prof. dr. S.W.C. (Saskia) van Mil
prof. dr. S.W.C. (Saskia) van Mil
- Center for Molecular Medicine
Research Programs
Biography
Biography
Saskia van Mil (PhD) is Professor of Molecular and Translational Metabolism at the University Medical Center Utrecht, The Netherlands. She received her PhD from the University of Utrecht in 2004, on the topic of genetic disorders of pediatric cholestasis. As a post-doc at Imperial College London, United Kingdom, she studied the role of the bile salt sensor farnesoid X receptor (FXR) in intrahepatic cholestasis of pregnancy.
Since then, she has been intrigued by the versatility in molecular mechanisms of transcription by the nuclear receptor FXR and its therapeutic potential. Having received funding from the Netherlands’ Organisation of Scientific Research, European Commission, Dutch Digestive Foundation and DSM, her group studies the molecular and translational aspects of energy metabolism in the liver and the intestine, with a specific focus on the role of FXR in metabolic disorders (e.g. NASH) and disorders of intestinal integrity (e.g. IBD) and optimising the efficacy of FXR agonist treatment. In partnerships with clinical and industrial collaborators, her group aims to translate these research findings to improve patient care.
Research Output (46)
de Jong Judith C.W., Ijssennagger Noortje, van Mil Saskia W.C. 1 nov 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867
Mukha Anna, Kalkhoven Eric, van Mil Saskia W.C. 1 okt 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867 , p. 1-13 13 p.
Ijssennagger Noortje, van Rooijen Kristel S, Magnúsdóttir Stefanía, Ramos Pittol José M, Willemsen Ellen C L, de Zoete Marcel R, Baars Matthijs J D, Stege Paul B, Colliva Carolina, Pellicciari Roberto, Youssef Sameh A, de Bruin Alain, Vercoulen Yvonne, Kuipers Folkert, van Mil Saskia W C okt 2021, In: JHEP reports : innovation in hepatology. 3 , p. 100344
Appelman Monique D, van der Veen Suzanne W, van Mil Saskia W C 27 sep 2021, In: Frontiers in Endocrinology. 12 , p. 729828
IJssennagger Noortje, van Rooijen Kristel, Magnusdottir Stefania, Pittol Jose M. Ramos, Willemsen Ellen C. L., de Zoete Marcel R., Baars Matthijs J. D., Stege Paul B., Colliva Carolina, Pellicciari Roberto, Vercoulen Yvonne, Kuipers Folkert, van Mil Saskia jul 2021, In: Journal of Hepatology. 75 , p. S457-S457
Selvaraj Emmanuel Anandraj, Mózes Ferenc Emil, Jayaswal Arjun Narayan Ajmer, Zafarmand Mohammad Hadi, Vali Yasaman, Lee Jenny A., Levick Christina Kim, Young Liam Arnold Joseph, Palaniyappan Naaventhan, Liu Chang Hai, Aithal Guruprasad Padur, Romero-Gómez Manuel, Brosnan M. Julia, Tuthill Theresa A., Anstee Quentin M., Neubauer Stefan, Harrison Stephen A., Bossuyt Patrick M., Pavlides Michael, Anstee Quentin, Daly Ann, Johnson Katherine, Govaere Olivier, Cockell Simon, Tiniakos Dina, Bedossa Pierre, Oakley Fiona, Cordell Heather, Day Chris, Wonders Kristy, Bossuyt Patrick, Zafarmand Hadi, Lee Jenny, Ratziu Vlad, Clement Karine, Pais Raluca, Schuppan Detlef, Schattenberg Jörn, Vidal-Puig Toni, Vacca Michele, Rodrigues-Cuenca Sergio, Allison Mike, Kamzolas Ioannis, Petsalaki Evangelia, Oresic Matej, Hyötyläinen Tuulia, McGlinchey Aiden, Mato Jose M., Millet Oscar, van Mil Saskia, 2021, In: Journal of Hepatology. 75 , p. 770-785 16 p.
Ramos Pittol Jose Miguel, Milona Alexandra, Morris Imogen, Willemsen Ellen C L, van der Veen Suzanne W, Kalkhoven Eric, van Mil Saskia W C nov 2020, In: Gastroenterology. 159 , p. 1853-1865.e10
Wolthuis Joanna C, Magnusdottir Stefania, Pras-Raves Mia, Moshiri Maryam, Jans Judith J M, Burgering Boudewijn, van Mil Saskia, de Ridder Jeroen 11 sep 2020, In: Metabolomics. 16 , p. 99
Milona Alexandra, Massafra Vittoria, Vos Harmjan, Naik Jyoti, Artigas Natalia, Paterson Helen A.B., Bijsmans Ingrid T.G.W., Willemsen Ellen C.L., Ramos Pittol Jose M., Miguel-Aliaga Irene, Bosma Piter, Burgering Boudewijn M.T., Williamson Catherine, Vernia Santiago, Dhillo Waljit S., van Mil Saskia W.C., Owen Bryn M. 1 dec 2019, In: Molecular Metabolism. 30 , p. 221-229 9 p.
Saeed Ali, Yang Jing, Heegsma Janette, Groen Albert K., van Mil Saskia W.C., Paulusma Coen C., Zhou Lu, Wang Bangmao, Faber Klaas Nico 1 dec 2019, In: Scientific Reports. 9 11 p.