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dr. H.M. van Santen

dr. H.M. van Santen

Associate Professor - medical
dr. H.M. van Santen
  • Endocrinology patient care

Biography

Biography

Dr. HM van Santen moved her career in 2013 to Utrecht to support the Máxima initiative and to coordinate the endocrine care for children with cancer in the Princess Máxima Center. 

She has co-authored > 100 articles on the endocrine effects of childhood cancer treatment, craniopharyngioma and pediatric thyroid cancer.

She is an associate professor, PI and clinical scientist in the research program of Child Health, WKZ, UMCU and co-PI in the Máxima Center for Pediatric Oncology. 

Her research program focuses on the endocrine and metabolic effects of children with severe disease such as childhood craniopharyngioma, the acute and late effects of childhood cancer treatment on the endocrine system, and on pediatric thyroid cancer. The overall aim of her work is to preserve an intact endocrine system in children with neoplasms enabling normal growth and development into adulthood.

She is chair of the SIOPe craniopharyngioma working group and of the MC4 group Craniopharyngioma in the Máxima Center for Pediatric Oncology. Also she chairs the Late Effects of Childhood Cancer International Guideline Harmonization Groups (IGHG) for thyroid and hypothalamic-pituitary disorders, and is member of the IGHG working groups for male and female gonadal toxicity and preservation of fertility and metabolic syndrome.

She is chair of the Dutch and the European Guideline for Thyroid cancer in children (ETA) and the coordinator of the NFU/ ENDO-ERN expertise center Thyroid Tumors in Utrecht.

Furthermore, Dr Hm van Santen is a member of the SIOP low grade glioma working group, the national consortium for Late effects of treatment for childhood thyroid carcinoma, the consortium of the Dexadagen-2 study, the Dutch Growth Hormone Advisory board and has a consultative function for the “Cyberpoli” for thyroid diseases and craniopharyngioma.

Side Activities

2020 - now   member of the WKZ Onderzoeksfonds Scientific Committee

2020             member of the Internal Grant committee Princess Maxima Center

2020             Chair SIOPe craniopharyngioma board

2020             Member of the Advisory board of the Academic Japanese Consortium for Juvenile Thyroid Cancer (JCJTC, president Dr Ohtsuru)  

2020             co-PI Prinses Maxima Center for Pediatric Oncology Utrecht

2019             BKO qualification UMCU

2019             Chair of the European Task Force for Recommendations of Treatment of Thyroid nodules and Carcinoma in Childhood

2016 – now  Deputy educator ( plaatsvervangend opleider) of the clinical fellow pediatric endocrinology in the Wilhelmina Children’s Hospital, UMCU

2018 - now   member of working group supportive care Princess Maxima Center

2017 - now   member of fertility working group Princess Maxima Center

2016 - now   Co-chair of the IGHG for surveillance of hypothalamic-pituitary disorders in Childhood Cancer Survivors

2016 - now   Participant/ member of the working group of the IGHG working group for  preservation of fertility in male childhood cancer survivors (in progress)

2016 – now  Participant / working group lead of the IGHG working group for preservation of fertility in female childhood cancer survivors (in progress)

2016 - now   Participant/ member of the working group of the IGHG recommendation for surveillance of the metabolic syndrome in childhood cancer survivors (in progress)

2016 - now   Co-chair of the Dutch Guideline for Treatment of Thyroid nodules and cancer in children (in progress)

2016 - now   Participant of  the SIOP supportive care group

2016 - now   Participant of the SIOP low grade glioma working group

2016 - now   Participant of the national consortium for Late effects of treatment for childhood thyroid carcinoma ( PI T Links, UMCG)

2016 - now   Participant of the consortium of the Dexadagen-2 study

2015 - now   Participant of the Dutch Growth Hormone Advisory board (SEK)

2015 - now   Consultative function for the “Cyberpoli” for thyroid diseases and craniopharyngioma(www.cyberpoli.nl)

 2015 – now    Participant of the SKION LATER Recommendations for screening Childhood Cancer Survivors https://www.skion.nl/workspace/uploads/vertaling-richtlijn-LATER-versie-final-okt-2014_2.pdf

 

Fellowship and Awards

2020                ZonMW Stimuleringssubsidie "Implementatie van nieuw behandelalgoritme voor hypothalame obesitas bij kinderen met een supra-sellaire tumor"

2019                KIKA project: THYRO-Dynamics Study (Prospective study on thyroid function during treatment with chemotherapy in 600 children)

2019                Princess Maxima Grant; research grant for 4-year PhD student: “Building an organoid model for craniopharyngioma”

2009-2011      Fellowship kinderendocrinologie in het Emma Kinderziekenhuis AMC

Research Output (141)

Hormone replacement in survivors of childhood cancer and brain tumors:safety and controversies

van Roessel Ichelle M A A, Bakker Boudewijn, van Santen Hanneke M, Chemaitilly Wassim 13 Dec 2022, In: Endocrine connections. 12

Cervical ultrasound surveillance in follow-up of pediatric differentiated thyroid carcinoma: a thyroglobulin first approach

van Santen HM, Lebbink Chantal, Czarniecka Agnieszka, Dias Renuka P, Elisei Rossella, Izatt Louise, Krude Heiko, Links Thera P, Lorenz Kerstin, Luster Markus, Newbold Katherine, Piccardo Arnoldo, Sobrinho Simões Manuel, Takano Toru, van Trotsenburg A. S. Paul, Verburg Frederik A. 19 Nov 2022,

Frailty and Sarcopenia within the Earliest Dutch Childhood Cancer Survivor Cohort (n=2,003): A Dccss-Later Study

Van Atteveld Jenneke E., de Winter Demi T.C., Pluimakers Vincent, Fiocco M., Nievelstein Rutger Jan, Hobbelink MGG, Kremer Leontien, Ronckers Cécile, Grootenhuis Martha, Maurice-Stam Heleen, Tissing Wim, de Vries Andrica C, Loonen Jacqueline J, van Dulmen-den Broeder E., van der Pal Helena J H, Pluijm Saskia, Van Der Heiden-Van Der Loo M., Versluijs Birgitta, Louwerens Marloes, Bresters Dorine, van Santen HM, Höfer IE, Van Den Berg Sjoerd A., Hoeijmakers Jan H. J., Neggers Sebastian J C M M, van den Heuvel-Eibrink M.M. 15 Nov 2022, In: Blood. 140 , p. 6026–6027

Modifiable Risk Factors Are Associated with Reduced Bone Mineral Density and Fractures in a National Cohort of 2,003 Dutch Childhood Cancer Survivors

de Winter Demi T.C., Van Atteveld Jenneke E., Pluimakers Vincent, Fiocco M., Nievelstein Rutger A. J., Hobbelink MGG, de Vries Andrica C, Loonen Jacqueline J, Van Dulmen-Den Broeder Eline, van der Pal Helena J H, Pluijm Saskia, Kremer Leontien, Ronckers Cécile, Van Der Heiden-Van Der Loo M., Olsson Daniel S., Höfer IE, Van Den Berg Sjoerd A., den Hartogh Jaap, Versluijs Birgitta, Tissing Wim, Neggers Sebastian J C M M, van den Heuvel-Eibrink M.M., van Santen HM, Louwerens Marloes, Bresters D. 15 Nov 2022, In: Blood. 140 , p. 922–923

Hydrocortisone or Placebo to Reduce Dexamethasone-Induced Neurobehavioral Side Effects: Results of a Phase 3 National, Double-Blind, Placebo-Controlled Randomized Trial with Crossover Design

van Hulst Annelienke M, van den Akker Erica L. T., Verwaaijen Emma, Fiocco M., Rensen Niki, van Litsenburg Raphaele R. L., Pluijm Saskia, Zwaan Michel, van Santen HM, Pieters Rob, Evers Andrea W M, Grootenhuis Martha, van den Heuvel-Eibrink M.M. 15 Nov 2022, In: Blood. 140 , p. 3162–3163

Cervical ultrasound surveillance in follow-up of pediatric differentiated thyroid carcinoma: a thyroglobulin first approach

van Santen HM, Lebbink Chantal, Czarniecka Agnieszka, Dias Renuka P, Elisei Rossella, Izatt Louise, Krude Heiko, Links Thera P, Lorenz Kerstin, Luster Markus, Newbold Katherine, Piccardo Arnoldo, Sobrinho Simões Manuel, Takano Toru, van Trotsenburg A. S. Paul, Verburg Frederik A. 19 Oct 2022,

Shrunken pore syndrome in childhood cancer survivors treated with potentially nephrotoxic therapy

Kooijmans Esmee C.M., van der Pal Helena J.H., Pilon Maxime C.F., Pluijm Saskia M.F., van der Heiden-van der Loo Margriet, Kremer Leontien C.M., Bresters Dorine, van Dulmen-den Broeder Eline, van den Heuvel-Eibrink Marry M., Loonen Jacqueline J., Louwerens Marloes, Neggers Sebastian J.C., van Santen Hanneke M., Tissing Wim J.E., de Vries Andrica C.H., Kaspers Gertjan J.L., Veening Margreet A., Bökenkamp Arend, 6 Oct 2022, In: Scandinavian Journal of Clinical and Laboratory Investigation. 82 , p. 541-548 8 p.

Editorial:Hypothalamic obesity: Today and future

van Santen H M, Spinedi E, Muller H L 3 Oct 2022, In: Frontiers in Endocrinology. 13

2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma

Lebbink Chantal A, Links Thera P, Czarniecka Agnieszka, Dias Renuka P, Elisei Rossella, Izatt Louise, Krude Heiko, Lorenz Kerstin, Luster Markus, Newbold Kate, Piccardo Arnoldo, Sorinho-Simoes Manuel, Takano Toru, Trotsenburg A S Paul van, Verburg Frederik A, van Santen Hanneke M 1 Oct 2022, In: European Thyroid Journal. 11

The effect of surveillance for differentiated thyroid carcinoma in childhood cancer survivors on survival rates:a decision-tree-based analysis

Heinzel Alexander, Müller Dirk, van Santen Hanneke M, Clement Sarah C, Schneider Arthur B, Verburg Frederik A 1 Oct 2022, In: Endocrine connections. 11

All research output

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