prof. dr. J.J. (Jim) van Os

Full Professor
prof. dr. J.J. (Jim) van Os
  • Division Neuroscience

Research Programs




I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.


Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Side Activities

Chairman of the Psychosenet Foundation

Member of the DeNieuweGGZ foundation

Member Editorial boards: Psychilogical Medicine, Schizophrenia Research, Schizophrenia Bulletin, Early intervention in Psychiatry, Acta Psychiatrica Scandinavica, Journal of Mental Health, Plos One

Member of the GGZ-VS Supervisory Board (GGZ nurse specialist training)

Fellowship and Awards

Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

Association of European Psychiatrists research price 2003 (20.000 euro)

Member, KNAW (2011).

Fellow, King’s College London (2016).

Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

Research Output (375)

Are All Psychotic-Like Experiences Really "Psychotic"?:Response to McLawhorn and Jackson

Rimvall Martin Køster, van Os Jim, Jeppesen Pia 1 dec 2020, In: American Journal of Psychiatry. 177 , p. 1179-1180 2 p.

Do Current Measures of Polygenic Risk for Mental Disorders Contribute to Population Variance in Mental Health?

Marsman Anne, Pries Lotta-Katrin, Ten Have Margreet, de Graaf Ron, van Dorsselaer Saskia, Bak Maarten, Kenis Gunter, Lin Bochao D, Luykx Jurjen J, Rutten Bart P F, Guloksuz Sinan, van Os Jim nov 2020, In: Schizophrenia bulletin. 46 , p. 1353-1362 10 p.

Early warning signals in psychopathology:what do they tell?

Schreuder Marieke J, Hartman Catharina A, George Sandip V, Menne-Lothmann Claudia, Decoster Jeroen, van Winkel Ruud, Delespaul Philippe, De Hert Marc, Derom Catherine, Thiery Evert, Rutten Bart P F, Jacobs Nele, van Os Jim, Wigman Johanna T W, Wichers Marieke 14 okt 2020, In: BMC Medicine. 18 , p. 1-11

Network approach of mood and functional gastrointestinal symptom dynamics in relation to childhood trauma in patients with irritable bowel syndrome and comorbid panic disorder

Drukker Marjan, Peters Jill C H, Vork Lisa, Mujagic Zlatan, Rutten Bart P F, van Os Jim, Masclee Ad A M, Kruimel Joanna W, Leue Carsten 2 okt 2020, In: Journal of Psychosomatic Research. 139

Dr. Strangelove, or how we learned to stop worrying and love uncertainty

Guloksuz Sinan, van Os Jim 1 okt 2020, In: World Psychiatry. 19 , p. 395-396 2 p.

Outcome of antidepressant drug discontinuation with taperingstrips after 1-5 years

Groot Peter C, van Os Jim sep 2020, In: Therapeutic advances in psychopharmacology. 10 , p. 1-8

Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia

Pries Lotta-Katrin, van Os Jim, Ten Have Margreet, de Graaf Ron, van Dorsselaer Saskia, Bak Maarten, Lin Bochao D, van Eijk Kristel R, Kenis Gunter, Richards Alexander, O'Donovan Michael C, Luykx Jurjen J, Rutten Bart P F, Guloksuz Sinan 12 aug 2020, In: JAMA Psychiatry. 77 , p. 1296-1304 9 p.

How user knowledge of psychotropic drug withdrawal resulted in the development of person-specific tapering medication

Groot Peter C, van Os Jim jul 2020, In: Therapeutic advances in psychopharmacology. 10

Association of preceding psychosis risk states and non-psychotic mental disorders with incidence of clinical psychosis in the general population:a prospective study in the NEMESIS-2 cohort

Guloksuz Sinan, Pries Lotta Katrin, ten Have Margreet, de Graaf Ron, van Dorsselaer Saskia, Klingenberg Boris, Bak Maarten, Lin Bochao D, van Eijk Kristel R., Delespaul Philippe, van Amelsvoort Therese, Luykx Jurjen J., Rutten Bart P.F., van Os Jim 1 jun 2020, In: World Psychiatry. 19 , p. 199-205 7 p.

Analysis of GWAS-Derived Schizophrenia Genes for Links to Ischemia-Hypoxia Response of the Brain

Schmidt-Kastner Rainald, Guloksuz Sinan, Kietzmann Thomas, van Os Jim, Rutten Bart P.F. 12 mei 2020, In: Frontiers in Psychiatry. 11 , p. 1-9

All research output

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