prof. dr. W.A. (Wilton A.) van Klei

Full Professor
prof. dr. W.A. (Wilton A.) van Klei
  • Anesthesiology

Research Programs

Circulatory Health



Wilton van Klei received his PhD in 2002 and completed his postgraduate training as anesthesiologist in the Netherlands (2006. After that he did a clinical and research fellowship in perioperative medicine (Ottawa, Ontario, 2007). He returned to the Netherlands to complete a fellowship in cardiothoracic anesthesia (2009), including training in TEE. From 2007 till 2012, he was the Medical Director of the Outpatient Preoperative Evaluation Clinic of the UMC Utrecht.
Currently, he is the Chair of the Department of Anesthesiology and the Director Research and Education of the Division of Anesthesiology, Intensive Care and Emergency Medicine of the UMC Utrecht. His interests focus on improving care for high-risk surgical patients, and involve collaborations with cardiologists, surgeons, clinical chemists, and epidemiologists within the UMC Utrecht’s Circulatory Health research programme. He is supervising several PhD students on clinical research projects in the field of cardiovascular perioperative medicine. Most projects aim to unravel further the etiology, detection and treatment of asymptomatic myocardial injury after surgery. He considers hisself a specialist in perioperative medicine.
Perioperative medicine starts before surgery with a preanesthesia assessment and currently often ends with the patient leaving the recovery room, except for a responsibility for postoperative pain management. However, anesthesiologists should be involved not only in pain management, but also in providing postoperative care on general wards, monitoring vital functions and monitoring for complications likely to be related to surgery and anesthesia. In fact, anesthesiologists should extend what they are doing in the operating room to the surgical floor in order to improve patient outcomes. He is working towards this goal by initiating research in those areas where evidence for optimal treatment is absent.

Fellowship and Awards

  • 2011 Research Award of the International Anesthesia Research Society (IARS)

Research Output (192)

Surging ICU capacity during the COVID-19 pandemic:Experiences from transforming a Post Anaesthesia Care Unit into a cohort ICU

Kersten Bas J., Salden Roy L.T.N., van Klei Wilton A., Hoff Reinier G., Schellekens Willem Jan M. 7 sep 2020, In: Journal of clinical anesthesia. 67 2 p.

Anaestnesia geriatric evaluation to guide patient selection tor preoperative multidisciplinary team care in cardiac surgery

Verwijmeren Lisa, Peelen Linda M., van Klei Wilton A., Daeter Edgar J., van Dongen Eric P.A., Noordzij Peter G. 1 apr 2020, In: British Journal of Anaesthesia. 124 , p. 377-385 9 p.

Patient and anesthesia characteristics of children with low pre-incision blood pressure, a retrospective observational study

Pasma Wietze, Peelen Linda M, van den Broek Stefanie, van Buuren Stef, van Klei Wilton A, de Graaff Jurgen C apr 2020, In: Acta Anaesthesiologica Scandinavica. 64 , p. 472-480 9 p.

Preoperative Risk and the Association between Hypotension and Postoperative Acute Kidney Injury

Mathis Michael R., Naik Bhiken I., Freundlich Robert E., Shanks Amy M., Heung Michael, Kim Minjae, Burns Michael L., Colquhoun Douglas A., Rangrass Govind, Janda Allison, Engoren Milo C., Saager Leif, Tremper Kevin K., Kheterpal Sachin, Aziz Michael F., Coffman Traci, Durieux Marcel E., Levy Warren J., Schonberger Robert B., Soto Roy, Wilczak Janet, Berman Mitchell F., Berris Joshua, Biggs Daniel A., Coles Peter, Craft Robert M., Cummings Kenneth C., Ellis Terri A., Fleishut Peter M., Helsten Daniel L., Jameson Leslie C., van Klei Wilton A., Kooij Fabian, LaGorio John, Lins Steven, Miller Scott A., Molina Susan, Nair Bala, Paganelli William C., Peterson William, Tom Simon, Wanderer Jonathan P., Wedeven Christopher, 1 mrt 2020, In: Anesthesiology. 132 , p. 461-475 15 p.

Intra-Operative Hypotension is a Risk Factor for Post-operative Silent Brain Ischaemia in Patients With Pre-operative Hypertension Undergoing Carotid Endarterectomy

Rots Marjolijn L, Fassaert Leonie M M, Kappelle L Jaap, de Groot Mark C H, Haitjema Saskia, Bonati Leo H, van Klei Wilton A, de Borst Gert J 5 feb 2020, In: European Journal of Vascular and Endovascular Surgery. 59 , p. 526-534 9 p.

Artifact Processing Methods Influence on Intraoperative Hypotension Quantification and Outcome Effect Estimates

Pasma Wietze, Peelen Linda M, van Buuren Stef, van Klei Wilton A, de Graaff Jurgen C 3 feb 2020, In: Anesthesiology. 132 , p. 723-737 15 p.

Methods to express intraoperative hypotension exposure in the anaesthesia literature

Vernooij Lisette M., van Klei Wilton A., Moons Karel G.M., van Waes Judith A., Peelen Linda M. 6 jan 2020, In: British Journal of Anaesthesia. 124 , p. e35-e37 3 p.

Risks to healthcare workers following tracheal intubation of patients with COVID-19:a prospective international multicentre cohort study

El-Boghdadly K., Wong D. J.N., Owen R., Neuman M. D., Pocock S., Carlisle J. B., Johnstone C., Andruszkiewicz P., Baker P. A., Biccard B. M., Bryson G. L., Chan M. T.V., Cheng M. H., Chin K. J., Coburn M., Fagerlund M. J., Myatra S. N., Myles P. S., O’Sullivan E., Pasin L., Shamim F., van Klei W. A., Ahmad I. 1 jan 2020, In: Anaesthesia. 75 , p. 1437-1447 11 p.

Effects of dobutamine and phenylephrine on cerebral perfusion in patients undergoing cerebral bypass surgery:a randomised crossover trial

Akkermans Annemarie, van Waes Judith A.R., van Doormaal Tristan P.C., de Waal Eric E.C., Rinkel Gabriël J.E., van der Zwan Albert, Kalkman Cor J., van Klei Wilton A. 1 jan 2020, In: British Journal of Anaesthesia. 125 , p. 539-547 9 p.

All research output