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prof. dr. F. (Femke) van Wijk

prof. dr. F. (Femke) van Wijk

Full Professor
prof. dr. F. (Femke) van Wijk
  • Center for Translational Immunology (CTI) Research

Biography

Biography

Dr. van Wijk obtained her PhD on mechanisms of oral tolerance and allergic sensitization to peanut at the Utrecht University in 2006. After her first postdoctoral training in human immunology in the lab of Prof. B. Prakken at the UMCU she obtained a KNAW fellowship for a 2-year postdoc in the lab of Prof. H. Cheroutre in the La Jolla Institute for Immunology in La Jolla (USA) to work on tissue T cell adaptation . After being awarded a VENI personal fellowship, she moved to the UMCU to start her own research group. For her research on how antigen presenting cells sabotage T cell regulation in local inflammation van Wijk was awarded a prestigious ZonMw VIDI career development grant (2014), and in 2021 she received a ZonMw VICI grant for her work on naïve T cell imprinting and immune development. Her research program aims to elucidate tissue T cell responses in health and inflammation and to translate these insights into tools for (pre-clinical) disease monitoring and therapeutic targeting in chronic inflammatory diseases.  She takes a disease- and age-overarching approach to decipher common and specific pathogenic processes underlying different inflammatory conditions and one of her specific interests is early imprinting of disease. Diseases her group is working on include atopic dermatitis, inflammatory bowel disease, juvenile idiopathic arthritis, juvenile dermatomyositis and immune toxicity following immune therapy in cancer.

 Dr. van Wijk is the author of 85 publications in leading peer-reviewed journals and has extensive experience with national and international scientific advisory committees (NWO off-road program, samenwerkende gezondheidsfondsen PPS Immunology consortia, Sanofi type 2 innovation grant, EU Horizon 2020 REA-FET-OPEN and COFUND). She is participating in several international networks including T_CELL_CONNECT_EUROPE, Eureka Institute for Translational Medicine, and Understanding Childhood Arthritis Worldwide Network that are aimed at (international) exchanges and training of young scientists, knowledge sharing, and enhancing reproducibility of human data. In 2017 Dr. van Wijk received the PhD supervisor of the year award by the Utrecht University Graduate School of Life Sciences.

Dr. van Wijk is a member of the Utrecht Life Sciences (ULS) Program Board for the domain One Health, and scientific director FOCIS (federation of clinical immunology societies) center of excellence.

Side Activities

Scientific director FOCIS (federation of clinical immunology societies) center of excellence UMC Utrecht. (honorary)

Member Utrecht Life Sciences Program Board, domain One Health (honorary)

Member scientific advisory committee "Samenwerkende Gezondheidsfondsen PPS Immunologie Consortia" (honorary)

Consultant/speaker for Takeda, Johnson&Johnson, Janssen, Sanofi, Regeneron, VC lspvc 

Collaborative research agreements/investigator initiated studies: Takeda, Pfizer, Nutricia, Leo Pharma, BMS, Janssen, Sanofi, and Regeneron.

 

Fellowship and Awards

ZonMw VICI (2021)

PhD Supervisor (co-promotor) of the year 2017, Graduate School of Life Sciences

Stimulerings Associate Professorship UMCU (2015)

ZonMw VIDI (2014)

ZonMw Veni (2010)

KNAW fellowship Ter Meulen Fund (2007)

 

 

Research Output (95)

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Mijnheer Gerdien, Lutter Lisanne, Mokry Michal, van der Wal Marlot, Scholman Rianne, Fleskens Veerle, Pandit Aridaman, Tao Weiyang, Wekking Mark, Vervoort Stephin, Roberts Ceri, Petrelli Alessandra, Peeters Janneke G C, Knijff Marthe, de Roock Sytze, Vastert Sebastiaan, Taams Leonie S, van Loosdregt Jorg, van Wijk Femke dec 2021, In: Nature Communications. 12 , p. 1-16

Unraveling heterogeneity in pediatric atopic dermatitis::identification of serum biomarker based patient clusters

Bakker D., de Graaf M., Nierkens S., Delemarre E., Knol E., van Wijk F., de Bruin-Weller M., Drylewicz J., Thijs J. okt 2021, In: Journal of Investigative Dermatology. 141 , p. S189-S189

Conjunctival inflammation in dupilumab-treated atopic dermatitis comprises a multicellular infiltrate with elevated T1/T17 cytokines:A case series study

Bakker Daphne S., ter Linde José J.M., Amini Mojtaba M., Ariëns Lieneke F.M., van Luijk Chantal M., de Bruin-Weller Marjolein S., Thijs Judith L., Vercoulen Yvonne, van Wijk Femke 4 sep 2021, In: Allergy. 76 , p. 3814-3817 4 p.

Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis

Bakker D S, van der Wal M M, Heeb L E M, Giovannone B, Asamoah M, Delemarre E M, Drylewicz J, Nierkens S, Boyman O, de Bruin-Weller M S, Thijs J L, Wijk F van 18 feb 2021, In: Journal of Investigative Dermatology. 141 , p. 1943-1953.e13

Tissue-Resident Memory T Cells in Chronic Inflammation-Local Cells with Systemic Effects?

Samat Anoushka Ashok Kumar, van der Geest Jolijn, Vastert Sebastiaan J, van Loosdregt Jorg, van Wijk Femke 16 feb 2021, In: Cells. 10 18 p.

Longitudinal analysis of T-cell receptor repertoires reveals persistence of antigen-driven CD4+ and CD8+ T-cell clusters in systemic sclerosis

Servaas N H, Zaaraoui-Boutahar F, Wichers C G K, Ottria A, Chouri E, Affandi A J, Silva-Cardoso S, van der Kroef M, Carvalheiro T, van Wijk F, Radstake T R D J, Andeweg A C, Pandit A feb 2021, In: Journal of Autoimmunity. 117 14 p.

Healthy cotwins share gut microbiome signatures with their inflammatory bowel disease twins and unrelated patients

Brand Eelco C, Klaassen Marjolein A Y, Gacesa Ranko, Vila Arnau Vich, Ghosh Hiren, de Zoete Marcel R, Boomsma Dorret I, Hoentjen Frank, Horjus Talabur Horje Carmen S, van de Meeberg Paul C, Willemsen Gonneke, Fu Jingyuan, Wijmenga Cisca, van Wijk Femke, Zhernakova Alexandra, Oldenburg Bas, Weersma Rinse K, 18 jan 2021, In: Gastroenterology. 160 , p. 1970-1985 16 p.

Homeostatic function and inflammatory activation of ileal CD8+ tissue-resident T cells is dependent on mucosal location

Lutter Lisanne, Roosenboom Britt, Brand Eelco C, Ter Linde José J, Oldenburg Bas, van Lochem Ellen G, Horje Talabur Horjus Carmen S, van Wijk Femke 1 jan 2021, In: Cellular and molecular gastroenterology and hepatology. 12 , p. 1567-1581 15 p.

Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation:A normal response to an abnormal situation

Spijkerman Roy, Bongers Suzanne H., Bindels Bas J.J., Tinnevelt Gerjen H., Giustarini Giulio, Jorritsma Nikita K.N., Buitenwerf Wiebe, van Spengler Daan E.J., Delemarre Eveline M., Nierkens Stefan, van Goor Harriët M.R., Jansen Jeroen J., Vrisekoop Nienke, Hietbrink Falco, Leenen Luke P.H., Kaasjager Karin A.H., Koenderman Leo, Nijdam Thomas M.P., van de Ven Nils L.M., Verhaegh Remi, Spanjaard Judith S., Verboeket Benjamin W., Laane Duco, van Wessem Karlijn, Mulder Eva, Heijerman Harry, Zabaleta Amely Daza, van den bos Frederiek, Stiphout Feikje, Rademaker Emma, Varkila Meri R.J., Mul Nikki d., Cremer Olaf L., Slooter Arjen, Limper Maarten, van Wijk Femke, Pandit Aridaman, Leavis Helen, Jukema Bernard N., Clark Chantal C., Barendrecht Arjan D., Seinen Cor W., Drost-Verhoef Sandra, Smits Simone, Parr Naomi M.J., Sebastian Sylvie A.E., van der Vries Erhard, Maas Coen, Haitjema Saskia, Hoefer Imo E., jan 2021, In: Journal of Leukocyte Biology. 109 , p. 99-114 16 p.

Chronically Activated T-cells Retain Their Inflammatory Properties in Common Variable Immunodeficiency

Berbers Roos-Marijn, van der Wal M Marlot, van Montfrans Joris M, Ellerbroek Pauline M, Dalm Virgil A S H, van Hagen P Martin, Leavis Helen L, van Wijk Femke 2021, In: Journal of Clinical Immunology. 41 , p. 1621-1632 12 p.

All research output

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