)

2014-               Member of the advisory board of PathXL

2015-               Member of the advisory board of Sectra

Invited Speaker on (Inter)National Meetings 121 in 2003-2019: 1 only 2018-9 below for brevity reasons

2018

 

  1. Sol Goldman Think-Tank Meeting on Artificial Intelligence as Applied to Pancreatic Cancer. Baltimore, MD, USA, April 16, 2018. Invited speaker.

  2. 11th joint meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland. Maastricht, The Netherlands, June 19-22 2018. Invited speaker.

  3. 30th European Congress of Pathology, Bilbao, Spain, September 8-12, 2018. Invited speaker.

  4. Hans Peterse Lecture at the NKI breast cancer symposium 2018. Amsterdam, The Netherlands, October 31, 2018. Invited speaker.

  5. Digital pathology in daily practice: The current status and the future. Utrecht, The Netherlands, November 2 2018. Organizer, speaker.

  6. 84th Annual Meeting of the Swiss Society of Pathology. Lugano, Switzerland, November 10, 2018. Invited speaker.

     

    2019

     

  7. European Congress of Radiology. Vienna, Austria, Febuary 27-March 3, 2019. Invited speaker.

  8. Artificial Intelligence in 2019: Where we are now. London UK, March 22, 2019. Invited speaker.

  9. 1e Wad 'n Workshop: Mammacarcinoom, Terschelling, The Netherlands, March 24-26. Invited speaker.

  10. European Working Group of Breast Screening Pathologists. Dublin, Ireland, March 29 2019. Invited speaker.

  11. Pathology week. Veenendaal, The Netherlands, April 9-12. Invited speaker.

  12. 5th Digital Pathology & AI congress: USA. NYC, NY, USA. June 13-14, 2019. Invited speaker

Yearly lectures 

1 NVvO Dutch Society of Oncology

2 ODDP, Oncology Drug Development in Practice

3 University of Siena

Contract research

OncoMark Ltd. Dublin, Ireland, Euro 15,000

Samantree Medical SA, Lausanne, Switzerland, Euro 18.000

Fellowship and Awards

Dutch Cancer Society (KWF)

Health Care Efficiency Research Programme of The Netherlands Organization for Health Research and Development (ZonMw)

Research Output (994)

Patient-centered research: how do women tolerate nipple fluid aspiration as a potential screening tool for breast cancer?

Patuleia Susana I S, Moelans Cathy B, Koopman Jasmijn, van Steenhoven Julia E C, van Dalen Thijs, van der Pol Carmen C, Jager Agnes, Ausems Margreet G E M, van Diest Paul J, van der Wall Elsken, Suijkerbuijk Karijn P M 27 Jun 2022, In: BMC Cancer. 22 , p. 1-8

Correction:Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Rätze Max A K, Koorman Thijs, Sijnesael Thijmen, Bassey-Archibong Blessing, van de Ven Robert, Enserink Lotte, Visser Daan, Jaksani Sridevi, Viciano Ignacio, Bakker Elvira R M, Richard François, Tutt Andrew, O'Leary Lynda, Fitzpatrick Amanda, Roca-Cusachs Pere, van Diest Paul J, Desmedt Christine, Daniel Juliet M, Isacke Clare M, Derksen Patrick W B 24 May 2022, In: Oncogene. 41 , p. 3507-3509 3 p.

Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Rätze Max A K, Koorman Thijs, Sijnesael Thijmen, Bassey-Archibong Blessing, van de Ven Robert, Enserink Lotte, Visser Daan, Jaksani Sridevi, Viciano Ignacio, Bakker Elvira R M, Richard François, Tutt Andrew, O'Leary Lynda, Fitzpatrick Amanda, Roca-Cusachs Pere, van Diest Paul J, Desmedt Christine, Daniel Juliet M, Isacke Clare M, Derksen Patrick W B 20 May 2022, In: Oncogene. 41 , p. 2932-2944 13 p.

Limiting systemic endocrine overtreatment in postmenopausal breast cancer patients with an ultralow classification of the 70-gene signature

Opdam M, van der Noort V, Kleijn M, Glas A, Mandjes I, Kleiterp S, Hilbers F S, Kruger D T, Bins A D, de Jong P C, Schiphorst P P J B M, van Dalen T, Flameling B, Rietbroek R C, Beeker A, van den Heiligenberg S M, Bakker S D, Wymenga A N M, Oving I M, Bijlsma R M, van Diest P J, Vermorken J B, van Tinteren H, Linn S C 19 May 2022, In: Breast Cancer Research and Treatment. 194 , p. 265-278 14 p.

Implementation of Artificial Intelligence in Diagnostic Practice as a Next Step after Going Digital:The UMC Utrecht Perspective

Flach Rachel N., Fransen Nina L., Sonnen Andreas F.P., Nguyen Tri Q., Breimer Gerben E., Veta Mitko, Stathonikos Nikolas, van Dooijeweert Carmen, van Diest Paul J. 21 Apr 2022, In: Diagnostics. 12 , p. 1-11

Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation

Vasmel Jeanine E., Groot Koerkamp Maureen L., Mandija Stefano, Veldhuis Wouter B., Moman Maaike R., Froeling Martijn, van der Velden Bas H.M., Charaghvandi Ramona K., Vreuls Celien P.H., van Diest Paul J., van Leeuwen A. M.Gijs, van Gorp Joost, Philippens Marielle E.P., van Asselen Bram, Lagendijk Jan J.W., Verkooijen Helena M., van den Bongard H. J.G.Desirée, Houweling Antonetta C. 8 Apr 2022, In: Advances in Radiation Oncology. 7 , p. 1-11

Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer:novel diagnostic tools for more selective central lymph node compartment dissection

Jonker Pascal K C, Metman Madelon J H, Sondorp Luc H J, Sywak Mark S, Gill Anthony J, Jansen Liesbeth, Links Thera P, van Diest Paul J, van Ginhoven Tessa M, Löwik Clemens W G M, Nguyen Anh H, Coppes Robert P, Robinson Dominic J, van Dam Gooitzen M, van Hemel Bettien M, Fehrmann Rudolf S N, Kruijff Schelto 7 Apr 2022, In: European Journal of Nuclear Medicine and Molecular Imaging. 49 , p. 3557-3570 14 p.

Prognostic Value of Stromal Tumor-Infiltrating Lymphocytes in Young, Node-Negative, Triple-Negative Breast Cancer Patients Who Did Not Receive (neo)Adjuvant Systemic Therapy

de Jong Vincent M T, Wang Yuwei, Ter Hoeve Natalie D, Opdam Mark, Stathonikos Nikolas, Jóźwiak Katarzyna, Hauptmann Michael, Cornelissen Sten, Vreuls Willem, Rosenberg Efraim H, Koop Esther A, Varga Zsuzsanna, van Deurzen Carolien H M, Mooyaart Antien L, Córdoba Alicia, Groen Emma J, Bart Joost, Willems Stefan M, Zolota Vasiliki, Wesseling Jelle, Sapino Anna, Chmielik Ewa, Ryska Ales, Broeks Annegien, Voogd Adri C, Loi Sherene, Michiels Stefan, Sonke Gabe S, van der Wall Elsken, Siesling Sabine, van Diest Paul J, Schmidt Marjanka K, Kok Marleen, Dackus Gwen M H E, Salgado Roberto, Linn Sabine C 30 Mar 2022, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40 , p. 2361-2374 14 p.

Analytical Validation of a Novel 6-Gene Signature for Prediction of Distant Recurrence in Estrogen Receptor-Positive, HER2-Negative, Early-Stage Breast Cancer

Loughman Tony, Barron Stephen, Wang Chan-Ju Angel, Dynoodt Peter, Fender Bozena, Lopez-Ruiz Cesar, Stapleton Sharon, Fabre Aurelie, Quinn Cecily, Nodin Bjorn, Jirström Karin, Razmara Fatemeh, O'Grady Anthony, Baird Anne-Marie, Gray Steven G, Freixo Ana, Moelans Cathy B, van Diest Paul J, Duffy Michael J, O'Leary Desmond, Crown John, Bracken Adrian P, Gallagher William M 21 Mar 2022, In: Clinical chemistry. 68 , p. 837-847 11 p.

Spatial collagen stiffening promotes collective breast cancer cell invasion by reinforcing extracellular matrix alignment

Koorman Thijs, Jansen Karin A, Khalil Antoine, Haughton Peter D, Visser Daan, Rätze Max A K, Haakma Wisse E, Sakalauskaitè Gabrielè, van Diest Paul J, de Rooij Johan, Derksen Patrick W B 15 Mar 2022, In: Oncogene. 41 , p. 2458-2469 12 p.

All research output

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