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prof. dr. J.J. (Jim) van Os

Full Professor

  • Division Neuroscience

prof. dr. J.J. (Jim) van Os

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Research Programs

Biography

I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.

Education

Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Side Activities

  • Chairman of the Psychosenet Foundation

    Member of the DeNieuweGGZ foundation

    Member Editorial boards: Psychilogical Medicine, Schizophrenia Research, Schizophrenia Bulletin, Early intervention in Psychiatry, Acta Psychiatrica Scandinavica, Journal of Mental Health, Plos One

    Member of the GGZ-VS Supervisory Board (GGZ nurse specialist training)

Fellowship and Awards

  • Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

    Association of European Psychiatrists research price 2003 (20.000 euro)

    Member, KNAW (2011).

    Fellow, King’s College London (2016).

    Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

Research Output (322)

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Lee Phil H., Anttila Verneri, Won Hyejung, Feng Yen-Chen A., Rosenthal Jacob, Zhu Zhaozhong, Tucker-Drob Elliot M., Nivard Michel G., Grotzinger Andrew D., Posthuma Danielle, Wang Meg M-J, Yu Dongmei, Stahl Eli A., Walters Ray-mond K., Anney Richard J. L., Duncan Laramie E., Ge Tian, Adolfsson Rolf, Banaschewski Tobias, Belangero Sintia, Cook Edwin H., Coppola Giovanni, Derks Eske M., Hoekstra Pieter J., Kaprio Jaakko, Keski-Rahkonen Anna, Kirov George, Kranzler Henry R., Luykx Jurjen J., Rohde Luis A., Zai Clement C., Agerbo Esben, Arranz M. J., Asherson Philip, Baekvad-Hansen Marie, Baldursson Gisli, Bellgrove Mark, Belliveau Richard A., Jr., Buitelaar Jan, Burton Christie L., Bybjerg-Grauholm Jonas, Casas Miguel, Cerrato Felecia, Chambert Kimberly, Churchhouse Claire, Gormand Bru, Ophoff Roel A., Adan Roger A. H., Kas Martien J. H., van Os Jim, 12 dec 2019, In: Cell. 179 , p. 1469-1482.e11

Reward anticipation in individuals with subclinical psychotic experience:A functional MRI approach

Michielse Stijn, Lange Iris, Bakker Jindra, Goossens Liesbet, Verhagen Simone, Papalini Silvia, Wichers Marieke, Lieverse Ritsaert, Schruers Koen, van Amelsvoort Therese, van Os Jim, Murray Graham K., Marcelis Machteld 1 dec 2019, In: European Neuropsychopharmacology. 29 , p. 1374-1385 12 p.

TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes:Risk and Protective Factors in a General Population Twin Sample

Pries Lotta-Katrin, Snijders Clara, Menne-Lothmann Claudia, Decoster Jeroen, van Winkel Ruud, Collip Dina, Delespaul Philippe, De Hert Marc, Derom Catherine, Thiery Evert, Jacobs Nele, Wichers Marieke, Guloksuz Sinan, van Os Jim, Rutten Bart P F dec 2019, In: Twin Research and Human Genetics. 22 , p. 460-466 7 p.

Cognitive Functioning in Psychotic Disorders Across the Lifespan and Illness-Stages

Velthorst Eva, Mollon Josephine, Reichenberg Abraham, Murray Robin, Myin-Germeys Inez, Bruggeman Richard, Glahn David, De Haan Lieuwe, Van Os Jim dec 2019, In: Neuropsychopharmacology. 44 , p. 166-167

Points to consider regarding DSM alternatives - Authors' reply

Vanheule Stijn, Adriaens Pieter, Bazan Ariane, Bracke Piet, Devisch Ignaas, Feys Jean-Louis, Froyen Brenda, Gerard Sylvie, Nieman Dorien H, Van Os Jim, Calmeyn Marc 1 nov 2019, In: The Lancet Psychiatry. 6 , p. 895 1 p.

Putting the psychotherapy spotlight back on the self-reflecting actors who make it work

van Os Jim, Kamp David 1 okt 2019, In: World Psychiatry. 18 , p. 292-293 2 p.

White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?

Schepers Elaine, Lousberg Richel, Guloksuz Sinan, Pries Lotta-Katrin, Delespaul Philippe, Kenis Gunter, Luykx Jurjen J., Lin Bochao D., Richards Alexander L., Akdede Berna, Binbay Tolga, Altinyazar Vesile, Yalincetin Berna, Gumus-Akay Guvem, Cihan Burcin, Soygur Haldun, Ulas Halis, Cankurtaran Eylem Sahin, Kaymak Semra Ulusoy, Mihaljevic Marina M., Petrovic Sanja Andric, Mirjanic Tijana, Bernardo Miguel, Cabrera Bibiana, Bobes Julio, Saiz Pilar A., Paz Garcia-Portilla Maria, Sanjuan Julio, Aguilar Eduardo J., Luis Santos Jose, Jimenez-Lopez Estela, Arrojo Manuel, Carracedo Angel, Lopez Gonzalo, Gonzalez-Penas Javier, Parellada Mara, Maric Nadja P., Atbasoglu Cem, Ucok Alp, Alptekin Koksal, Saka Meram Can, Arango Celso, Rutten Bart P. F., van Os Jim 25 sep 2019, In: Frontiers in Psychiatry. 10

Belgian Superior Health Council advises against the use of the DSM categories

Vanheule Stijn, Adriaens Pieter, Bazan Ariane, Bracke Piet, Devisch Ignaas, Feys Jean-Louis, Froyen Brenda, Gerard Sylvie, Nieman Dorien H, Van Os Jim, Calmeyn Marc 1 sep 2019, In: The Lancet Psychiatry. 6 , p. 726 1 p.

Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples:The Results From the EUGEI Study

Pries Lotta Katrin, Lage-Castellanos Agustin, Delespaul Philippe, Kenis Gunter, Luykx Jurjen J., Lin Bochao D., Richards Alexander L., Akdede Berna, Binbay Tolga, Altinyazar Vesile, Yalinçetin Berna, Gümüş-Akay Güvem, Cihan Burçin, Soygür Haldun, Ulaş Halis, Cankurtaran Eylem Şahin, Kaymak Semra Ulusoy, Mihaljevic Marina M., Petrovic Sanja Andric, Mirjanic Tijana, Bernardo Miguel, Cabrera Bibiana, Bobes Julio, Saiz Pilar A., García-Portilla María Paz, Sanjuan Julio, Aguilar Eduardo J., Santos José Luis, Jiménez-López Estela, Arrojo Manuel, Carracedo Angel, López Gonzalo, González-Peñas Javier, Parellada Mara, Maric Nadja P., Atbaşoğlu Cem, Ucok Alp, Alptekin Köksal, Saka Meram Can, Arango Celso, O'Donovan Michael, Rutten Bart P.F., van Os Jim, Guloksuz Sinan, 1 sep 2019, In: Schizophrenia Bulletin. 45 , p. 960-965 6 p.

Trust and the city:Linking urban upbringing to neural mechanisms of trust in psychosis

Lemmers-Jansen Imke Lj, Fett Anne-Kathrin J, van Os Jim, Veltman Dick J, Krabbendam Lydia 14 aug 2019, In: Australian and New Zealand Journal of Psychiatry. 54 , p. 138-149 12 p.

All Research Output (322)