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prof. dr. S.W.C. (Saskia) van Mil

prof. dr. S.W.C. (Saskia) van Mil

Full Professor
prof. dr. S.W.C. (Saskia) van Mil
  • Center for Molecular Medicine

Biography

Biography

Saskia van Mil (PhD) is Professor of Molecular and Translational Metabolism at the University Medical Center Utrecht, The Netherlands. She received her PhD from the University of Utrecht in 2004, on the topic of genetic disorders of pediatric cholestasis. As a post-doc at Imperial College London, United Kingdom, she studied the role of the bile salt sensor farnesoid X receptor (FXR) in intrahepatic cholestasis of pregnancy.
Since then, she has been intrigued by the versatility in molecular mechanisms of transcription by the nuclear receptor FXR and its therapeutic potential. Having received funding from the Netherlands’ Organisation of Scientific Research, European Commission, Dutch Digestive Foundation and DSM, her group studies the molecular and translational aspects of energy metabolism in the liver and the intestine, with a specific focus on the role of FXR in metabolic disorders (e.g. NASH) and disorders of intestinal integrity (e.g. IBD) and optimising the efficacy of FXR agonist treatment. In partnerships with clinical and industrial collaborators, her group aims to translate these research findings to improve patient care.

Research Output (40)

FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs

Ramos Pittol Jose Miguel, Milona Alexandra, Morris Imogen, Willemsen Ellen C L, van der Veen Suzanne W, Kalkhoven Eric, van Mil Saskia W C nov 2020, In: Gastroenterology. 159 , p. 1853-1865.e10

MetaboShiny:interactive analysis and metabolite annotation of mass spectrometry-based metabolomics data

Wolthuis Joanna C, Magnusdottir Stefania, Pras-Raves Mia, Moshiri Maryam, Jans Judith J M, Burgering Boudewijn, van Mil Saskia, de Ridder Jeroen 11 sep 2020, In: Metabolomics. 16 , p. 99

Steroidogenic control of liver metabolism through a nuclear receptor-network

Milona Alexandra, Massafra Vittoria, Vos Harmjan, Naik Jyoti, Artigas Natalia, Paterson Helen A.B., Bijsmans Ingrid T.G.W., Willemsen Ellen C.L., Ramos Pittol Jose M., Miguel-Aliaga Irene, Bosma Piter, Burgering Boudewijn M.T., Williamson Catherine, Vernia Santiago, Dhillo Waljit S., van Mil Saskia W.C., Owen Bryn M. 1 dec 2019, In: Molecular Metabolism. 30 , p. 221-229 9 p.

Farnesoid X receptor and bile acids regulate vitamin A storage

Saeed Ali, Yang Jing, Heegsma Janette, Groen Albert K., van Mil Saskia W.C., Paulusma Coen C., Zhou Lu, Wang Bangmao, Faber Klaas Nico 1 dec 2019, In: Scientific Reports. 9 11 p.

Identification of FDA-approved drugs targeting the Farnesoid X Receptor

van de Wiel Sandra M W, Bijsmans Ingrid T G W, van Mil Saskia W C, van de Graaf Stan F J 18 feb 2019, In: Scientific Reports. 9 , p. 2193

Farnesoid X receptor:A "homeostat" for hepatic nutrient metabolism

Massafra Vittoria, van Mil Saskia W C jan 2018, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1864 , p. 45-59 15 p.

Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice

Massafra Vittoria, Milona Alexandra, Vos Harmjan R., Ramos Rúben J J, Gerrits Johan, Willemsen Ellen C.L., Ramos Pittol José M., Ijssennagger Noortje, Houweling Martin, Prinsen Hubertus C.M.T., Verhoeven-Duif Nanda M., Burgering Boudewijn M.T., van Mil Saskia W.C. 1 mei 2017, In: Gastroenterology. 152 , p. 1462-1476.e10

Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation

Massafra Vittoria, Milona Alexandra, Vos Harmjan R., Burgering Boudewijn M T, Van Mil Saskia W C 1 feb 2017, In: PLoS ONE [E]. 12

Gut Microbial Diversity Is Reduced in Smokers with Crohn's Disease

Opstelten Jorrit L, Plassais Jonathan, van Mil Saskia W C, Achouri Emna, Pichaud Matthieu, Siersema Peter D, Oldenburg Bas, Cervino Alessandra C L sep 2016, In: Inflammatory bowel diseases. 22 , p. 2070-2077 8 p.

Splenic dendritic cell involvement in FXR-mediated amelioration of DSS colitis

Massafra Vittoria, Ijssennagger Noortje, Plantinga Maud, Milona Alexandra, Ramos Pittol José M., Boes Marianne, van Mil Saskia W C 1 feb 2016, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1862 , p. 166-173 8 p.

All research output

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