dr. H.M. van Santen
Associate Professor - medical
- Endocrinology patient care
Contact
Biography
Dr. HM van Santen moved her career in 2013 to Utrecht to support the Máxima initiative and to coordinate the endocrine care for children with cancer in the Princess Máxima Center.
She has co-authored > 50 publications on the endocrine effects of childhood cancer treatment, of which 27 as first or last author.
She is an associate professor and PI in the research program of Child Health, WKZ, UMCU and collaborates closely together with the Máxima Center for Pediatric Oncology . Internationally, she collaborates closely with the endocrine and late effects department of the St Jude’s Hospital (Dr W Chemaitilly, Dr M Hudson).
Her research program focusses on craniopharyngioma and thyroid cancer in childhood and on the endocrine effects of childhood cancer treatment, with special interest for the thyroid gland, pituitary gland and hypothalamus aiming to preserve an intact endocrine system in children with cancer enabling normal growth and development of the child during and after childhood cancer treatment.
She is chair of the Late Effects of Childhood Cancer International Guideline Harmonization Groups (IGHG) for thyroid and hypothalamic-pituitary disorders, and member of the IGHG working groups for male and female gonadal toxicity and preservation of fertility and metabolic syndrome. She is chair of the Dutch and the European Guideline for Thyroid cancer in children and the coordinator of the NFU/ ENDO-ERN expertise center Thyroid Tumors in Utrecht. She is member of the SKION craniopharyngioma working group, the SIOP supportive care group, the SIOP low grade glioma working group, the national consortium for Late effects of treatment for childhood thyroid carcinoma, the consortium of the Dexadagen-2 study, the Dutch Growth Hormone Advisory board and has a consultative function for the “Cyberpoli” for thyroid diseases and craniopharyngioma.
Side Activities
2019 BKO qualification UMCU
2019 Chair of the European Task Force for Recommendations of Treatment of Thyroid nodules and Carcinoma in Childhood
2016 – now Deputy educator ( plaatsvervangend opleider) of the clinical fellow pediatric endocrinology in the Wilhelmina Children’s Hospital, UMCU
2018 - now member of working group supportive care Princess Maxima Center
2017 - now member of fertility working group Princess Maxima Center
2016 - now Co-chair of the IGHG for surveillance of hypothalamic-pituitary disorders in Childhood Cancer Survivors
2016 - now Participant/ member of the working group of the IGHG working group for preservation of fertility in male childhood cancer survivors (in progress)
2016 – now Participant / working group lead of the IGHG working group for preservation of fertility in female childhood cancer survivors (in progress)
2016 - now Participant/ member of the working group of the IGHG recommendation for surveillance of the metabolic syndrome in childhood cancer survivors (in progress)
2016 - now Co-chair of the Dutch Guideline for Treatment of Thyroid nodules and cancer in children (in progress)
2016 - now Participant of the SIOP supportive care group
2016 - now Participant of the SIOP low grade glioma working group
2016 - now Participant of the national consortium for Late effects of treatment for childhood thyroid carcinoma ( PI T Links, UMCG)
2016 - now Participant of the consortium of the Dexadagen-2 study
2015 - now Participant of the Dutch Growth Hormone Advisory board (SEK)
2015 - now Consultative function for the “Cyberpoli” for thyroid diseases and craniopharyngioma(www.cyberpoli.nl)
2015 – now Participant of the SKION LATER Recommendations for screening Childhood Cancer Survivors https://www.skion.nl/workspace/uploads/vertaling-richtlijn-LATER-versie-final-okt-2014_2.pdf
Fellowship and Awards
2019 KIKA project: THYRO-Dynamics Study (Prospective study on thyroid function during treatment with chemotherapy in 600 children)
2019 Princess Maxima Grant; research grant for 4-year PhD student: “Building an organoid model for craniopharyngioma”
2009-2011 Fellowship kinderendocrinologie in het Emma Kinderziekenhuis AMC
Research Output (74)
Leydig Cell Function in Male Survivors of Childhood Cancer:A Report From the St Jude Lifetime Cohort Study
Chemaitilly Wassim, Liu Qi, van Iersel Laura, Ness Kirsten K., Li Zhenghong, Wilson Carmen L., Brinkman Tara M., Klosky James L., Barnes Nicole, Clark Karen L., Howell Rebecca M., Smith Susan A., Krasin Matthew J., Metzger Monika L., Armstrong Gregory T., Bishop Michael W., van Santen Hanneke M., Pui Ching Hon, Srivastava Deo Kumar, Yasui Yutaka, Hudson Melissa M., Robison Leslie L., Green Daniel M., Sklar Charles A. 26 sep 2019, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37 , p. 3018-3031 14 p.
Hypothyroidism (HT) after Radiotherapy (RT) in Children: Initial Results of Thyroid Gland Dose-Response Relationship from the Pediatric Normal Tissue Effects in the Clinic (PENTEC) Initiative
Vogelius Ivan, Vargo John Austin, Ronckers C. M., Yorke E.D., Kremer L.C., Chafe S.M.J.M.J., van Santen HM, Bentzen S.M., Constine Louis S, Milano M.T. 1 sep 2019, In: International Journal of Radiation Oncology Biology Physics. 105 , p. S81-S81
Hypothalamic-Pituitary Disorders in Childhood Cancer Survivors:Prevalence, Risk Factors and Long-Term Health Outcomes
van Iersel Laura, Li Zhenghong, Srivastava Deo Kumar, Brinkman Tara M., Bjornard Kari L., Wilson Carmen L., Green Daniel M., Merchant Thomas E., Pui Ching Hon, Howell Rebecca M., Smith Susan A., Armstrong Gregory T., Hudson Melissa M., Robison Leslie L., Ness Kirsten K., Gajjar Amar, Krull Kevin R., Sklar Charles A., van Santen Hanneke M., Chemaitilly Wassim 2 aug 2019, In: The Journal of clinical endocrinology and metabolism. 104 , p. 6101-6115 15 p.
Clinical Importance of Free Thyroxine Concentration Decline after Radiotherapy for Pediatric and Adolescent Brain Tumors
Van Iersel Laura, Xu Jiahui, Potter Brian S., Conklin Heather M., Zhang Hui, Chemaitilly Wassim, Van Santen Hanneke M., Merchant Thomas E. 7 jun 2019, In: The Journal of clinical endocrinology and metabolism. 104 , p. 4998-5007 10 p.
Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors among Long-term Survivors of Childhood Cancer
Kok Judith L., Teepen Jop C., Van Der Pal Helena J., Van Leeuwen Flora E., Tissing Wim J.E., Neggers Sebastian J.C.M.M., Loonen Jacqueline J., Louwerens Marloes, Versluys Birgitta, Van Den Heuvel-Eibrink Marry M., Van Dulmen-Den Broeder Eline, Jaspers Monique M.W., Van Santen Hanneke M., Van Der Heiden-Van Der Loo Margriet, Janssens Geert O., Maduro John H., Bruggink Annette H., Jongmans Marjolijn C., Kremer Leontien C.M., Ronckers Cécile M. 1 mei 2019, In: JAMA Oncology. 5 , p. 671-680 10 p.
Body Mass Index at Diagnosis and Hypothalamic-Pituitary Dysfunction during Follow-Up in Childhood Brain Tumor Survivors
van Roessel Ichelle, van Iersel L, Schouten-van Meeteren Antoinette Y. N., Clement SC, Boot Annemieke M, Claahsen-van der Grinten Hedi L, Granzen Bernd, Han KS, Janssens GORJ, Michiels Erna M., van Trotsenburg A. S. Paul, Vandertop W. P., van Vuurden Dannis G, Kremer Leontien C M, van Santen HM 30 apr 2019, 1 p.
BMI at diagnosis and Hypothalamic-Pituitary dysfunction during follow-up in Childhood Brain Tumor Survivors
van Roessel Ichelle, van Iersel Laura, Schouten-van Meeteren Antoinette Y. N., Clement Sarah C, Boot Annemieke M, Claahsen-van der Grinten Hedi L, Granzen Bernd, Han KS, Janssens GORJ, Michiels Erna M., van Trotsenburg A. S. Paul, Vandertop W. Peter, van Vuurden Dannis G, Kremer Leontien C M, van Santen HM 23 mrt 2019,
Hypothalamic-Pituitary Disorders after Conformal Radiation Therapy for Childhood and Young Adult Low-Grade Glioma or Ependymoma
van Iersel L, van Santen HM, Potter Brian, Li Zhenghong, Conklin Heather M., Zhang Hui Z., Chemaitilly Wassim, Merchant Thomas E. mrt 2019, 1 p.
Radiological alterations of the hypothalamic-pituitary region after craniospinal irradiation for medulloblastoma during childhood
van Ommen CCN, van Iersel L, Lequin MH, Clement S., Janssens G.O., Boot Annemieke M, Caron Huib N., Claahsen-van der Grinten Hedi L, Granzen Bernd, Han KS, Michiels Erna M., van Trotsenburg A. S. Paul, Vandertop W. Peter, van Vuurden Dannis G, Schouten-van Meeteren Annetteke Y N, van Santen HM, Kremer Leontine C M mrt 2019, 1 p.
Long-term effects of radioiodine treatment on salivary gland function in adult survivors of pediatric differentiated thyroid carcinoma
Selvakumar Tharsana, Nies Marloes, Klein Hesselink Mariëlle S., Brouwers Adrienne H., Van Der Horst-Schrivers Anouk N.A., Klein Hesselink Esther N., Tissing Wim J.E., Vissink Arjan, Links Thera P., Bocca Gianni, Burgerhof Johannes G.M., Van Dam Eveline W.C.M., Havekes Bas, Van Den Heuvel-Eibrink Marry M., Corssmit Eleonora P.M., Kremer Leontine C.M., Netea-Maier Romana T., Van Der Pal Heleen J.H., Peeters Robin P., Smit Johannes W.A., Plukker John T.M., Ronckers Cecile M., Van Santen Hanneke M., 1 feb 2019, In: Journal of Nuclear Medicine. 60 , p. 172-177 6 p.