prof. dr. J.J. (Jim) van Os

prof. dr. J.J. (Jim) van Os

Full Professor
prof. dr. J.J. (Jim) van Os
  • Division Neuroscience

Research Programs




I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.


Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Side Activities

Chairman of the Psychosenet Foundation

Member of the DeNieuweGGZ foundation

Member Editorial boards: Psychilogical Medicine, Schizophrenia Research, Schizophrenia Bulletin, Early intervention in Psychiatry, Acta Psychiatrica Scandinavica, Journal of Mental Health, Plos One

Member of the GGZ-VS Supervisory Board (GGZ nurse specialist training)

Fellowship and Awards

Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

Association of European Psychiatrists research price 2003 (20.000 euro)

Member, KNAW (2011).

Fellow, King’s College London (2016).

Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

Research Output (518)

Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults

Marchi Mattia, Elkrief Laurent, Alkema Anne, van Gastel Willemijn, Schubart Chris D, van Eijk Kristel R, Luykx Jurjen J, Branje Susan, Mastrotheodoros Stefanos, Galeazzi Gian M, van Os Jim, Cecil Charlotte A, Conrod Patricia J, Boks Marco P Dec 2022, In: Translational Psychiatry. 12 , p. 1-10

Long-term treatment of antipsychotics and combined therapy with other psychotropic medications inducing weight gain in patients with non-affective psychotic disorder:Evidence from GROUP, a longitudinal study

Burin Luisa M., Hahn Margaret K., da Rocha Neusa S., van Amelsvoort Therese, Bartels-Velthuis Agna A., Bruggeman Richard, de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., van Os Jim, Cahn Wiepke Aug 2022, In: Psychiatry Research. 314

The validation of a serious game for teaching ultrasound skills

Olgers T J, van Os J M, Bouma H R, Ter Maaten J C 23 Jul 2022, In: The ultrasound journal. 14 , p. 1-7

Gender differences in the association between environment and psychosis

Pence Aysegul Yay, Pries Lotta Katrin, Ferrara Maria, Rutten Bart P.F., van Os Jim, Guloksuz Sinan May 2022, In: Schizophrenia Research. 243 , p. 120-137 18 p.

Early intervention service systems for youth mental health:integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis

Shah Jai L, Jones Nev, van Os Jim, McGorry Patrick D, Gülöksüz Sinan May 2022, In: The Lancet Psychiatry. 9 , p. 413-422 10 p.

Movement Disorders and Mortality in Severely Mentally Ill Patients:The Curacao Extrapyramidal Syndromes Study XIV

Willems Anne E, Mentzel Charlotte L, Bakker Pieter Roberto, van Os Jim, Tenback Diederik E, Gelan Petra, Daantjes Erna, Matroos Glenn E, Hoek Hans W, van Harten Peter N 29 Apr 2022, In: Schizophrenia bulletin. 48 , p. 766-773 8 p.

General psychopathology and its social correlates in the daily lives of youth

Achterhof Robin, Kirtley Olivia J., Schneider Maude, Hagemann Noëmi, Hermans Karlijn S.F.M., Hiekkaranta Anu P., Lecei Aleksandra, Decoster Jeroen, Derom Catherine, De Hert Marc, Gülöksüz Sinan, Jacobs Nele, Menne-Lothmann Claudia, Rutten Bart P.F., Thiery Evert, van Os Jim, van Winkel Ruud, Wichers Marieke, Myin-Germeys Inez 29 Apr 2022, In: Journal of Affective Disorders. 309 , p. 428-436 9 p.

Negative life events and stress sensitivity in youth's daily life:an ecological momentary assessment study

Rauschenberg Christian, Schulte-Strathaus Julia C C, van Os Jim, Goedhart Matthieu, Schieveld Jan N M, Reininghaus Ulrich 25 Apr 2022, In: Social Psychiatry and Psychiatric Epidemiology. 57 , p. 1641-1657 17 p.

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Trubetskoy Vassily, Pardiñas Antonio F, Qi Ting, Panagiotaropoulou Georgia, Awasthi Swapnil, Bigdeli Tim B, Bryois Julien, Chen Chia-Yen, Dennison Charlotte A, Hall Lynsey S, Lam Max, Watanabe Kyoko, Frei Oleksandr, Ge Tian, Harwood Janet C, Koopmans Frank, Magnusson Sigurdur, Richards Alexander L, Sidorenko Julia, Wu Yang, Zeng Jian, Grove Jakob, Kim Minsoo, Li Zhiqiang, Voloudakis Georgios, Zhang Wen, Adams Mark, Agartz Ingrid, Atkinson Elizabeth G, Agerbo Esben, Al Eissa Mariam, Albus Margot, Alexander Madeline, Alizadeh Behrooz Z, Alptekin Köksal, Als Thomas D, Amin Farooq, Arolt Volker, Arrojo Manuel, Athanasiu Lavinia, Azevedo Maria Helena, Bacanu Silviu A, Bass Nicholas J, Cahn Wiepke, Gülöksüz Sinan, Rutten Bart P F, Kahn René S, Ophoff Roel A, van Os Jim, Weinberger Daniel R, 8 Apr 2022, In: Nature. 604 , p. 502-508 7 p.

Be(com)ing social:Daily-life social interactions and parental bonding

Achterhof Robin, Schneider Maude, Kirtley Olivia J, Wampers Martien, Decoster Jeroen, Derom Catherine, De Hert Marc, Guloksuz Sinan, Jacobs Nele, Menne-Lothmann Claudia, Rutten Bart P F, Thiery Evert, van Os Jim, van Winkel Ruud, Wichers Marieke, Myin-Germeys Inez Apr 2022, In: Developmental Psychology. 58 , p. 792-805 14 p.

All research output

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