prof. dr. S.W.C. (Saskia) van Mil
prof. dr. S.W.C. (Saskia) van Mil
- Center for Molecular Medicine
Research Programs
Biography
Biography
Saskia van Mil (PhD) is Professor of Molecular and Translational Metabolism at the University Medical Center Utrecht, The Netherlands. She received her PhD from the University of Utrecht in 2004, on the topic of genetic disorders of pediatric cholestasis. As a post-doc at Imperial College London, United Kingdom, she studied the role of the bile salt sensor farnesoid X receptor (FXR) in intrahepatic cholestasis of pregnancy.
Since then, she has been intrigued by the versatility in molecular mechanisms of transcription by the nuclear receptor FXR and its therapeutic potential. Having received funding from the Netherlands’ Organisation of Scientific Research, European Commission, Dutch Digestive Foundation and DSM, her group studies the molecular and translational aspects of energy metabolism in the liver and the intestine, with a specific focus on the role of FXR in metabolic disorders (e.g. NASH) and disorders of intestinal integrity (e.g. IBD) and optimising the efficacy of FXR agonist treatment. In partnerships with clinical and industrial collaborators, her group aims to translate these research findings to improve patient care.
Research Output (40)
Ramos Pittol Jose Miguel, Milona Alexandra, Morris Imogen, Willemsen Ellen C L, van der Veen Suzanne W, Kalkhoven Eric, van Mil Saskia W C nov 2020, In: Gastroenterology. 159 , p. 1853-1865.e10
Wolthuis Joanna C, Magnusdottir Stefania, Pras-Raves Mia, Moshiri Maryam, Jans Judith J M, Burgering Boudewijn, van Mil Saskia, de Ridder Jeroen 11 sep 2020, In: Metabolomics. 16 , p. 99
Milona Alexandra, Massafra Vittoria, Vos Harmjan, Naik Jyoti, Artigas Natalia, Paterson Helen A.B., Bijsmans Ingrid T.G.W., Willemsen Ellen C.L., Ramos Pittol Jose M., Miguel-Aliaga Irene, Bosma Piter, Burgering Boudewijn M.T., Williamson Catherine, Vernia Santiago, Dhillo Waljit S., van Mil Saskia W.C., Owen Bryn M. 1 dec 2019, In: Molecular Metabolism. 30 , p. 221-229 9 p.
Saeed Ali, Yang Jing, Heegsma Janette, Groen Albert K., van Mil Saskia W.C., Paulusma Coen C., Zhou Lu, Wang Bangmao, Faber Klaas Nico 1 dec 2019, In: Scientific Reports. 9 11 p.
van de Wiel Sandra M W, Bijsmans Ingrid T G W, van Mil Saskia W C, van de Graaf Stan F J 18 feb 2019, In: Scientific Reports. 9 , p. 2193
Massafra Vittoria, van Mil Saskia W C jan 2018, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1864 , p. 45-59 15 p.
Massafra Vittoria, Milona Alexandra, Vos Harmjan R., Ramos Rúben J J, Gerrits Johan, Willemsen Ellen C.L., Ramos Pittol José M., Ijssennagger Noortje, Houweling Martin, Prinsen Hubertus C.M.T., Verhoeven-Duif Nanda M., Burgering Boudewijn M.T., van Mil Saskia W.C. 1 mei 2017, In: Gastroenterology. 152 , p. 1462-1476.e10
Massafra Vittoria, Milona Alexandra, Vos Harmjan R., Burgering Boudewijn M T, Van Mil Saskia W C 1 feb 2017, In: PLoS ONE [E]. 12
Opstelten Jorrit L, Plassais Jonathan, van Mil Saskia W C, Achouri Emna, Pichaud Matthieu, Siersema Peter D, Oldenburg Bas, Cervino Alessandra C L sep 2016, In: Inflammatory bowel diseases. 22 , p. 2070-2077 8 p.
Massafra Vittoria, Ijssennagger Noortje, Plantinga Maud, Milona Alexandra, Ramos Pittol José M., Boes Marianne, van Mil Saskia W C 1 feb 2016, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1862 , p. 166-173 8 p.