prof. dr. J.J. (Jim) van Os

prof. dr. J.J. (Jim) van Os

Full Professor
prof. dr. J.J. (Jim) van Os
  • Division Neuroscience
  • Division Neuroscience

Research Programs




I have a background in Epidemiology (London School of Hygiene and Tropical Medicine) and Psychiatry (Institute of Psychiatry, King’s College London). My research has focused on elucidating the nature of mental variation in relation to context, and identifying the interactions between environment and genetic liability driving this variation. Over the course of my career, I have developed a passion for making psychiatry more relevant for its users in terms of diagnostic practice, the use of scientific findings to create clinical impact, health service organization, teaching and co-creation with users. I think there is an urgent need to balance the discourse and the scientific focus of the psychiatric profession on the one hand, and the needs and wishes of patients and their relatives on the other. In my work as Neuroscience Division leader at MUMC and now UMCU, I have attempted to forge collaboration between the clinical neurosciences in order to create patient value, for example in the area of neuromodulation. After several decades of directing activities in health care and research, I think effective leadership is about facilitating others, creating a community and fostering the network – in the shared belief that our work serves to inspire students and impact the lives of patients.


Basic Teaching Qualification, BROK certified

Ten most important scientific publications

  • Van Os, J., Hanssen, M., Bijl, R.V. & Vollebergh, W. (2001) Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Archives of General Psychiatry, 58, 663-668.

  • Van Os, J., Hanssen, M., Bak, M., et al (2003) Do urbanicity and familial liability coparticipate in causing psychosis? American Journal of Psychiatry, 160, 477-482.
  • Van Os, J., Altamura, A.C., Bobes, J. et al (2004) Evaluation of the Two-Way Communication Checklist as a clinical intervention. Results of a multinational, randomised controlled trial. British Journal of Psychiatry, 184, 79-83.
  • van Os, J. & Kapur, S. (2009) Schizophrenia. Lancet, 374, 635-645.
  • van Os, J., Kenis, G. & Rutten, B.P. (2010) The environment and schizophrenia. Nature, 468, 203-212.
  • van Os, J. & Reininghaus, U. (2016) Psychosis as a transdiagnostic and extended phenotype in the general population. World Psychiatry, 15, 118-124.
  • Van Os J, Marsman A, Van Dam D, Simons CJ, GROUP Investigators (2017). Evidence That the Impact of Childhood Trauma on IQ Is Substantial in Controls, Moderate in Siblings, and Absent in Patients With Psychotic Disorder. Schizophrenia Bulletin, 43(2), 316-324.
  • Van Os J, Van Der Steen Y, Islam MA, Guloksuz S, Rutten BP, Simons CJ, GROUP Investigators (2017). Evidence that polygenic risk for psychotic disorder is expressed in the domain of neurodevelopment, emotion regulation and attribution of salience. Psychological Medicine, 47(14), 2421-2437.
  • Van Os, J. & Güloksuz, S. (2017). A critique of the popular “ultra-high risk” and “transition” paradigm in psychiatry. World Psychiatry,16, 200-206
  • Van Os, J., Verhagen, S., Marsman, et al. (2017) The Experience Sampling Method as an mHealth Tool to Support Self-monitoring, Self-Insight and Personalised Health Care in Clinical Practice. Depression and Anxiety, 34(6), 481-493.

Side Activities

Chairman of the Psychosenet Foundation

Member of the DeNieuweGGZ foundation

Member Editorial boards: Psychilogical Medicine, Schizophrenia Research, Schizophrenia Bulletin, Early intervention in Psychiatry, Acta Psychiatrica Scandinavica, Journal of Mental Health, Plos One

Member of the GGZ-VS Supervisory Board (GGZ nurse specialist training)

Fellowship and Awards

Ramaer Medal Outstanding Research, Dutch Psychiatric Association, 1997

Association of European Psychiatrists research price 2003 (20.000 euro)

Member, KNAW (2011).

Fellow, King’s College London (2016).

Thompson-Reuter WoS list of ‘most influential scientific minds’ and ‘highly cited researchers’

Research Output (572)

Prevalence, time trends, and correlates of major depressive episode and other psychiatric conditions among young people amid major social unrest and COVID-19 in Hong Kong:a representative epidemiological study from 2019 to 2022

Wong Stephanie M.Y., Chen Eric Y.H., Suen Y. N., Wong Corine S.M., Chang W. C., Chan Sherry K.W., McGorry Patrick D., Morgan Craig, van Os Jim, McDaid David, Jones Peter B., Lam T. H., Lam Linda C.W., Lee Edwin H.M., Tang Eric Y.H., Ip Charlie H., Ho Winky W.K., McGhee Sarah M., Sham P. C., Hui Christy L.M. Nov 2023, In: The Lancet Regional Health - Western Pacific. 40

Psychotic experiences and mental health outcomes in the general population

Austin Stephen F, Hastrup Lene Halling, van Os Jim, Simonsen Erik 24 Aug 2023, In: Schizophrenia Research. 260 , p. 85-91 7 p.

Gene-environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding

Klingenberg Boris, Guloksuz Sinan, Pries Lotta Katrin, Cinar Ozan, Menne-Lothmann Claudia, Decoster Jeroen, Van Winkel Ruud, Collip Dina, Delespaul Philippe, De Hert Marc, Derom Catherine, Thiery Evert, Jacobs Nele, Wichers Marieke, Lin Bochao D., Luykx Jurjen, Van Os Jim, Rutten Bart P.F. 4 Aug 2023, In: Personality Neuroscience. 6 , p. 1-9 9 p.

The Involvement of Service Users and People With Lived Experience in Mental Health Care Innovation Through Design:Systematic Review

Veldmeijer Lars, Terlouw Gijs, Os Jim Van, Dijk Olga Van, t' Veer Job Van, Boonstra Nynke 25 Jul 2023, In: JMIR mental health. 10

Differences in Patterns of Stimulant Use and Their Impact on First-Episode Psychosis Incidence:An Analysis of the EUGEI Study

Rodríguez-Toscano Elisa, Alloza Clara, Fraguas David, Durán-Cutilla Manuel, Roldán Laura, Sánchez-Gutiérrez Teresa, López-Montoya Gonzalo, Parellada Mara, Moreno Carmen, Gayer-Anderson Charlotte, Jongsma Hannah E, Di Forti Marta, Quattrone Diego, Velthorst Eva, de Haan Lieuwe, Selten Jean-Paul, Szöke Andrei, Llorca Pierre-Michel, Tortelli Andrea, Bobes Julio, Bernardo Miguel, Sanjuán Julio, Luis Santos José, Arrojo Manuel, Tarricone Ilaria, Berardi Domenico, Ruggeri Mirella, Lasalvia Antonio, Ferraro Laura, La Cascia Caterina, La Barbera Daniele, Menezes Paulo Rossi, Del-Ben Cristina Marta, Rutten Bart P, van Os Jim, Jones Peter B, Murray Robin M, Kirkbride James B, Morgan Craig, Díaz-Caneja Covadonga M, Arango Celso, 19 Jul 2023, In: Schizophrenia bulletin. 49 , p. 1269-1280 12 p.

The use of experiential knowledge in the role of a psychiatrist

Boomsma-van Holten Marjolein, Weerman Alie, Karbouniaris Simona, Van Os Jim 15 Jun 2023, In: Frontiers in Psychiatry. 14 11 p.

Six-year trajectories and associated factors of positive and negative symptoms in schizophrenia patients, siblings, and controls:Genetic Risk and Outcome of Psychosis (GROUP) study

Habtewold Tesfa Dejenie, Tiles-Sar Natalia, Liemburg Edith J., Sandhu Amrit Kaur, Islam Md Atiqul, Boezen H. Marike, Alizadeh Behrooz Z., van Amelsvoort Therese, Bartels-Velthuis Agna A., de Haan Lieuwe, Schirmbeck Frederike, Simons Claudia J.P., van Os Jim, Bruggeman Richard, Alizadeh Behrooz Z., 9 Jun 2023, In: Scientific Reports. 13

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Hsu Yu Han H., Pintacuda Greta, Liu Ruize, Nacu Eugeniu, Kim April, Tsafou Kalliopi, Petrossian Natalie, Crotty William, Suh Jung Min, Riseman Jackson, Martin Jacqueline M., Biagini Julia C., Mena Daya, Ching Joshua K.T., Malolepsza Edyta, Li Taibo, Singh Tarjinder, Ge Tian, Egri Shawn B., Tanenbaum Benjamin, Stanclift Caroline R., Apffel Annie M., Ripke Stephan, Neale Benjamin M., Corvin Aiden, Walters James T.R., Farh Kai How, Holmans Peter A., Lee Phil, Bulik-Sullivan Brendan, Collier David A., Huang Hailiang, Pers Tune H., Agartz Ingrid, Agerbo Esben, Albus Margot, Alexander Madeline, Amin Farooq, Bacanu Silviu A., Begemann Martin, Belliveau Richard A., Bene Judit, Bergen Sarah E., Bevilacqua Elizabeth, Cahn Wiepke, Kahn René S., Van Os Jim, Ophoff Roel A., Weinberger Daniel R., Kahn René S., , , , 19 May 2023, In: iScience. 26

Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls

Lin Bochao Danae, Vermeulen Jentien M., Bolhuis K., Chang Xiao, Schirmbeck Frederike, van Eijk Kristel R., Alizadeh Behrooz Z., Bartels-Velthuis Agna A., van Amelsvoort Therese, Bruggeman Richard, Cahn Wiepke, de Haan Lieuwe, Rutten Bart P.F., Guloksuz Sinan, Luykx Jurjen J., van Os Jim, Simons Claudia J.P., van Winkel Ruud, Blankers Matthijs, van den Brink W., May 2023, In: Psychiatry Research. 323 , p. 1-8

Managing withdrawal symptoms using tapering strips

Groot Peter C, van Os Jim May 2023, In: The British journal of general practice : the journal of the Royal College of General Practitioners. 73 , p. 203-204 2 p.

All research output

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