dr. T.P.C. (T.P.C.) van Doormaal

dr. T.P.C. (T.P.C.) van Doormaal

Associate Professor - medical
dr. T.P.C. (T.P.C.) van Doormaal
  • Neurochirurgen



My research focusses on the bench to bedside development of devices that improve outcome of patients with a neurosurgical disease. 

I started my research carreer as a PhD in the group of Prof CAF Tulleken and Prof A van der Zwan at the UMC Utrecht, and I co-invented several ways to make a bypass in the brain. These techniques were ultimately used to treat patients.

After my PhD, during my neurosurgical trianing, I invented and co-developed a new sealant (in the media it is referred to as 'plaster') to prevent cerebrospinal fluid leakage after brain surgery.  I did all developents under public private flag together with Polyganics BV, and the intellectual property (IP) was transferred from UMC Utrecht to this company to make the technique available for patients. The device (formally called 'Liqoseal') is now standard of care in Europe and under research in the USA.

A few years ago I started to do research with Augmented Reality to inform patients, train residents and provide active guidance during brain surgery. The IP I developed was tranferred to a UMC Utrecht spinoff called 'Augmedit'. I combine my function as a neurosurgeon, nowadays both in the UMC Utrecht and the University Medical Center in Zurich, Switserland, with being Chief Medical Officer of this company. My research group in the UMCU works closely together with Augmedit, the Prinsess Maxima Center and University Medical Center Zurich to design optimal software to inform patients, train residents and to ultimately prevent complications during brainsurgery. 

Side Activities

Consultant Polyganics BV, Groningen, The Netherlands

Chief Medical Officer Augmedit bv, Amsterdam, The Netherlands

Neurosurgeon University Medical Center Zurich, Switserland

Research Output (52)

Development of the SAFETEA Scores for Predicting Risks of Complications of Preventive Endovascular or Microneurosurgical Intracranial Aneurysm Occlusion

Algra Annemijn M, Greving Jacoba P, de Winkel Jordi, Kurtelius Arttu, Laban Kamil, Verbaan Dagmar, van den Berg René, Vandertop William, Lindgren Antti, Krings Timo, Ming Woo Peter Yat, Chu Wong George Kwok, Roozenbeek Bob, van Es Adriaan C G M, Dammers Ruben, Etminan Nima, Boogaarts Hieronymus, van Doormaal Tristan, van der Zwan Albert, van der Schaaf Irene C, Rinkel Gabriël J E, Vergouwen Mervyn D I 2 Sep 2022, In: Neurology. 99 , p. E1725-E1737

Evaluate the safety and efficacy of dura sealant patch in reducing cerebrospinal fluid leakage following elective cranial surgery (ENCASE II):study protocol for a randomized, two-arm, multicenter trial

Carlson Andrew P, Slot Emma M H, van Doormaal Tristan P C, Voormolen E H J, Dankbaar J W, Depauw P, Brouwers B, Germans M R, Baert E, Vandersteene J, Freyschlag C F, Freyschlag J, Thomé C, Zenga F, Penner F, Abdulazim A, Sabel M, Rapp M, Beez T, Zuccarello M, Sauvageau E, Abdullah K, Welch B, Langer D, Ellis J, Dehdashti A, VanGompel J, Bendok B, Chaichana K, Liu J, Dogan A, Lim M K, Hayden M G, 20 Jul 2022, In: Trials. 23 , p. 1-10

Spinal fixation after laminectomy in pigs prevents postoperative spinal cord injury

Slot Emma M.H., de Boer Bart, Redegeld Saskia, van Thoor Sander, Moayeri Nizar, Slooff Willem Bart, Schaafsma Irene A., Meij Björn, van Doormaal Tristan P.C. Apr 2022, In: Animal models and experimental medicine. 5 , p. 153-160 8 p.

Safety and biodegradability of a synthetic dural sealant patch (Liqoseal) in a porcine cranial model

Kinaci Ahmet, Bergmann Wilhelmina, van Thoor Sander, Redegeld Saskia, van der Zwan Albert, van Doormaal Tristan P C Dec 2021, In: Animal models and experimental medicine. 4 , p. 398-405 8 p.

Neurocap Use for the Treatment of Iatrogenic Neuropathic Pain:Preliminary Operative Results in 3 Patients

de Ru J. Alexander, Hans Hans G.X., Tijink Bernard M., van Doormaal Tristan P.C. 1 Sep 2021, In: Ear, Nose and Throat Journal. 100 , p. 830S-834S

Hearing outcome after linear accelerator-based radiotherapy for vestibular schwannomas:A retrospective analysis of a single center

de Jel Dominique Valérie Clarence, Smid Ernst J., van Doormaal Tristan P.C., Thomeer Hans G.X.M. Sep 2021, In: Journal of International Advanced Otology. 17 , p. 426-432 7 p.

Fully automatic brain tumor segmentation for 3D evaluation in augmented reality

Fick Tim, Van Doormaal Jesse A.M., Tosic Lazar, Van Zoest Renate J., Meulstee Jene W., Hoving Eelco W., Van Doormaal Tristan P.C. Aug 2021, In: Neurosurgical Focus. 51 , p. 1-8 8 p.

Single-arm, open-label, multicentre first in human study to evaluate the safety and performance of dural sealant patch in reducing CSF leakage following elective cranial surgery:The ENCASE trial

Van Doormaal Tristan, Germans Menno R., Sie Mariska, Brouwers Bart, Carlson Andrew, Dankbaar Jan Willem, Fierstra Jorn, Depauw Paul, Robe Pierre, Regli Luca 28 Jul 2021, In: BMJ Open. 11 , p. 1-6

Ex vivo evaluation of a multilayered sealant patch for watertight dural closure:cranial and spinal models

Kinaci A., van Thoor S., Redegeld S., Tooren M., van Doormaal T. P.C. 23 Jul 2021, In: Journal of Materials Science: Materials in Medicine. 32 , p. 1-10

Visual Outcomes after Endoscopic Endonasal Transsphenoidal Resection of Pituitary Adenomas:Our Institutional Experience

Van Essen Max J., Muskens Ivo S., Lamba Nayan, Belunek Stephan F.J., Van Der Boog Arthur T.J., Amelink G. Johan, Gosselaar Peter H., Van Doormaal Tristan P.C., Stades Aline M.E., Verhoeff Joost J.C., Van Genderen Maria M., Eenhorst Christine A.E., Broekman Marike L.D. 1 Jul 2021, In: Journal of Neurological Surgery, Part B: Skull Base. 82 , p. E79-E87

All research output

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