prof. dr. F. (Femke) van Wijk
Full Professor
- Laboratory for Translational Immunology (LTI)
Contact
Biography
Femke van Wijk obtained her PhD on mechanisms of oral tolerance and allergic sensitization to peanut at the Utrecht University in 2006. After her first postdoctoral training in human immunology in the lab of Prof Prakken she obtained a KNAW fellowship for a 2-year postdoc in the lab of Dr. Cheroutre in the La Jolla Institute for Allergy and Immunology in San Diego. In this basic immunology institute she worked on T cell plasticity and tissue-controlled T cell differentiation. After being awarded a VENI fellowship in 2010, she moved to the UMC Utrecht to further develop her research program in translational immunology. For her research on how antigen presenting cells sabotage T cell regulation in inflammation van Wijk was awarded a VIDI grant (2014) and starting 2015 she has been appointed Associate Professor. Her research is embedded in the Laboratory of Translational Immunology and Pediatric Immunology group and addresses conceptual and mechanistic immunological questions with a strong link to the clinic. She is participating in several worldwide networks including Eureka Institute for Translational Medicine (www.eurekainstitute.org) and Understanding Childhood Arthritis Worldwide Network (www.ucan-u.org) that are aimed at (international) exchanges and training of people, knowledge sharing, and enhancing reproducibility of human data.
Side Activities
Member scientific committee ZonMW Off-road program
Fellowship and Awards
PhD Supervisor (co-promotor) of the year 2017, Graduate School of Life Sciences
Stimulerings Associate Professorship UMCU (2015)
KNAW fellowship Ter Meulen Fund
NWO VIDI (2014)
NWO Veni (2010)
Research Output (73)
Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry
Ariens Lieneke F. M., van der Schaft Jorien, Bakker Daphne S., Balak Deepak, Romeijn Margreet L. E., Kouwenhoven Tessa, Kamsteeg Marijke, Giovannone Barbara, Drylewicz Julia, van Amerongen Cynthia Catalina Aurora, Delemarre Evelien M., Knol Edward F., van Wijk Femke, Nierkens Stefan, Thijs Judith L., Schuttelaar Marie L. A., de Bruin-Weller Marjolein S. 1 jan 2020, In: Allergy. 75 , p. 116-126 11 p.
Endotyping of adult and paediatric atopic dermatitis; is it one disease?
Thijs J., Bakker D., Delemarre E., de Graaf M., Knol E., Drylewicz J., van Wijk F., Nierkens S., de Bruin-Weller M. sep 2019, In: Journal of Investigative Dermatology. 139 , p. S285-S285
The identification of CCL18 as biomarker of disease activity in localized scleroderma
Mertens J. S., de Jong E. M.G.J., van den Hoogen L. L., Wienke J., Thurlings R. M., Seyger M. M.B., Hoppenreijs E. P.A.H., Wijngaarde C. A., van Vlijmen-Willems I. M.J.J., van den Bogaard E., Giovannone B., van Wijk F., van Royen-Kerkhof A., Marut W., Radstake T. R.D. 1 jul 2019, In: Journal of Autoimmunity. 101 , p. 86-93 8 p.
T-Cell Compartmentalization and Functional Adaptation in Autoimmune Inflammation: Lessons From Pediatric Rheumatic Diseases.
Mijnheer Gerdien, van Wijk Femke mei 2019, In: Frontiers in Immunology [E]. 10
Dupilumab:Eerste resultaten vanuit het BioDay-register
Ariëns Lieneke F.M., van der Schaft J., Bakker D. S., Balak D. M.W., Giovannone B., Romeijn M., Kouwenhoven T., Kamsteeg M., Drylewicz J., van Wijk F., Nierkens Stefan, Thijs J. L., Schuttelaar M. L., de Bruin-Weller M. S. 1 apr 2019, In: Nederlands Tijdschrift voor Dermatologie en Venereologie. 29 , p. 29-34 6 p.
Galectin-9 and CXCL10 as biomarkers for disease activity in juvenile dermatomyositis:a longitudinal cohort study and multi-cohort validation
Wienke Judith, Bellutti Enders Felicitas, Lim Johan, Mertens Jorre S., van den Hoogen Luuk L., Wijngaarde Camiel A., Yeo Joo Guan, Meyer Alain, Otten Henny G., Fritsch-Stork Ruth D.E., Kamphuis Sylvia S.M., Hoppenreijs Esther P.A.H., Armbrust Wineke, van den Berg J. Merlijn, Hissink Muller Petra C.E., Tekstra Janneke, Hoogendijk Jessica E., Deakin Claire T., de Jager Wilco, van Roon Joël A.G., van der Pol W. Ludo, Nistala Kiran, Pilkington Clarissa, de Visser Marianne, Arkachaisri Thaschawee, Radstake Timothy R.D.J., van der Kooi Anneke J., Nierkens Stefan, Wedderburn Lucy R., van Royen-Kerkhof Annet, van Wijk Femke 12 mrt 2019, In: Arthritis & Rheumatology. 71 , p. 1377-1390 14 p.
Goblet cell scarcity and conjunctival inflammation during treatment with dupilumab in patients with atopic dermatitis
Bakker D S, Ariens L F M, van Luijk C, van der Schaft J, Thijs J L, Schuttelaar M L A, van Wijk F, Knol E F, Balak D M W, van Dijk M R, de Bruin-Weller M S 30 dec 2018, In: British Journal of Dermatology. 180 , p. 1248-1249 2 p.
Systemic and Tissue Inflammation in Juvenile Dermatomyositis:From Pathogenesis to the Quest for Monitoring Tools
Wienke Judith, Deakin Claire T., Wedderburn Lucy R., van Wijk Femke, van Royen-Kerkhof Annet 18 dec 2018, In: Frontiers in Immunology. 9
PD-1<sup>+</sup>CD8<sup>+</sup> T cells are clonally expanding effectors in human chronic inflammation
Petrelli Alessandra, Mijnheer Gerdien, Hoytema Van Konijnenburg David P., Van Der Wal Maria M., Giovannone Barbara, Mocholi Enric, Vazirpanah Nadia, Broen Jasper C., Hijnen Dirkjan, Oldenburg Bas, Coffer Paul J., Vastert Sebastian J., Prakken Berent J., Spierings Eric, Pandit Aridaman, Mokry Michal, Van Wijk Femke 1 okt 2018, In: Journal of Clinical Investigation. 128 , p. 4669-4681 13 p.
The elusive case of human intraepithelial T cells in gut homeostasis and inflammation
Lutter Lisanne, Hoytema van Konijnenburg David P., Brand Eelco C., Oldenburg Bas, van Wijk Femke 1 okt 2018, In: Nature Reviews. Gastroenterology & Hepatology. 15 , p. 637-649 13 p.