prof. dr. J.J. (Jim) van Os

prof. dr. J.J. (Jim) van Os

Full Professor
prof. dr. J.J. (Jim) van Os
  • Division Neuroscience

Research Programs




I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.


Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Side Activities

Chairman of the Psychosenet Foundation

Member of the DeNieuweGGZ foundation

Member Editorial boards: Psychilogical Medicine, Schizophrenia Research, Schizophrenia Bulletin, Early intervention in Psychiatry, Acta Psychiatrica Scandinavica, Journal of Mental Health, Plos One

Member of the GGZ-VS Supervisory Board (GGZ nurse specialist training)

Fellowship and Awards

Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

Association of European Psychiatrists research price 2003 (20.000 euro)

Member, KNAW (2011).

Fellow, King’s College London (2016).

Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

Research Output (466)

The complex and dynamic interplay between self-esteem, belongingness and physical activity in daily life:An experience sampling study in adolescence and young adulthood

Mazereel Victor, Vansteelandt Kristof, Menne-Lothmann Claudia, Decoster Jeroen, Derom Catherine, Thiery Evert, Rutten Bart P.F., Jacobs Nele, van Os Jim, Wichers Marieke, De Hert Marc, Vancampfort Davy, van Winkel Ruud okt 2021, In: Mental Health and Physical Activity. 21 , p. 1-9

The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis:findings from the EU-GEI study

Quattrone Diego, Reininghaus Ulrich, Richards Alex L, Tripoli Giada, Ferraro Laura, Quattrone Andrea, Marino Paolo, Rodriguez Victoria, Spinazzola Edoardo, Gayer-Anderson Charlotte, Jongsma Hannah E, Jones Peter B, La Cascia Caterina, La Barbera Daniele, Tarricone Ilaria, Bonora Elena, Tosato Sarah, Lasalvia Antonio, Szöke Andrei, Arango Celso, Bernardo Miquel, Bobes Julio, Del Ben Cristina Marta, Menezes Paulo Rossi, Llorca Pierre-Michel, Santos Jose Luis, Sanjuán Julio, Arrojo Manuel, Tortelli Andrea, Velthorst Eva, Berendsen Steven, de Haan Lieuwe, Rutten Bart P F, Lynskey Michael T, Freeman Tom P, Kirkbride James B, Sham Pak C, O'Donovan Michael C, Cardno Alastair G, Vassos Evangelos, van Os Jim, Morgan Craig, Murray Robin M, Lewis Cathryn M, Di Forti Marta, 10 aug 2021, In: Translational Psychiatry. 11 10 p.

Incidentie van psychose onder migranten in Nederland

Temorshuizen Fabian, van der Ven Els M.A., Velthorst Eva, van Dam Daniëlla S., Rutten Bart P., van Os Jim, De Haan Lieuwe, Selten Jean Paul 22 jul 2021, In: Nederlands Tijdschrift voor Geneeskunde. 165

What makes the psychosis 'clinical high risk' state risky:psychosis itself or the co-presence of a non-psychotic disorder?

Hasmi Laila, Pries Lotta-Katrin, Ten Have Margreet, de Graaf Ron, van Dorsselaer Saskia, Bak Maarten, Kenis Gunter, Richards Alexander, Lin Bochao D, O'Donovan Michael C, Luykx Jurjen J, Rutten Bart P F, Guloksuz Sinan, van Os Jim 6 jul 2021, In: Epidemiology and Psychiatric Sciences. 30 10 p.

Precursors of self-reported subclinical hypomania in adolescence:A longitudinal general population study

Nielsen Louise Gunhard, Rimvall Martin Køster, van Os Jim, Verhulst Frank, Rask Charlotte Ulrikka, Skovgaard Anne Mette, Olsen Else Marie, Jeppesen Pia jun 2021, In: PLoS ONE. 16 15 p.

En attendant Godot:Waiting for the Funeral of “Schizophrenia” and the Baby Shower of the Psychosis Spectrum

Guloksuz Sinan, van Os Jim 28 mei 2021, In: Frontiers in Psychiatry. 12 5 p.

Estimating Aggregate Environmental Risk Score in Psychiatry:The Exposome Score for Schizophrenia

Pries Lotta Katrin, Erzin Gamze, Rutten Bart P.F., van Os Jim, Guloksuz Sinan 28 mei 2021, In: Frontiers in Psychiatry. 12 , p. 1-7

Stress reactivity as a putative mechanism linking childhood trauma with clinical outcomes in individuals at ultra-high-risk for psychosis:Findings from the EU-GEI High Risk Study

Paetzold I, Myin-Germeys I, Schick A, Nelson B, Velthorst E, Schirmbeck F, van Os J, Morgan C, Hartmann J, van der Gaag M, de Haan L, Valmaggia L, McGuire P, Kempton M, Reininghaus U, 28 mei 2021, In: Epidemiology and Psychiatric Sciences. 30 , p. 1-13

Prevalence and correlates of anxiety and depression in frontline healthcare workers treating people with COVID-19 in Bangladesh

Tasnim Rafia, Sujan Md Safaet Hossain, Islam Md Saiful, Ritu Asmaul Husna, Siddique Md Abid Bin, Toma Tanziha Yeasmin, Nowshin Rifat, Hasan Abid, Hossain Sahadat, Nahar Shamsun, Islam Salequl, Islam Muhammad Sougatul, Potenza Marc N, van Os Jim 25 mei 2021, In: BMC Psychiatry. 21 14 p.

Relationship between social cognition, general cognition, and risk for suicide in individuals with a psychotic disorder

Dickhoff Justine, Opmeer Esther Marije, Heering Henriette Dorotheé, Bruggeman Richard, van Amelsvoort Therese, Bartels-Velthuis Agna A., Cahn Wiepke, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., van Os Jim, Aleman André, van Tol Marie José 14 mei 2021, In: Schizophrenia Research. 231 , p. 227-236 10 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet