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prof. dr. J.E. (Jacco) van Rheenen

Full Professor
  • Molecular Cancer Research
  • Hubrecht Institute

Research Programs

Strategic Program Cancer

Side Activities

Editorial board of the journal IntraVital

groepsleider Nederlands Kanker Institute (1-10-2017)

groepsleider Oncode Institute

Beoordelingscommissie Exploratie KWF

Fellowship and Awards

2015    Awarded an ERC consolidator grant by the European Research Council

2013    Stem Cells Young Investigator Award 2013 (10,000 dollar personal money)

2008    Awarded a VIDI grant by the Netherlands Organisation for Scientific Research (NWO).

2006    Fellowship for fundamental and (pre-)clinical cancer research from the Dutch Cancer Society (KWF).

Research Output (49)

How the COVID-19 pandemic highlights the necessity of animal research (vol 30, pg R1014, 2020):How the COVID-19 pandemic highlights the necessity of animal research (Current Biology (2020) 30(18) (R1014–R1018), (S0960982220311842), (10.1016/j.cub.2020.08.030))

Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen J.J.P., Blokland Arjan, Boddeke Erik H.W.G.M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C.J.J., van Dam Anne Marie, Deen Peter M.T., van Dijk K. W., Eggen Bart J.L., Elgersma Ype, Erdogan Izel, Englitz Bernhard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes J.A.G., Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A.B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer Jaap, Kersten Sander, Kiliaan Amanda J., Kooij Taco W.A., Kooijman Sander, Koopman Werner J.H., Lesscher Heidi M.B., Meye Frank J., Mul Joram D., Pasterkamp R. Jeroen, van Rheenen Jacco, Vanderschuren Louk J.M.J., Homberg Judith R., 2 nov 2020, In: Current Biology. 30 , p. 4328-4328 1 p.

How the COVID-19 pandemic highlights the necessity of animal research

Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen, Blokland Arjan, Boddeke Erik H.W.G.M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C.J.J., Dam Anne Marie van, Deen Peter M.T., van Dijk K. W., Eggen Bart J.L., Elgersma Ype, Erdogan Izel, Englitz Bernard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes, Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A.B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer J., Kersten Sander, Kiliaan Amanda J., Kooij Taco W.A., Kooijman Sander, Koopman Werner J.H., Lesscher Heidi, Meye Frank J., Mul Joram D., Pasterkamp R. Jeroen, van Rheenen Jacco, Vanderschuren Louk J.M.J., Homberg Judith R., 21 sep 2020, In: Current Biology. 30 , p. R1014-R1018

Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

Bruens Lotte, Ellenbroek Saskia Inge Johanna, Suijkerbuijk Saskia Jacoba Elisabeth, Azkanaz Maria, Hale Alexander James, Toonen Pim, Flanagan Dustin James, Sansom Owen James, Snippert Hugo Johannes, van Rheenen Jacco 21 jul 2020, In: Cell Reports. 32 , p. 1-10

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Fumagalli Arianna, Oost Koen C., Kester Lennart, Morgner Jessica, Bornes Laura, Bruens Lotte, Spaargaren Lisa, Azkanaz Maria, Schelfhorst Tim, Beerling Evelyne, Heinz Maria C., Postrach Daniel, Seinstra Danielle, Sieuwerts Anieta M., Martens John W.M., van der Elst Stefan, van Baalen Martijn, Bhowmick Debajit, Vrisekoop Nienke, Ellenbroek Saskia I.J., Suijkerbuijk Saskia J.E., Snippert Hugo J., van Rheenen Jacco 2 apr 2020, In: Cell stem cell. 26 , p. 569-578.e7

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

de Jong Olivier G., Murphy Daniel E., Mäger Imre, Willms Eduard, Garcia-Guerra Antonio, Gitz-Francois Jerney J., Lefferts Juliet, Gupta Dhanu, Steenbeek Sander C., van Rheenen Jacco, El Andaloussi Samir, Schiffelers Raymond M., Wood Matthew J.A., Vader Pieter 28 feb 2020, In: Nature Communications. 11 , p. 1-13

C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition

Lourenço Ana Rita, Roukens M. Guy, Seinstra Danielle, Frederiks Cynthia L., Pals Cornelieke E., Vervoort Stephin J., Margarido Andreia S., van Rheenen Jacco, Coffer Paul J. 7 feb 2020, In: Nature Communications. 11 , p. 1-18

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids

Artegiani Benedetta, van Voorthuijsen Lisa, Lindeboom Rik G.H., Seinstra Daniëlle, Heo Inha, Tapia Pablo, López-Iglesias Carmen, Postrach Daniel, Dayton Talya, Oka Rurika, Hu Huili, van Boxtel Ruben, van Es Johan H., Offerhaus Johan, Peters Peter J., van Rheenen Jacco, Vermeulen Michiel, Clevers Hans 6 jun 2019, In: Cell Stem Cell. 24 , p. 927-943.e6

Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion

Alieva Maria, Leidgens Verena, Riemenschneider Markus J., Klein Christoph A., Hau Peter, van Rheenen Jacco 14 feb 2019, In: Scientific Reports. 9

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Huels D. J., Bruens L., Hodder M. C., Cammareri P., Campbell A. D., Ridgway R. A., Gay D. M., Solar-Abboud M., Faller W. J., Nixon C., Zeiger L. B., McLaughlin M. E., Morrissey E., Winton D. J., Snippert H. J., Van Rheenen J., Sansom O. J. 1 dec 2018, In: Nature Communications. 9

Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

Steenbeek Sander C., Pham Thang V., de Ligt Joep, Zomer Anoek, Knol Jaco C., Piersma Sander R., Schelfhorst Tim, Huisjes Rick, Schiffelers Raymond M., Cuppen Edwin, Jimenez Connie R., van Rheenen Jacco 1 aug 2018, In: EMBO Journal. 37

All research output

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