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prof. dr. ir. A. (Alexander) van Oudenaarden

prof. dr. ir. A. (Alexander) van Oudenaarden

Full Professor
  • Molecular Cancer Research
  • Hubrecht Institute

Research Programs

Strategic Program Cancer

Side Activities

  • Director of the Hubrecht Institute
  • Professor of Quantitative Biology of Gene Regulations at the University Medical Center Utrecht and at Utrecht University
  • Member of the Koninklijke Hollandsche Maatschappij der Wetenschappen (KHMW)
  • Member of the Royal Netherlands Academy of Arts and Sciences (KNAW)
  • Member of the organizing committee of Single Cell Genomics (yearly conference)
  • Member of the advisory board of Single Cell Discoveries B.V.
  • Member of the national scientific advisory board of The Netherlands Cancer Institute (NKI)
  • Member of the advisory editorial board of Molecular Systems Biology
  • Member of the scientific advisory board at the Whitehead Institute for Biomedical Research

Research Output (115)

Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development

Sen Maya, Mooijman Dylan, Chialastri Alex, Boisset Jean Charles, Popovic Mina, Heindryckx Björn, Chuva de Sousa Lopes Susana M., Dey Siddharth S., van Oudenaarden Alexander Dec 2021, In: Nature Communications. 12

Single-cell transcriptomics links loss of human pancreatic β-cell identity to er stress

Groen Nathalie, Leenders Floris, Mahfouz Ahmed, Munoz-Garcia Amadeo, Muraro Mauro J., de Graaf Natascha, Rabelink Ton J., Hoeben Rob, van Oudenaarden Alexander, Zaldumbide Arnaud, Reinders Marcel J.T., de Koning Eelco J.P., Carlotti Françoise Dec 2021, In: Cells. 10

Molecular characterization of Barrett's esophagus at single-cell resolution

Busslinger Georg A, de Barbanson Buys, Oka Rurika, Weusten Bas L A, de Maat Michiel, van Hillegersberg Richard, Brosens Lodewijk A A, van Boxtel Ruben, van Oudenaarden Alexander, Clevers Hans 23 Nov 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118 , p. 1-12

H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity

Methot Stephen P., Padeken Jan, Brancati Giovanna, Zeller Peter, Delaney Colin E., Gaidatzis Dimos, Kohler Hubertus, van Oudenaarden Alexander, Großhans Helge, Gasser Susan M. Nov 2021, In: Nature Cell Biology. 23 , p. 1163-1175 13 p.

Single-cell Ribo-seq reveals cell cycle-dependent translational pausing

VanInsberghe Michael, van den Berg Jeroen, Andersson-Rolf Amanda, Clevers Hans, van Oudenaarden Alexander 23 Sep 2021, In: Nature. 597 , p. 561-565 5 p.

3D gastruloids:a novel frontier in stem cell-based in vitro modeling of mammalian gastrulation

van den Brink Susanne C., van Oudenaarden Alexander Sep 2021, In: Trends in Cell Biology. 31 , p. 747-759 13 p.

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky Nikolaus, Almouzni Geneviève, Gorski Stanislaw A., Aerts Stein, Amit Ido, Bertero Michela G., Bock Christoph, Bredenoord Annelien L., Cavalli Giacomo, Chiocca Susanna, Clevers Hans, De Strooper Bart, Eggert Angelika, Ellenberg Jan, Fernández Xosé M., Figlerowicz Marek, Gasser Susan M., Hubner Norbert, Kjems Jørgen, Knoblich Jürgen A., Krabbe Grietje, Lichter Peter, Linnarsson Sten, Marine Jean Christophe, Marioni John C., Marti-Renom Marc A., Netea Mihai G., Nickel Dörthe, Nollmann Marcelo, Novak Halina R., Parkinson Helen, Piccolo Stefano, Pinheiro Inês, Pombo Ana, Popp Christian, Reik Wolf, Roman-Roman Sergio, Rosenstiel Philip, Schultze Joachim L., Stegle Oliver, Tanay Amos, Testa Giuseppe, Thanos Dimitris, Theis Fabian J., Torres-Padilla Maria Elena, van Oudenaarden Alexander, Bruining Hilgo, Jongsma Karin R., Pasterkamp R. Jeroen, van Oudenaarden Alexander, 1 Apr 2021, In: Nature. 592 , p. E8

An in vitro model of early anteroposterior organization during human development

Moris Naomi, Anlas Kerim, van den Brink Susanne C, Alemany Anna, Schröder Julia, Ghimire Sabitri, Balayo Tina, van Oudenaarden Alexander, Martinez Arias Alfonso 18 Jun 2020, In: Nature. 582 , p. 410-415 6 p.

Publisher Correction:Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

van den Brink Susanne C, Alemany Anna, van Batenburg Vincent, Moris Naomi, Blotenburg Marloes, Vivié Judith, Baillie-Johnson Peter, Nichols Jennifer, Sonnen Katharina F, Martinez Arias Alfonso, van Oudenaarden Alexander 19 Mar 2020, In: Nature. 579 , p. E11-E11

Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies

Battich Nico, Beumer Joep, de Barbanson Buys, Krenning Lenno, Baron Chloé S, Tanenbaum Marvin E, Clevers Hans, van Oudenaarden Alexander 6 Mar 2020, In: Science. 367 , p. 1151-1156 6 p.

All research output

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