prof. dr. J.M. (Jaap) van Laar

prof. dr. J.M. (Jaap) van Laar

Full Professor
prof. dr. J.M. (Jaap) van Laar
  • Rheumatology & Clinical Immunology



Jacob M. van Laar is Professor at the Department of Rheumatology and Clinical Immunology at UMC Utrecht, the Netherlands. After obtaining his MD and PhD degrees at Leiden University, he specialised in Internal Medicine and Rheumatology in Leiden University Medical Center and worked at the Department of Rheumatology as clinical academic in various roles from 1997-2007, interrupted by a postdoctoral research fellowship at the National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, USA. From 2007 until 2013 he held a Chair in Clinical Rheumatology at Newcastle University, and post as honorary consultant rheumatologist at The James Cook University Hospital, Middlesbrough, UK. He has been working as Professor of Rheumatology at UMC Utrecht since 1 November 2013. His main research interests involve clinical and pathogenetic aspects of systemic sclerosis and rheumatoid arthritis, aimed at improving the outcome of patients with rheumatic diseases by innovative clinical-translational research.

Side Activities

Member EULAR Scientific Programme Committee 

Chair Society for Rheumatology Research Utrecht (SRU)

Founding Member Stichting ARCH

Member Scientific Advisory Board Edith Busch Stiftung

Member of EUSTAR (EULAR Scleroderma Trials and Research)

Ad hoc expert advice Central Board of Appeal, consultancies pharmaceutical companies (, postgraduate teaching (including Artrose Instituut Nederland), patient consultations (Reumazorg Zuid-West Nederland).



Fellowship and Awards

Marie Parijs award for pioneering work in the field of clinical stem cell research in rheumatic autoimmune diseases (2002, Leiden University Medical Center)

ZonMW Clinical Fellow (2007)

Fellow of the Royal College of Physicians Edinburgh (2009)

NVLE Award (2015) 

Research Output (280)

Predictors for progressive fibrosis in patients with connective tissue disease associated interstitial lung diseases

Chiu Yu Hsiang, Spierings Julia, de Jong Pim A., Hoesein Firdaus Mohamed, Grutters Jan C., van Laar Jacob M., Voortman Mareye 18 aug 2021, In: Respiratory Medicine. 187 8 p.


Chiu Y. H., Voortman M., Delemarre E. M., Nierkens S., De Jong P., Hoesein F. Mohamed, Van Laar J. M., Spierings J. jun 2021, In: Annals of the Rheumatic Diseases. 80 , p. 1430-1431


Chiu Y. H., Spierings J., De Jong P., Hoesein F. Mohamed, Van Laar J. M., Voortman M. jun 2021, In: Annals of the Rheumatic Diseases. 80 , p. 993-993

A randomised, open-label trial to assess the optimal treatment strategy in early diffuse cutaneous systemic sclerosis:the UPSIDE study protocol

Spierings Julia, van Rhenen Anna, Welsing Paco Mw, Marijnissen Anne Ca, De Langhe Ellen, Del Papa Nicoletta, Dierickx Daan, Gheorghe Karina R, Henes Joerg, Hesselstrand Roger, Kerre Tessa, Ljungman Per, van de Loosdrecht Arjan A, Marijt Erik Waf, Mayer Miro, Schmalzing Marc, Schroers Roland, Smith Vanessa, Voll Reinhard E, Vonk Madelon C, Voskuyl Alexandre E, de Vries-Bouwstra Jeska K, Walker Ulrich A, Wuttge Dirk M, van Laar Jacob M 18 mrt 2021, In: BMJ Open. 11

Text Mining of Electronic Health Records Can Accurately Identify and Characterize Patients With Systemic Lupus Erythematosus

Brunekreef Tammo E, Otten Henny G, van den Bosch Suzanne C, Hoefer Imo E, van Laar Jacob M, Limper Maarten, Haitjema Saskia feb 2021, In: ACR open rheumatology. 3 , p. 65-71 7 p.

EULAR definition of difficult-to-treat rheumatoid arthritis

Nagy György, Roodenrijs Nadia Mt, Welsing Paco Mj, Kedves Melinda, Hamar Attila, van der Goes Marlies C, Kent Alison, Bakkers Margot, Blaas Etienne, Senolt Ladislav, Szekanecz Zoltan, Choy Ernest, Dougados Maxime, Jacobs Johannes Wg, Geenen Rinie, Bijlsma Hans Wj, Zink Angela, Aletaha Daniel, Schoneveld Leonard, van Riel Piet, Gutermann Loriane, Prior Yeliz, Nikiphorou Elena, Ferraccioli Gianfranco, Schett Georg, Hyrich Kimme L, Mueller-Ladner Ulf, Buch Maya H, McInnes Iain B, van der Heijde Désirée, van Laar Jacob M jan 2021, In: Annals of the Rheumatic Diseases. 80 , p. 31-35 5 p.

Tocilizumab in systemic sclerosis:a randomised, double-blind, placebo-controlled, phase 3 trial

Khanna Dinesh, Lin Celia J F, Furst Daniel E, Goldin Jonathan, Kim Grace, Kuwana Masataka, Allanore Yannick, Matucci-Cerinic Marco, Distler Oliver, Shima Yoshihito, van Laar Jacob M, Spotswood Helen, Wagner Bridget, Siegel Jeffrey, Jahreis Angelika, Denton Christopher P, okt 2020, In: The Lancet Respiratory Medicine. 8 , p. 963-974 12 p.

From “being at war” to “getting back on your feet”:A qualitative study on experiences of patients with systemic sclerosis treated with hematopoietic stem cell transplantation

Spierings Julia, de Bresser Carolijn J.M., van Rhijn-Brouwer Femke C.C., Pieterse Arwen, Vonk Madelon C., Voskuyl Alexandre E., de Vries-Bouwstra Jeska K., van Laar Jacob M., Kars Marijke C. okt 2020, In: Journal of Scleroderma and Related Disorders. 5 , p. 202-209

CXCL4 Links Inflammation and Fibrosis by Reprogramming Monocyte-Derived Dendritic Cellsin vitro

Silva-Cardoso Sandra C., Tao Weiyang, Angiolilli Chiara, Lopes Ana P., Bekker Cornelis P. J., Devaprasad Abhinandan, Giovannone Barbara, van Laar Jaap, Cossu Marta, Marut Wioleta, Hack Erik, de Boer Rob J., Boes Marianne, Radstake Timothy R. D. J., Pandit Aridaman 17 sep 2020, In: Frontiers in Immunology. 11

Effectiveness and safety over 3 years after the 2-year U-Act-Early trial of the strategies initiating tocilizumab and/or methotrexate

Verhoeven Maxime M.A., Tekstra Janneke, Welsing Paco M.J., Pethö-Schramm Attila, Borm Michelle E.A., Bruyn George A.W., Bos Reinhard, Griep Ed N., Klaasen Ruth, van Laar Jacob M., Lafeber Floris P.J.G., Bijlsma Johannes W.J., de Hair Marjolein J.H., Jacobs Johannes W.G. 1 sep 2020, In: Rheumatology (Oxford, England). 59 , p. 2325-2333 9 p.

All research output

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