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dr. S.J. Vastert

dr. S.J. Vastert

Associate Professor
dr. S.J. Vastert
  • Center for Translational Immunology (CTI) Research
  • Immuno/reuma onderzoek 5

Biography

Biography

Bas is a pediatric rheumatologist in the “EULAR center of excellence in rheumatology" Wilhelmina Children’s Hospital Utrecht. Besides being an esteemed clinician in the field of Pediatric Rheumatology, he has developed into a translational researcher, with a PhD on mechanisms of disease and therapy in severe JIA in 2013. From 2015, he has been starting a translational research group together with Jorg van Loosdregt, molecular biologist. They currently supervise 5 PhD students, 1 post-doc and 2 technicians together, within the Center of Translational Immunology in Utrecht (v Loosdregt-Vastert group). Their labgroup aims to translate cutting edge science into clinical benefit for patients and their research focusses on systemic JIA and on development of novel treatment strategies for JIA. Bas is currently leading a multi-center prospective trial implementing a biomarker driven stop-strategy for rIL-1RA therapy in systemic JIA in the Netherlands (the ESTIS trial).

In addition, as a designated Young Investigator, Bas is the Dutch lead for all translational laboratory studies within UCAN CAN DU (major infrastructural research project 2017-2021 in Canada and the Netherlands).

Key words: Translational research in childhood arthritis, biology of systemic JIA, (regulation of) auto-inflammation, regulation of autoimmune inflammation, epigenetics.

Side Activities

  • member editoreal board van Pediatric Rheumatology Online Journal
  • associate editor Rheumatology

Fellowship and Awards

- 2007: Young investigator Meeting, Pediatric rheumatology European Society: Award for best basic abstract .

- 2014: Wilhelmina Research Fund (co-applicant), € 150 000 : Dissecting the complex role of S100-proteins in systemic juvenile idiopathic arthritis.

- 2015: ZonMW Rational Pharmacotherapy grant, € 340 000 : Biomarker guided treatment and stop strategy for rIL-1RA therapy in systemic JIA.

- 2016-2019: Wilhelmina Kinderziekenhuis Fonds, Rosenberg foundation / Vrienden WKZ (€340 000): Modulation of Treg in JIA by Nicotinamide. Principal Investigator, no overlap.

- 2016-2021: ZonMW grant, Rational Pharmacotherapy for implementation of biomarker guided tapering strategy of rIL-1RA in systemic JIA (€340 000 + €190 000 contribution Sobi). Principal Investigator, clinical trial, no overlap.

- 2017-2021: UCAN CAN DU: (8,0 mln Can$). Canada – Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic diseases. Young Investigator, NL lead for laboratory studies within UCAN CAN DU. (PI: R. Yeung, NM Wulffraat, co-PI JF Swart, S. Benseler).   

 

Research Output (124)

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Mijnheer Gerdien, Lutter Lisanne, Mokry Michal, van der Wal Marlot, Scholman Rianne, Fleskens Veerle, Pandit Aridaman, Tao Weiyang, Wekking Mark, Vervoort Stephin, Roberts Ceri, Petrelli Alessandra, Peeters Janneke G C, Knijff Marthe, de Roock Sytze, Vastert Sebastiaan, Taams Leonie S, van Loosdregt Jorg, van Wijk Femke dec 2021, In: Nature Communications. 12 , p. 1-16

Immunometabolic factors in adolescent chronic disease are associated with Th1 skewing of invariant Natural Killer T cells

Ververs Francesca, Engelen Suzanne, Nuboer Roos, Vastert SJ, van der Ent Kors , van 't Land Belinda, Garssen Johan, Monaco Claudia, Boes Marianne, Schipper Henk 11 okt 2021, In: Scientific Reports. 11 11 p.

Long-term efficacy and safety of canakinumab in patients with mevalonate kinase deficiency:results from the randomised Phase 3 CLUSTER trial

Jeyaratnam Jerold, Simon Anna, Calvo Inmaculada, Constantin Tamas, Shcherbina Anna, Hofer Michael, Gattorno Marco, Martini Alberto, Bader-Meunier Brigitte, Vastert Bas, Levy Jeremy, Dekker Elise, de Benedetti Fabrizio, Frenkel Joost 23 sep 2021, In: Rheumatology (Oxford, England).

Tissue-Resident Memory T Cells in Chronic Inflammation-Local Cells with Systemic Effects?

Samat Anoushka Ashok Kumar, van der Geest Jolijn, Vastert Sebastiaan J, van Loosdregt Jorg, van Wijk Femke 16 feb 2021, In: Cells. 10 18 p.

COMPARTMENTALIZATION, PERSISTENCE AND CONSERVED SHARED MOTIFS OF DOMINANT (REGULATORY) T CELL CLONES IN AUTOIMMUNE INFLAMMATION

Mijnheer G., Servaas N., Lutter L., Leong J. Y., Spierings E., Chen P., Petrelli A., Vastert S., de Boer R., Albani S., van Loosdregt J., Pandit A., van Wijk F. 2021, In: Clinical and Experimental Rheumatology. 39 , p. 1153-1154

Costs of medication use among patients with juvenile idiopathic arthritis in the Dutch healthcare system

Kip Michelle M A, de Roock Sytze, Currie Gillian, Marshall Deborah A, Grazziotin Luiza R, Twilt Marinka, Yeung Rae S M, Benseler Susanne M, Schreijer Maud A, Vastert Sebastiaan J, Wulffraat Nico, van Royen-Kerkhof Annet, Swart Joost F, IJzerman Maarten J 28 dec 2020, In: Expert Review of Pharmacoeconomics and Outcomes Research. 21 , p. 975-984 10 p.

Consensus-based recommendations for the management of juvenile systemic sclerosis

Foeldvari Ivan, Culpo Roberta, Sperotto Francesca, Anton Jordi, Avcin Tadej, Baildam Eileen, Boros Christina, Chaitow Jeffrey, Constantin Tamas, Kasapcopur Ozgur, Knupp Feitosa de Oliveira Sheila, Pilkington Clarissa, Toplak Natasa, van Royen Annet, Saad Magalhaes Claudia, Vastert Sebastiaan J, Wulffraat Nico, Zulian Francesco 4 nov 2020, In: Rheumatology (Oxford, England). 60 , p. 1651-1658 8 p.

How autoinflammation may turn into autoimmune inflammation:Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases

ter Haar N. M., Jansen M. H.A., Frenkel J. F., Vastert S. J. okt 2020, In: Clinical Immunology. 219 8 p.

Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis

Wennink Roos A.W., Pandit Aridaman, Haasnoot Anne Mieke J.W., Hiddingh Sanne, Kalinina Ayuso Viera, Wulffraat Nico M., Vastert Bas J., Radstake Timothy R.D.J., de Boer Joke H., Kuiper Jonas J.W. 17 sep 2020, In: Frontiers in Immunology. 11

Aiming high:quantifying inflammation in systemic onset juvenile idiopathic arthritis (sJIA), a multi-faceted and complex inflammatory disease

Murray Grainne M, Vastert Sebastiaan J, Ramanan Athimalaipet V 26 aug 2020, In: Rheumatology (Oxford, England). 59 , p. 3124-3126 3 p.

All research output

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