prof. dr. J.J. (Jim) van Os

Full Professor

  • Division Neuroscience

prof. dr. J.J. (Jim) van Os



Research Programs


I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.


Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Side Activities

  • Chairman of the Psychosenet Foundation

    Member of the DeNieuweGGZ foundation

    Member Editorial boards: Psychilogical Medicine, Schizophrenia Research, Schizophrenia Bulletin, Early intervention in Psychiatry, Acta Psychiatrica Scandinavica, Journal of Mental Health, Plos One

    Member of the GGZ-VS Supervisory Board (GGZ nurse specialist training)

Fellowship and Awards

  • Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

    Association of European Psychiatrists research price 2003 (20.000 euro)

    Member, KNAW (2011).

    Fellow, King’s College London (2016).

    Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

Research Output (356)

Early warning signals in psychopathology:what do they tell?

Schreuder Marieke J, Hartman Catharina A, George Sandip V, Menne-Lothmann Claudia, Decoster Jeroen, van Winkel Ruud, Delespaul Philippe, De Hert Marc, Derom Catherine, Thiery Evert, Rutten Bart P F, Jacobs Nele, van Os Jim, Wigman Johanna T W, Wichers Marieke 14 okt 2020, In: BMC Medicine. 18 , p. 269

Dr. Strangelove, or how we learned to stop worrying and love uncertainty

Guloksuz Sinan, van Os Jim 1 okt 2020, In: World Psychiatry. 19 , p. 395-396 2 p.

Outcome of antidepressant drug discontinuation with taperingstrips after 1-5 years

Groot Peter C, van Os Jim sep 2020, In: Therapeutic advances in psychopharmacology. 10 , p. 2045125320954609

Association of preceding psychosis risk states and non-psychotic mental disorders with incidence of clinical psychosis in the general population:a prospective study in the NEMESIS-2 cohort

Guloksuz Sinan, Pries Lotta Katrin, ten Have Margreet, de Graaf Ron, van Dorsselaer Saskia, Klingenberg Boris, Bak Maarten, Lin Bochao D, van Eijk Kristel R., Delespaul Philippe, van Amelsvoort Therese, Luykx Jurjen J., Rutten Bart P.F., van Os Jim 1 jun 2020, In: World Psychiatry. 19 , p. 199-205 7 p.

Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain

Schmidt-Kastner Rainald, Guloksuz Sinan, Kietzmann Thomas, van Os Jim, Rutten Bart P.F. 12 mei 2020, In: Frontiers in Psychiatry. 11

Blended care in the treatment of subthreshold symptoms of depression and psychosis in emerging adults:A randomised controlled trial of Acceptance and Commitment Therapy in Daily-Life (ACT-DL)

van Aubel Evelyne, Bakker Jindra Myrthe, Batink Tim, Michielse Stijn, Goossens Liesbet, Lange Iris, Schruers Koen, Lieverse Ritsaert, Marcelis Machteld, van Amelsvoort Thérèse, van Os Jim, Wichers Marieke, Vaessen Thomas, Reininghaus Ulrich, Myin-Germeys Inez 1 mei 2020, In: Behaviour Research and Therapy. 128

Polygenic risk score for schizophrenia was not associated with glycemic level (HbA1c) in patients with non-affective psychosis:Genetic Risk and Outcome of Psychosis (GROUP) cohort study

Habtewold Tesfa Dejenie, Islam Md Atiqul, Liemburg Edith J., Bartels-Velthuis Agna A.A., van Beveren Nico J., Cahn Wiepke, de Haan Lieuwe, Delespaul Philippe, Meijer Carin J., Myin-Germeys Inez, Kahn Rene S., Schirmbeck Frederike, Simons Claudia J.P., van Amelsvoort Therese, van Haren Neeltje E., van Os Jim, van Winkel Ruud, Bruggeman Richard, Alizadeh Behrooz Z., 1 mei 2020, In: Journal of Psychosomatic Research. 132

Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder

Atagun Murat Ilhan, Drukker Marjan, Hall Mei Hua, Altun Ilkay Keles, Tatli Safiye Zeynep, Guloksuz Sinan, van Os Jim, van Amelsvoort Thérèse 26 apr 2020, In: Psychiatry Research - Neuroimaging. 300

Mental Health Service Use and Psychopharmacological Treatment Following Psychotic Experiences in Preadolescence

Rimvall Martin Køster, van Os Jim, Verhulst Frank, Wolf Rasmus Trap, Larsen Janne Tidselbak, Clemmensen Lars, Skovgaard Anne Mette, Rask Charlotte Ulrikka, Jeppesen Pia 1 apr 2020, In: American Journal of Psychiatry. 177 , p. 318-326 9 p.

Sex differences in cognitive functioning of patients at-risk for psychosis and healthy controls:Results from the European Gene-Environment Interactions study

Menghini-Müller Stephanie, Studerus Erich, Ittig Sarah, Valmaggia Lucia R., Kempton Matthew J., van der Gaag Mark, de Haan Lieuwe, Nelson Barnaby, Bressan Rodrigo A., Barrantes-Vidal Neus, Jantac Célia, Nordentoft Merete, Ruhrmann Stephan, Sachs Garbiele, Rutten Bart P., van Os Jim, Riecher-Rössler Anita, 13 mrt 2020, In: European Psychiatry. 63 , p. e25

All Research Output (356)