prof. dr. J.J. (Jim) van Os

prof. dr. J.J. (Jim) van Os

Full Professor
prof. dr. J.J. (Jim) van Os
  • Division Neuroscience

Research Programs




I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.


Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Side Activities

Chairman of the Psychosenet Foundation

Member of the DeNieuweGGZ foundation

Member Editorial boards: Psychilogical Medicine, Schizophrenia Research, Schizophrenia Bulletin, Early intervention in Psychiatry, Acta Psychiatrica Scandinavica, Journal of Mental Health, Plos One

Member of the GGZ-VS Supervisory Board (GGZ nurse specialist training)

Fellowship and Awards

Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

Association of European Psychiatrists research price 2003 (20.000 euro)

Member, KNAW (2011).

Fellow, King’s College London (2016).

Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

Research Output (540)

Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls

Lin Bochao Danae, Vermeulen Jentien M., Bolhuis K., Chang Xiao, Schirmbeck Frederike, van Eijk Kristel R., Alizadeh Behrooz Z., Bartels-Velthuis Agna A., van Amelsvoort Therese, Bruggeman Richard, Cahn Wiepke, de Haan Lieuwe, Rutten Bart P.F., Guloksuz Sinan, Luykx Jurjen J., van Os Jim, Simons Claudia J.P., van Winkel Ruud, Blankers Matthijs, van den Brink W., May 2023, In: Psychiatry Research. 323 , p. 1-8

Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults

Solmi Marco, Thompson Trevor, Estradé Andrés, Agorastos Agorastos, Radua Joaquim, Cortese Samuele, Dragioti Elena, Leisch Friedrich, Vancampfort Davy, Thygesen Lau Caspar, Aschauer Harald, Schlögelhofer Monika, Aschauer Elena, Schneeberger Andres, Huber Christian G., Hasler Gregor, Conus Philippe, Do Cuénod Kim Q., von Känel Roland, Arrondo Gonzalo, Fusar-Poli Paolo, Gorwood Philip, Llorca Pierre Michel, Krebs Marie Odile, Scanferla Elisabetta, Kishimoto Taishiro, Rabbani Golam, Skonieczna-Żydecka Karolina, Brambilla Paolo, Favaro Angela, Takamiya Akihiro, Zoccante Leonardo, Colizzi Marco, Bourgin Julie, Kamiński Karol, Moghadasin Maryam, Seedat Soraya, Matthews Evan, Wells John, Vassilopoulou Emilia, Gadelha Ary, Su Kuan Pin, Kwon Jun Soo, Kim Minah, Lee Tae Young, Papsuev Oleg, Manková Denisa, Boscutti Andrea, Sommer Iris, van Os Jim, 1 Apr 2023, In: Journal of Affective Disorders. 326 , p. 249-261 13 p.

Impact of adverse childhood experiences on educational achievements in young people at clinical high risk of developing psychosis

Tognin Stefania, Catalan Ana, Kempton Matthew J., Nelson Barnaby, McGorry Patrick, Riecher-Rössler Anita, Bressan Rodrigo, Barrantes-Vidal Neus, Krebs Marie Odile, Nordentoft Merete, Ruhrmann Stephan, Sachs Gabriele, Rutten Bart P.F., Van Os Jim, De Haan Lieuwe, Van Der Gaag Mark, McGuire Philip, Valmaggia Lucia R. 18 Jan 2023, In: European Psychiatry. 66

Taalachterstand en psychose onder mensen met een migratieachtergrond

Jongsma H E, van der Ven E M A, Velthorst E, de Haan L, Rutten B P F, van Os J 2023, In: Tijdschrift voor Psychiatrie. 65 , p. 175-180 6 p.

Methods for detecting heat stress in hutch-housed dairy calves in a continental climate

Dado-Senn B, Ouellet V, Lantigua V, Van Os J, Laporta J 19 Dec 2022, In: Journal of Dairy Science. 106 , p. 1039-1050 12 p.

Effect of stressful life events on subclinical psychotic symptoms in first-degree relatives and healthy controls

Lachowicz Aleksandra M., Vaessen Thomas, van Aubel Evelyne, Butjosa Anna, Reininghaus Ulrich, Myin-Germeys Inez, van Amelsvoort Therese, Bartels-Velthuis Agna A., Bruggeman Richard, Cahn Wiepke, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., van Os Jim, Dec 2022, In: Schizophrenia Research. 250 , p. 92-99 8 p.

Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults

Marchi Mattia, Elkrief Laurent, Alkema Anne, van Gastel Willemijn, Schubart Chris D, van Eijk Kristel R, Luykx Jurjen J, Branje Susan, Mastrotheodoros Stefanos, Galeazzi Gian M, van Os Jim, Cecil Charlotte A, Conrod Patricia J, Boks Marco P Dec 2022, In: Translational Psychiatry. 12 , p. 1-10

Assessing optimal frequency for image acquisition in computer vision systems developed to monitor feeding behavior of group-housed Holstein heifers

Bresolin T, Ferreira R, Reyes F, Van Os J, Dórea J R R 1 Nov 2022, In: Journal of Dairy Science. 106 , p. 664-675 12 p.

Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis:findings from the multinational EU-GEI study

Pignon B, Peyre H, Ayrolles A, Kirkbride J B, Jamain S, Ferchiou A, Richard J R, Baudin G, Tosato S, Jongsma H, de Haan L, Tarricone I, Bernardo M, Velthorst E, Braca M, Arango C, Arrojo M, Bobes J, Del-Ben C M, Di Forti M, Gayer-Anderson C, Jones P B, La Cascia C, Lasalvia A, Menezes P R, Quattrone D, Sanjuán J, Selten J P, Tortelli A, Llorca P M, van Os J, Rutten B P F, Murray R M, Morgan C, Leboyer M, Szöke A, Schürhoff F 27 Sep 2022, In: Epidemiology and Psychiatric Sciences. 31

The association between cannabis use and facial emotion recognition in schizophrenia, siblings, and healthy controls:Results from the EUGEI study

Fusar-Poli Laura, Pries Lotta-Katrin, van Os Jim, Radhakrishnan Rajiv, Pençe Ayşegül Yay, Erzin Gamze, Delespaul Philippe, Kenis Gunter, Luykx Jurjen J, Lin Bochao D, Akdede Berna, Binbay Tolga, Altınyazar Vesile, Yalınçetin Berna, Gümüş-Akay Güvem, Cihan Burçin, Soygür Haldun, Ulaş Halis, Cankurtaran Eylem Şahin, Kaymak Semra Ulusoy, Mihaljevic Marina M, Andric-Petrovic Sanja, Mirjanic Tijana, Bernardo Miguel, Mezquida Gisela, Amoretti Silvia, Bobes Julio, Saiz Pilar A, García-Portilla Maria Paz, Sanjuan Julio, Aguilar Eduardo J, Santos José Luis, Jiménez-López Estela, Arrojo Manuel, Carracedo Angel, López Gonzalo, González-Peñas Javier, Parellada Mara, Maric Nadja P, Atbaşoğlu Cem, Üçok Alp, Alptekin Köksal, Saka Meram Can, Aguglia Eugenio, Arango Celso, Rutten Bart Pf, Guloksuz Sinan, 30 Aug 2022, In: European Neuropsychopharmacology. 63 , p. 47-59 13 p.

All research output

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