prof. dr. J.J. (Jim) van Os

Full Professor
prof. dr. J.J. (Jim) van Os
  • Division Neuroscience

Research Programs




I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.


Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Side Activities

Chairman of the Psychosenet Foundation

Member of the DeNieuweGGZ foundation

Member Editorial boards: Psychilogical Medicine, Schizophrenia Research, Schizophrenia Bulletin, Early intervention in Psychiatry, Acta Psychiatrica Scandinavica, Journal of Mental Health, Plos One

Member of the GGZ-VS Supervisory Board (GGZ nurse specialist training)

Fellowship and Awards

Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

Association of European Psychiatrists research price 2003 (20.000 euro)

Member, KNAW (2011).

Fellow, King’s College London (2016).

Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

Research Output (446)

Prevalence and correlates of anxiety and depression in frontline healthcare workers treating people with COVID-19 in Bangladesh

Tasnim Rafia, Sujan Md Safaet Hossain, Islam Md Saiful, Ritu Asmaul Husna, Siddique Md Abid Bin, Toma Tanziha Yeasmin, Nowshin Rifat, Hasan Abid, Hossain Sahadat, Nahar Shamsun, Islam Salequl, Islam Muhammad Sougatul, Potenza Marc N, van Os Jim 25 mei 2021, In: BMC Psychiatry. 21 14 p.

Social Defeat, Psychotic Symptoms, and Crime in Young Caribbean Immigrants to Rotterdam

Vinkers David J, Van de Vorst Micha, Hoek Hans W, Van Os Jim 7 apr 2021, In: Frontiers in Psychiatry. 12 7 p.

Prevalence of depression, anxiety and associated factors among school going adolescents in Bangladesh:Findings from a cross-sectional study

Islam Md Saiful, Rahman Md Estiar, Moonajilin Mst Sabrina, van Os Jim apr 2021, In: PLoS ONE. 16 13 p.

Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls:results from the EUGEI study

Erzin Gamze, Pries Lotta-Katrin, van Os Jim, Fusar-Poli Laura, Delespaul Philippe, Kenis Gunter, Luykx Jurjen J, Lin Bochao D, Richards Alexander L, Akdede Berna, Binbay Tolga, Altınyazar Vesile, Yalınçetin Berna, Gümüş-Akay Güvem, Cihan Burçin, Soygür Haldun, Ulaş Halis, Cankurtaran Eylem Şahin, Kaymak Semra Ulusoy, Mihaljevic Marina M, Andric-Petrovic Sanja, Mirjanic Tijana, Bernardo Miguel, Mezquida Gisela, Amoretti Silvia, Bobes Julio, Saiz Pilar A, García-Portilla Maria Paz, Sanjuan Julio, Aguilar Eduardo J, Santos Jose Luis, Jiménez-López Estela, Arrojo Manuel, Carracedo Angel, López Gonzalo, González-Peñas Javier, Parellada Mara, Maric Nadja P, Atbaşoğlu Cem, Ucok Alp, Alptekin Köksal, Saka Meram Can, Arango Celso, O'Donovan Micheal C, Rutten Bart Pf, Guloksuz Sinan, 19 mrt 2021, In: European Psychiatry. 64 33 p.

Schizophrenia and the Environment:Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association-The Example of Cannabis and Psychosis

van Os Jim, Pries Lotta-Katrin, Ten Have Margreet, de Graaf Ron, van Dorsselaer Saskia, Bak Maarten, Wittchen Hans-Ulrich, Rutten Bart P F, Guloksuz Sinan 8 mrt 2021, In: Schizophrenia bulletin. 47 , p. 594-603 10 p.

Network dynamics of momentary affect states and future course of psychopathology in adolescents

Kuranova Anna, Wigman Johanna T W, Menne-Lothmann Claudia, Decoster Jeroen, van Winkel Ruud, Delespaul Philippe, Drukker Marjan, de Hert Marc, Derom Catherine, Thiery Evert, Rutten Bart P F, Jacobs Nele, van Os Jim, Oldehinkel Albertine J, Booij Sanne H, Wichers Marieke mrt 2021, In: PLoS ONE. 16 18 p.

DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia

Hannon Eilis, Dempster Emma L, Mansell Georgina, Burrage Joe, Bass Nick, Bohlken Marc M, Corvin Aiden, Curtis Charles J, Dempster David, Di Forti Marta, Dinan Timothy G, Donohoe Gary, Gaughran Fiona, Gill Michael, Gillespie Amy, Gunasinghe Cerisse, Hulshoff Hilleke E, Hultman Christina M, Johansson Viktoria, Kahn René S, Kaprio Jaakko, Kenis Gunter, Kowalec Kaarina, MacCabe James, McDonald Colm, McQuillin Andrew, Morris Derek W, Murphy Kieran C, Mustard Colette J, Nenadic Igor, O'Donovan Michael C, Quattrone Diego, Richards Alexander L, Rutten Bart Pf, St Clair David, Therman Sebastian, Toulopoulou Timothea, Van Os Jim, Waddington John L, Sullivan Patrick, Vassos Evangelos, Breen Gerome, Collier David A, Murray Robin M, Schalwyk Leo, Mill Jonathan, 26 feb 2021, In: eLife. 10 , p. 1-53 53 p.

Association of the kynurenine pathway metabolites with clinical, cognitive features and IL-1β levels in patients with schizophrenia spectrum disorder and their siblings

Noyan Handan, Erdağ Ece, Tüzün Erdem, Yaylım İlhan, Küçükhüseyin Özlem, Hakan Mehmet Tolgahan, Gülöksüz Sinan, Rutten Bart P.F., Saka Meram Can, Atbaşoğlu Cem, Alptekin Köksal, van Os Jim, Üçok Alp 17 feb 2021, In: Schizophrenia Research. 229 , p. 27-37 11 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet