prof. dr. W.A. (Wilton A.) van Klei

Full Professor

  • Anesthesiology

prof. dr. W.A. (Wilton A.) van Klei

Research Programs


Wilton van Klei received his PhD in 2002 and completed his postgraduate training as anesthesiologist in the Netherlands (2006. After that he did a clinical and research fellowship in perioperative medicine (Ottawa, Ontario, 2007). He returned to the Netherlands to complete a fellowship in cardiothoracic anesthesia (2009), including training in TEE. From 2007 till 2012, he was the Medical Director of the Outpatient Preoperative Evaluation Clinic of the UMC Utrecht.
Currently, he is the Chair of the Department of Anesthesiology and the Director Research and Education of the Division of Anesthesiology, Intensive Care and Emergency Medicine of the UMC Utrecht. His interests focus on improving care for high-risk surgical patients, and involve collaborations with cardiologists, surgeons, clinical chemists, and epidemiologists within the UMC Utrecht’s Circulatory Health research programme. He is supervising several PhD students on clinical research projects in the field of cardiovascular perioperative medicine. Most projects aim to unravel further the etiology, detection and treatment of asymptomatic myocardial injury after surgery. He considers hisself a specialist in perioperative medicine.
Perioperative medicine starts before surgery with a preanesthesia assessment and currently often ends with the patient leaving the recovery room, except for a responsibility for postoperative pain management. However, anesthesiologists should be involved not only in pain management, but also in providing postoperative care on general wards, monitoring vital functions and monitoring for complications likely to be related to surgery and anesthesia. In fact, anesthesiologists should extend what they are doing in the operating room to the surgical floor in order to improve patient outcomes. He is working towards this goal by initiating research in those areas where evidence for optimal treatment is absent.

Fellowship and Awards

  • 2011 Research Award of the International Anesthesia Research Society (IARS)

Research Output (183)

Anaestnesia geriatric evaluation to guide patient selection tor preoperative multidisciplinary team care in cardiac surgery

Verwijmeren Lisa, Peelen Linda M., van Klei Wilton A., Daeter Edgar J., van Dongen Eric P.A., Noordzij Peter G. 1 apr 2020, In: British Journal of Anaesthesia. 124 , p. 377-385 9 p.

Patient and anesthesia characteristics of children with low pre-incision blood pressure, a retrospective observational study

Pasma Wietze, Peelen Linda M, van den Broek Stefanie, van Buuren Stef, van Klei Wilton A, de Graaff Jurgen C apr 2020, In: Acta Anaesthesiologica Scandinavica. 64 , p. 472-480 9 p.

Preoperative Risk and the Association between Hypotension and Postoperative Acute Kidney Injury

Mathis Michael R., Naik Bhiken I., Freundlich Robert E., Shanks Amy M., Heung Michael, Kim Minjae, Burns Michael L., Colquhoun Douglas A., Rangrass Govind, Janda Allison, Engoren Milo C., Saager Leif, Tremper Kevin K., Kheterpal Sachin, Aziz Michael F., Coffman Traci, Durieux Marcel E., Levy Warren J., Schonberger Robert B., Soto Roy, Wilczak Janet, Berman Mitchell F., Berris Joshua, Biggs Daniel A., Coles Peter, Craft Robert M., Cummings Kenneth C., Ellis Terri A., Fleishut Peter M., Helsten Daniel L., Jameson Leslie C., van Klei Wilton A., Kooij Fabian, LaGorio John, Lins Steven, Miller Scott A., Molina Susan, Nair Bala, Paganelli William C., Peterson William, Tom Simon, Wanderer Jonathan P., Wedeven Christopher, 1 mrt 2020, In: Anesthesiology. 132 , p. 461-475 15 p.

Artifact Processing Methods Influence on Intraoperative Hypotension Quantification and Outcome Effect Estimates

Pasma Wietze, Peelen Linda M, van Buuren Stef, van Klei Wilton A, de Graaff Jurgen C 3 feb 2020, In: Anesthesiology. 132 , p. 723-737 15 p.

Methods to express intraoperative hypotension exposure in the anaesthesia literature

Vernooij Lisette M., van Klei Wilton A., Moons Karel G.M., van Waes Judith A., Peelen Linda M. 6 jan 2020, In: British Journal of Anaesthesia. 124 , p. e35-e37 3 p.

Effect of Phenylephrine and Ephedrine on Cerebral (Tissue) Oxygen Saturation During Carotid Endarterectomy (PEPPER):A Randomized Controlled Trial

Fassaert Leonie M.M., de Borst Gert J., Pennekamp Claire W.A., Specken-Welleweerd Jantine C., Moll Frans L., van Klei Wilton A., Immink Rogier V. 1 dec 2019, In: Neurocritical Care. 31 , p. 514-525 12 p.

Risk of Major Complications after Perioperative Norepinephrine Infusion through Peripheral Intravenous Lines in a Multicenter Study

Pancaro Carlo, Shah Nirav, Pasma Wietze, Saager Leif, Cassidy Ruth, Van Klei Wilton, Kooij Fabian, Vittali Dave, Hollmann Markus W., Kheterpal Sachin, Lirk Philipp 27 sep 2019, In: Anesthesia and Analgesia. 131 , p. 1060-1065 6 p.

Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative:clinical indicators

Haller Guy, Bampoe Sohail, Cook Tim, Fleisher L. A., Grocott Michael P.W., Neuman Mark, Story D., Myles Paul S., Myles P., Grocott M., Biccard B., Blazeby J., Boney O., Chan M., Diouf E., Fleisher L., Kalkman C., Kurz A., Moonesinghe R., Wijeysundera D., Gan T. J., Peyton P., Sessler D., Tramèr M., Cyna A., De Oliveira G. S., Wu C., Jensen M., Kehlet H., Botti M., Haller G., Cook T., Neuman M., Story D., Gruen R., Bampoe S., Evered L., Scott D., Silbert B., van Dijk D., Grocott H., Eckenhoff R., Rasmussen L., Eriksson L., Beattie S., Landoni G., Leslie K., Dieleman S., van Klei W., Jackson S. 1 aug 2019, In: British Journal of Anaesthesia. 123 , p. 228-237 10 p.

Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative:infection and sepsis

Barnes Jonathan, Hunter Jennifer, Harris Steve, Shankar-Hari Manu, Diouf Elisabeth, Jammer Ib, Kalkman Cor, Klein Andrew A., Corcoran Tomas, Dieleman Stefan, Grocott Michael P.W., Mythen Michael G., Myles Paul, Gan Tang Joon, Kurz Andrea, Peyton Phil, Sessler Dan, Tramèr Martin, Cyna Alan, De Oliveira Gildasio S., Wu Christopher, Jensen Mark, Kehlet Henrik, Botti Mari, Boney Oliver, Haller Guy, Grocott Mike, Cook Tim, Fleisher Lee, Neuman Mark, Story David, Gruen Russell, Bampoe Sam, Evered Lis, Scott David, Silbert Brendan, van Dijk Diederik, Chan Matthew, Grocott Hilary, Eckenhoff Rod, Rasmussen Lars, Eriksson Lars, Beattie Scott, Wijeysundera Duminda, Landoni Giovanni, Leslie Kate, Biccard Bruce, Howell Simon, Nagele Peter, van Klei Wilton, apr 2019, In: British Journal of Anaesthesia. 122 , p. 500-508

Association of Overlapping Surgery with Perioperative Outcomes

Sun Eric, Mello Michelle M., Rishel Chris A., Vaughn Michelle T., Kheterpal Sachin, Saager Leif, Fleisher Lee A., Damrose Edward J., Kadry Bassam, Jena Anupam B., Kooij Fabian, Wilczak Janet, Soto Roy, Berris Joshua, Price Zachary, Urman Richard D., Lins Steven, Harris John M., Cummings Kenneth C., Berman Mitchell F., Nanamori Masakatsu, Adelman Bruce T., Wedeven Christopher, Bittner Edward A., LaGorio John, McCormick Patrick J., Tom Simon, Aziz Michael F., Coffman Traci, Ellis Terri A., Molina Susan, Peterson William, Mackey Sean C., Van Klei Wilton A., Mahajan Aman, Jameson Leslie C., Biggs Daniel A., Neuman Mark D., Craft Robert M., Pace Nathan L., Paganelli William C., Durieux Marcel E., Nair Bala J., Wanderer Jonathan P., Miller Scott A., Helsten Daniel L., Turnbull Zachary A., Schonberger Robert B., 26 feb 2019, In: JAMA - Journal of the American Medical Association. 321 , p. 773-785 13 p.

All Research Output (183)